Rajalingam Sinniah

• The University of Western Australia

Badrchacha Quand un article scientifique (ou article de recherche) est publié en ligne, il est souvent accompagné d'un résumé. Cela lui donne de la visibilité et permet aux lecteurs d'avoir une idée du sujet afin de pouvoir rapidement s'y plonger. Dans cet article, nous abordons tous les points essentiels liés au résumé scientifique : définition, c...

Formation, fiche métier, Badrchacha Travailler dans les Ressources Humaines La gestion des ressources humaines n'est pas un secteur économique mais une fonction transversale dont toutes les entreprises ont besoin. Gérer les relations sociales, manager les ressources humaines, valoriser les carrières, recruter de bons profils sont autant de facteurs...

Background BK virus is a polyoma virus causing renal allograft nephropathy. Reduction of immunosuppression with the early recognition of significant BK viral loads in urine and plasma can effectively prevent BKV associated nephropathy (BKVN), however the optimal compartment and frequency of BK viral load measurement post renal transplantation are u...

Glycogenic hepatopathy (GH) is an under-recognised complication of type 1 diabetes mellitus (T1DM) not controlled to target resulting in hepatomegaly and elevated liver transaminases. We report the case of a 19-year-old man with T1DM not controlled to target who presented with abdominal pain, hepatomegaly and deranged liver transaminases. He was su...

Adalimumab (Humira) is a tumour necrosis factor α (TNFα) inhibitor that is approved for the treatment of rheumatoid arthritis, psoriasis, psoriatic arthritis, Crohn's disease, ankylosing spondylitis, and juvenile idiopathic arthritis (Sullivan and Preda (2009), Klinkhoff (2004), and Medicare Australia). Use of TNFα inhibitors is associated with the...

Australia's Indigenous people have high rates of chronic kidney disease and kidney failure. To define renal disease among these people, we reviewed 643 renal biopsies on Indigenous people across Australia, and compared them with 249 biopsies of non-Indigenous patients. The intent was to reach a consensus on pathological findings and terminology, qu...

We report a 29 year old male cystic fibrosis patient with end stage lung disease and normal renal function who underwent a sequential double lung transplant. Medical history included: an ileal resection and pancreatic exocrine dysfunction. The postoperative period was complicated with haemorrhage and repeat surgery, requiring multiple blood transfu...

We present a case of sclerosing lipogranuloma of the penis in a 25-year-old man of Burmese origin complicating injection of an unknown non-biodegradable oily foreign material into his external genitalia. Despite frequent complications, penile augmentation with exogenous paraffin material is still practised in some parts of the world. Sclerosing lip...

Chronic kidney disease (CKD) is one component of a spectrum of chronic disease in Aboriginal Australians. CKD is marked by albuminuria, which predicts renal failure and nonrenal natural death. Rates vary greatly by community and region and are much higher in remote areas. This reflects the heterogeneous characteristics and circumstances of Aborigin...

A growth study of an acaulescent palm, Johannesteijsmannia lanceolata J.Dransfield was carried out in Angsi Forest Reserve, Negeri Sembilan, Malaysia for a period of 19 months. A total of 32 adults, 24 juveniles and 32 seedlings from 3 different plots were censused every two-weeks. The results showed that the average numbers of new leaves entering...

Long acting thyroid stimulator (LATS) has been implicated in the pathogenesis of pretibial myxoedema (PTM). The objective of the present study was to seek evidence for a pathogenic role for LATS in PTM by immunofluorescent antibody study of skin biopsies from these lesions. Six patients (five males and one female) with PTM were studied; one had ass...

A 35-year-old morbidly obese woman on home haemodialysis presented with painful indurated subcutaneous nodules histologically characteristic of calciphylaxis. After failing to respond to conventional treatment, she was commenced on an intravenous infusion of 25 g of sodium thiosulfate three times per week. Two weeks after commencing sodium thiosulf...

