Rajesh RajanIndian Association of Clinical Cardiologists
Rajesh Rajan
Dr. Rajesh Rajan MD, Ph.D, FRCP(Lon), FRCP(Edin), FRCP(Glasg), FRCP(Ire), FESC, FACC, FAHA, FASE
Currently works at Sabah Al-Ahmad Cardiac Center, Al-Amiri Hospital.
About
123
Publications
45,198
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Introduction
Dr. Rajesh Rajan MD,Ph.D, FRCP(Edin),FRCP(Glasg),FRCP(Ire),FESC,FACC,FAHA is the current Chairman – Board of Governors of the Indian Association of Clinical Cardiologists & the President of Association of MD Physicians. He has been the recipient of several distinguished fellowships, including those from the Royal College of Physicians UK, European Society of Cardiology, American College of Cardiology, and American Heart Association.
Dr. Rajan is a board certified cardiologist with more than a decade of experience in general cardiology. He has been in charge of various clinical research registries in heart failure and authored several publications. He serves on the editorial boards of more than 50 cardiology journals. He currently works at Sabah Al-Ahmad Cardiac Center, Al-Amiri Hospital.
Additional affiliations
December 2019 - March 2020
Position
- Editor
Description
- www.onlineacc.org
September 2019 - present
Position
- CEO
Description
- www.accindia.org
August 2019 - present
Education
June 2008 - June 2010
Indira Gandhi National University (IGNOU)
Field of study
- Clinical Cardiology
March 2008 - June 2013
September 2003 - September 2005
Bakulev Scientific Center of Cardiovascular Surgery
Field of study
- Cardiac Surgery
Publications
Publications (123)
Across the world, heart failure is one of the leading cause of frequent hospitalizations.1 The etiology of heart
failure may differ in various ethnic groups,2 and may be due to multiple factors like non-adherence of the patient to medications, endstage heart failure, or a lack of proper follow-up.3 We encounter many ambulatory heart failure patient...
Objective
The purpose of this study was to evaluate the impact of R-heart failure (R-hf) risk score on all-cause mortality in acute heart failure (AHF) patients in the Middle East.
Methods
Data was analyzed from 776 consecutive patients. R-hf risk score were derived by multiplying (eGFR (mL/min), left ventricular ejection fraction (%) and hemoglob...
Background
The aim of this study was to validate R-heart failure (R-hf) risk score in ischemic heart failure patients.
Methods
We prospectively recruited a cohort of 179 ischemic and 107 non-ischemic heart failure patients. This study mainly focused on ischemic heart failure patients. Non-ischemic heart failure patients were included for the purpo...
We recently published a case report in European Heart Journal Case Reports. We proposed a modified version of Lipton’s classification, a new classification for single coronary artery (SCA), named Rajan’s and Kotevski’s TYPE-IV (R-IV-C) modified Lipton’s classification, which we describe in detail.
Background
There is a paucity of data regarding acute myocardial infarction (MI) complicated by cardiogenic shock (AMI-CS) in the Gulf region. This study addressed this knowledge gap by examining patients experiencing AMI-CS in the Gulf region and analyzing hospital and short-term follow-up mortality.
Methods
The Gulf-CS registry included 1,513 pa...
Background
Risk stratification for patients undergoing coronary artery bypass surgery (CABG) for left main coronary artery (LMCA) disease is essential for informed decision-making. This study explored the potential of machine learning (ML) methods to identify key risk factors associated with mortality in this patient group.
Methods
This retrospect...
Background
Heart failure (HF) is a prevalent condition in our society, frequently accompanied by various interacting comorbidities. Among these, brain-related comorbidities such as stroke and transient ischemic attack (TIA) play a crucial role in exacerbating the severity of HF. The relationship between cerebrovascular accidents (CVAs) and HF acros...
A comparison of the recommendations for the diagnosis and treatment of mitral regurgitation (MR), the second-most common valvular heart ailment in high-income countries, from the European Society of Cardiology/European Association for Cardio-Thoracic Surgery 2021 and American College of Cardiology/American Heart Association 2020 guidelines. We syst...
Background
The dimensionless Rajan’s heart failure (R-hf) risk score was proposed to predict all-cause mortality in patients hospitalized with chronic heart failure (HF) and reduced ejection fraction (EF) (HFrEF).
Purpose
To examine the association between the modified R-hf risk score and all-cause mortality in patients with HFrEF.
Methods
Retros...
Background
Chronic kidney disease (CKD) is a common comorbid condition in patients undergoing TAVR. Reported outcome studies on the association of baseline CKD and mortality is currently limited.
