Rajeev K Singla

Rajeev K Singla
Sichuan University | SCU · West China School of Medicine/West China Hospital

M.Pharmacy (Pharmaceutical Chemistry; Manipal University), PhD (University of Delhi)

About

210
Publications
219,081
Reads
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1,950
Citations
Introduction
Presently serving Institutes for Systems Genetics, West China Hospital, Sichuan University, China as Assistant Researcher. Previously, I was associated with School of Medical and Allied Sciences, KR Mangalam University as Assistant Professor. As a Principal Investigator(PI), I had handled a research project funded by Science & Engineering Research Board, Govt. of India(Project No. SR/FT/LS-149/2011) and also received SERB-Young Scientist Fellowship from July 2012 .to Dec 2014 in NSIT (NSUT).
Additional affiliations
January 2020 - present
Sichuan University
Position
  • PostDoc Position
September 2018 - December 2019
K.R. MANGALAM UNIVERSITY
Position
  • Professor (Assistant)
Description
  • I have taught D.Pharm, B.Pharm, M.Pharm and B.PT students for their theory and practical subjects.
December 2015 - August 2018
Netaji Subhas Institute of Technology
Position
  • Research Assistant
Education
December 2013 - May 2018
University of Delhi
Field of study
  • Phytoconstituents of Cocos nucifera Linn. Endocarp: Isolation, Characterization & their Therapeutic Properties
August 2007 - July 2009
Manipal Academy of Higher Education
Field of study
  • Synthesis of Medicinal Compounds
July 2003 - June 2007
Maharshi Dayanand University
Field of study
  • Pharmaceutical Sciences

Publications

Publications (210)
Article
Full-text available
The aligned manuscript reports synthesis, screening and QSAR analysis of twenty six 1, 2, 4-triazole analogues from their respective aromatic carboxylic acids. The structures of synthesized analogues were characterized using physical and spectral analysis. 1,2,4-Triazole analogs antioxidant capacity was determined using DPPH radical scavenging assa...
Article
Full-text available
The use of natural products for the treatment of disease is one of the oldest cultures that exists. Currently, the research of new drugs using natural products shows a poorly explored biodiversity and a great interest of marketing. The enzymatic inhibition by some natural products investigated among these is the inhibition of hyaluronidase and the...
Article
Full-text available
Background: Ursolic acid, a bioactive pentacyclic triterpenoid had been evaluated for its interaction with the neurological targets associated with antidepressant drugs. Current study was to mechanistically analyze the probable site of action for ursolic acid on the target proteins. Methods: Ursolic acid has been docked with monoamine oxidase is...
Article
It is imperative to interrupt the link between arthritis and regulation of oxidative stress with the administration of antioxidants. Suramin is known for its anti-inflammatory, antineoplastic and antiangiogenic activities implying its possible antioxidant property. In this study, the antioxidant activity of suramin in cell free system was found to...
Article
Full-text available
Breast cancer (BC) is the most prevalent neoplasm among women. Genetic and environmental factors lead to BC development and on this basis, several preventive – screening and therapeutic interventions have been developed. Hormones, both in the form of endogenous hormonal signaling or hormonal contraceptives, play an important role in BC pathogenesis...
Article
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Due to an unhealthy lifestyle, gastric ulcers have become a very common disease these days. Moreover, the side effects linked with the prolonged use of conventional treatments have shifted the paradigm towards herbal therapies. The leaves of Morus alba L. (Family-Moraceae) have been traditionally used for a large number of metabolic diseases. In th...
Chapter
Crateva adansonii has a wide range of medicinal properties and is an important part of traditional folk medicine. The leaves and bark are used to treat joint discomfort, ear and toothaches, eye infection, asthma, rheumatoid arthritis, and epilepsy. Other important uses of this plant have also been investigated by folklore medicine. Inflammation, ut...
Article
Full-text available
Background: Bergenin, 4-O-methyl gallic acid glucoside, is a bioactive compound found in the cortex of Mallotus japonicus (L.f.) Müll.Arg. along with many other natural resources including that from Bergenia species. The present study delineates the neuroprotective potential of bergenin through the modulation of PPAR-γ receptors. Method: Dementia w...
Article
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Each biopharmaceutical research and new drug development investigation is targeted at discovering novel and potent medications for managing specific ailments. Thus, to discover and develop new potent medications, it should be performed sequentially or step by step. This is because drug development is a lengthy and risky work that requires significa...
