Rajesh S Jadon

• M.Pharm, PhD*
• Jiwaji University

The advances in bionanotechnology have put forward a great opportunity for studying biocompatible, nontoxic, and highly efficient organic and inorganic biomaterials as treatment modalities in various diseases. Gold nanoparticles (NPs) are one such exceptionally versatile bionanotechnological materials that can exhibit different size and shape-depen...

The fundamental goal of creating a drug delivery system is to properly distribute the drug to its intended place while minimizing adverse effects. Many drugs lack the necessary therapeutic efficiency using traditional drug delivery techniques due to a variety of problems such as limited bioavailability, sensitive toxicity, and poor specificity. Nan...

Nail psoriasis is a chronic condition which causes pain and functional impairment; thus, it restricts the activities of daily living and worsens the quality of life. Different chemotherapeutic options are available for treating nail psoriasis such as systemic, intralesional, and topical therapies. However, current chemotherapy suffers from several...

Solid Lipid Nanoparticles (SLNs) are comparatively novel class of nanocarriers with the advantages including high biocompatibility, better target-ability, low toxicity, better stability, over existing drug carrier(s). SLNs the particulate drug carrier system may improve therapeutic efficacy and safety of chemotherapeutic agents. They have been used...

The new generation of nanoparticles (NPs) encompass attributes of lipids and polymers and are referred to as 'lipid-polymer hybrid nanoparticles' (LPHNPs). LPHNPs have helped shed light on the mechanisms involved in targeted and non-specific drug delivery. Research has also highlighted the opportunities and challenges faced by the use of nanomedici...

p>Cefadroxil (CFD) is a broad spectrum antibiotic that acts against an extensive variety of bacteria, including Gram-positive and Gram-negative bacteria. The major drawback of orally administered drug like cefadroxil is its shorter half life of 1.2 hrs. The goal of the study is to prolong the drug release, producing a desired blood serum level, red...

As transdermal immunization results in poor immunogenicity, which is attributed to poor permeability of antigens through the skin, we believed ultradeformable lipid vesicles (elastic liposome) might address the challenges encountered during transdermal immunization. The elastic liposome, versatile carrier, proves better vehicle for transcutaneous d...

Nanotechnology is considered to be significant innovative revolution that have found wide spectrum of applications in the fields ranging from medicine, diagnostics, electronics, and communications. Currently used pharmaceutical nanocarriers, such as dendrimers, micelles, nanoparticles, polymeric nanoparticles, microspheres, and many of the nanocarr...

Leprosy is a neuropathic disease caused by the M.laprae, which specially affect the nerves of the dermal tissue and multiply here. Conventional treatment is based on antibiotics and essentially Dapsone, which is the core drug for all leprosy treatment. Leprosy requires high doses of Dapsone for very long period of time, which in turn, is responsibl...

The Carboxyl-terminal 19 kDa fragment of merozoite surface protein-1 of Plasmodium falciparum (PfMSP-119) was delivered directly into the cytoplasm via pH sensitive liposome. we have reported the preparation and characterization of PfMSP-119 encapsulated pH-sensitive liposomal formulations using oleyl alcohol (OAlc) in combination with egg phosphat...

The petroleum ether, chloroform, acetone, methanol and aqueous extracts of the aerial parts of Leptadenia reticulata Wight and Arn. (Asclepiadaceae) were studied for in vitro antifungal activity against Aspergillus flavus, Aspergillus ruantti, Candida tropicalis, Candida albicans, Trichodermata viride and Trichodermata koningii respectively. The me...

The aim of the present study was to develop evaluate mouth dissolving tablet of meloxicam. Drug delivery systems became sophisticated as pharmaceutical scientists acquire a better understanding of the physicochemical and biochemical parameters pertinent to their performance. Over the past three decades, mouth dissolving or orally disintegrating tab...

The aim of the present report was to develop nonionic surfactant vesicles (niosomes) to improve poor and variable oral bioavailability of griseofulvin. Niosomes were prepared by using different nonionic surfactants span 20, span 40, and span 60. The lipid mixture consisted of surfactant, cholesterol, and dicetyl phosphate in the molar ratio of 125:...

The crown of Solanum melongena was removed from fruit, dried, extracted and percentage yield was calculated. Phytochemical examination of the methanolic and aqueous extracts showed the presence of alkaloids, saponins, steroids, tannins/ phenolics, flavonoids, proteins and carbohydrates. It was concluded that the extracts of crown contains important...

Lornoxicam is a non steroidal anti-inflammatory drug with analgesic properties and belongs to the class oxicams. It is extremely bitter in taste. The purpose of this research was to develop a bitterless oral disintegrating tablet of Lornoxicam. Taste masking was done by complexing Lornoxicam with aminoalkyl methacrylate copolymer (Eudragit EPO) in...

The present study forecasts the extensive damage caused by radiotherapy and chemotherapy treatment for cancer in the genetic setup of an individual. To counteract this damage, radioprotective potentiality of 50% Methanolic extract of Adhatoda vasica was evaluated through Cyto-Geno analysis. 50% Methanolic extract of Adhatoda vasica leaves was used...

The two sweeteners when combined have a synergistic effect that is the sweetness of the combination is greater than the sum of the individual parts. This is true for most sweetener blends”1. Introduction : A sweetening agent can play a number of important roles in solid and oral liquid formulations such as enhancing flavor, masking bitter taste and...

In the present study, cytosolic delivery of Doxorubicin was performed by means of novel pH sensitive liposomes, composed of PC:CHEMS:Tween 80:Oleyl alcohol (50:50:2:0:80). The pH sensitive liposomes were prepared by film extrusion method and were characterized for shape, size, % entrapment and % release profile. Transmission electron microscopy rev...

The Carboxyl-terminal 19 kDa fragment of merozoite surface protein-1 of Plasmodium falciparum (PfMSP-119) was delivered directly into the cytoplasm via pH sensitive liposome. In the present study, we have reported the preparation and characterization of PfMSP-119 encapsulated pH-sensitive liposomal formulations using oleyl alcohol (OAlc) in combina...

A method for estimating ethanol in alcoholic-drinks by direct reaction is presented. The method consist of color reaction of ethanol with sodium dichromate. The colorimetric quantification was based on the formation of green colored chromate ions resulting from treatment of ethanol and sodium dichromate as limiting reactant in presence of sulfuric...