Rajib De

Rajib De
Nilratan Sircar Medical College · Department of Hematology

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52
Publications
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Publications

Publications (52)
Article
Full-text available
Background & objectives: Evaluation of bone marrow infiltration in lymphoma is usually done by bone marrow biopsy (BMB). This study analyzed the utility of 18F-fluorodeoxyglucose positron emission tomography/computerized tomography (18F-FDG PET/CT) to detect bone marrow involvement (BMI) compared to BMB. Methods: Treatment-naïve lymphoma patient...
Article
Full-text available
Purpose: Autologous stem cell transplantation (ASCT) is an established therapy for many hematological diseases. This study assessed the pattern of ASCTs at a tertiary care center and associated factors, including pre-harvest CD34+ stem cell levels, leading to improved engraftment outcomes. Methodology: A retrospective study was conducted in India,...
Chapter
In acquired aplastic anemia (AAA) exogenous antigen initiates the obliteration of hematopoietic stem cells (HSc) instigating excessive secretion of antihematopoietic cytokines. Cytogenetic abnormalities (CAs) are infrequent in AAA. This study emphasized CA and the level of Interleukin-2 in bone marrow plasma (BMP) and peripheral blood plasma (PBP)...
Article
Full-text available
Objectives Myelodysplastic syndrome (MDS) is a group of myeloid neoplasms. The clinical manifestations and treatments vary depending on the subtype and risk stratification of the disease. There is a paucity of data on Indian patients with MDS. This study was undertaken to understand MDS with regard to their clinical presentation, pathological, cyto...
Article
Full-text available
Introduction : Acute leukemia (AL) is among the most common treatable cancers in childhood but many children are forced to abandon therapy. Objective : We have explored reasons for treatment abandonment through this study. Materials and Methods : Retrospective analysis from an ongoing registry data of childhood AL patients, where all newly diagnose...
Article
Objectives To describe the case series of patients with myeloid sarcoma with their clinicopathological characteristics, cytogenetics, molecular markers, prognosis, and outcome. Material and Methods Retrospective retrieval of data of myeloid sarcoma cases in acute myeloid leukemia was done from the electronic health records of our hospital and this...
Article
Introduction Hemoglobin (Hb)-F inducers are known to improve Hb level and transfusion dependence in thalassemia. This pilot study was conducted to assess the efficacy and safety of Hb-F inducer thalidomide compared to hydroxyurea (HU) in Hb E-β thalassemia patients. Methods This was a prospective interventional single-centre study with 45 Hb E-bet...
Article
Full-text available
Purple urine bag syndrome (PUBS) is a rare benign condition seen mainly in elderly female patients who are immobilized or have chronic kidney diseases and have a long-standing urinary catheterization. Very rarely PUBS has been noted in patients with hematological malignancies. Here, we highlight a rare case of a young female patient with Acute Lymp...
Article
Imatinib, the first Tyrosine Kinase Inhibitor (TKI) used for the treatment of chronic myeloid leukaemia (CML) has revolutionized the management by inhibiting BCR-ABL tyrosine kinase. According to earlier reports there are concerns regarding the adverse effect of imatinib on haemostasis by causing platelet dysfunction. Here we studied platelet funct...
Conference Paper
Introduction:Sickle cell disorders were originally found in the African regions, Arabian Peninsula and parts of India. However, in today's age of globalization patients with homozygous or compound heterozygous Sickle cell disorders can be found all over the world. The objective of our study was to assess the distribution and clinical presentation o...
Article
Objectives To investigate the effectiveness of low dose secondary/tertiary prophylaxis in severe Hemophilia A children and determine improvements in their daily life.Methods Thirty Hemophilia A children (≤ 12 y) with factor VIII <2% and less than two joint bleeds without inhibitors, were given prophylaxis with recombinant Fc fusion long acting fact...
Article
Although aplastic anemia has been extensively investigated, little is known about their circulating cytokine pattern. The present study was done to evaluate the severity of the disease with the 3 major anti-hematopoietic cytokines interleukin-2 (IL-2), tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ). This study is ethically cleare...