Objectives
To determine the prevalence of chronic kidney disease in patients undergoing TAVR and analyse their overall procedural outcomes
Methods
This...
This study aimed to evaluate the clinical outcomes of patients with acute heart failure (AHF) stratified by mitral regurgitation (MR) in the Arabian Gulf. Patients from the Gulf CARE registry were identified from 47 hospitals in seven Arabian Gulf countries (Yemen, Oman, Kuwait, Qatar, Bahrain, the United Arab Emirates, and Saudi Arabia) from Febru...
We report a rare case of arrhythmogenic right ventricular cardiomyopathy (ARVC). Middle aged Kuwaiti gentleman presented to a polyclinic with complaints of dizziness and palpitation. Electrocardiogram (ECG) at polyclinic showed polymorphic ventricular tachycardia (VT) and hence he was referred to our center. ECG at emergency room (ER) showed Brugad...
Background:
Health care resource utilization (HCRU) and costs are important metrics of health care burden, but they have rarely been explored in the setting of cardiac ion channelopathies.
Hypothesis:
This study tested the hypothesis that attendance-related HCRUs and costs differed between patients with Brugada syndrome (BrS) and congenital long...
Aim:
To assess the current dyslipidemia management in the Arabian Gulf region by describing the demographics, study design, and preliminary results of out-patients who achieved low-density lipoprotein cholesterol (LDL-C) goals at the time of the survey.
Background:
The Arabian Gulf population is at high risk for atherosclerotic cardiovascular di...
Objectives:
The Rajan's heart failure (R-hf) score was proposed to aid risk stratification in heart failure patients. The aim of this study was to validate R-hf risk score in patients with acute decompensated heart failure.
Methods:
R-hf risk score is derived from the product estimated glomerular filtration rate (mL/min), left ventricular ejecti...
Background
Anaemia is a multifactorial, pervasive, extra-articular manifestation that is a significant burden in RA. The most common types of anaemia in RA are chronic anaemia and iron-deficiency anaemia. A number of existing studies observed anaemia in 24.0%–70.6% of RA patients.
Objectives
The primary objective of this study was to examine the a...
Cardiac ion channelopathies encompass a set of inherited or acquired conditions that are due to dysfunction in ion channels or their associated proteins, typically in the presence of structurally normal hearts. They are associated with the development of ventricular arrhythmias and sudden cardiac death. The aim of this review is to provide a histor...
Crohn’s disease (CD) and Takayasu arteritis (TA) are distinct clinical entities. The likelihood of both diseases coexisting is low, and although CD co-occurs with all types of vasculitis, TA is the most common subtype. Herein, we report the case of a 31-year-old female who was diagnosed with TA following an initial diagnosis of CD. Coronary angiogr...
Tricuspid regurgitation (TR) is a common finding. Any changes to the components of the tricuspid valve (TV), such as the tricuspid annulus, valve leaflets, papillary muscles, and chordae tendinae can lead to TR. This valvular disease has recently sparked interest after it was long forgotten. This paper examines the anatomy of the TV, etiology of TR...
Introduction
Clinical outcomes after transcatheter aortic valve implantation (TAVI) have not been reported in the Gulf region. This study aims to identify baseline characteristics of patients undergoing TAVI, based on nationality, and analyze their overall outcomes at a single center in Kuwait.
Methods
A retrospective study of 61 patients with sev...
Background: Systemic congestion is the leading pathophysiological mechanism of decompensated heart failure (HF), and hospitalization and poor prognosis. Unfortunately, patients are discharged with residual congestion, possibly due to the lack of a clear strategy for its assessment. The existing criteria for discharge of patients from the hospital a...
Introduction: Healthcare resource utilisation and costs are important metrics of healthcare burden, but they have rarely been explored in the setting of cardiac ion channelopathies.
Purpose: The aim of this study is to compare HCRUs and costs between patients with Brugada syndrome (BrS) and congenital long QT syndrome (LQTS) in a single city of Chi...
Objectives:
Initial reports indicate a high incidence of abnormal aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in patients with COVID-19 and possible association with acute kidney injury (AKI). We aimed to investigate clinical features of elevated transaminases on admission, its association with AKI, and outcomes in p...
Аbstrасt
Objectives
This study aimed to investigate in-hospital mortality rates in patients with coronavirus disease (COVID-19) according to enoxaparin and heparin use.
Methods
This retrospective cohort study included 962 patients admitted to two hospitals in Kuwait with a confirmed diagnosis of COVID-19. Cumulative all-cause mortality rate was t...
