Rahmat Ali khan

University of Science & Technology Bannu · Biotechnology

Nanotechnology is one of the modern techniques of material science which have received much importance in the last many years. Nanotechnology is concerned with the production of nanoparticles (NPs) with restricted sizes and shapes through a facile, straightforward, and medicinally active phytochemical route. This study aims to develop an easy and j...

Objectives: To estimate the existence of phyto-chemicals and then to determine the antidiabetic activity against α-amylase and β-glucosidase inhibition . Methods: The study was carried out by following standard procedures. Results: Phytochemicals analysis indicated the presence of different phytochemicals. The total phenolic content was 6.055...

Nanotechnology is one of the modern techniques of material science which have received much importance in the last many years. Nanotechnology is concerned with the production of nanoparticles (NPs) with restricted sizes and shapes through a facile, straightforward, and medicinally active phytochemical route. In this work silver nanoparticles (AgNPs...

Wild medicinal herbs have been used as folk and traditional medicines all across the world since well before recorded history. This present study was designed to test the antimicrobial activities of five different solvent extracted samples (n-hexane, n-butanol, ethyl acetate, methanol, and water) of Peganum harmala using stems and seeds. Two differ...

Wild medicinal herbs have been used as folk and traditional medicines all across the world since well before recorded history. This present study was designed to test the antimicrobial activities of five different solvent extracted samples (n-hexane, n-butanol, ethyl acetate, methanol, and water) of Peganum harmala using stems and seeds. Two differ...

Background: Using a variety of chemical compounds and biomolecules, researchers have been working on new antidiabetic drugs for many years. Anti-diabetic research is increasingly using nanomaterials because of their unique qualities, such as their tiny size, biocompatibility, and ability to penetrate cell membranes for drug delivery. Using extract...

Abstract: Background: Using a variety of chemical compounds and biomolecules, researchers have been working on new antidiabetic drugs for many years. Anti-diabetic research is increasingly using nanomaterials because of their unique qualities, such as their tiny size, biocompatibility, and ability to penetrate cell membranes for drug delivery. Usin...

Abstract: Background: Type-2 diabetes mellitus (T2DM) is a non-communicable, life-threatening syndrome that is present all over the world. The use of eco-friendly, cost-effective and green synthesised nanoparticles (NPs) as a medicinal therapy in the treatment of T2DM is an attractive option. Aim: The present study aimed to evaluate the anti-diabet...

Plants are the most important source of biological compounds that are used to achieve biological activity. The originating of crude extracts of plants is broadly used as therapeutic drugs to treat various infectious damages. The present study was arranged to investigate the potential of Alkanna tinctoria Tausch, roots extract, collected from distri...

Background: Acute kidney injury may increase the risk for CKD and end-stage renal disease. In an attempt to summarize the literature and provide more compelling evidence, we conducted a systematic review comparing the risk for CKD (chronic kidney disease), AKI (Acute kidney injury), Acute gastroententeritis, postnatal AKI, Acute MI (myocardial infa...

Emerging resistance in microorganisms is a growing threat to human beings due to its role in pathological manifestations in different infectious diseases. This study was designed to investigate the antimicrobial and cytotoxic potential of methanol extract of Dicliptera roxburghiana and all its derived fractions. Antibacterial (against six bacterial...

Among various Nano-technological fields, green chemistry is an eco-friendly, inexpensive, easy, and fast method for synthesizing nanoparticles. Therefore, it has influenced researchers and scientists from various fields to create an innovative way to produce nanoparticles. In the present study, silver nanoparticles (AgNPs) were synthesized using an...

Nowadays, data is increasing exponentially, although cloud computing is an eminent approach for the organization, processing, and availability of data for organizational growth over the internet. Besides, a lot of advantages of cloud computing, yet it is suffered from security challenges, which affect big data while using cloud services on the inte...

The Brain Imaging Data Structure (BIDS) established community consensus on the organization of data and metadata for several neuroimaging modalities. Traditionally, BIDS had a strong focus on functional magnetic resonance imaging (MRI) datasets and lacked guidance on how to store multimodal structural MRI datasets. Here, we present and describe the...