Article
Full-text available
T-cell non-Hodgkin’s lymphoma (T-NHL) is rare and heterogeneous disease. There is a marked difference in biology, clinical presentation and therapeutic outcomes worldwide. This is a retrospective study from May 2014 to May 2018. Patients with established T-NHL after diagnosis were included, and their clinical presentation and therapeutic outcomes w...
Article
Full-text available
Patients with immune thrombocytopenia (ITP) exhibit striking heterogeneity in bleeding manifestations even at similar platelet counts. We report the prevalence and impact of thrombophilia marker expression in chronic ITP patients. For the present study, patients with chronic ITP were clinically assessed at regular intervals using the bleeding asses...
Article
The current study was conducted to assess response to immunosuppressive therapy (IST) in acquired aplastic anaemia (AA). It was a retrospective and prospective observational study. Patients were diagnosed as per standard international guidelines and IST was started as per standard protocol. Patients were followed up at 3 months and 6 months for ass...
Article
The origin of acquired aplastic anaemia (AAA) is unidentified in maximum cases. AA has long been credited to many aetiological agents e.g. drugs, chemicals and viruses. A case-control study was executed depending on the hypothesis that AA can be triggered by lifestyle, occupational and environmental exposures to certain established/ nonestablished...
Article
Full-text available
Background and Aim: Large number of Haemoglobin E-beta thalassaemia (Hb E/β-thalassaemia) patients show iron overloads and related end-organ damage irrespective of transfusion requirements. The prevalence of hypothyroidism in Indian population is approximately 11%. We studied the relationship between thyroid dysfunction and iron overload in Hb E/β-...
Article
Introduction: β Haemoglobinopathy, is one of the commonest inherited disorders, with a higher prevalence in the eastern part of India. In view of the lack of facilities for allogeneic stem cell transplantation, including financial constraints, this disease is considered to be incurable in this part of India. So, preventing the birth of a symptomati...
Conference Paper
Aims & objective: Management of myeloma has evolved over years with higher response rate and prolonged progression free survival with the advent of novel agents. VTD is a standard induction regimen in myeloma. Newly diagnosed myeloma patient treated with VTD chemotherapy was retrospectively analyzed. The primary end points were depth of response an...
Conference Paper
Background and objective: Evaluation of bone marrow infiltration in lymphoma is usually done by bone marrow biopsy (BMB). PET/CT scan is now routinely done for lymphoma staging. This study analyzed theutility of PET/CT to detect BMI compared to BMB. Material and methods: Newly diagnosed, treatment naive lymphoma cases from January 2017 to July 20...
Article
Full-text available
Background: Burkholderia cepacia, an aerobic gram-negative bacillus, is a frequent colonizer of fluids used in the hospital ward. It poses little risk of infection to healthy people; however it is a known important opportunistic pathogen causing morbidity and mortality due to its intrinsic resistance to most of the antibiotics in hospitalized patie...
Article
Full-text available
Objectives: Interleukin-2 (alias: IL-2, TCGF, Lymphokine), a type of interleukin, is also a potent signalling molecule in the signalling cascade of the immune-mediated activation of T Lymphocytes leading to the destruction of haematopoietic stem cell (HSC) which is the basis of acquired aplastic anaemia (AAA). The objective was to study the associa...
Article
Full-text available
Acquired aplastic anemia (AA) is a bone marrow failure that is associated with auto-immune destruction of hematopoietic stem cells (HSCs). Although somatic mutations have been identified in AA patients, mutations alone would not suffice understanding AA pathophysiology. SWI/SNF is an evolutionarily conserved, multi-subunit, ATP-dependent chromatin...
Article
Full-text available
Objectives: Fanconi anaemia (FA) is a rare inherited bone marrow failure and autosomal recessive blood disorder. FA patients have a higher risk of cancer, including acute myeloid leukaemia and squamous cell carcinoma. Maximum, but not all, affected individuals have one or more somatic abnormalities, including skin, skeletal, genitourinary, gastroin...
