Rajan Kanth

Rajan Kanth
WellSpan Medical Group · Gastroenterology

MD

About

75
Publications
3,805
Reads
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273
Citations
Additional affiliations
July 2015 - present
Carilion Clinic
Position
  • Fellow

Publications

Publications (75)
Article
Stroke is a major public health burden worldwide. Prevention programme are essential to reduce the incidence of stroke and to prevent the all but inevitable stroke epidemic, which will hit our population (developing countries) hard as our population age and adopt lifestyle of the more developed countries. In this study we have tried to find the cli...
Article
Full-text available
Objective Nearly four decades ago, a circadian pattern of acute myocardial infarction (AMI) with a peak in the early morning waking hours was described. The goal of the present study was to determine whether major changes in lifestyle and significant advances in medical therapy have altered this pattern in the intervening years.DesignRetrospective...
Article
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Statins are an extensively used class of drugs, and myopathy is an uncommon, but well-described side effect of statin therapy. Inflammatory myopathies, including polymyositis, dermatomyositis, and necrotizing autoimmune myopathy, are even rarer, but debilitating, side effects of statin therapy that are characterized by the persistence of symptoms e...
Article
Pancreas divisum (PD) is the most common congenital variant of the pancreas and has been implicated as a cause of pancreatitis; however, endoscopic treatment is controversial. Our objective was to examine patient response to endotherapy for treatment of symptomatic PD in adult patients in a systematic review of the literature. A systematic review o...
Article
Dieulafoy's lesion (DL) is a rare, but serious cause of gastrointestinal bleeding, most frequently treated with endoscopic therapy. We examined 10 years of data to assess clinical outcomes in DL. Data were captured by retrospective chart review to assess 109 patients treated endoscopically for bleeding DL from 2003 to 2013. Data collected included...
Article
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Background: Liver cirrhosis is one of the major causes of morbidity and mortality. The threatening complication of Liver cirrhosis is variceal bleeding. Early diagnosis and initiation of therapy can reduce mortality associated with variceal bleeding. This study is designed to predict the esophageal varices by non-invasive method using aspartate am...
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Background: Liver cirrhosis is one of the major causes of morbidity and mortality. The threatening complication of Liver cirrhosis is variceal bleeding. Early diagnosis and initiation of therapy can reduce mortality associated with variceal bleeding. This study is designed to predict the esophageal varices by non-invasive method using aspartate ami...
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An isolated descending colonic stricture is an unlikely complication of acute pancreatitis, with the nonspecific symptoms of colonic stricture making the overall diagnosis difficult. Crohn’s disease (CD) and tuberculosis (TB) are the two common etiologies of an isolated colonic stricture and may present similarly to colonic stricture related to acu...
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Background Helicobacter pylori (H. pylori) is one of the most common human infections worldwide particularly in the developing countries. We aimed to study an association of H. Pylori infection with endoscopic and histological findings in the Nepalese population. Materials and Methods We conducted a study between Oct 2014 and Jan 2015 after meetin...
Article
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Background Non-alcoholic fatty liver disease (NAFLD) is emerging as the most common chronic liver condition. Approximately 70% of type 2 diabetes mellitus (T2DM) patients have a fatty liver; the progression to non-alcoholic steatohepatitis (NASH) dramatically increases the risks of cirrhosis and hepatocellular carcinoma. The aim of our study was to...
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Background Contrast-induced nephropathy (CIN) is one of the leading causes of morbidity and mortality including increased financial burden in high risk patients undergoing percutaneous coronary intervention (PCI). Methods This is an observational prospective study. We aimed to study the incidence of CIN in Nepalese populations and compare the outco...
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Introduction: Acute variceal bleeding in liver cirrhosis is an immediate life-threatening condition and amajor complication of portal hypertension associated with higher morbidity, mortality and hospital costs than any other causes of UGI bleeding. Therefore, early stratification and initiation of therapy based on several factors can reduce mortal...
Article
Background: Primary biliary cholangitis (PBC) is a rare disease with incidence that varies with time and geography. Only two studies have assessed PBC incidence of in the United States, with the most recent appearing over a decade ago. The objective of the present study was to assess PBC incidence in the United States in a more recent era. Method...
Article
Full-text available
Superficial vein thrombosis (SVT) may be associated with complications such as venous thromboembolism (VTE) and recurrent SVT. The purpose of this study was to explore risk factors among patients with a first isolated episode of SVT (index SVT) involving upper and lower extremities and to estimate the prevalence of VTE complications within 1 year o...
Article
Introduction: Postoperative recurrence (POR) of Crohn’s disease is common after surgical resection. How to best manage POR remains uncertain. Areas covered: In this review, we will first describe the natural course and the best modalities to diagnose this surgical sequela. We will then focus on the potential risk factors for relapse and highlight t...