Providing home hemodialysis (HHD) therapy is a complex process that not only requires the use of a complex technology but also involves a diverse group of stakeholders, and each stakeholder has their requirements and may not share a common interest. Bringing them together will require the alignment of their interests. A process management perspecti...

Hyoscyamus insanus (family Solanaceae) was traditionally used for treatment of asthma, relieving pain and increasing female body weight. The present project was intended to assess the phytochemicals, total phenolic content, cytotoxic, antioxidant and antidiabetic activities of Hyoscyamus insanus leaves methanolic extract and its special fractions....

Background and Objectives: Oxidative stress that may be the source of different disorders is caused by reactive oxygen species. CCl4 may cause oxidative stress. Antioxidant enzymes that are created by the body may scavenge the reactive oxygen species. The protective effects of Nicotiana plumbaginifolia (Linn) methanolic extract (NPME) against CCl4...

Objective: To examine the efficacy of Silene arenosa extract on acetylcholinesterase (AChE) of krait (Bungarus Sindanus) snake venom. Methods: The present project designed to evaluate the inhibition of AChE by following standard procedures. Results: Statistical analysis of the results showed that Silene arenosa exerted 73% inhibition against t...

Psychological disturbance (PD) or cerebral dysfunction (CD) occupying several clinical areas having defining features of mental retardation. Currently we have designed to investigate heritable heterogeneity in Pakistani consanguineous couples with recessive autosomal intellectual abnormilaties. Department of Biotechnology UST-Bannu and WJC Panum in...

The photoinduced synthesis of zinc oxide nanoparticles (ZnO NPs) was carried out to unveil the effects of change in wavelength of photons. ZnO NPs were synthesized by the coprecipitation technique exposed to different light regimes [dark environment, daylight, and blue-, green-, yellow-, and red-colored light-emitting diodes (LEDs)] at room tempera...

Background: The venom of the krait (Bungarus sindanus), an Elapidae snake, is highly toxic to humans and contains a great amount of acetylcholinesterase (AChE). The enzyme AChE provokes the hydrolysis of substrate acetylcholine (ACh) in the nervous system and terminates nerve impulse. Different inhibitors inactivate AChE and lead to ACh accumulatio...

Abstract Background Owing to the side effects of synthetic medicine and less effectiveness against different syndromes, the researchers have focused on phytotherapy to overcome these problems. The purpose of this project was to study the in vitro phytochemical, cytotoxic, total phenolic, antioxidant and antidiabetic activities of the methanol extra...

Mushrooms are used traditionally as nutrition, medicines and as a tonic for ages. This study was aimed to evaluate the free radical scavenging potential of Phallus impudicus aqueous extract (PIAE) using (DPPH), (ABTS +) and Hydrogen peroxide (H 2 O 2), While for in-vivo hypoglycemic characterization of (PIAE), Body weight, Blood glucose level, Seru...

A number of electrolytes are involved in the regulation of blood pressure (BP) and the pathophysiology of heart attack (HA). In present study, we have studied blood sodium (Na), calcium (Ca) and potassium (K) concentration in hypertensive and heart attack patients. Our hypothesis was that whether the hypertensive and heart attack patients have high...

The presence of phytochemical constituents and estimation of total phenolic contents in Iphiona aucheri (Bioss.) Anderb. stem and assessment of their cytotoxic, total antioxidant and anti-diabetic activity were investigated. All fractions were assessed for phytochemicals, cytotoxic activity, total phenolic contents, antioxidant and anti-diabetic ch...

Mushrooms are used traditionally as nutrition, medicines and as a tonic for ages. This study was aimed to evaluate the free radical scavenging potential of Phallus impudicus aqueous extract (PIAE) using (DPPH), (ABTS +) and Hydrogen peroxide (H 2 O 2), While for in-vivo hypoglycemic characterization of (PIAE), Body weight, Blood glucose level, Seru...