Article
Aplastic anaemia, an uncommon hematologic complication, arises from the incidence of bone marrow failure. Universally it has been acknowledged as a deadly blood disorder. Fortunately few years back some specific treatment has been evolved. With the upgradation of the existing knowledge, it is known that stem-cell transplantation and immunosuppressi...
Article
Full-text available
Depending on contemporary treatment approach of aggressive immunosuppression, Aplastic Anemia (AA) is caused by immunological destruction of otherwise normal hematopoietic stem cells. The aim was to summarize the cytogenetic abnormalities in AA patients and the frequency of Fanconi Anemia (FA) in morphologically normal AA patients in eastern India....
Poster
We have been using GIMEMA protocol with All-trans retinoic acid (ATRA)/Arsenic trioxide (ATO) in treating low and intermediate risk APL for the last 2 years. Surprisingly, the two most difficult cases to manage during induction had a body mass index (BMI) of > 30, compared to the 16 cases with BMI< 30, during the same period. A summary of the 18 ne...
Article
Introduction : Fanconi anaemia (FA) is an autosomal recessivedisease, characterized by pancytopenia, bonemarrow failure, congenital malformation (skeletalmalformation, hyperpigmentation, urogenital,renal and cardiac anomalies). FA patients aresusceptible to DNA cross linking agents. Positivestress cytogenetics has implication for thetreatment decis...
Article
Introduction Haemoglobin E-beta-thalassaemia (EBT) represent approximately 50 per cent of those affected with severe beta thalassemia.The highest frequencies are observed in India, Bangladesh and throughout Southeast Asia. Endocrinopathies are now amongst the common complications of thalassaemia and it is multifactorial in origin. Iron overload in...
Article
Introduction Primary immune thrombocytopenia (ITP) is an acquired autoimmune disorder that involves antibody and cell mediated destruction of platelets as well as suppression of their production. Corticosteroids are initial standard therapy in adults. Initially Rituximab (dose375mg/m2) was approved as one of the important second line therapy in chr...
Article
Introduction: Immune suppression is a crucial pillar for treatment of aplastic anemia. Cyclosporine monotherapy is an easily available, affordable therapeutic option with good safety profile. Methods and materials: This prospective study was conducted over a period of 2 years from June 2012 to July 2014. The diagnosis and response to treatment o...
Article
One hundred and fifty four children with ALL who were admitted in our institution from 2007 to 2013, constituted the study cohort. The aim of our study is to analyze the outcome of children up to 18 years age treated with ALL-BFM 90. The outcomes of children with ALL are shown in Figure 1. Mean age was 10.9 ± 5.3 years (range 1.3 to 18 years). Mean...
Article
Full-text available
There is paucity of information from eastern India with regard to observed dominant micro-organisms causing febrile neutropenia (FN) in patients with haematological malignancies. To identify the prevalence of pathogenic microorganisms associated with FN. A total number of 268 episodes of FN were analysed from September’2010 to October’2013. The blo...
Article
Full-text available
The patient presented with the classic triad of HUS. Although the most common cause of HUS in childhood is infection with a Shiga toxin-containing strain of E. coli, such an etiology was unlikely for this patient because of the absence of any suggestive history and a negative stool culture. We therefore considered aHUS, a genetic disorder in which...
Patent
Disclosed herein are methods of diagnosing, monitoring and treating iron disorders using assays of serum ferritin. Some embodiments relate to detection and management of iron and iron-containing proteins in the body. For instance, the level of ferritin may be determined by contacting a sample with one or more magnetic nanoparticles; measuring an ab...
Article
5303 The state of West Bengal in the eastern part of India has a high prevalence of the carrier states of beta thalassemia and Hb E. Analysis of Hb HPLC screening data from 200 individuals, including adults and children from urban areas around Kolkata in West Bengal, carried out in our institution1, reveals a prevalence 6.5% for beta trait and 5.5%...
Conference Paper
Background: Neutropenia, resulting from cytotoxic chemotherapy is the most common risk factor for severe infections in hematological malignancies. Febrile neutropenia during chemotherapy is a medical emergency and early administration of antimicrobial agents is recommended. The pattern of infection in febrile neutropenia is changing – showing a tr...

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