Calciphylaxis is a small vessel vasculopathy with medial calcification associated with intimal proliferation, fibrosis and thrombosis. This study discusses the clinical features and treatment of calciphylaxis and assesses the prognosis of patients with calciphylaxis. All patients admitted to vascular or renal wards from January 2003 to December 200...

The flowering event of an understorey palm; Johannesteijsmannia lanceolata J. Dransfield was investigated in the Angsi Forest Reserve, Malaysia for a total period of 18 months. The study commenced from the appearance of the inflorescence until the fall of mature ripe fruits. Results showed that the flowering phase lasted between 8.7 to 9.4 months a...

A 27-year-old Australian Aboriginal man was transferred from prison with a 1-week history of fever, upper abdominal pain, sore throat, and a productive cough. He had a history of alcohol misuse. 3 months before his incarceration, he was prescribed phenytoin 400 mg daily for a seizure that had probably been caused by alcoholwithdrawal. He denied rec...

We report a rare presentation of mitochondrial disorder in a child with recurrent carpopedal spasms due to hypocalcemia and hypomagnesemia, secondary to renal proximal tubulopathy and possible hypoparathyroidism. At least two mutant mitochondrial DNA species were identified, and abnormal mitochondria were found in the muscle and renal biopsy specim...

We report a rare presentation of mitochondrial disorder in a child with recurrent carpopedal spasms due to hypocalcemia and hypomagnesemia, secondary to renal proximal tubulopathy and possible hypoparathyroidism. At least two mutant mitochondrial DNA species were identified, and abnormal mitochondria were found in the muscle and renal biopsy specim...

Mefenamic acid ingestion, usually in excess and over prolonged period is known to produce interstitial nephritis, or less commonly papillary necrosis, with acute renal failure. However, it is not dose-dependent for the induction of tubulointerstitial damage. Excess iodine ingestion is known to produce toxicity and possible death, but acute renal fa...

Injury to renal tubules and interstitium occur in various glomerular diseases, leading to functional impairment. Tubular basement membrane (TBM) is an important component in maintaining tubular epithelial cell integrity. Because ultrastructural changes in these structures had not been studied in detail, the authors analyzed 30 patients with various...

Vascular casting techniques were used to measure arteriole diameters (0, 25, 50, 75, and 100 μ from glomerulus) and vessel lengths in paired interlobular, afferent (AA) and efferent (EA) vessels, following vehicle, 0.1, 1 or 5 ng/kg/min ANG II infusions into the renal artery. Renal blood flow decreased (P<0.05) and filtration fraction increased (P<...

We report triggering of the thumb in a 2-year-old female child caused by intratendinous granulation tissue after trauma to the thumb.

The use of computers for the automated image analysis of tissue sections is becoming increasingly important. The paper presents an overview of current methodologies and summarizes developments in this field. A brief introduction followed by a survey is provided in each of these areas: image transformation, image segmentation and classification.

We report a case of mucoepidermoid carcinoma of the middle ear, a site which does not appear to have been previously described. A discussion of four possible theories of pathogenesis are presented.

Deposition of immunoglobulins, complement proteins C1q, C3c, C3d, C4, C5, C6, C7, C8, C9, and terminal complement complex neoantigens in the renal tubulointerstitium was studied in serial sections by immunofluorescence microscopy. Renal tissue from 45 cases with various glomerular diseases, including 8 controls, was studied. The patients were divid...

In renal pathology glomerular changes have been studied in greater detail than the tubulointerstitium. Interest in the glomeruli was due to their function as the filtration barrier, and also they showed a variety of specific histological and immunohistochemical changes in various glomerulonephritides. In contrast, the tubulointerstitial changes in...

Chondroblastoma represents approximately one per cent of all primary bone tumours. It is even rarer in the temporal bone and so far only 34 cases have been reported. We report here two cases with chondroblastoma of the temporal bone. The first case was discovered as a small lesion of the attic and root of zygoma. It was removed via mastoidectomy an...

