Rajesh Dabur

Rajesh Dabur
Maharshi Dayanand University | MDU · Department of Biochemistry

MSc PhD (Biochemistry)

About

96
Publications
47,352
Reads
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3,035
Citations
Citations since 2016
31 Research Items
1836 Citations
20162017201820192020202120220100200300
20162017201820192020202120220100200300
20162017201820192020202120220100200300
20162017201820192020202120220100200300
Additional affiliations
January 2013 - present
Maharshi Dayanand University
April 2012 - March 2016
Maharshi Dayanand University
Position
  • Professor

Publications

Publications (96)
Article
Full-text available
The skeletal muscle (SkM) is the largest organ, which plays a vital role in controlling musculature, locomotion, body heat regulation, physical strength, and metabolism of the body. A sedentary lifestyle, aging, cachexia, denervation, immobilization, etc. Can lead to an imbalance between protein synthesis and degradation, which is further responsib...
Article
Purpose: Hypertriglyceridemia (HTG) is strongly associated with the various types of disease conditions and evolving as epidemics. Hence, it is important to identify molecules that lower the triglyceride and chylomicron levels. Tinospora cordifolia is an illustrious Ayurveda drug, has proved juvenile and immunomodulatory properties. Methods: Twe...
Article
Full-text available
Phytoecdysteroids are known for anabolic and adaptogenic properties. Hence, these are the point of interest in sports medicine and the pharmaceutical industry. Phytoecdysteroid occurrence varies in different plant parts, and also due to seasons and geographical locations. However, variations due to interspecific interactions of plants have not been...
Article
Skeletal muscles are considered the largest reservoirs of the protein pool in the body and are critical for the maintenances of body homeostasis. Skeletal muscle atrophy is supported by various physiopathological conditions that lead to loss of muscle mass and contractile capacity of the skeletal muscle. Lysosomal mediated autophagy and ubiquitin-p...
Article
Objective Detailed analysis of un-processed and un-derivatized free and conjugated urinary steroids is useful to avoid miscalculations and to diagnose sports doping and adrenal problems including abnormal steroidogenesis, congenital deficiency of related enzymes, cancer, and other disease conditions. Hence, the present study was conducted to develo...
Article
Full-text available
Among the four proteolytic systems in the cell, autophagy and the ubiquitin-proteasome system (UPS) are the main proteolytic events that allow for the removal of cell debris and proteins to maintain cellular homeostasis. Previous studies have revealed that these systems perform their functions independently of each other. However, recent studies in...
Article
Skeletal muscle atrophy has been characterizedas a state of uncontrolled inflammation and oxidative stress that escalates the protein catabolism. Recent advancement supportsthat impinging signaling molecules in the muscle fibers controlled throughtoll-like receptors (TLR). Activated TLR signalingpathways have been identified as inhibitors of muscle...
Article
PurposeHypertriglyceridemia (HG) is an independent risk factor with more prevalence than hypercholesterolemia and its attributes to cardiovascular disease (CVD) and pancreatitis. Hence, it becomes imperative to search for new triglyceride (TG) lowering agents. Tinospora cordifolia (TC) is a well-known Ayurvedic drug and a rich source of protoberber...
Article
Ethnopharmacological relevance Tinospora cordifolia (TC) is being used as a blood purifier in Ayurveda since ancient time. It is a very popular immunomodulator and holds anti-inflammatory and anti-oxidative potential, hence anti-aging properties. Therefore, it is also known as ‘Amrita’ in Ayurveda and is widely used to treat diabetes mellitus type...
Article
Background Oxidative stress is crucial player in skeletal muscle atrophy pathogenesis. S-allyl cysteine (SAC), an organosulfur compound of Allium sativum, possesses broad-spectrum properties including immuno- and redox-modulatory impact. Considering the role of SAC in regulating redox balance, we hypothesize that SAC may have a protective role in o...
Article
Ethanopharmacological relevance: Tinospora cordifolia (TC) is widely being used as immunomodulatory and re-juvenile drug and well described in Indian Ayurveda system of medicine. Rejuvenation also means the fine tuning of the skeletal muscles. Skeletal muscle related disorder, i.e. atrophy is major problem which arise due to cachexia, sarcopenia an...
Article
Ethanopharmacological relevance Tinospora cordifolia (TC) is widely being used as immunomodulatory and re-juvenile drug and well described in Indian Ayurveda system of medicine. Rejuvenation also means the fine tuning of the skeletal muscles. Skeletal muscle related disorder, i.e. atrophy is major problem which arise due to cachexia, sarcopenia and...
Article
Full-text available
Tinospora cordifolia (TC) is scientifically proven immunomodulatory drug being used for centuries. Ancient literature reported that inter-specific interactions change medicinal properties of TC. Thus, the current study is aimed to understand the influence of interspecific biotic interactions on chemo-profiles of TC. To explore it, TC samples collec...
