Raghavendra Hl

Raghavendra Hl
São Paulo State University | Unesp · Faculty of Medicine (FMB)

PhD in Biochemistry

About

145
Publications
83,220
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Introduction
Raghavendra Hl currently works at the Faculty of Medicine, Sao Paulo State University (UNESP). Raghavendra does research in Diabetology, Toxicology, Biochemistry and Phytopharmacology.
Additional affiliations
October 2011 - May 2018
Wollega University
Position
  • Managing Director
April 2005 - November 2010
Kuvempu University
Position
  • Project Fellow
Education
December 2011 - December 2015
Kuvempu University
Field of study
  • Biochemistry

Publications

Publications (145)
Article
Mild gestational hyperglycemia (MGH), as assessed using the normal oral glucose tolerance test (OGTT) and detection of an altered glycemic profile, is associated with adverse perinatal outcome. This study described the results of 40 years of research conducted at the Perinatal Diabetes Research Centre at São Paulo State University (UNESP), Brazil,...
Article
Full-text available
Background: Pelvic floor muscles (PFM) and rectus abdominis muscles (RAM) of pregnant diabetic rats exhibit atrophy, co-localization of fast and slow fibers and an increased collagen type I/III ratio. However, the role of similar PFM or RAM hyperglycemic-related myopathy in women with gestational diabetes mellitus (GDM) remains poorly investigated...
Article
Aims To evaluate the effects of gestational diabetes mellitus (GDM) on the structural characteristics of the rectus abdominis muscle (RAM) and its indirect effects on pregnancy-specific urinary incontinence (PSUI). Methods A total of 92 pregnant women were divided into four groups, according to their clinical conditions: non-GDM continent, non-GDM...
Article
Full-text available
Aim To evaluate the pelvic floor (PF) biometry using three‐dimensional ultrasound (US) at two‐time points of gestational in pregnant women with gestational diabetes mellitus (GDM). Methods A prospective cohort study conducted at the Perinatal Diabetes Research Center including 44 pregnant women with GDM and 66 pregnant women without GDM at 24 to 2...
Article
Full-text available
Background There is ample evidence that gestational diabetes mellitus has a direct influence on urinary incontinence and pelvic floor muscles. There are no standardized pelvic floor muscle exercise programs in the literature for the physiotherapy and differ in the type of exercise, intensity, type and duration of application, and the frequency and...
Article
Full-text available
Gestational diabetes mellitus (GDM) plus rectus abdominis muscle (RAM) myopathy predicts long-term urinary incontinence (UI). Atrophic and stiff RAM are characteristics of diabetes-induced myopathy (DiM) in pregnant rats. This study aimed to determine whether swimming exercise (SE) has a therapeutic effect in mild hyperglycemic pregnant rats model....
Article
Aim: This study aimed to assess, for the first time, the dynamic morphometry of pelvic floor muscles (PFM) using three-dimensional transperineal ultrasound (3D-TPUS) and its progression at two-time points of gestation between women with and without gestational diabetes mellitus (GDM), and whether the PFM dysfunction is connected to GDM. Methods:...
Article
Full-text available
Introduction and Aim: Reactive oxygen species are implicated in the pathophysiology of several human ailments. Antioxidants from plants are shown to be promising in terms of their health benefits. Glochidion ellipticum Wight is belonging to the family Phyllanthaceae. This study investigated the antioxidant potential of solvent extracts of G. ellipt...
Article
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Rubus steudneri Schweinf. (Rosaceae) is one of the three unstudied Rubus species that grow in Ethiopia. The present work was aimed to determine the physicochemical characteristics, micronutrients, anthocyanins, and antinutrients of ripe and unripe R. steudneri fruits using a range of analytical protocols. The present work also investigated the α-gl...
Preprint
Full-text available
Background Gestational Diabetes Mellitus and long-term urinary incontinence (UI) have a severe impact on women's health. New methods to identify pregnant predictor risk factors of UI are needed. Our study investigated clinical and pelvic floor 3D-ultrasound markers in pregnant women at the second and third trimesters to predict 6-18 months postpart...