Spirochaetes are an important group of bacteria that cause a number of diseases in man. The major pathogenic organisms are Treponema, Leptospira and Borrelia, and they contain both DNA and RNA and are susceptible to the bactericidal action of antibiotics. Of the spirochaetal diseases, syphilis is of world-wide distribution, but the non-venereal tre...

Renal diseases prevalent in developed Western countries are also seen in tropical countries, but these latter countries have their own special problems usually associated with parasitic infections. In some tropical countries the commonest cause of nephrotic syndrome is infection by Plasmodium malariae (Kibukamusoke 1984). In parts of Africa and Sou...

Worms are among the most persistent and widespread agents of disease in humans. Though historical documentation is surprisingly scarce, helminthic disease has affected the health, social, and political development of people since prehistoric times.

We present a novel method of decomposing digital binary clumps into constituent convex parts. The algorithm is based on the analysis of concavities to determine where splitting should occur. Two relative concavity measures, concavity degree and concavity weight, are also defined.

The treatment of lipoid pneumonia, an uncommon chronic lung condition, is generally conservative. We describe a patient with idiopathic lipoid pneumonia who was successfully treated with oral steroids with improvement of chest radiographic abnormalities.

This paper presents an automated clump decomposition system for the image analysis of cervical tissue sections. The system consists of two parts: the training stage and the decomposition stage. The basis of the system is a clump splitting method which analyzes concavities to determine split points

This paper describes the implementation of autofocusing for tissue microscopy. We first investigate the suitability of several criterion functions for the evaluation of image sharpness. Since tissue sections are invariably stained, we also discuss the selection of the colour component on which autofocusing will be performed. In tissue microscopy, w...

Renal tissues from forty cases of IgA nephropathy, 20 Singapore and 20 British patients, and 38 patients with non-immune glomerulonephritis were studied by in situ hybridization using DNA probes for the herpes simplex virus (HSV) and Epstein Barr virus (EBV). Two Singapore patients with IgA nephropathy showed HSV antigens in the glomerular mesangiu...

An algorithm for the detection and measurement of the glomerular basement membrane in kidney electron micrographs by image analysis techniques is described. Starting from a user-specified point, local features within a small window are computed to give a feature score. Feature scores for adjacent neighbourhoods are also determined, and windows that...

Crohn's disease is extremely rare among Asians. Resection of strictures causing obstruction has traditionally been the accepted choice in surgical therapy. This may lead to problems such as iatrogenic short bowel syndrome and its sequelae. Stricturoplasty is an acceptable and safe alternative. We report a case where combined stricturoplasty and res...

A method for decomposing a digital image binary clump into constituent convex parts is described. It is based on a novel contour tracing and labelling technique which simultaneously erodes selective parts of the clump while checking for splitting into disjoint blobs.

The accurate measurement of kidney glomerular basement membrane (GBM) width from transmission electron micrographs provides vital information in the diagnosis of some kidney diseases. A novel and effective algorithm has been developed for the semi-automatic detection of the GBM by image analysis techniques. The method makes use of the gradual varia...

The aims of our study were to investigate the effect of dietary palm oil on the levels of lipoprotein lipase, hepatic lipase, fat distribution (in the aorta and liver), and total cholesterol, HDL, LDL, and triacylglycerol levels in young rats (70 g body wt) over a period of 10 weeks. Palm oil-fed rats showed higher growth rate and lower triacylglyc...

Idiopathic bronchiolitis obliterans organizing pneumonia (BOOP) has become accepted as a distinct disease entity. We report a patient who presented with the classical clinical, radiological and pathologic features of this uncommon condition. To our knowledge, this is first case to be reported in Singapore. This case also illustrates the difficulty...