Article
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Background: Crowdsourcing is a low-cost, adaptable, and innovative method to collect ideas from numerous contributors with diverse backgrounds. Crowdsourcing from social media like Twitter can be used for generating ideas in a noticeably brief time based on contributions from globally distributed users. The world has been challenged by the COVID-19...
Article
Full-text available
For various ailments, natural remedies have been traditionally used. To defend against common disorders, medicinal plants are progressively used as nutritional supplements. Gingivitis and periodontitis are widespread and can affect most of the world’s population. Gingivitis is a very common, nondestructive inflammatory disease of gums that causes r...
Article
Full-text available
In this pilot study, we aimed to explore the feasibility of conducting a questionnaire-based health survey (on the preference of different systems of medicine for the treatment of various health problems) as a Twitter poll. We had a mean 4358.6±590.3 poll reach with the engagement of 108.2±36.87 Twitter users and 67.6±28.06 votes. Most of the respo...
Chapter
The disease related to parathyroid glands is mostly occurred due to abnormal serum calcium levels. Hypoparathyroidism mostly occurs due to the removal of the parathyroid gland during neck surgery. Several causes of hypoparathyroidism include postsurgical, postradiation, autoimmune, heavy metal deposition, and metastatic infiltration responsible for...
Article
Full-text available
Alzheimer's disease (AD) is perceived with various pathophysiological characteristics such oxidative stress, senile plaques, neuroinflammation, altered neurotransmission immunological changes, neurodegenerative pathways, and age-linked alterations. A great deal of studies even now are carried out for comprehensive understanding of pathological proc...
Article
Phenolic acids are now receiving a great deal of interest as pervasive human dietary constituents that have various therapeutic applications against chronic and age-related diseases. One such phenolic acid that is being utilized in traditional medicine is chlorogenic acid (CGA). It is one of the most readily available phytochemicals that can be iso...
Article
Alzheimer’s disease (AD) is a neurodegenerative disease that aects a wide range of populations and is the primary cause of death in various countries. The treatment of AD is still restricted to oral conventional medicines that act only superficially. Fabrication of intranasal solid lipid nanoparticulate system for the uptake of therapeutic agents w...
Article
Full-text available
Since 2020, we are witnessing a COVID-19 pandemic that has ruled out all other pandemics ever happened in our history. Countries are still not be able to manage the COVID-19 threat properly, and while we are still dealing with it, here comes another deadlyinfectious disease, monkeypox. Rapid circulation of monkeypox infections worldwide has forced...
Article
Full-text available
Alzheimer's disease (AD) is a neurodegenerative disease that affects a wide range of populations and is the primary cause of death in various countries. The treatment of AD is still restricted to oral conventional medicines that act only superficially. Fabrication of intranasal solid lipid nanoparticulate system for the uptake of therapeutic agents...
Article
C. pluricaulis Choisy (C. pluricaulis), a perennial herb aka C. microphyllus Sieb. and C. Prostratus Forsk. is being used as a traditional folk medicine for a variety of ailments. In this article, we collected information about C. pluricaulis through electronic search using PubMed, SciFinder, Google Scholar, and Web of Science as well as network ph...
Chapter
Foods (and beverages above all) are generally water-dissolved solutions. This is a normal condition and also a pre-requisite for all edible products in human history, also meaning that dehydration treatments may be considered as one of the many tracts of anthropic activities and civilization in general. The simple production of more or less dehydra...
Chapter
In India, the prevalence of obesity is rapidly increasing due to many factors such as globalization, urbanization, sedentary lifestyle, and dietary patterns. The consequences are immense as it results in type-2 diabetes, cardiovascular disease, liver illness, arthritis, cancer, and many other associated complications. Diet counselling and optimum d...
Chapter
Food preservation can be defined as the science that deals with the process of prevention of decay or spoilage of food and helps it to be stored in a fit condition for future use. It helps to increase the shelf life of food thus increasing the food supply. It can be saved by means of proper food preservation methods during scarcity, stabilizing foo...
Chapter
This chapter concerns a general introduction to the category of natural and synthetic antioxidants. The current situation in the food and beverage industries and the market is showing many interesting challenges for food technologists. Several points of discussion should be considered, including the historical, technological, and nutritional divers...
Chapter
Food additives can be defined as chemical substances deliberately added to foods directly or indirectly in known and regulated quantities for the purposes of assisting in the processing of foods, preservation, and improving flavour, texture, and/or appearance of foods. These compounds have important roles in the production of processed products. At...