Genetic testing is used for the diagnosis and risk stratification of Brugada syndrome (BrS), but few studies have systematically evaluated regional differences and variations of its use worldwide. This study investigated the rates and yields of genetic testing reported by various BrS cohorts. PubMed was searched systematically for cohort studies on...
Background
Electronic frailty indices can be useful surrogate measures of frailty.
Objective
This study is to develop an electronic frailty index that incorporates patient demographics, baseline comorbidities, health-care utilization characteristics, electrocardiographic measurements, and laboratory examinations for predicting all-cause mortality...
The goal of this study was to investigate in-hospital mortality in patients suffering from acute respiratory syndrome coronavirus 2 (SARS-CoV-2) relative to the neutrophil to lymphocyte ratio (NLR) and to determine if there are gender disparities in outcome. Between February 26 and September 8, 2020, patients having SARS-CoV-2 infection were enroll...
The present work deals with the design of a cylinder-piston arrangement to deliver the required tidal volume (TV) of air to the patient through the respiratory tract especially in the setting of severe acute respiratory syndrome corona virus 2 (SARS CoV-2) or corona virus disease (COVID-19). The design ensures that only the desired volume of air is...
Background
Anemia is a prevalent comorbidity in patients undergoing aortic valve replacement.
Objectives
The objectives of this study were to define baseline parameters of patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) to determine procedural risk and mortality outcomes stratified by hemoglobin (...
Background
Clinical outcomes after transcatheter aortic valve implantation (TAVI) patients have not been reported in the Gulf region.
Objectives
To define the baseline electrocardiographic (ECG), echocardiographic, and computed tomographic findings of patients undergoing TAVI and analyze the predictors of developing new-onset persistent left bundl...
Background
The aim of this study was to determine in-hospital mortality in patients presenting with acute respiratory syndrome corona virus 2 (SARS-CoV-2) and to evaluate for any differences in outcome according to sex differences.
Methods
Patients with SRS-CoV-2 infection were recruited into this retrospective cohort study between February 26 and...
Аbstrасt
Objective
To investigate COVID-19 related mоrtаlity according to the use of corticosteroid therapy.
Design
Retrospective cohort study.
Setting
Two tertiary hospitals in Kuwait.
Participants
Overall, 962 patients with confirmed SARS-CoV-2 infection, were stratified according to whether they were treated with corticosteroids (dexamethaso...
Funding Acknowledgements
Type of funding sources: None.
Background
Meditation can induce changes in autonomic balance, which can benefit cardiovascular health. The present meta-analysis evaluated changes in heart rate variability (HRV) in meditators.
Methods
PubMed and Embase were searched for primary prospective studies using the search terms ‘h...
Introduction
To define baseline echocardiographic, electrocardiographic (ECG) and computed tomographic (CT) findings of patients with heart failure undergoing transcatheter aortic valve replacement (TAVR) and analyze their overall procedural outcomes.
Methods
Between 2018 and 2021, patients with severe aortic stenosis (AS) who performed transcathe...
Background
This study investigates in‐hospital mortality amongst patients with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and its relation to serum levels of gamma‐glutamyl transferase (GGT).
Methods
Patients were stratified according to serum levels of gamma‐glutamyl transferase (GGT) (GGT<50 IU/L or GGT≥50 IU/L).
Results
A tot...
Brugada syndrome (BrS) is a rare disorder characterized by coved or saddle-shaped ST-segment elevation in the right precordial leads on the electrocardiogram. Risk stratification in BrS remains challenging. A number of clinical, electrocardiographic, programmed ventricular stimulation and genetic risk factors have been identified as important predi...
As the aging population increases, a concurrent rise in the incidence of aortic stenosis (AS) is projected. Early recognition and diagnosis of AS are cardinal in preventing the progression of the disease into its more fatal effects. Precision in diagnosis and risk stratification is paramount, as therapy can be opted accordingly. Current therapeutic...
Background
Chronic coronary syndrome (CCS) is a recently defined entity that necessitates evaluating individual clinical risk factors in this cohort.
Objective
The objective of the present study was to evaluate patients with CCS and examine their coronary profiles in order to delineate differences between genders.
Methods
A cross-sectional analys...
Objectives
To assess the effectiveness and safety of tocilizumab, a humanised anti‐interleukin‐6 receptor antibody, in the treatment of critical or severe coronavirus disease 2019 (COVID‐19) patients.
Methods
This was a retrospective cohort study of severe or critical COVID‐19 patients (≥18 years) admitted to one hospital in Kuwait. Fifty‐one pati...
