Rajiv Dahiya

Rajiv Dahiya
University of the West Indies, St. Augustine | UWI · School of Pharmacy

M.Pharm, Ph.D, D.Sc, FAPP, FICCE

About

98
Publications
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Introduction
Director, School of Pharmacy, The University of the West Indies, St. Augustine, Trinidad & Tobago Principal - Globus College of Pharmacy, Bhopal (MP), India President - Association of Pharmacy Professionals (APP) Editor-in-Chief - Bulletin of Pharmaceutical Research (BPR) Executive Editor - APP Scientific Updates (ASU)
Education
November 2003 - December 2008
UP Technical University, Lucknow (UP) / Rajiv Academy for Pharmacy, Mathura (UP)
Field of study
  • Pharmaceutical Sciences
July 1999 - September 2001
Rajiv Gandhi University of Health Sciences, Karnataka / NGSM Institute of Pharmaceutical Sciences, Mangalore, Karnataka
Field of study
  • Pharmaceutical Chemistry
August 1994 - September 1998
Gulbarga University, Karnataka / SCS College of Pharmacy, Harapanahalli, Karnataka
Field of study
  • Pharmacy

Publications

Publications (98)
Chapter
Dendrimers are unique macromolecules with distinguished structural, physicochemical and biological features that have been explored for diversified biomedical and pharmaceutical applications. Dendrimers are studied for their pulmonary drug delivery potential in treatment of various respiratory and non-respiratory diseases by developing inhalable de...
Article
Aims: The present investigation is targeted toward the synthesis of a novel analogue of a natural peptide of marine origin. Background: Marine sponges are enriched with bioactive secondary metabolites especially circular peptides. Heterocycles are established organic compounds with potential biological value. Taking into consideration the bio-pro...
Article
Background Peptides and peptide-based therapeutics are biomolecules that demarcate a significant chemical space to bridge small molecules with biological therapeutics such as antibodies, recombinant proteins, and protein domains. Introduction Cyclooligopeptides and depsipeptides, particularly cyanobacteria-derived thiazoline-based cyclopolypeptide...
Article
Among peptide‐based drugs, naturally occurring bicyclic compounds have been established as molecules with unique therapeutic potential. The diverse pharmacological activities associated with bicyclic peptides from marine tunicates, sponges, and bacteria render them suitable to be employed as effective surrogate between complex and small therapeutic...
Article
The cyanobacterial oligopeptides are recognized for being highly selective, efficacious and relatively safer compounds with diverse bioactivities. Azoline-based natural compounds consist of heterocycles which are reduced analogs of five-membered heterocyclic azoles. Among other varieties of azoline-based natural compounds, the heteropeptides bearin...
Article
Full-text available
Evidence suggests that stem cells exert regenerative potential via the release of extracellular vesicles. Mesenchymal stem cell extracellular vesicles (MSCEVs) offer therapeutic benefits for various pathophysiological ailments by restoring tissues. Facts suggest that MSCEV action can be potentiated by modifying the mesenchymal stem cells culturing...
Article
Cyclopolypeptides are among the most predominant biomolecules in nature, especially those derived from plant seeds. This category of compounds has gained extraordinary attention due to remarkable variety of structures and valuable biofunctions. These congeners display enormous variation in terms of both structure and function and are the most signi...
Article
The Annona L. is one of the most significant genus of the Annonaceae family due to its widespread medicinal properties. This genus has a variety of active metabolites, including alkaloids, isoquinolines, peptides, acetogenins, lectins, volatile oils etc. Due to the constitution of cyclopeptides with an expanded spectrum of distinctive bioproperties...
Chapter
In recent years, various nanocarriers have gained increasing attention in drug delivery and biomedicine due to their abilities to overcome several challenges of conventional drug delivery including restricted effectiveness, low biodistribution, unwanted side effects, and deficit sensitivity. Among various nanocarriers, self-assembling nanostructure...
