Rajat Hegde

Rajat Hegde
Karnataka Institute for DNA Research [KIDNAR] · Human Genetics

Master of Science
Senior Project Research Fellow

About

22
Publications
879
Reads
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6
Citations
Citations since 2016
22 Research Items
6 Citations
20162017201820192020202120220246810
20162017201820192020202120220246810
20162017201820192020202120220246810
20162017201820192020202120220246810
Additional affiliations
July 2017 - May 2018
Karnatak University, Dharwad
Position
  • Guest Lecturer

Publications

Publications (22)
Article
Background The isolation of nucleic acids is a frequently performed procedure in the molecular biology area. Although several rapid DNA isolation techniques from human peripheral blood and saliva have been developed, there are still some disadvantages – volume, time, cost, and yield are a few notable ones. Objective We aim to develop a rapid and i...
Article
Introduction: Isolation of genomic DNA is an initial step in molecular biology techniques. The quality of isolated DNA depends on procedures and chemicals, as well as source and types of the sample used. Several existing procedures are expensive and time consuming. In this study, we isolated high quality genomic DNA with an inexpensive and least t...
Article
Drosophila polychaeta belongs to the polychaeta species group along with Drosophila latifshahi, Drosophila daruma, Drosophila asper and Drosophila hirtipes. The Polychaeta species group has been recorded from tropical and sub tropical regions. Drosophila polychaeta is less studied biogeographically, chromosomally, genetically from the view points o...
Article
DNA barcoding is a powerful tool for species identification, DNA taxonomy, forensic medicine and ecological studies. The DNA barcoding using part of the COI region from the mitochondrial DNA was proposed to be a faster and accurate method to identify the phylogeny of the species because of its simple genomic structure and highly conserved regions a...
Article
Full-text available
Trace elements are essential for the human body’s various physiological processes but if they are present in higher concentration, these elements turn to be toxic and cause adverse effect on physiological processes. Similarly, deficiency of these essential elements also affects physiological processes and leads to abnormal metabolic activities. The...
Article
Grasserie is a deadly viral disease which turns a clean creamy white silkworm into zombie worm. The nuclear polyhedrosis of B. mori caused by Nuclear Polyhedrosis Virus strain Bm (BmNPV) showing jaundice-like symptoms is collectively referred to as polyhedrosis. This DNA virus multiplies only in the nucleus of the host cells forming its complete st...
Article
Full-text available
Objective The goal of this research was to investigate the gap junction beta 2 (GJB2) gene mutations associated with nonsyndromic hearing loss individuals in North Karnataka, India. Materials and Methods For this study, patients with sensorineural genetic hearing abnormalities and a family history of deafness were included. A total of 35 patients f...
Article
Full-text available
Objective: To assess the influence of oxidative stress on the gene expression of nitric oxide synthases (NOS 3 and NOS 2) and, hence, the cardiovascular responses in preeclampsia. Methods: This was a case control study in which patients with preeclampsia (PE group) and normal pregnancy controls (NP group) were included according to the guideline...
Article
Full-text available
Background Autism is a heterogeneous neurodevelopmental disorder. Human homeostatic iron regulator (HFE) codes for HFE protein. HFE protein is very essential for inhibitory regulation of the endocytosis of iron. Objective Present study aims to screen C282Y and H63D polymorphism of the HFE gene in autistic children. Method 30 autistic children and...
Article
Full-text available
Background: The most prevalent severe inherited hemorrhagic condition is hemophilia, which means “love of blood.” Hemophilia A and B are caused by a lack or malfunction of the factor VIII and factor IX proteins. Objective: The present study is to determine the prevalence and clinical profile of hereditary coagulation disorder, particularly hemophil...
Article
Full-text available
Autism is a complex neurodevelopmental disorder, the prevalence of which has increased drastically in India in recent years. Neuroligin is a type I transmembrane protein that plays a crucial role in synaptogenesis. Alterations in synaptic genes are most commonly implicated in autism and other cognitive disorders. The present study investigated the...
Article
Full-text available
Background: Hemophilia B (HB) is an X-linked bleeding disorder resulting from coagulation factor IX (FIX) defects. Over 3,000 pathogenic, HB-associated mutations in the F9 gene have been identified. We aimed to investigate the role of F9 variants in 150 HB patients using sequencing technology. Methods: F9 gene sequences were amplified from perip...
Article
Viral diseases take the lives of n number of silkworms each year resulting in 30-40% of average crop loss. Grasserie is one of the deadly diseases caused by NPV (Nuclear Polyhedrosis virus) for silkworm. BmNPV was observed throughout the year with increased severity in the summer and autumn crops. During the World War II, accidentally effective pes...
Article
Full-text available
Background Autism is one of the most complex, heterogeneous neurological disorders. It is characterized mainly by abnormal communication, impaired social interaction, and restricted behaviors. Prevalence of autism is not clear in Indian population. Aim The present study hypothesizes that Y chromosome plays role in sex bias of autism in Indian autis...
Data
mitochondrial cytochrome c oxidase subunit I (COX1) gene sequence of Drosophila bipectinata submitted to NCBI. GenBank Accession No: OK090470.1
Data
mitochondrial cytochrome c oxidase subunit I (COX1) gene sequence of Drosophila malerkotliana submitted to NCBI. GenBank Accession No: OK090473.1
Article
Autism is a complex neurodevelopmental condition which is clinically, etiologically and genetically heterogeneous. The predisposition of genes and genetic loci has been under study over the last few decades. Autism is increasing dramatically over the last few years in India. Mutations in two x-linked neuroligin genes viz. NLGN3 and NLGN4X have been...
Article
Full-text available
Non-syndromic sensory neural hearing defect is one of the genetic diseases inherited from parents to offerings. The autosomal recessive form affects a large population worldwide and has become a major concern in the social and professional lives of many people. There are many factors and genes which are involved in hearing loss but the Gap Junction...
Article
Introduction: Haemophilia is one of the “Bleeder Disorder” that causes abnormal bleeding or poor blood clotting. It occurs due to the defect in the clotting factors even in their functions and in some cases structures are altered. The frequency of haemophilia is 1 in 10,000 and there are approximately 4,00,000 patients all over the world. Haemophil...
Article
Introduction: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder that manifests before the age of three. ASD is characterized by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypic patterns of interests and behavior. More than 1 million cases...
Article
Introduction: Hearing deficiency is the most common sensory incompetence that affects millions of people all over the world. Profound Deafness is a common disorder that occurs in 1:1000 neonates and the cause is hereditary. Gap Junction Beta2 (GJB2) gene which codes for connexion 26 protein is implicated in hearing. Mutation or defect in this gene...
Article
Full-text available
Abbreviations Deafness caused due to mutations in more than 400independent genes as a series of etiologically heterogeneous disorders. However , in diverse Indian population several studies have been conducted and causes for syndromic and non syndromic forms of deafness occurs because of the defects in just few genes. In India high prevalence of ge...

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Projects

Project (1)
Project
To find the frequency of autism and disease-causing mutations of Neurligin genes in Autistic population of India