Article
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Introduction and Aim: Rubus steudneri Schweinf. and Rubus apetalus Poir. belonging to the family Rosaceae is one of the ethnomedicinal plants used widely in Ethiopia as food, for construction and as medicine. To the best of our knowledge, insecticidal activity of R. steudneri and R. apetalus has not been investigated so far. In this study, we repor...
Article
Full-text available
Diabetes mellitus is one of the metabolic disorders that affect the well-being of people all over the world. Inhibition of α-amylase activity seems to be an attractive strategy for managing type II diabetes mellitus. Interest in botanicals with α-amylase inhibitory activity is triggered due to some drawbacks that are associated with the use of comm...
Article
Full-text available
Aim: Rubus steudneri Schweinf. (Rosaceae) is one of three Rubus species that grow in Ethiopia. Studies of this species have been restricted to in vitro antioxidant, antidiabetic, and nutritional evaluation. Until today, no identification has been made of its phytochemical fingerprints, resulting in an unclear picture of its phytochemical constituen...
Preprint
Full-text available
We investigated the subchronic immunotoxicity of the phosphoramidothioate organophosphorous insecticide, acephate in white leghorn cockerels (WLH). The cockerels were divided into five groups; C1 (plain control), C2 (vehicle control), T1, T2, and T3 which received acephate suspended groundnut oil for 60 days at doses of 21.3, 28.4 and 42.6 mgkg − 1...
Article
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Recent epidemiological studies suggest that postprandial hyperglycemia is an independent risk factor for cardiovascular disease. A human's high carbohydrate diet majorly consists of a high carbohydrate diet and α-glucosidase is a glucosidase located in the brush border of the small intestine is involved in glycosidic cleavage of starch at α-glycosi...
Chapter
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Phyllodium pulchellum (L.) Desv. [Syn: Desmodium pulchellum (L.) Benth] is a shrub belonging to the family Leguminosae. In this review, a comprehensive information on the ethnomedicinal uses, phytochemistry and pharmacological activities of P. pulchellum is discussed. P. pulchellum is reported to be used as fodder and as an edible plant. The plant...
Poster
Full-text available
HYPOTHESIS / AIMS OF STUDY In the light of the complex interrelationships among diabetes mellitus, pregnancy and urinary incontinence, the hypothesis was that gestational diabetes mellitus (GDM) associated with pregnancy-specific urinary incontinence (PS-UI) will increase the occurrence and severity of UI, having a negative impact on the QoL during...
Article
Full-text available
Introduction and Aim: Rubus steudneri Schweinf. and Rubus apetalus Poir. are two of the three Rubus species that grow in Ethiopia belongs to the Rosaceae family consumed as food and used in traditional medicine. Studies of this species have been restricted to in vitro antioxidant studies. Keeping this into consideration, we determined physicochemic...
Article
It has been shown that 17β-estradiol (E2) helps to prevent bone loss. This study was undertaken to verify whether E2 action in human osteoblasts involves changes in the transcriptional profile of the TNF-α, IFN-γ, NF-κB, TRAIL, TGF-β, MMP2, MMP9, RECK, TIMP1, TIMP2, CDK2, CDK4, SRC, RUNX2, and SHH genes. Infraphysiological doses of E2 elevated mRNA...
Article
Full-text available
Background and objective In the present study, we compared the effect of diabetic pregnancy on the rectus abdominis muscle (RAM) in humans and rats. We hypothesized that our animal model could provide valuable information about alterations in the RAM of women with Gestational Diabetes (GDM). Method Newborns female rats (n = 10/group) were administ...
Article
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Aim: Osteoporosis is a common disease worldwide and characterized by low bone mass and the progressive destruction of bone microstructure, resulting in an increased bone fragility and risk of fracture. The objective of this study was to evaluate the anti-osteoporotic activity of ethanolic extract of Punica granatum seeds (EPGS) in ovariectomized (O...
Article
Full-text available
Background: The 6-mercaptopurine (6-MP) is an effective immunosuppressant and anti-cancer drug. However, the usage of 6-MP is limited due to its well-known side effects, such as myelotoxicity and hepato-renal toxicity. To curtail the potential toxic effects, we have used chitosan as a natural biodegradable and biocompatible polysaccharide to synth...