Аbstrасt
Introduction
This study aims to investigate in-hоsрitаl mоrtаlity in severe асute resрirаtоry syndrоme соrоnаvirus 2 раtients strаtified by serum ferritin levels.
Methods
Patients were stratified based on ferritin levels (ferritin levels ≤ 1000 or >1000).
Results
Approximately 89% (118) of the patients with ferritin levels > 1000 had pn...
Background:
Lung ultrasound (LUS) is a bedside imaging tool that has proven useful in identifying and assessing the severity of pulmonary pathology. The aim of this study was to determine LUS patterns, their clinical significance, and how they compare to CT findings in hospitalized patients with coronavirus infection.
Methods:
This observational...
Background: The aim of this study was to determine in-hospital mortality in patients presenting with acute respiratory syndrome corona virus 2 (SARS-CoV-2) and to evaluate for any differences in outcome according to gender.
Methods: Patients with SRS-CoV-2 infection were recruited into this retrospective cohort study between February 26 and Septemb...
Аbstrасt
This study is to estimаte in-hоsрitаl mоrtаlity in severe асute resрirаtоry syndrоme соrоnаvirus 2 (SАRS-СоV-2) раtients strаtified by Vitamin-D (Vit-D) levels. Раtients were strаtified ассоrding tо by serum 25-Hydroxy-Vitamin D (25(OH)Vit-D) levels intо twо grоuрs, i.e., 25(OH)Vit-D less thаn 40 nmol/L аnd 25(OH)Vit-D greаter thаn 40 nmol...
Background: The impact of mineralocorticoid receptor antagonist (MRA) use in acute heart failure (AHF) patients in the Middle East is not well studied.
Objective: The objective of this study was to examine the impact of MRA therapy on all-cause mortality in AHF patients in the Middle East stratified by left ventricular ejection fraction.
Methods:...
This study is to estimate in-hospital mortality in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients stratified by hemoglobin (Hb) level. Patients were stratified according to hemoglobin level into two groups, that is, Hb <100 g/L and Hb >100 g/L. A total of 6931 patients were included. Of these, 6377 (92%) patients had hemoglob...
Background: Heart failure (HF) burden in the developing world is not well quantified. Objectives: The objective is to evaluate the demographics and outcomes of acute HF patients with reduced ejection fraction (EF) (<40%) (HFrEF), HF with midrange EF (40%-49%) (HFmrEF) and HF with preserved EF (≥50%) (HFpEF) in the Arabian Gulf. Methods: Gulf CARE r...
Chronic coronary syndrome (CCS) is a newly proposed entity by the European Society of Cardiology that replaces stable coronary artery
disease (CAD), which is defined as a progressive process of plaque accumulation in coronary circulation with associated functional changes. CCS has replaced stable CAD to raise awareness that despite the clinically s...
The scope of this journal will be broadly based in order to realize three objectives. First and foremost the objective is to publish high quality research which deals with problems which are of universal relevance but with greater focus on work targeting locally relevant problems. Secondly, the journal will be a forum for cardiologists and other sp...
Novel Wuhan Coronavirus (COVID-19) induced atypical viral pneumonia was first reported in Wuhan city, China in December 2019. As reported earlier, severe acute respiratory syndrome coronavirus (SARS-CoV) is a milder version of coronavirus with 10% mortality rate whereas Middle East respiratory syndrome coronavirus (MERS-CoV) has a mortality rate of...
Objectives:
We sought to estimate the mortality and morbidity in diabetic acute heart failure (AHF) patients stratified by left ventricular ejection fraction.
Methods:
We analyzed the data of patients with AHF from seven Middle Eastern countries (Bahrain, Oman, Yemen, Kuwait, UAE, Qatar, and Saudi Arabia) from February to November 2012, who were...
In the United States, 30% of cardiovascular disease-related
mortality is due to Tobacco smoking [1]. Electronic (e) cigarettes
have nicotine content ranging between 16 and 24 mg/ml. The adverse
impact of e-cigarettes can affect the respiratory tract, central nervous
system and, immune system [2]. Most of the flavoring chemicals used
in e-cigarettes...
Background and Objectives: The use of digoxin in acute heart failure (AHF) is not without controversy. The aim of this study was to examine the impact of digoxin therapy on all-cause mortality and re-hospitalizations for heart failure (HF) at 3 months and 12 months in AHF patients in the Arabian Gulf stratified by left ventricular ejection fraction...
A 24‑year‑old female presented to the emergency room with sudden‑onset palpitations and shortness of breath for 4 h. We report a rare cause
of anterior fascicular ventricular tachycardia.
