Rajan Kumar Tiwari

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• Doctor of Philosophy Neuroscience
• Postdoc Associates at George Washington University

The word “cancer” evokes myriad emotions, ranging from fear and despair to hope and determination. Cancer is aptly defined as a complex and multifaceted group of diseases that has unapologetically led to the loss of countless lives and affected innumerable families across the globe. The battle with cancer is not only a physical battle, but also an...

In the past years, PDE5 has emerged as a promising therapeutic target for many cancers due to its highly upregulated expression. Interestingly, a recent in vitro study by our group has shown the antitumor and chemopotentiating action of sildenafil against T cell lymphoma. Our study showed that lower doses of sildenafil (50 μM) and cisplatin (0.5 μg...

Accumulating evidence has shown a vital role of stress-regulatory hormones, including epinephrine, in the progression of numerous cancers, including T cell lymphoma. Further, the antitumor and chemosensitizing potential of propranolol, an inexpensive β-adrenergic receptor antagonist has also been reported against breast, colon, ovarian, and pancrea...

In recent years, studies have reported the role of stress-regulatory hormones, including epinephrine, in regulating the progression of a few cancers. However, the tumor-promoting action of epinephrine is not yet investigated in T cell malignancy, a rare and complicated neoplastic disorder. More so, very little is known regarding the implication of...

Cyclic nucleotide phosphodiesterase 5 (PDE5) has been recently identified to play a crucial role in the progression of many cancers. PDE5 promotes tumorigenesis by dysregulating various cellular processes such as proliferation, apoptosis, angiogenesis, and invasion and migration. Interestingly, multiple studies have reported the promising chemosens...

Fungal endophytes are known to be a paragon for producing bioactive compounds with a variety of pharmacological importance. The current study aims to elucidate the molecular alterations induced by the bioactive compounds produced by the fungal endophyte Colletotrichum gloeosporioides in the tumor microenvironment of human breast cancer cells. GC/MS...

Transition metal dichalcogenides (TMDs) based materials have grabbed striking attention to a great extent owing to their intriguing characteristics for biological, optical, chemical, and medicinal applications. Herein, we report in-situ one-pot hydrothermal synthesis of molybdenum ditelluride@carbon nano-dots (MoTe2@C NDs) and then explored its pot...

Arene ruthenium complexes [(η⁶–arene)Ru(L)Cl] (η⁶–arene = benzene, R1; p-cymene, R2) containing the chelating ligand (2–chloro–3– (di(1H–pyrrol–2–yl)methyl)quinoline) (L) have been synthesized and carefully characterized by various studies (¹H and ¹³C NMR, IR, ESI–MS, UV–vis). The structure of R1 has been verified by X–ray single crystal analyses....

T cell lymphoma represents an aggressive subgroup of lymphoma having a poor prognosis. Many factors, including psychological stress, define the onset/progression of the disease. Although psychological stress can cause several health problems, preclinical and clinical reports regarding its role in cancer have been mixed. Therefore, in this study, we...

Synthesis of the azo–Schiff base ligands 2-((E)-((4-(diethylamino)phenyl)imino)methyl)-4-((E)-(2-(phenylthio)phenyl)diazenyl)phenol (L1) and-((E)-((4-(diethylamino)phenyl)-imino)methyl)-4-((E)-(2-phenoxyphenyl)diazenyl)phenol (L2) and Zn(II) complexes (C1-C2) containing these ligands have been described. Characterization of the ligands and complexe...

T cell lymphoma is a rare malignancy that belongs to the class of non-Hodgkin lymphoma. NHL shares 2.8% and a death rate of 2.6% of total lymphoma cases. Lymphoma accounts for 3.23% of all existing cancers, with a concerning death rate of 2.83%. Among all the NHL, T cell lymphoma alone stakes 15%, with poor survival prognosis affecting a wide range...

Fungal endophytes have remarkable potential to produce bioactive compounds with numerous pharmacological significance that are used in various disease management and human welfare. In the current study, a total of eight fungal endophytes were isolated from the leaf tissue of Amoora rohituka, and out of which ethyl acetate (EA) extract of Penicilliu...

EGCG, the most abundant catechins of green tea exhibits several beneficial impacts on human health and helps in the amelioration of various pathological conditions including cardiovascular diseases, obesity, and cancer. The anti-obesity potential of EGCG depends on its potent antioxidant property, lipid metabolism modulatory action, and adipogenesi...

Colon cancer is one of the leading causes of cancer-associated deaths in men as well as in women worldwide. Therefore, various researches are being conducted to identify suitable therapeutic targets for designing the safer and effective therapeutic regimens against colon cancer. In view of this, aerobic glycolysis has been identified as one of the...

Nimbolide is a tetranortriterpenoid derived from the leaves and flowers of Azadirachta indica (Neem). It exhibits anticancer activity against a variety of cancers by modulating various crucial features, including cell proliferation, apoptosis, and invasion and metastasis. More importantly, the cytotoxic effect of nimbolide has also been observed ag...

Title: Epinephrine, a key stress player mediates cell survival in T cell lymphoma via altering the level of biophysical components of tumor micro environment. Abstract Background-Stress is ubiquitous and universally pervasive in last few decades, it has been emerged as one of the the most calamitous complications associated with the people of all a...

Lysophosphatidic acid (LPA) is a bioactive lipid, which plays an indispensable role in various physiological and pathological processes. Moreover, an elevated level of LPA has been observed in malignancies of different origins and implicated in their progression via modulation of proliferation, apoptosis, invasion and metastasis. Interestingly, few...

Cervical mucus plays a vital role in female fertility. Infertility is most important factor arising in reproductive health. It helps in the sperm migration through the female reproductive tract, biochemical and morphological changes to sperm, and sperm egg interaction in the oviduct. The maximum cases of infertility have been found in human populat...

Diabetes is a disorder mainly related to the endocrine system, which is characterized by the failure of kidney, increasing secretion of urine because of the osmotic effect of glucose. It’s a major problem of our society. The amylin and polypeptide-p both play a crucial role in diabetes these are having antidiabetic properties. Polypeptide-p, vi...