Article
Background: Metabolic pathways perturbations lead to skeletal muscular atrophy in the cachexia and sarcopenia due to increased catabolism. Pro-inflammatory cytokines induce the catabolic pathways that impair the muscle integrity and function. Hence, this review primarily concentrates on the effects of pro-inflammatory cytokines in regulation of sk...
Preprint
Full-text available
Aspergillus infections have become an important health problem with the increasing number of patients. Available antifungal drugs are lack with their spectrum, toxic or immunosuppressive in nature, so that need to develop new compound with high efficacy. To evaluate antifungal efficacy of synthesized compound and to identify the protein profile of...
Article
Full-text available
Type-2 diabetes mellitus (T2DM) is a global disease, which leads to various other life threatening diseases and affects the quality of life. Current therapies of T2DM have various side effects and ultimately lead to insulin resistance, along with financial burden. Therefore, comparative study of natural compounds along with their mechanisms has bee...
Article
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The present study reports beneficial effect of hydroxytyrosol (HT) against arsenic (As)-induced oxidative stress in the rat brain. Rats were orally administered with sodium arsenite dissolved in distilled water (25 ppm, by oral gavage) for 8 weeks or HT (10 mg/kg b. wt.) in combination with As. Results showed increase in protein oxidation and lipid...
Article
Full-text available
The article describes the use of facile one-pot, high-yielding reactions to synthesize substituted 3,4-dimethyl-1H-pyrrole-2-carboxamides 3a-m and carbohydrazide analogues 5a-l as potential antifungal and antimicrobial agents. The structural identity and purity of the synthesized compounds were assigned based on appropriate spectroscopic techniques...
Article
Background: Excessive alcohol consumption damages the intestine and liver cells directly as well as through unbalancing the gut microbiota. Objective: The current study was undertaken to correlate the alcohol consumption and change in urinary metabolites profile linked with gut microbiota. Method: Non-alcoholic (control) healthy (n=22) and mod...
Preprint
Full-text available
The article describes facile one-pot, hi-yielding reactions to synthesize substituted 3,4-dimethyl-1H-pyrrole-2-carboxamide (3a–m) and carbohydrazide analogues (5a–l) as potential antifungal and antimicrobial agents. The structural integrity and purity of the synthesized compounds were assigned based on appropriate spectroscopic techniques. Synthes...
Article
Full-text available
This study was conducted to explore the antimicrobial mechanism of metabolites from Saraca asoca (SA1) using differential proteomics and metabolic profile of Pseudomonas aeruginosa after treatment with effective sub-MIC dose of 312 µg/mL. SA1 fraction was found to contain antibacterial metabolites catechol, protocatechuic acid, and epigallocatechin...
Article
Full-text available
Background: Ayurveda, an ancient Indian medicinal system, has categorized human body constitutions in three broad constitutional types (prakritis) i.e. Vata, Pitta and Kapha. Objective: Analysis of plasma metabolites and related pathways to classify Prakriti specific dominant marker metabolites and metabolic pathways. Materials and methods: 38...
Article
The heartwood of Pterocarpus marsupium Roxb. has a history of traditional use in Ayurveda and traditional systems of medicines for the management of conditions such as diabetes and hyperlipidemia. The present study was conducted to identify the molecular pathways affected by a Heartwood Water Extract of P. marsupium (HWE). The effects of HWE on glu...
Article
An increasing array of anti-diabetic drugs are available today, yet Type-2 diabetes mellitus (T2DM) – remains a life threatening disease, causing high mortality and morbidity in developing and developed countries. As of now, no effective therapy is available for the complete eradication/cure of diabetes and its associated complications. Therefore,...
Article
Tinospora cordifolia (Guduchi Sawras) though has been clearly demonstrated in literature for its hypolipidemic and anti-alcoholism properties but its anti-hyperlipidemia mechanistic approach is still missing. Moreover, its direct implication with alcohol induced hyperlipidemia has also not been reported till date. In order to explore the answers of...
Article
Aims: A series of acylated coumarin derivatives have been evaluated for their in silico ADMET properties and in vitro antibacterial activities. Methods and results: In silico analysis confirmed their physicochemical properties in conformation with various layout filters and further their ADMET properties were predicted. Antibacterial activities...
Article
Fatty acid amides (FAAs) in alcoholism lead to liver diseases. These amides have been reported in plasma and in other organs of the body, while their detection or presence in the urine is still unknown. Therefore, the focus of the current study was to detect and analyze FAAs qualitatively in urine samples of alcoholics. Furthermore, the effects of...