Diabetes mellitus is considered, the sixth main cause of death throughout the world, and every ten seconds a person dies from causes related to diabetes, mainly due to cardiovascular complications. Mushrooms have been used for traditional foods and medicines globally. The current study was tried to evaluate the in-vitro anti-oxidant and antidiabeti...

Mushrooms are used traditionally as nutrition, medicines and as a tonic for ages. This study was aimed to evaluate the free radical scavenging potential of Phallus impudicus aqueous extract (PIAE) using (DPPH), (ABTS +) and Hydrogen peroxide (H 2 O 2), While for in-vivo hypoglycemic characterization of (PIAE), Body weight, Blood glucose level, Seru...

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The methanolic extract of Iphiona aucheri leaves and its n-hexane, chloroform and aqueous fractions were screened for phytochemicals, cytotoxic effects, total phenolic contents, antioxidant and anti-diabetic properties. The methanolic extract was assessed for its in vivo anti-diabetic effects. The results indicated the presence of alkaloid, protein...

Objective: The main objective of study was to determine the frequency of restless leg syndrome in End stage Renal Disease patients on Hemodialysis in our setup. Material and methods: This descriptive cross sectional study was conducted at Department of Nephrology, Khyber Teaching Hospital for duration of six months from June 2014 till December 2014...

We have previously reported that squalene overproducing yeast self-downregulate the expression of the ethanol pathway (non-essential pathway) to divert the metabolic flux to the squalene pathway. In this study, the effect of co-production of squalene and ethanol on other non-essential pathways (fusel alcohol pathway, FA) of Saccharomyces cerevisiae...

Abstract Introduction Science and technology is always progressing and old technologies replaced. Nanotechnology is one of the new growth areas that has emerged during this century. Nanotechnology deals with the synthesis of nanoparticles and nanomaterials of variable size, shape and its application in numerous fields. Biological methods also have...

Intellectual disability (ID) or Mental Retardation (MR) is a broad term, which occupies several medical directions. It is extremely heterogeneous and has about reported 25,000 genes of which half of the genes expression have been found in the brain. Intellectual disability causes severe disability and has a worldwide prevalence of around 2% while a...

The farmer and researcher are globally comprehending more concentration on allelopathic activities of plants as compare to the times of yore. Allelopathy is alleged for the stumpy production and malfunction of crops due to reseeding, crops alteration and over cropping. Additionally, the researcher and farmer give attention to the inexpensive, biode...

The aim of the current project was to evaluate the antibacterial and antifungal activities of Iphiona aucheri leaves methanolic extract and its n-hexane, chloroform and aqueous fractions. Fine powder of Iphiona aucheri leaves were extracted in 70% methanol and then subjected to sequential fractionation through n-hexane, chloroform and water. All th...

In the current study the occurrence and severity of iron deficiency anemia (IDA) was recorded from September, 2014 to April, 2015 in children of school age in District Tank. Random sampling of blood and questionnaires were planned to record general information while blood was analyzed through automatic haematological analyzer model Sysmex Kx- 21 St...

Fine powder of Oligomeris linifolia was extracted with 70% methanol. Crude Oligomeris linifolia methanol extract (OLME) were assessed for antioxidant, antibacterial and antifungal characteristics. All the tested OLME showed potent antioxidant, antibacterial, and antifungal activities. The results clearly showed that Oligomeris linifolia methanol ex...

Phytochemical screening, cytotoxic activity, total phenolic content, antioxidant and anti-diabetic activities of the Sorghum halepense methanolic extract and its different fractions were evaluated. Methanolic extract and its various fractions revealed the presence of reducing sugars, tannins, steroids, glycosides, flavonoids in the methanolic extra...

Chenopodium murale Linn. is an evergreen annuals herb, and can be found throughout the year. Chenopodium murale are thought to possess therapeutic effects on many illnesses in worldwide. Present study was aimed to investigate an antioxidant, cytotoxic activities and phytochemical analysis of Chenopodium murale ethanol extract. The antioxidant activ...