Chapter
Nutrition education is an essential component in improving dietary habits and food choices and nutritional status of a population. The basic aim of this book has been to give a heterogeneous and complete overview of the complexity of nutritional education, mainly from the viewpoint of research chemists and technologists in the first part of the wor...
Chapter
Food safety and quality control ensure the food is safe for human consumption. Proper food supply chain management benefits both the manufacturers and consumers. Quality assurance and quality control processes are implemented to supply safe food and beverage products to the consumer. National regulatory guidelines of each country monitor the activi...
Chapter
Phytochemicals are naturally found in plants and have disease-preventing functions. They have an important role in preventing chronic diseases. They act as synergistic agents allowing nutrients to be used more effectively by the body. The beneficial medicinal effect can be used as therapeutic agents against many communicable and non-communicable di...
Article
Cancer is a fatal disease, with a collection of related diseases in various body parts. The conventional therapies cannot show the desired results of treatment due to their imprecise targeting, deprived drug delivery, and side effects. Therefore, it is required to make the drug engineered in such a way that it can target only cancerous cells and ca...
Article
Full-text available
Traumatic brain injuries due to sudden accidents cause major physical and mental health problems and are one of the main reasons behind the mortality and disability of patients. Research on alternate natural sources could be a boon for the rehabilitation of poor TBI patients. The literature indicates the Marrubium vulgare Linn. and its secondary me...
Article
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Ethnopharmacological relevance: The genus Alternanthera ( Amaranthaceae ) comprises 139 species including 14 species used traditionally for the treatment of various ailments such as hypertension, pain, inflammation, diabetes, cancer, microbial and mental disorders. Aim of the review: To search research gaps through critical assessment of pharmacolo...
Chapter
Physical activity (PA) boosts mental health and well-being in both healthy and diseased populations. As regards to the latter, its therapeutic effects have been noted in patients diagnosed with various neurodegenerative disorders, and in this chapter we summarize these effects. The neuroprotective effects of PA are conferred via improved neuronal h...
Article
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The incidence of obesity and over bodyweight is emerging as a major health concern. Obesity is a complex metabolic disease with multiple pathophysiological clinical conditions as comorbidities are associated with obesity such as diabetes, hypertension, cardiovascular disorders, sleep apnea, osteoarthritis, some cancers, and inflammation-based clini...
Article
Full-text available
Endometrial cancer (EC) is the sixth most prevalent type of cancer among women. Kinases, enzymes mediating the transfer of adenosine triphosphate (ATP) in several signaling pathways, play a significant role in carcinogenesis and cancer cells' survival and proliferation. Cyclin-dependent kinases (CDKs) are involved in EC pathogenesis; therefore, CDK...
Article
Full-text available
Depression, a neurological disorder, is a universally common and debilitating illness where social and economic issues could also become one of its etiologic factors. From a global perspective, it is the fourth leading cause of long-term disability in human beings. For centuries, natural products have proven their true potential to combat various d...
Chapter
The host immune system recognizes and responds to the selective antigens or epitopes (immunome) of the intruding pathogen over an entire organism. The immune response so generated is ample to confer the desired immunity and protection to the host. This led to the conception of immunome-derived vaccines that exploit selective genome-derived antigens...
Chapter
Viral infections have remained a serious public health burden despite significant improvements in medical and pharmaceutical research in recent years. In silico approaches for drug discovery and design are fruitful for the management of a plethora of viral diseases. Virtual screening of libraries is performed using various computational tools to se...
Article
Full-text available
Background: The world has been unprecedentedly hit by a global pandemic which broke the record of deadly pandemics that faced humanity ever since its existence. Even kids are well-versed in the terminologies and basics of the SARS-CoV-2 virus and COVID-19 now. The vaccination program has been successfully launched in various countries, given that t...
Article
Full-text available
In the rural communities of sub-Saharan African (sSA) countries, malaria is being managed using phytocompounds. Artesunate is reported to inhibit Gephyrin E, a central, multi-domain scaffolding protein of inhibitory post-synapses. Neem plant and its metabolites like azadirachtin are being indicated for management of malaria by traditional healers....
Article
Full-text available
Prostate cancer is the most common type of cancer among men and the second most frequent cause of cancer-related mortality around the world. The progression of advanced prostate cancer to castration-resistant prostate cancer (CRPC) plays a major role in disease-associated morbidity and mortality, posing a significant therapeutic challenge. Resistan...