Article
Full-text available
Peptides are distinctive biomacromolecules that demonstrate potential cytotoxicity and diversified bioactivities against a variety of microorganisms including bacteria, mycobacteria, and fungi via their unique mechanisms of action. Among broad-ranging pharmacologically active peptides, natural marine-originated thiazole-based oligopeptides possess...
Article
Full-text available
A new bioactive proline-rich cyclohexapeptide - diandrine C (6), previously isolated from whole plant of Drymaria diandra (Caryophyllaceae), was synthesized through coupling reactions of tetrapeptide unit Boc-Gly--Pro--Tyr--Trp-OH with dipeptide unit -Pro-Gly-OMe using N,N-diisopropylcarbodiimide (DIPC) as the coupling agent, followed by cyclizatio...
Article
Full-text available
An N-methylated analog of a marine bacteria-derived natural proline-rich tetracyclopeptide was synthesized by coupling the deprotected dipeptide fragments Boc-l-prolyl-l-N-methylleucine-OH and l-prolyl-l-N-methylphenylalanine-OMe. A coupling reaction was accomplished utilizing N,N′-Dicyclohexylcarbodidimde (DCC) and 1-Ethyl-3-(3-dimethylaminopropyl...
Chapter
The delivery of protein and peptide therapeutics through ocular route requires considerable knowledge and understanding about eye’s anatomy and physiology. Although this delivery route has high potency and specificity, it exhibits difficulty in absorption through barriers resulting in lower bioavailability as well as crucial stability issues. Due t...
Article
Full-text available
The synthesis of a proline-rich cyclic heptapeptide, fanlizhicyclopeptide A (8), previously isolated from the fruits of Annona squamosa (sugar-apples), is described via coupling of tetrapeptide -prolyl--tyrosyl--leucyl--proline methyl ester with tripeptide Boc-glycyl--valyl--proline followed by cyclization of the linear fragment having seven amino...
Article
Full-text available
The present investigation reports the synthesis of a phenylalanine-rich N-methylated cyclopeptide, cordyheptapeptide A (8), previously isolated from the insect pathogenic fungus Cordyceps sp. BCC 1788, accomplished through the coupling of N-methylated tetrapeptide and tripeptide fragments followed by cyclization of the linear heptapeptide unit. Str...
Article
A cyclopentapeptide, fanlizhicyclopeptide B, previously isolated from the fruits of Annona squamosa, was synthesized via coupling of dipeptide l-Isoleucyl-l-Tyrosyl methyl ester with tripeptide Boc-l-Alanyl-Glycyl-l-Proline followed by cyclization of the linear pentapeptide fragment. Structure of the synthesized cyclooligopeptide was confirmed usin...
Article
Full-text available
A natural heptacyclopeptide, stylissamide G (7), previously isolated from the Bahamian marine sponge Stylissa caribica from the Caribbean Sea, was synthesized via coupling of the tetrapeptide l-phenylalanyl-l-prolyl-l-phenylalanyl-l-proline methyl ester with the tripeptide Boc-l-leucyl-l-isoleucyl-l-proline, followed by cyclization of the linear he...
Article
Aims: A simple, selective, rapid and precise stability indicating HPTLC method was developed for the quantitative estimation of Risperidone in tablet dosage form and validated. Study design: The method was performed by using of HPTLC plates (Merck) pre-coated with silica gel 60F-254 on aluminium sheets and a mobile phase comprising of Acetonitrile...
Article
Peptides have gained increased interest as therapeutics during recent years. More than 60 peptide drugs have reached the market for the benefit of patients and several hundreds of novel therapeutic peptides are in preclinical and clinical development. The key contributor to this success is the potent and specific, yet safe, mode of action of peptid...
Article
Synthesis of a natural glycine-rich heptacyclopeptide - mahafacyclin A (7) was accomplished by solution-phase technique of peptide synthesis via coupling of tetrapeptide unit Boc-L-Thr-L-Ile-L-Leu-Gly-OH with tripeptide unit L-Val-L-Phe-Gly-OMe followed by cyclization of linear heptapeptide fragment. Structure of the newly synthesized cyclopolypept...