Background: This study examines the inhibition of alpha amylase (α-amylase) via using Silene arenosa water extract. To the best of our knowledge, there are no previous studies on the α-amylase inhibition activities of S. arenosa extracts. For this aim, S. arenosa extracted with water by maceration method and their α-amylase enzyme inhibition activi...

Background: Anemia is one the most important complications of chronic kidney disease. Anemia contributes to increased morbidity, mortality and poor quality of life of such patients especially those on maintenance hemodialysis. Multiple therapies are established in prevention and treatment of anemia of chronic kidney disease. Despite use of such mea...

The objective of this research work was to assess the hyperglycemic and hyperlipidemiceffects of Stellaria media in alloxan induced diabetic rats using different experimental models. Standard documented protocols were used to concede the in vitro and in vivo activities. Biochemical markers studies were also done. The results of the study showed str...

Background In the southern and tribal districts of Khyber Pakhtunkhwa mainly reside Pashtun ethnic cultures that preferably use local plants to combat various health issues. We conducted surveys in this terrain to make an inventory of plants used traditionally for the treatment of diabetes. Methods A purposive sampling method was applied in the...

Plasmodium is the causative agent of malaria, transmit with the bites of female mosquito anopheles called malarial vectors. The four species P. Falciparum, P. vivax, P. ovale and P. Malariae are the causative agents of the malaria. Malaria is major cause of morbidity and mortality with high risk areas of Pakistan, mainly located in Sindh, Baluchist...

Traditional medicines are composed of herbal formulations and their active ingredients and constituents which play a crucial role in the treatment of various human ailments. Astragalus eremophilus and Melilotus indicus (L.) All. (syn. Melilotus parviflora Desf.) are used traditionally as antiperspirant, tonic, diuretic, laxative and narcotic agents...

In the present study, we investigated the hypolipidemic and hepatoprotective potential of the commercially available crushed Ajwa date seed-extract on the toxicity caused by the atorvastatin in high-fat diet (HFD)- induced hyperlipidemic rats. Male albino rats were divided into two main groups, Group I (normal control) and Group II (HFD); Group II...

Objective(s) The objective of this study was to evaluate pharmacological effect of Calligonum polygonoides against Krait snake’s venom acetylcholinesterase (AChE) and to extent it for the treatment of Alzheimer’s disease. Materials and Methods Acetylcholinesterase activity was measured using Ellman method with some modification. The kinetic studie...

Background and Objective: Ischemia is a stern decline or absolute obstruction in blood, flowing to various parts of the body. This pathophysiological episode causes cerebral mutilation, a protuberant feature of stroke, which is the 3rd leading cause of demise after cancer and heart attack globally. The principal objective of this work was to unders...

In pharmaceutical industry, plant mediated nanoparticles, predominantly silver nanoparticles (SNPs) are extensively under consideration for the production of novel drugs. These plant mediated nanoparticles do not harm the nature and therefore, their synthesis is called "Green Synthesis". In the current study, toxic effects of plant mediated SNPs we...

This was a cross-sectional descriptive study for determining the effect of vaccination in children suffering from measles in district Bannu and FR regions. It was conducted at the Paediatric Unit of Women and Children Teaching Hospital, Bannu Medical College Bannu, from July 2015 to June 2016.A total of 7,200 children were examined both from indoor...

Madam, breast cancer is identified as the most common malignancy among Pakistani women accounting for 34.6% of all female cancers. 1 In Asian countries, Pakistan has the highest rate of breast cancer incidences excluding (Jewish females) due to the many factors. According to an earlier report estimated age-standard (world) annual rate of breast can...

This was a cross-sectional descriptive study for determining the effect of vaccination in children suffering from measles in district Bannu and FR regions. It was conducted at the Paediatric Unit of Women and Children Teaching Hospital, Bannu Medical College Bannu, from July 2015 to June 2016.A total of 7,200 children were examined both from indoor...

