Rahul Biradar

Rahul Biradar
University of Turku | UTU · Turku Bioscience

PhD candidate

About

10
Publications
1,363
Reads
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8
Citations
Education
August 2013 - May 2018

Publications

Publications (10)
Article
Full-text available
Th17 cells are essential for protection against extracellular pathogens, but their aberrant activity can cause autoimmunity. Molecular mechanisms that dictate Th17 cell-differentiation have been extensively studied using mouse models. However, species-specific differences underscore the need to validate these findings in human. Here, we characteriz...
Article
Full-text available
Dysregulated function of Th17 cells has implications in immunodeficiencies and autoimmune disorders. Th17 cell differentiation is orchestrated by a complex network of transcription factors, including several members of the activator protein (AP-1) family. Among the latter, FOSL1 and FOSL2 modulate the effector functions of Th17 cells. However, the...
Article
Full-text available
Dysregulated function of Th17 cells has implications in immunodeficiencies and autoimmune disorders. Th17 cell differentiation is orchestrated by a complex network of transcription factors, including several members of the activator protein (AP-1) family. Among the latter, FOSL1 and FOSL2 modulate the effector functions of Th17 cells. However, the...
Preprint
Full-text available
Dysregulated function of Th17 cells has implications in immunodeficiencies and autoimmune disorders. Th17 cell-differentiation is orchestrated by a complex network of transcription factors, including several members of the activator protein (AP-1) family. Among these, FOSL1 and FOSL2 influence the effector responses of Th17 cells. However, the mole...
Preprint
Full-text available
Th17 cells protect mucosal barriers, but their aberrant activity can cause autoimmunity. Molecular networks dictating human Th17 function are largely unexplored, and this hinders disease-studies. Here, we investigated the roles of the AP-1 factors, FOSL1 and FOSL2, in inducing human Th17 responses. Transient knockdown and over-expression strategies...
Article
Full-text available
SATB1 is a genome organizer protein that is expressed in a lineage specific manner in CD4+ T-cells. SATB1 plays a crucial role in expression of multiple genes throughout the thymic development and peripheral differentiation of T cells. Although SATB1 function has been subjected to intense investigation, regulation of SATB1 gene expression remains p...
Technical Report
Full-text available
With the aim of developing a novel diagnostic method for Mycobacterium tuberculosis detection in an in vitro setting, we have tested components a synthetic genetic circuit, Mycobacterium Revelio. This hypothetical circuit will need three components: an ‘oscillator’ based on a hybrid promoter, a pigment-based ‘detection’ and a population growth ‘ter...
Article
With the aim of developing a novel diagnostic method for Mycobacterium tuberculosis detection in an in vitro setting, we have tested components a synthetic genetic circuit, Mycobacterium Revelio. This hypothetical circuit will need three components: an ‘oscillator’ based on a hybrid promoter, a pigment-based ‘detection’ and a population growth ‘ter...

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Projects

Project (1)
Project
To delineate the role of different transcription factors downstream of TCR and cytokine signaling on the novel gene. Further, which genes are regulated by these factors at a genome-wide level.