Conference Paper
Full-text available
A simple, sensitive, precise, accurate and specific high performance thin layer chromatographic (HPTLC) method has been developed and validated for estimation of risperidone in solid dosage form. The stationary phase used was precoated silica gel 60F254 plate. The mobile phase used was acetonitrile: triethylamine (5:0.2 v/v). The detection of spots...
Article
Full-text available
A novel series of 4-[2-(3-bromophenyl)-7-nitro-4-oxo-3,4-dihydro-3-quinazolinyl]benzoyl amino acids and di/tripeptides was synthesized using diisopropylcarbodiimide (DIPC) as the coupling agent and N-methylmorpholine (NMM) as the base. Structures of all the newly synthesized peptide analogs were elucidated using IR, 1H/13C NMR, MS spectral data and...
Article
Full-text available
In past years, a lot of naturally occurring cyclopeptide antibiotics have been discovered based on their ability to inhibit the growth of microbial pathogens. These antimicrobial peptides participate in the innate immune response by providing a rapid first-line defence against infection. Among these, cyclopeptides especially large depsipeptides hav...
Article
Full-text available
The primary focus of the profession of pharmacy, the world over, has shifted from a technical, product-oriented to patient-oriented, professional service. Unfortunately, despite India excelling in all other industries, the health care industry has been very slow on the uptake of pharmacist as an integral tool in improving health services. Hence, th...
Article
Full-text available
In present study, a novel series of trisubstituted phenoxyacetyl amino acids and peptide derivatives was synthesized by coupling 2-(2,6-dibromo-4-formylphenoxy)acetic acid with amino acid methyl ester hydrochlorides/peptide methyl esters using DIPC as coupling agent and TEA as base. The structures were elucidated by IR, 1H NMR, 13C NMR and MS spect...
Article
A natural proline-rich tetrapeptide cyclo-(prolyl-leucyl-prolyl-phenylalanyl) was prepared employing solution-phase method of peptide synthesis through coupling of dipeptide fragments Boc-L-Pro-L-Leu-OH and L-Pro-L-Phe-OMe utilizing diisopropylcarbodiimide (DIPC) as coupling agent and N-methylmorpholine (NMM) as the base. Deprotection of linear tet...
Article
Full-text available
In present study, it was of interest to synthesize a natural proline-rich cyclooligopeptide - cyclomontanin D (8) by coupling of tripeptide Boc-L-Asn(bzh)-L-Pro-Gly-OH and tetrapeptide L-Leu-L-Pro-L-Tyr-L-Ala-OMe followed by cyclization of linear polypeptide fragment. Structure of synthesized cyclopeptide was confirmed by detailed spectral analysis...
Article
Full-text available
A natural phenylalanine-rich cyclic peptide - cordyheptapeptide B was synthesized by coupling of N-methylated tetrapeptide and tripeptide units after proper deprotection at carboxyl and amino terminals followed by cyclization of linear heptapeptide fragment. Required tetrapeptide and tripeptide units were prepared by coupling of Boc-protected dipep...
Article
Full-text available
The first synthesis of a naturally occurring tetrapeptide cyclo-(isoleucyl-prolyl-leucyl-alanyl) has been achieved using a solution-phase technique via coupling of dipeptide segments Boc-L-Pro-L-Leu-OH and L-Ala-L-Ile-OMe. Deprotection of the linear tetrapeptide unit and its subsequent cyclization gave a cyclopeptide, identical in all aspects to th...
Article
Full-text available
Present study deals with synthesis of a novel proline-rich cyclopeptide - gypsin B 7 via coupling of tripeptide units Boc-L-Tyr-L-Phe-L-Pro-OH and Gly-L-Leu-L-Pro-OMe utilizing two different carbodiimides, followed by cyclization of linear polypeptide fragment. Structure elucidation of newly synthesized peptide was done on basis of FT-IR, 1H-NMR, 1...