Article
Full-text available
Background: With prostate cancer being the fifth-greatest cause of cancer mortality in 2020, there is a dire need to expand the available treatment options. Castration-resistant prostate cancer (CRPC) progresses despite androgen depletion therapy. The mechanisms of resistance are yet to be fully discovered. However, it is hypothesized that androgen...
Article
Bergenin, 4-O-methyl gallic acid glucoside, is a bioactive compound present in various plants belonging to different families. The present work compiles scattered information on pharmacology, structure activity relationship and nanotechnological aspects of bergenin, collected from various electronic databases such as Sci Finder, PubMed, Google scho...
Article
Background Neurological disorder, depression is the globally 4th leading cause of chronic disabilities in human beings. Objective This study aimed to model a 2D-QSAR equation that can facilitate the researchers to design better aplysinopsin analogs with potent hMAO-A inhibition. Methods Aplysinopsin analogs dataset were subjected to ADME assessme...
Article
Background: The plant Acacia leucophloea (Roxb.) Wild. Family Fabaceae is of paramount importance in Indian medicine. Objectives: We sought to evaluate the in vitro antimicrobial activity of A. leucophloea stem bark extract together with its phytochemical characterization and exploration of drug-likeness attributes. Methods: In vitro Kirby-Bauer...
Article
Full-text available
The natural product specialized metabolites produced by microbes and plants are the backbone of our current drugs. Ironically, we are in a golden age of understanding natural product biosynthesis, biochemistry, and engineering. These advances have the potential to usher in a new era of natural product exploration and development, taking full advant...
Article
Full-text available
Lycopene is a pigment belonging to the group of carotenoids and it is among the most carefully studied antioxidants found especially in fruit and vegetables. As a carotenoid, lycopene exerts beneficial effects on human health by protecting lipids, proteins, and DNA from damage by oxidation. Lycopene is a powerful oxygen inactivator in the singlet s...
Chapter
The efficacy of herbal extracts has been often questioned due to presence of natural toxin loads like alkaloids and terpenes as well as farm-level applied synthetic crop protection chemicals called pesticides, if any, and fungal toxins like aflatoxins. In addition, the efficacy of synthetically prepared drugs is challenged on account of containing...
Chapter
This chapter discusses the importance of phenolic substances in vegetable products in India with reference to claimed antioxidant power. The most interesting compounds with claimed and demonstrable antioxidant power concern different molecules in the ambit of natural materials, especially when speaking of phenolics compounds. Antioxidant power is a...
Chapter
This chapter concerns the possible use of natural molecules from vegetable sources in food and pharma preparations, including also the ambit of cosmetic industries. This possibility has been often considered with success in the recent years because of ‘natural’ claimed properties. In general, polyphenols and other substances named as ‘natural’ addi...
Chapter
This chapter discusses several features concerning the most interesting compounds with claimed and demonstrable antimicrobial action, provided these substances are of vegetable origin. This discussion concerns different types of molecules and materials, and some differences may be also evaluated when speaking of ambits of use. The available uses co...
Article
Full-text available
Parkinson’s disease (PD) is a neurodegenerative disorder in elderly people. The personalized diagnosis and treatment remain challenges all over the world. In recent years, natural products are becoming potential therapies for many complex diseases due to their stability and low drug resistance. With the development of informatics technologies, data...
Article
Full-text available
Background 6-Fluoro-3-(4H-1,2,4-triazol-3-yl)quinolin-4(1H)-ones are promising antitumor agents with enormous data on their profound cytotoxic effects on the human cancer cell lines. Objectives: We sought to perform a Quantitative structure cytotoxicity relationship (QSCR) analysis of a series of previously reported fluoroquinolone analogues using...
Article
Full-text available
The open innovation hub Digital Health and Patient Safety Platform (DHPSP) was recently established with the purpose to invigorate collaborative scientific research and the development of new digital products and personalized solutions aiming to improve human health and patient safety. In this study, we evaluated the effectiveness of a Twitter-base...
Book
This book discusses the scope and limitations of the antimicrobial and antioxidant properties of foods as medicines or medicinal coadjuvants in traditional Indian herbal therapies. The first chapter introduces readers to the relevance of the Ayurveda system, its holistic classification approach, applications of selected herbs and the demonstrable e...