Objective: To highlight the role of habitat evaluation in reducing the potential transmission risk of malaria. Methods: This study was conducted from January to June, 2015, in District Bannu in Khyber Pakhtunkhwa, Pakistan, where 64 larval habitats were characterised in 10 villages of the district. The larvae habitat features, like its permanent...

Tamarix dioca (L.) belongs to family Tamaricaceae is traditionally a vital plant used for treatment of various diseases. Efforts were made to investigate the antimicrobial efficiency of T. dioca.There was three concentrations of crude methanolic extracts of 200µg/ml, 100µg/ml and 50 µg/ml were checked against six pathogenic fungi Aspergillus fumiga...

The current study was focused on the phytochemical investigation and pharmacological activities of the various solvent fractions (methanolic, n-hexane, dichloromethane, ethyl acetate and water) of Taverniera nummularia (T. nummularia). The various solvent fractions were screened for phytochemicals, antibacterial assay, antifungal assay, DPPH (1, 1-...

In pharmaceutical industry, plant mediated nanoparticles, predominantly silver nanoparticles (SNPs) are extensively under consideration for the production of novel drugs. These plant mediated nanoparticles do not harm the nature and therefore, their synthesis is called "Green Synthesis". In the current study, toxic effects of plant mediated SNPs we...

The present study was carried out to record and evaluate the effect of Rosa brunonii, Calligonum polygonoides, Sueda fruticosa and Pegnum harmala L., extracts on brine shrimp collected during March-June 2013 from different regions of District Bannu. These four plants were medicinal xerophytes and widely distributed throughout Pakistan. Rosa brunoni...

Snake bite poisoning is a matter of great trepidation around the globe, particularly in developing countries. Every year, approximately 5 million cases of snake bite are reported resulting in 125,000 deaths worldwide. The morbidity and mortality remains un-documented in most of the rural parts as the victims are first attended by the traditional he...

Erythraea ramosissimais traditionally used for the treatment of various human diseases. In the present study was aimed at the in-vitro pharmacological and phytochemical analysis of the methanol extract of Erythraea ramosissima. The sample extract of Erythraea ramosissima showed potent antioxidant activities (98.1±5.2%) inhibition of DPPH, Hydrogen...

Background and Objective: Various parts of medicinal plants have been used to treat specific disorder from ancient times. Swertia chirayita (Roxb. ex Fleming) is a customary folklore medicine, used in the treatment of liver disorders, fevers, dysentery, diarrhea, stomach problems and other disorders. The present study was carried out in order to as...

This work is focusing on the synthesis and application of new potential ionic liquids (ILs) for biodiesel production from waste palm cooking oil. For this propose total eleven ionic liquids were synthesized containing various types of cations and anions and characterized with nuclear magnetic resonance (NMR), fourier-transform infrared (FTIR) and e...

Background Launaea procumbens (Roxb.) Amin is traditionally used in Pakistan for the treatment of hormonal disorders and oxidative stress. The present study was aimed to evaluate the efficacy of Launaea procumbens methanol extract (LPME) against KBrO3-induced oxidative stress and hormonal dysfunction in thyroid. Methods To examine the effects of L...

Cardia obaliqua was used traditionally in Pakistan for the treatment of diabetes, microbial infection and jaundice. In the present study we arranged to evaluate the antimicrobial, antioxidant and cytotoxic activities of Cardia obaliqua methanol extract. Cardia obaliqua was obtained from Surrani, District Bannu for preparation of crude methanol extr...

Background Rumex hastatus leaves have been widely used as food additive and for the treatment of various liver ailments. According to our previous studies, ethyle acetate (ERL) and methanolic (MRL) fractions of R. hastatus leaves are an accessible source of natural antioxidants. In the present research work we arranged to investigate the R. hastatu...

Abstract Background: Carissa opaca leaves were conventionally recommended by local hakims in Pakistan for curing various human diseases including renal, hepatic and jaundice. In this work we arranged to study the antioxidant status of various fractions of C. opaca leaves through nine multifaceted assay systems. Methods: Various fractions were prepa...