Article
Full-text available
The present study deals with the first total synthesis of the proline-rich cyclopolypeptide stylisin 2 via a solution phase technique by coupling of the Boc-L-Pro-L-Ile-L-Pro-OH tripeptide unit with the L-Phe-L-Pro-L-Pro-L-Tyr-OMe tetrapeptide unit, followed by cyclization of the resulting linear heptapeptide fragment. The chemical structure of the...
Article
Full-text available
In this investigation, it was of interest to synthesize novel series of peptide analogs of 3-bromocoumarins and 2-methylimidazoles. Substituted coumarinyl-oxyacetic acids 1, 2 were synthesized by alkylation of corresponding hydroxycoumarins with chloroacetic acid. The imidazolyl derivatives 13, 14 were prepared by interaction of 2-methylimidazole w...
Article
Present investigation comprises of synthesis of a novel glycine and serine-rich cyclopeptide - gypsin D 8 via coupling of tripeptide unit Boc-L-Trp-L-Pro-Gly-OH and tetrapeptide unit Gly-L-Ser-L-Ser-L-Leu-OMe utilizing dicyclohexylcarbodiimide (DCC) as coupling agent, followed by cyclization of linear heptapeptide fragment. Structure elucidation of...
Article
Full-text available
The present investigation deals with the synthesis of a N-methylated cyclotetrapeptide, hirsutide (2), by coupling of the dipeptide units Boc-L-phenylalanyl-L-N-methylphenylalanine-OH and L-valyl-L-N-methylphenylalanine-OMe followed by cyclization of the linear tetrapeptide fragment. The chemical structure was established on the basis of analytical...
Article
Full-text available
The prodrugs designed by classical approach increase lipophilicity of the drug, which decreases the water solubility thus decreasing the concentration gradient, which controls drug absorption. To overcome the limitations of traditional prodrug approach, water soluble prodrugs can be designed by adding selected amino acid to the drug moiety that are...
Article
Present study describes the first total synthesis of a cyclic heptapeptide, stylisin 1 (8) via coupling of tetrapeptide Boc-L-tyrosinyl-L-prolyl-L-leucyl-L-proline-OH and tripeptide L-phenylalanyl-L-isoleucyl-L-proline-OMe followed by cyclization of linear heptapeptide segment. Structure elucidation of synthesized cyclopeptide was done on basis of...
Article
Full-text available
The first total synthesis of annomuricatin B (8) is described via coupling of the tripeptide Boc-L-asparaginyl(benzhydryl)-L-alanyl-L-tryptophan-OH and the tetrapeptide L-leucyl-glycyl-L-thryl-L-proline-OMe followed by cyclization of the linear heptapeptide fragment. On pharmacological investigation, it was observed that the cycloheptapeptide 8 dis...
Article
Full-text available
Present study describes the synthesis of a novel series of 3,5-diiodo-4-(5-nitro-1H-2-imidazolyl)benzoyl amino acids and di/tri/tetrapeptides using diisopropylcarbodiimide/dicyclohexylcarbodiimide (DIPC/DCC) as coupling agents and N-methylmorpholine/triethylamine (NMM/TEA) as bases. Structure elucidation of all the newly synthesized compounds was d...
Article
Full-text available
Plant-originated cyclopolypeptide (XIII) was synthesized by coupling of dipeptide Boc-l-asn(bzh)-l-phe-OH and tetrapeptide gly-l-leu-l-ala-l-tyr-OMe followed by cyclization of a linear hexapeptide segment. Structure elucidation of XIII was done on basis of detailed spectral analysis including FTIR, 1H NMR, 13C NMR, FAB MS and elemental analysis. Fr...
Article
Present work reports the first total synthesis of a phenylalanine and glycine-rich cyclopolypeptide podacycline B by coupling of tripeptide Boc-L-phe-gly-L-phe-OH and tetrapeptide L-ala-gly-L-thr-L-ile-OMe followed by cyclization of linear heptapeptide segment. The chemical structure of the compound was elucidated by FTIR, 1H NMR, 13C NMR, FAB MS s...