Article
Purpose: Albumin is recommended for the treatment of spontaneous bacterial peritonitis (SBP) in patients at high risk for mortality. We assessed adherence to guidelines for administration of albumin for SBP in clinical practice at a private tertiary care hospital. Methods: A retrospective clinical analysis of all cases of SBP diagnosed at a tertia...
Article
Purpose- Gatroesophageal reflux disease is a common gastrointestinal disorder during pregnancy. Proton pump inhibitors (PPI) are efficacious for the treatment of this disorder and are frequently used during pregnancy. Several cohort studies have assessed the safety of PPI in pregnancy. We performed a meta-analysis of cohort studies to evaluate the...
Article
Introduction: Pancreatic cancer is common in the developed world. Several risk factors for pancreatic cancer have been identified. Recent studies have evaluated gastrectomy as a risk factor for pancreatic cancer. We conducted a meta-analysis of case-control studies to assess the role of gastrectomy as a risk factor for pancreatic cancer. Methods: P...
Article
Purpose: Magnetic endoscopic imaging is a technique used for the direct visualization of endoscope configuration within the colon. Theoretically magnetic endoscopic imaging is thought to facilitate successful cecal intubation and prompt removal of loops thereby reducing patient discomfort. Several randomized controlled trials have studied the role...
Article
Background: Post ERCP acute pancreatitis is the most alarming complication of endoscopic retrograde cholangiopancreatography (ERCP) with frequency of 1-9% although it may increase to 40% in high risk groups. Guidewire is thought to reduce the frequency of post ERCP pancreatitis by reducing papillary trauma but still controversial. We conducted a me...
Article
Full-text available
PURPOSE-Upper gastrointestinal bleeding (UGIB) is a clinically significant condition with important implications for health care costs worldwide. Selective serotonin reuptake inhibitors (SSRI) inhibit uptake of serotonin in to platelets and thereby decrease platelet aggregation. Several recent case- control studies have assessed the association of...
Article
Purpose: Post ERCP pancreatitis (PEP) is a common complication after ERCP and contributes significantly to the morbidity and mortality of the procedure. Nafamostat, a protease inhibitor, inhibits serine proteases such as trysin, kallikrien, C1r and C1s, thrombin, plasmin and thereby decrease the risk of PEP. Several randomized controlled trials (RC...
Article
PURPOSE- Emergency surgery is a traditional treatment option for patients with malignant left sided colonic obstruction which involves defunctioning stoma with or without primary anastomosis. Colonic stenting as a bridge to elective surgery has been proposed as an alternative to emergency surgery. Recent randomized controlled trials have assessed t...
Article
Purpose- Endoscopic retrograde cholangio pancreaticography(ERCP) is the procedure of choice for biliary decompression. Endoscopic ultrasound(EUS) guided rendezvous procedure has been suggested as an alternative for patients who failed ERCP. Several studies have evaluated the role of EUS rendezvous procedure in biliary drainage. We performed a syste...
Article
Background: Post ERCP acute pancreatitis is the most common complication of endoscopic retrograde cholangiopancreatography (ERCP). The efficacy of prophylactic pancreatic duct stent for prevention of post-ERCP pancreatitis (PEP) has been studied in several randomized controlled trials (RCTs). We conducted an updated meta-analysis to evaluate the ef...
Article
Purpose: Several studies have suggested association between hepatitis C virus (HCV) and non-hodgkin lymphoma (NHL). But the role of hepatitis B virus (HBV) in the pathogenesis of lymphoproliferative malignancy is not clear. We performed a meta-analysis of case-control studies to evaluate the role of HBV infection in NHL. Method: Pubmed, Embase, Web...
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Full-text available
Ensuring optimal readiness for surgery using a preoperative checklist has been shown to reduce perioperative morbidity and mortality in both elective and urgent surgeries. We recently introduced hemodynamic optimization as part of our preoperative preparedness strategy for cardiothoracic surgery. Here we describe the case of a patient with severe m...
Conference Paper
Purpose: Pancreas divisum (PD) is most common congenital pancreatic anomaly resulting from failure of embryological ventral and dorsal duct fusion. It has been associated with recurrent acute pancreatitis (RAP), chronic pancreatitis (CP) and chronic abdominal pain (CAP). Several studies have reported the effectiveness of endotherapy in symptomatic...
Article
Full-text available
Bisphosphonate such as pamidronate initially described for the treatment of neoplastic hypercalcemia, currently is being used off label to treat sever hypercalcemia of any etiology. Multiple dyselectrolytemias are a potential adverse effect of this drug, and are considered infrequent. We describe a case of transient electrolyte abnormalities after...
Article
Full-text available
Objectives: Popular opinion holds that the phase of the moon influences human behavior, and several re-ports substantiate this claim; however, reports of correlation between the lunar cycle and cardiac events remain controversial. The purpose of the pre-sent study was to determine whether a relationship exists between lunar cycle and the occurrence...
Article
Sleep apnoea syndrome is a well recognized entity. Sleep studies of diagnosed patients with sleep apnoea were analyzed to understand the clinical profiles of Nepalese patients with this disorder. Eighty nine patients were diagnosed to have sleep apnoea syndrome during the period of 15 months starting from November 2003. All these patients were subj...

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