Article
Aims: Heavy alcohol intake depletes the plasma vitamins due to hepatotoxicity and decreased intestinal absorption. However, moderate alcohol intake is often thought to be healthy. Therefore, effects of chronic moderate alcohol intake on liver and intestine were studied using urinary vitamin levels. Furthermore, effects of Tinospora cordifolia wate...
Article
Over the last two decades, new insights into the etiology of skeletal muscle wasting/atrophy under diverse clinical settings including denervation, AIDS, cancer, diabetes, and chronic heart failure have been reported in the literature. However, the treatment of skeletal muscle wasting remains an unresolved challenge to this day. About nineteen pote...
Article
diverse clinical settings including denervation, AIDS, cancer, diabetes, and chronic heart failure have been reported in the literature. However, the treatment of skeletal muscle wasting remains an unresolved challenge to this day. About nineteen potential drugs that can regulate loss of muscle mass have been reported in the literature. This paper...
Article
We have studied urine metabolic signature of chronic alcoholism (CA) before and after treatment with an Ayurvedic drug Tinospora cordifolia aqueous extract (TCE). Urinary metabolites of chronic alcoholics and apparently healthy subjects were profiled using HPLC-Q-TOF-MS. Discrimination models from the initial data sets were able to correctly assign...
Article
Cation sensing behaviour of a pyrrole-based derivative (2-hydroxyl 3 methyl 6 isopropyl benzaldehyde}-3,4-dimethyl-1H-pyrrole-2-carbohydrazide (receptor 3) has been explored and is found to be selective towards Zn(2+) over a variety of tested cations. The receptor 3 has shown high selectivity and sensitivity towards Zn(2+) over the other alkali, al...
Article
Full-text available
Barleria grandiflora Dalz. (Acanthaceae) is being used in India to treat different types of disorders including skin infections. Therefore, there are good possibilities to find antifungal compounds in its extracts with novel mechanism of action. The main objectives of the present study were to evaluate the antifungal activity of plant extracts and...
Article
Full-text available
Despite advances in therapeutic modalities, aspergillosis remains a leading cause of mortality. This has necessitated the identification of effective and safe antifungal molecules. In the present study, in vivo safety and antifungal efficacy of a coumarin derivative, N, N, N-Triethyl-11-(4-methyl-2-oxo-2H-benzopyran-7-yloxy)-11-oxoundecan-1-aminium...
Article
Full-text available
Diabetes mellitus is a chronic disease and known to be associated with obesity, hypertension, hyperlipidemia, neuropathy and cardiovascular diseases. Currently available treatment options for this disease are limited and have several adverse effects. Plants provide the best option for search of desired safe and effective medications due to the pres...
Article
Objective: Multi drug resistance is a major medical concern. Medicinal plants have been accepted as potential reserviour of lead compounds for drug design and development. However, molecular mechanism of antimicrobial action of phytoconstituents with medicinal properties, still needs to be explored. Therfore, proteomic analysis technique was carrie...
Article
Full-text available
Herbal medicines are highly complex and have unknown mechanisms in diseases treatment. Saraca asoca (Roxb.), De. Wild has been recommended to treat gynecological disorders and used in several commercial polyherbal formulations. In present study, efforts have been made to explore antimicrobial activity and its co-relation with the distributions of c...
Article
Large-scale studies in the field of omics have been successfully exploring the differences in gene expression, protein and metabolite abundance and modification of post-translational protein, and providing a different level of views for the cellular processes occur in cells. Proteomics and metabolomics are new addition to the ‘omics’ field, but bot...
Article
Full-text available
In the pathogenesis of invasive pulmonary aspergillosis both fungal and host factors play roles. Though cytokines and phagocyte, as host factors, have been shown to participate in defence against Aspergillus species yet the role of cysteine proteases, that is cathepsins, a lysosomal enzymes of phagocytes, remains unknown in fungal infection. Studie...
Article
Therapeutic options for many infections are extremely limited and at crisis point. We run the risk of entering a second pre-antibiotic era. There had been no miracle drug for the patients infected by resistant microbial pathogens. Most of the very few new drugs under development have problems with their toxicity, or pharmacokinetics and pharmacodyn...
Article
Aim: Synthesis of some novel formazan derivatives from condensation of aniline diazonium salt with a variety of Schiff bases of 3,4-dimethyl-1H-pyrrole-2-carbohydrazide moiety and evaluate their potential antimicrobial and antioxidant activities. Methods: Novel substituted formazans (2a-j) were prepared from Schiff bases of 3,4- dimethyl-1H-pyrrole...
Article
Background: As described in Unani and Ayurveda, herbal medicines are sources of treating the morbid conditions. The drugs that obtained from trees, shrubs or herbs contribute about 25 percent of the total prescription drugs. Antimicrobial potential of ten medicinal plants i.e. Picrorhiza kurroa, Datura metel, Acacia catechu, Cissus quadrangularis,...