Article
A novel series of 2,3-diphenyl-6-quinoxalinoyl amino acids and peptides was synthesized by using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and diisopropylcarbodiimide (EDC.HCl/DIPC) as coupling agents and N-methylmorpholine (NMM) as base. The chemical structures of the newly synthesized compounds were established on basis of IR,...
Article
Synthesis of a novel phenylalanine-rich cyclopeptide - delavayin B (12) was accomplished by coupling of dipeptide Boc-L-ser-L-ile-OH and tetrapeptide L-phe-L-phe-L-ala-gly-OMe followed by cyclization of linear hexapeptide fragment. Structure elucidation of newly synthesized peptide was done on basis of FT-IR, 1H-NMIR, 13C-NMR, FABMS and elemental a...
Article
The present work reports the synthesis of a plant-originated cyclooctapeptide--psammosilenin A 8--by cyclization of linear peptide fragment phe-pro-phe-phe-ala-pro-leu-pro-Opfp which was prepared by coupling of tetrapeptide units Boc-phe-pro-phe-phe-OH and ala-pro-leu-pro-OMe followed by proper deprotection of terminal groups and activation of the...
Article
The present investigation describes the synthesis of a novel series of methylimidazolopeptides via interaction of 2-methylimidazole with diazotized p-aminobenzoic acid in the presence of aqueous cupric chloride, using diisopropylcarbodiimide as a coupling agent and N-methylmorpholine as a base. Characterization of all the newly synthesized compound...
Article
A novel series of 2-(4-bromo-2-formyl-phenoxy)acetyl amino acid and peptide analogs was synthesized by the coupling of 2-(4-bromo-2-formyl-phenoxy)acetic acid with different amino acid methyl ester hydrochlorides, dipeptide and tripeptide methyl esters using dicyclohexylcarbodiimide as the coupling agent and N-methylmorpholine as the base. Structur...
Article
A novel series of 1,2,5-trisubstituted benzimidazole derivatives was synthesized by coupling 2-mercapto-5-methoxybenzimidazol-1-acetic acid with several amino acid methyl ester hydrochlorides/dipeptides/tripeptides using dicyclohexylcarbodiimide (DCC) as the coupling agent and triethylamine (TEA) as the base. All newly synthesized compounds were ch...
Article
A natural cyclic peptide previously isolated from Citrus medica was synthesized by coupling of tetrapeptide units Boc-Leu-Pro-Trp-Leu-OMe and Boc-Ile-Ala-Ala-Gly-OMe after proper deprotection at carboxyl and amino terminals followed by cyclization of linear octapeptide segment. Solution phase technique was adopted for the synthesis of cyclooctapept...
Article
A natural cyclic octapeptide cherimolacyclopeptide G (8) was synthesized by coupling of tetrapeptide units Boc-Gly-Ala-Val-Pro-OMe (5) and Boc-Ile-Tyr-Ala-Pro-OMe (6) after proper deprotection at carboxyl and amino terminals followed by cyclization of the linear peptide segment. The structure was elucidated by IR, 1H-NMR, 13C-NMR, FAB MS spectral d...
Article
Full-text available
Two substituted quinazolinyl/imidazolyl-salicylic acids 5, 6 were synthesized by the reaction of 6-iodo-2-methylbenzoxazin-4-one/5-nitroimidazole with 5-aminosalicylic acid (5-ASA). Coupling of compounds 5 and 6 with different amino acid ester hydrochlorides, dipeptide and tripeptide methyl esters yielded novel quinazolino/imidazolopeptide derivati...
Article
In present study, a natural phenylalanine-rich cycloheptapeptide segetalin C (compound VIII) was synthesized by coupling and cyclization of peptide units Boc-gly-L-leu-L-his-OH and L-Phe-L-alaL-phe-L-pro-OMe and examined for different bioactivities. The structure of compound VIII was elucidated by IR, 1H NMR, 13C NMR, mass spectral data and element...
