Rajesh Dubey

Rajesh Dubey

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17
Publications
6,385
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357
Citations
Citations since 2017
2 Research Items
103 Citations
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20172018201920202021202220230510152025
20172018201920202021202220230510152025
20172018201920202021202220230510152025

Publications

Publications (17)
Article
The neurovascular theory explains migraine to be a result of complex pathophysiological changes leading to activation of trigeminal nociceptors by several inflammatory mediators. Different classes of drugs have been used to control migraine where specific class of drugs inhibit only specific mediators while sparing others, resulting into suboptimal...
Article
Subcutaneous triptan provides immediate analgesia in migraine and cluster headache but is limited by high pain recurrence due to rapid drug elimination. A dual-acting subcutaneous formulation providing immediate release of a triptan and slow but sustained release of a nonsteroidal anti-inflammatory drug may provide a longer duration of relief. A mi...
Article
Introduction: Controlled-release injectable (CRI) formulations hold significant value for several indications. However, there have been very few successful developments and approvals due to various challenges that include limited polymer options, drug-excipient process incompatibility and complex scale-up/validation processes. Microemulsion techno...
Article
Enhanced therapeutics are drug products derived from existing generic drugs that provide additional benefits to the patients and the healthcare system. Enhanced therapeutics are considered to be an important and relatively low risk source of innovation. Pulmonary drug delivery is the major delivery route to treat chronic respiratory diseases and ha...
Article
Introduction: Bioequivalence study is a critical step in the development of novel fixed-dose combination products (FDCPs). While bioequivalence of prototype FDCP to the approved monocomponent products facilitates speedier development and approval, lack of bioequivalence often leads to development delays due to reformulation. Areas covered: Pharm...
Article
Purpose – This paper aims to analyze the present trends in pharmaceutical innovation and the impact of generic competition. Design/methodology/approach – A secondary research was conducted to collect data related to new drug approvals of various classes over previous years; trends of investment in research and development; and the pipeline of new...
Article
Combining drugs with synergistic mechanisms of action yields some indisputable benefits; improved efficacy, reduced dosing, enhanced patient compliance, to name just a few. But is there a downside to combining active pharmaceuticals with distinctly different characteristics and behaviours? Specifically, will the combined product be chemically stabl...
Article
The paper discusses the emerging role of product differentiation in the pharmaceutical sector, and evaluates its impact on sustainability of the industry. Secondary data were used to study various differentiation strategies and their effect on market life of certain drug products. The study found that product differentiation is being increasingly e...
Article
The authors developed and evaluated a transdermal gel formulation of ketorolac tromethamine (ketorolac) for the treatment of nociceptive somatic pain. The formulation was optimized for skin permeation enhancers, pH of the system, and dosage strength using in vitro and in vivo techniques. Of the various permeation enhancers evaluated, dimethyl sulfo...
Article
The World Trade Organization (WTO) has set rules for international trade, with the objective to provide maximum benefits to the consumers. One of its aims is to remove trade barriers to international competition. The Organization is based on the principles of free trade; predictability through binding and transparency; national treatment...
Article
In this article, the authors describe a study into the factorial effect of selected process parameters on the pharmaceutical characteristics of poly(DL-lactide-co-glycolide) microspheres containing methotrexate. A study of the microspheres' stability at refrigerated temperatures is also examined.
Article
Full-text available
The objective of the present study was to optimize the concentration of a chitosan solution, stirring speed, and concentration of drugs having different aqueous solubility for the formulation of chitosan microspheres. Chitosan microspheres (unloaded and drug loaded) were prepared by the chemical denaturation method and were subjected to measurement...
Article
Full-text available
The objective of this research was to optimize the processing parameters for poly(D,L-lactide-co-glycolide) (PLGA) microspheres of 5-fluorouracil (5-FU) and to mathematically relate the process parameters and properties of microspheres. Microspheres were prepared by a water-in-oil-in-water emulsion solvent evaporation technique. A 3(2) factorial de...
Article
Full-text available
Conclusion In this study, we found that both heating temperature and heating time affect mean particle size, particle size distribution, and drug entrapment efficiency of albumin microspheres. The change in heating temperature may affect the particle size of the product, especially when heating is carried out at a lower temperature (90°C–120°C). He...

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