Keywords: Anterior fascicular ventricular tachycardia, palpitations, wide QRS complex tachycardia
Aims
The aim of this study is to determine the impact of diabetes mellitus on all‐cause mortality and rehospitalization rates at 3 months and at 1 year in patients admitted with acute heart failure (AHF) stratified by left ventricular ejection fraction (EF).
Methods and results
We analysed consecutive patients admitted to 47 hospitals in seven Mid...
Background
Quadfurcation of single coronary artery (SCA) from the right is an extremely rare anomaly and acute coronary syndrome in such patients is catastrophic.
Case summary
We report a 56-year-old Bangladeshi male who presented with an acute inferior wall ST-elevation myocardial infarction. He was taken to the Cath lab for primary percutaneous...
Objective: We aimed to determine the mortality and re-hospitalization rates in diabetic heart failurepatients with HFrEF, HFmrEF and HFpEF.
Methods: We analysed 5005 patients with acute heart failure (AHF) who were enrolled in Gulf CARE, amultinational registry of patients with HF. We compared the the mortality and re-hospitalization rates in diab...
Objective: The purpose of this study was to describe the clinical characteristics and outcomes of the cardiorenal anemia syndrome (CRAS) patients from the Gulf acute heart failure registry (Gulf CARE) stratified by left ventricular ejection fraction (LVEF) (≤35% vs >35%).
Methods: Data was analyzed from 1,190 consecutive patients admitted to 47 h...
Objective: The purpose of this study was to describe the clinical characteristics and outcomes of the cardiorenal anemia syndrome (CRAS) patients from the Gulf acute heart failure registry (Gulf CARE) stratified by admission diagnosis.
Methods: Data was analyzed from 1,319 consecutive patients admitted to 47 hospitals in 7 Middle Eastern countrie...
A 54-year-old Kuwaiti male presented an inferior wall ST elevation myocardial infarction (STEMI). Clopidogrel 600mg was administered by the first medical contact and Ticagrelor 180 mg with intravenous (IV) glycoprotein IIb/IIIa (GP IIb/IIIa) inhibitor infusion for 24 hours after primary percutaneous intervention. Despite this, several episodes of s...
Atrial fibrillation is the most common arrhythmia in the elderly population and is an important cause of stroke. The role of antiplatelet therapy remains controversial. Treatment with aspirin and clopidogrel significantly reduced the rate of stroke in randomised clinical trials. Dual antiplatelet therapy (DAPT) could be an alternative treatment opt...
Objective: The clinical features, treatment and outcomes in patients with EF ≥40% (HFmrEF/HFpEF) have been shown to vary by geographical region. We aimed to determine the characteristics of HFmrEF/HFpEF in the Arabian Gulf region, which have not been previously reported.
Methods: We analysed the features of 4577 patients with HF who were enrolled...
Aims
This study aims to evaluate the incidence and impact of cardiorenal anaemia syndrome (CRAS) on all‐cause mortality in acute heart failure (AHF) patients stratified by left ventricular ejection fraction (LVEF) status in the Middle East.
Methods and results
Data were analysed from 4934 consecutive patients admitted to 47 hospitals in seven Midd...
Aim
To evaluate the prevalence, clinical associations and outcomes of anemia in patients with chronic heart failure (CHF).
Material and methods
We studied 170 patients with CHF, including 137 males, at the average age of 53.1±12.5 years. Arterial hypertension was present in 56.5% of patients, previous myocardial infarction with ST-segment elevatio...
Background: To Study the coronary artery profile in young Kuwaiti
patients who are using anabolic steroids for bodybuilding.
Subjects and methods: We have done a retrospective analysis of
all young Kuwaiti male patients ≤ 30 years who underwent coronary
angiogram in Sabah Al Ahmed Cardiac Center, Al Amiri Hospital
during the period of 2014 to 2017...
Coronary artery disease is one of the major cause of death in human immunodeficiency virus (HIV) positive patients. It can be due to endothelial dysfunction, hypercoagulability and inflammatory changes associated with HIV and highly active antiretroviral therapy (HAART) induced metabolic complications. This is one of the first reported deferred ste...
Aim:
To study the impact of digoxin in acutely decompensated chronic heart failure (ADCHF).
Subjects & methods:
Data was analyzed from 5005 consecutive patients admitted to 47 hospitals in 7 Middle Eastern countries with AHF from February to November, 2012. Patients were categorized into ADCHF patients off digoxin therapy (A1) and ADCHF patient...