Article
Abstract Background High performance liquid chromatography coupled with electro-spray ionization and quadrupole time of flight mass spectrometry was used for separation and identification of phenolic and other compounds in the water extracts prepared from Terminalia tomentosa, a medicinal plant being used for the treatment of rheumatism, urinary di...
Article
Background: Bark of Saraca asoca is clinically proved female tonic being used from centuries to treat excessive loss of blood during menstruation in presence of leucorrhea, uterine fibroids and other reasons. However, due to growing demand, all of its parts are in use as substituent instead of bark. Methods: In the present report, ultra performance...
Article
Full-text available
β-sitosterol is an important component in food and herbal products and beneficial in hyperlipidemia. Its higher concentrations in serum may lead to coronary artery disease in case of sitosterolemia. Therefore, it is essential to determine the quantity of β-sitosterol in food and herbal drugs. Saraca asoca and its preparations have been widely used...
Article
Background: Juice of Tinospora cordifolia is well reported for its immuno-modulatory and adaptogenic properties. Importance of the plant is well understood as its stem juice was widely used during the Swine flu break in India as an immuno-modulator. On the contrary, there are no data available on the shelf-life of juice. Therefore, effects of cold...
Data
Full-text available
Ayurveda and other traditional medicinal systems use whole plants or their parts for combating a great number of disorders. Hence maintaining the purity and quality of herbal drugs are necessary to identify the substitutes and adulterants. Using traditional identification methods to identify the correct plant part can be difficult especially in cas...
Article
Full-text available
High performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometer was used for separation and identification of phenolic and other compounds in the water extracts of Saraca asoca (Roxb.), De. Wilde. The aim of the study was to identify and evaluate the distribution of phenolic compounds in the different parts of the pl...
Article
Full-text available
Saraca asoca is used worldwide to treat various kinds of human disorders. Increasing demand and destructive harvesting of bark has led to the depletion of this valuable medicinal tree. Scarcity of this plant leads toward the use of various substitutes/adulterants. Hence, it is very important to develop methods for the authentication of bark samples...
Article
Full-text available
In the present study, clinical efficacy and safety profile of juice of Bryophyllum pinnatum Salisb for treatment of lithiasis by performing a non comparative open clinical study was accessed. Patients of lithiasis having <10 mm stones were treated with fresh leave juice of B. pinnatum in a single dose of 10 ml/day × 30 days by oral administration....
Article
Full-text available
Plants may favorably or adversely affect other plants through allelochemicals. The objective of this study was to examine the allelopathic effects of P. pinnata, A. indica and Z. jujuba on phytochemical profile of Tinospora cordifolia. In current study auxiliary buds of plant were cultured on Murasinge and Skoog medium, proved to be the good for sh...
Article
Full-text available
In the present study, clinical efficacy and safety profile of juice of Bryophyllum pinnatum Salisb for treatment of lithiasis by performing a non comparative open clinical study was accessed. Patients of lithiasis having <10 mm stones were treated with fresh leave juice of B. pinnatum in a single dose of 10 ml/day × 30 days by oral administration....
Article
Full-text available
Lysosomal cysteine proteases play important roles in our immune-system by processing pathogens but their involvement in fungal mediated diseases remains unknown. In this study we observed that cysteine proteases (cathepsin B, L and C) are involved in fungal disease progression. In the mice model of pulmonary aspergillosis, cathepsin (CP)B and CPL a...
Article
Full-text available
Jasminum grandiflorum L. is described in Ayurveda to treat several diseases such as ulcer, stomatilis, gingivitis and skin disease. Leaves are used to apply locally as in single or compound formulation in Leprosy (Kushta roga- Skin disease). In the present study, extracts of Jasminum grandiflorum L. leaves in various solvents were screened for anti...
Chapter
Full-text available
As new spectrums of human fungal infections are increasing due to increased cancer and AIDS patients. The increased use of antifungal agents also resulted in the development of resistance to these drugs. It makes necessary to discover new classes of antifungal compounds to treat fungal infections. The research on natural products and natural produc...
Article
This chapter provides insights into the medicinal potential of gray nickerbean. In Ayurvedic medicine, and also in traditional medicine, C. bonduc seeds are used for the treatment of different diseases, such as fever, diabetes, inflammation, liver disorders, cysts, tumors, etc. Preparations of the seeds and other plant parts are used to treat a lar...
Article
Full-text available
A new spectrum of human fungal infections is increasing due to increased cancer, AIDS, and immunocompromised patients. The increased use of antifungal agents also resulted in the development of resistance to the present drugs. It makes necessary to discover new classes of antifungal compounds to cure fungal infections. Plants are rich source of bio...