Endoscopic biopsies of antral mucosa from 26 patients with Helicobacter pylori-associated gastritis were studied by electron microscopy (EM). Scanning electron microscopy (SEM) showed clustering of H. pylori in the intercellular areas, being entrapped by the microvilli which were decreased at the sites where the bacilli were seen. The observations...

A light, electron and immunofluorescence microscopy study was performed on 102 consecutive patients on whom suitable percutaneous renal biopsies were obtained. In this selected group of patients primary IgA glomerulonephritis was diagnosed in 6 (5.9%) cases. On light microscopy the glomerular lesions were predominantly focal (WHO class III) and dif...

L'etude a pour but d'analyser la reponse immunitaire a mediation cellulaire conferrant une immunite vis-a-vis de la malaria. Pour cela, la cyclosporine est administree a doses variables 24 heures avant l'infestation par plasmodium berghei

Mesangial IgA nephropathy was first identified in France by Berger in 1968 [1, 2], and has been referred to as Berger’s disease. The lesion is characterized by diffuse mesangial deposition of immunoglobulins, with IgA predominating. There should be no systemic manifestations, and secondary diseases of systemic lupus erythematosus [3], Henoch-Schönl...

The occurrence of glomerular capillary aneurysms in light-chain nephropathy and a morphologic pattern of development as determined by electron microscopy are described. Renal biopsies from 4 patients with nodular glomerulopathy were evaluated. Light-chain deposition in mesangium and capillary walls was associated with monocyte accumulation in capil...

Kidney and liver sections were obtained from 75 consecutive autopsy cases with liver cirrhosis discovered at post-mortem. Mesangial IgA as the predominant immunoglobulin was found in 36% (27) cases, with accompanying IgM in 10, and IgG in three subjects. IgA deposits occurred more frequently in micronodular cirrhosis than in macronodular and mixed...

An 18-year-old 46 XY patient with the syndrome of incomplete testicular feminization was investigated. The clinical phenotypic features were distinctive and typical of the 4 46 XY cases previously reported. The findings of elevated plasma T4 with evidence of incomplete development of female secondary sex characteristics suggest partial end organ in...

Malignant tumours with teratoid or blastomatous features are exceptionally rare in the upper respiratory tract with only 8 documented cases, including the 3 in this report. The tumours occurred in adults aged 27 to 62 yr, and the sites of origin were the ethmoid sinus (4 cases), ethmoid and other paranasal sinuses (2 cases), unspecified sinuses (1...

Kidney sections were obtained from 200 consecutive control necropsies of patients who died of traumatic injuries, with no clinical history of renal disease or other organic disease discovered at necropsy. Mesangial IgA as the predominant immunoglobulin was found in 8/200 (4%) cases, with accompanying IgM in two of them; and IgM alone in two (1%) su...

In mesangial IgA glomerulonephritis (Berger's disease), the immunoproteins appeared to gain access from the capillary lumen to the mesangium via endothelial fenestrae or via channels between the endothelial cells. The deposits are transported into the deeper mesangium by a process of inhibition or diffusion, with the matrix acting as the head. Ther...

Systemic lupus erythematosus (SLE) is a disease of unknown aetiology. Its hallmark is anti-nucleic acid antibodies and it is accompanied by variable clinical, serologic, and histologic signs. Renal involvement in SLE has been documented for over 50 years; it represents one of the most serious complications of this systemic disorder. Although our un...

Of 710 patients in whom renal biopsies with immunofluorescence, light and electron microscopic and clinical data were available, 239 had idiopathic mesangial IgA nephritis. In these 239 cases IgA was found alone in 45.7%, accompanied by IgG in 50.1%, IgM in 21.4%, C3 in 82.4% and fibrin in 37.2%. Serum immunoglobulin levels including IgA were not s...

A case of systemic lupus erythematosus is described in which for 10 years the only significant findings were erythema multiforme and vasculitis. Gross hepatosplenomegaly with persistent pancytopenia developed, and bone marrow examination revealed the presence of sideroblasts. The patient's condition deteriorated, and subsequently she developed a se...