Chapter
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The global demand for fossil fuels is very high, but their use is not sustainable since its reserves are declining. Additionally, fossil fuels are responsible for the generation and accumulation of greenhouse gases. Thus, renewable fuels capable of sequestering carbon dioxide are in high demand. The production of first‐generation biofuels from conv...
Article
Background: The prevalence of gestational diabetes mellitus (GDM) is increasing worldwide, and this condition may be compromising female sexual function. However, there are controversial findings regarding the impact of GDM diagnosis and proposed treatments on sexual function during pregnancy. Therefore, this study seeks to elucidate the impact of...
Article
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Aim: This study aims to investigate antimicrobial and antioxidant activity of leaf, stem, and inflorescence of Pleocaulus sessilis (Nees) Bremek belonging to Acanthaceae. Materials and Methods: The leaves, inflorescences, and stems were separated, dried under shade, powdered, and extracted using methanol by maceration process. Preliminary phytochem...
Article
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Objectives: The aims of the study was to investigate and compare the long-term risk to develop type 2 diabetes mellitus (T2DM) or the metabolic abnormalities among mother-infant pairs of low income Brazilian Gesta- tional Diabetes Mellitus (GDM) and non-GDM mother 5-11 years after delivery. Methods: The study participants were obtained from an exis...
Article
Full-text available
Objectives:To assess the pre-pregnancy metabolic syndrome (MetS) exposure and its effects on the perinatal outcomes (large-for- estationalage infants, macrosomic and preterm birth) and on short and long-termrisk for the development of MetS and metabolic repercussions among offspring of low income population of Brazilian mother. Methods:This unplan...
Article
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The present article deals with study of pharmacognostic analysis of Curcuma vamana plant. In this, microscopic analysis of Curcuma vamana was done by transverse sections of rhizome, root, stem and leaf. The physicochemical evaluation; ash values, namely total ash, acid-insoluble ash, water-soluble ash, and sulfated ash; extractive values, namely al...
Conference Paper
Full-text available
Introduction: Gestational diabetes mellitus (GDM) is an important risk factor for urinary incontinence (UI) two-year post caesarean section (CS). Previous studies using rectus abdominis muscle (RAM) of pregnant rats with severe and moderate diabetes confirmed diabetic myopathy as a risk factor to UI. But the pathophysiological mechanisms of UI are...
Conference Paper
Full-text available
Mesenchymal stem cells (MSCs) have an important role for regenerative medicine through their self‐renewal and differentiation capability; besides its involvement in tissue development, maintenance, and repair, being useful for skeletal muscle regeneration by the production of secretory factors with trophic and engraftment functions. We propose to u...
Article
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Background and objective: Chronic hyperglycemia in diabetes determines the overproduction of free radicals, and evidence is increasing that these contribute to the development of diabetic complications. Aim of the present study was to evaluate the antidiabetic and antioxidant activity of R. apelatus Poir. and R. steudneri Schweinf leaf extract in a...
Article
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Ethnobotany is the scientific study concerned with the study of relationship between plants and man, in particular, how people use their traditional knowledge with respect to utilization of plant resources for their wellbeing. Plants have been extensively used since time immemorial as an indispensible source such as food, fodder, medicine, dyes, fl...
Article
Full-text available
Gentamicin induced renal complications are well known in humans and animals. Medicinal properties of Withania somnifera (L.) Dunal, Solanaceae, are recognized to improve renal functions. However, the pharmacological function of W. somnifera is not completely understood. We sought to unravel medicinal therapeutic function of W. somnifera on gentamic...
Chapter
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Diabetes is a complex, chronic illness requiring continuous medical care with multifactorial risk-reduction strategies beyond glycemic control. The chronic hyperglycemia of diabetes is associated with long term damage, dysfunction, and failure of various organs. Long term complications of diabetes include retinopathy, nephropathy, peripheral neurop...