Article
Plant-originated cyclopolypeptide (XIII) was synthesized by coupling of dipeptide Boc-L-asn(bzh)-L-phe-OH and tetrapeptide gly-L-leu-L-ala-L-tyr-OMe followed by cyclization of a linear hexapeptide segment. Structure elucidation of XIII was done on basis of detailed spectral analysis including FTIR, 1H NMR, 13C NMR, FAB MS and elemental analysis. Fr...
Article
A novel series of 3,5-diiodo-4-(2-methyl-1H-imidazol-5-yl)benzoic acid analogs of amino acids, dipeptides and tripeptides was synthesized by using dicyclohexylcarbodiimide and diisopropylcarbodiimide (DCC/DIPC) as coupling agents and triethylamine (TEA) as base. Structures of all the newly synthesized compounds were confirmed by elemental analysis...
Article
A novel series of 3,5-diiodo-4-(2-methyl-1H-imidazol-5-yl)benzoic acid analogs of amino acids, dipeptides and tripeptides was synthesized by using dicyclohexylcarbodiimide and diisopropylcarbodiimide (DCC/DIPC) as coupling agents and triethylamine (TEA) as base. Structures of all the newly synthesized compounds were confirmed by elemental analysis...
Article
A novel series of 1,2-disubstituted benzimidazole derivatives was synthesized by coupling 2-mercaptobenzimidazol-1-acetic acid with various amino acid methyl ester hydrochlorides/dipeptides/tripeptides using dicyclohexylcarbodilmide as the coupling agent and triethylamine as the base. All newly synthesized compounds were characterized by spectral a...
Article
Present investigation describes the first total synthesis of a proline-rich cyclic peptide segetalin E (8) by solution phase technique. The chemical structure of the compound was elucidated by FT-IR, 1H-NMR, 13C-NMR, FAB-MS spectral data and elemental analyses. The newly synthesized peptide was subjected to pharmacological screening and found to ex...
Article
Full-text available
A natural cyclic heptapeptide segetalin D [VIII] was synthesized by coupling of tripeptide unit Boc-Pro-Gly-Leu-OMe [V] with tetrapeptide unit Boc-Ser-Phe-Ala-Phe-OMe [VI] after proper deprotection at carboxyl and amino ends followed by cyclization of linear peptide segment. Structure of VIII was confirmed by spectral and elemental analyses. The ne...
Article
Full-text available
Present investigation describes the synthesis of a natural phenylalanine-rich cyclopolypeptide longicalycinin A (10) by coupling of dipeptide unit Boc-L-phe-L-tyr-OH with tripeptide unit L-pro-L-phe-gly-OMe followed by cyclization of linear segment. Synthesized cyclic pentapeptide was characterized by spectral techniques including FTIR, 1H/13C NMR,...
Article
Full-text available
The synthesis of a natural cyclic peptide cherimolacyclopeptide E (12) by coupling of tripeptide units Boc-gly-leu-gly-OCH3 (9) and Boc-phe-tyr-pro-OCH3 (10) after proper deprotection at carboxyl and amino terminals followed by cyclization of linear hexapeptide segment, is described. Structure elucidation of the cyclopeptide 12 is based on detailed...
Article
A simple, sensitive and reproducible spectrophotometric method was developed for quantitative determination of tizanidine hydrochloride in bulk and pharmaceutical formulations, using factorial design for optimization of reaction parameters. In this method, tizanidine hydrochloride was made to react with p-dimethylaminobenzaldehyde (PDAB) reagent in...
Article
Four substituted benzimidazolyl-benzoic/salicylic acids 5-8 were synthesized by interaction of 5,6-dimethyl-/6-nitrobenzimidazoles with diazotized substituted/unsubstituted aminobenzoic acids in the presence of cupric chloride. The coupling of compounds 5-8 with different amino acid ester hydrochlorides/dipeptide/tripeptide/tetrapeptide methyl este...