This is a report of an 18-year old girl with an unusual giant cell tumour. Although it is difficult to distinguish between a multifocal giant cell tumour of bone and a primary giant cell tumour with metastases in other bones, we believe that our case is either a multicentric or a multifocal giant cell tumour.

Ten cases of death due to heat stroke are described. They were all young men who collapsed during running exercise or route march and died in hospital later. Post-mortem examination was carried out in all cases. Death was due to disseminated intravascular coagulation with widespread microthrombus formation and coagulative necrosis involving many or...

The present study showed that papain, indomethacin and alcohol, when injected intra-articularly in rabbit knees, produce depletion of the glycosaminoglycans of the articular cartilage with progressive cartilage damage demonstrable roentgenographically and by histochemical methods. Contrary to the observations of other authors, similar cartilage cha...

Twenty-four patients, 12 children and 12 adults, with the Henoch-Schoenlein syndrome had their renal biopsy specimens studied by light and electron microscopic and immunofluorescent antibody techniques. The principal glomerular lesion was a focal and segmental proliferative glomerulonephritis in 15, a diffuse proliferative glomerulonephritis in 6 a...

Ten cases of small intestinal obstruction seen over a period of 6 years (1971-6) in young girls within the narrow age range of 13-18 years are described. The patients were all within 2 years of menarche. In all these cases the obstruction was due to a membrane encasing the small intestine in the manner of a cocoon. There was no previous history of...

Ten cases of small intestinal obstruction seen over a period of 6 years (1971-6) in young girls within the narrow age range of 13-18 years are described. The patients were all within 2 years of menarche. In all these cases the obstruction was due to a membrane encasing the small intestine in the manner of a cocoon. There was no previous history of...

In a study of 37 non-azotemic patients with systemic lupus erythematosus over a 4 yr period, 23 patients (62%) were unable to acidify their urine to below pH 5.35 (mean ± SD) after a standard ammonium chloride load. 21 out of 31 patients tested (70%) were unable to concentrate their urine. 75% of the patients show an improvement in tubular function...

The incidence of asymptomatic proteinuria in young healthy men entering the army service in Singapore was 0.94%; 0.56% had intermittent orthostatic proteinuria and 0.38% with persistent proteinuria. Renal biopsies from 45 cases with persistent proteinuria and 10 cases with orthostatic proteinuria were studied by light microscopy, electron microscop...

Percutaneous renal biopsies from 56 patients with systemic lupus erythematosus were studied to determine the relationship between renal function and the light microscopic, electron microscopic and immunofluorescent antibody findings. The glomerular lesions were classified into 5 major groups: diffuse membranoproliferative glomerulonephritis (34%),...

Renal biopsies from 145 patients with asymptomatic microscopic hematuria were studied with light microscopic, electron microscopic and immunofluorescence antibody techniques. The predominant lesions were a diffuse proliferative glomerulonephritis (mesangial hypercellularity) with focal epithelial crescents and focal segment and/or global sclerosis...

A case of systemic lupus erythemaosus with an unusual complication of pulmonary hypertension leading to cor pulmonale is reported. Lung biopsy showed an interstitial pneumonitis with pulmonary vascular narrowing causing pulmonary hypertension. These changes appeared to be immunologically mediated by the utilization of IgG and C3. Microtubular virus...

Waldenstrom's macroglobulinaemia was found in a 60 yr old Indian male with the characteristic clinical, chemical, immunological and histopathological findings. In spite of treatment he died of a fulminating infection and at autopsy, the diagnosis was confirmed. The literature of this rare disease was briefly reviewed.

In 52 cases studied a good correlation existed between renal function and underlying histology in lupus nephritis. In patients with normal urinary finding or mild abnormalities, 38% had no obvious or focal lesions, 54% had diffuse proliferative lesions, the majority of which were mild and 8% had membrano proliferative lesions. In the moderate and s...