Chapter
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Gymnema sylvestris R. Br. (Gurmar), which means sugar destroyer, is a member of the milkweed belonging to the family Asclepiadaceae. It is a wild plant that grows in the open forest in India, China, Indonesia, Japan, Malaysia, Sri Lanka, Vietnam, South Africa and Australia that has been proven as antidiabetic drug. In traditional medicine the plant...
Article
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Objectives: A free radical is a molecular species characterized by the presence of an unpaired electron in its outer orbital. Free radicals are highly reactive and are known to damage biomolecules including lipids resulting in a myriad of pathophysiological conditions. The present investigation was carried out to screen antiradical and lipid peroxi...
Article
Full-text available
Rubus apetalus Poir. is a scrambling shrub and belongs to the family Rosaceae. The present study investigates antioxidant activity of leaf extract of R. apetalus. Extraction of powdered leaf material was carried out by maceration process using water. Preliminary phytochemical analysis was carried out by standard tests. In vitro antioxidant activity...
Article
Full-text available
Article Information In the present study, we determined antiradical, cytotoxic and antimicrobial potential of leaf extract of Flacourtia indica (Burm. f.) Merr. (Salicaceae). Antiradical activity of extract was evaluated by DPPH and ABTS assay. Cytotoxic activity was screened by brine shrimp lethality assay. Antibacterial and antifungal activity of...
Article
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Article Information The present study was conducted to determine antimicrobial activity of leaf extract of two Capparidaceae members namely Capparis zeylanica L and Capparis sepiaria L. Antibacterial and antifungal activity of leaf extracts was screened by Agar well diffusion and Poisoned food technique respectively. The extracts exhibited varied a...
Article
Full-text available
Objectives: Free radical is a molecular species that contain an unpaired electron in an atomic orbital. Free radicals are highly reactive, capable of damaging biomolecules such as proteins, nucleic acid, and lipids, and cause oxidative damage. The present study was carried out to determine antiradical and lipid peroxidation inhibitory activity of l...
Article
Full-text available
Article Information Synthetic chemicals are extensively used to control plant diseases caused by fungi. Interest in botanicals with antifungal activity increased because of drawbacks associated with the use of synthetic chemicals. The present study was conducted to determine antifungal potential against three seed-borne fungi (Curvularia sp., Alter...
Article
Full-text available
Peperomia pellucida (L.) Kunth is a herb belonging to the family Piperaceae. In this review, an extensive literature survey was carried out to compile information available on medicinal uses, phytochemistry and pharmacological properties of P. pellucida. The plant is used as food, flavoring agent and as medicine. The plant is used as medicine for t...
Article
Full-text available
Antigonon leptopus Hook. & Arn., belonging to the family Polygonaceae, is an invasive evergreen, woody liana. It is native to Mexico and is distributed in various parts of the world including India. In the present review, an extensive literature survey was carried out to update information available on the medicinal uses, phytochemistry and pharmac...
Article
Full-text available
Plants have been used for various purposes of humans including medicinal purposes since time immemorial. Plants are an integral part of traditional medicine. Leea indica (Burm.f.) is a large shrub and belongs to the family Vitaceae. The plant L. indica is used traditionally in various countries of the world such as India, Malaysia, Thailand, Nepal,...
Article
Full-text available
Objectives: Nicotiana plumbaginifolia Viv. belongs to the family Solanaceae. The present study was carried out to determine insecticidal, antibacterial, and antiradical activity of aerial parts of N. plumbaginifolia.Methods: Extraction was carried out by maceration process using methanol. Insecticidal activity was assessed, in terms of larvicidal e...
Article
Full-text available
Objectives: The present study was conducted to determine antimicrobial, antiradical, and insecticidal activity of methanolic extract of the whole plant of Solanum virginianum L. (Solanaceae).Methods: Extraction of shade dried and powdered plant material was carried out by maceration process. Antibacterial and antifungal activities of extract were d...
Article
Full-text available
Objective: The present study was carried out to investigate antimicrobial, antiradical and insecticidal potential of leaf and fruit of Gardenia gummifera L. f. (Rubiaceae).Methods: The leaf and fruits were shade dried, powdered and extracted by maceration process using methanol. Antibacterial activity was evaluated against Gram positive and Gram ne...