Article
Cell death is currrently the subject of considerable research activity. This interest stems from the possibility of exploiting the cell death program for therapeutic purposes. Cell injury can be irreversible or reversible. Apoptosis (pronounced “ay-puh-TOE-sis”) is a reversible pathway of cellular “suicide” which usually takes place by two major ro...
Article
A new potent bioactive cyclic tetrapeptide halolitoralin B (7) has been synthesized by solution phase technique which was previously isolated from the marine sediment-derived bacterial strain Halobacillus litoralis YS3106. The structure of the peptide was characterized by IR, 1H NMR, 13C NMR, FAB MS spectral data as well as elemental analysis. Synt...
Article
Full-text available
A new potent bioactive alanine-rich cyclic hexapeptide halolitoralin A(8), which was previously isolated from the marine sediment-derived bacterial strain Halobacillus litoralis YS3016, has been synthesized by the solution phase technique. All the coupling reactions were performed at room temperature utilizing dicyclohexylcarbodiimide (DCC) as the...
Article
Present investigation describes the synthesis of a novel series of 3,4,5-trisubstitutedphenoxy acetyl amino acids and peptides by coupling the 2-(4-chloro-3,5-dimethylphenoxy)acetic acid with different amino acid methyl ester hydrochlorides/peptide methyl esters using dicyclohexylcarbodiimide (DCC) as the coupling agent and N-methylmorpholine (NMM)...
Article
Full-text available
A new potent bioactive, proline-rich cyclic heptapeptide hymenamide E (13) was synthesized using the solution phase technique by cyclization of the linear peptide Boc-Phe-Pro-Thr-Thr-Pro-Tyr-Phe-OMe (12) after proper deprotection at carboxyl and amino terminals. Linear peptide segment was prepared by coupling the tripeptide unit Boc-Phe-Pro-Thr-OH...
Article
A series of new 2-(2'-isopropyl-5'-methylphenoxy)acetyl amino acids and peptides have been synthesized by coupling the 2-(2'-isopropyl-5'-methylphenoxy)acetic acid with amino acid methyl esters/dipeptides using DCC as coupling agent and TEA as base. The structures were elucidated by elemental analyses as well as FTIR, 1H NMR, 13C NMR and MS spectra...
Article
Fever is the multiphasic response of elevation and decline of the body core temperature regulated by central thermoregulatory mechanisms localized in the preoptic area of the hypothalamus. Fever is a common response to infection throughout the vertebrates, which appears to be induced by a variety of substances such as bacteria, viruses and fungi. T...
Article
A new series of 5-(4-methylcarboxamidophenyl)-2-furoic acid derivatives of amino acids, peptides and their methyl esters was synthesized by using DCC as coupling agent and TEA as base. All the synthesized compounds were characterized by IR, 1H NMR, 13C NMR and MS spectral data as well as elemental analysis and screened for antibacterial and antifun...
Article
Full-text available
A new potent bioactive, proline-rich cyclic heptapeptide hymenamide E (13) was synthesized using the solution phase technique by cyclization of the linear peptide Boc-Phe-Pro-Thr-Thr-Pro-Tyr-Phe-OMe (12) after proper deprotection at carboxyl and amino terminals. Linear peptide segment was prepared by coupling the tripeptide unit Boc-Phe-Pro-Thr-OH...
Article
A series of new 4-[2'-(6'-nitro)benzimidazolyl]benzoyl amino acids and peptides have been synthesized by coupling the 4-[2'-(6'-nitro)benzimidazolyl]benzoic acid with amino acid methyl esters/dipeptides using DCC as the coupling agent. All the synthesized compounds were found to exhibit potent anthelmintic activity along with moderate antimicrobial...
Article
A new series of 6-nitrobenzimidazole derivatives of amino acids and peptides and their methyl esters was synthesized, characterized and evaluated for antimicrobial and anthelmintic activities. Some of the compounds showed highly potent anthelmintic activity as compared to the standard drug.

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