Raghavendra Kumar Gunda

Vignan University · Department of Pharmaceutical Sciences

Objective: The current study’s objective is to develop and evaluate fast-dissolving tablets (FDT) for Empagliflozin. Empagliflozin, new class of oral hypoglycemic agent. It is indicated as an adjunct to exercise and diet to improve glycemic control in adult patients of type-2 diabetes. It acts by inhibiting sodium glucose co-transporter (SGLT-2)....

Objective: The aim of the current research work is to develop a bi-layered Divalproex sodium tablet with an immediate release layer and a sustained release layer. Divalproex sodium is regarded as the most significant antiepileptic medication and is frequently used to treat bipolar illness, epilepsy, and migraine prevention. Methods: Wet granulation...

Objective: The main objective of the study is to assess the prescribing patterns of antidiabetic drugs in type 2 diabetic patients. Methodology: A prospective observational study was conducted in Department of Endocrinology in Sri Care Hospitals, Narasaraopet for a period of 6 months. Patient of both genders who were diagnosed with diabetes were in...

Objective: This prospective observational study aims to evaluate the safety of immunization in infants and children below 1 year of age. Methods: This study we have observed the immunity in the children of age 0-12 months and followed the list of vaccinations given by the National Immunization Schedule. Data was collected from ANMs (Auxiliary Nurse...

Objective: The current study's objective is to develop and evaluate Floating Pulsatile delivery systems (FDT) for Carvedilol. Carvedilol, Non selective α, β- receptor blocking agent. It is indicated for the treatment of moderate heart failure, Hypertension. Methods: The rapid release core tablets were formulated using various concentrations of supe...

Objective: This prospective observational study aims to evaluate effectiveness of combination of topical benzoyl peroxide and minocycline gel comparing it with and without added chemical peel in acne vulgaris treatment Methods: In This study we have observed the effectiveness of two different treatment regimens in acne treatment. Based on the GAGS...

Objective: This observational study aims to determine the prevalence and incidence of anaemia in pregnant women in the city of narsaraopeta, India. Methods and Methodology: Information on total of 130 pregnant women who attended to ANCs from September 2023 to February 2024 were taken. Information about age, parity, educational status, no. of aborti...

Objective: The main objective of current study was to assess the prevalence of dyslipidemia and cardiovascular complications in Hypothyroid patients. Methods: In this prospective observational study, 110 subjects have been participated. ASCVD scale is used which assess the next 10years cardiovacular risk of a patient. ASCVD score categorizes into l...

Objective: The current study's objective is to check the impact of superdisintegrants on the drug release of Vildagliptin by developing oral disintegrating tablets (ODT). Vildagliptin, new class of oral hypoglycemic agent. It acts by inhibiting dipeptidyl peptidase-4. Conventional Vildagliptin tablets are (due to its first pass effect) unsuitable w...

A sophisticated microbiome has colonized the human gastrointestinal tract. In addition to being symbiotic, intestinal bacteria coevolve with their host in a process known as synbiotic coevolution. By inhibiting the growth of deadly bacteria and encouraging the growth of beneficial species, synbiotics are thought to have a stimulating impact. Synbio...

Transdermal drug delivery system (TDDS) is an integral part of novel drug delivery system. The first transdermal system was approved by FDA in the year 1979 for the prevention of nausea, vomiting associated with travel (motion sickness). Transdermal drug delivery is the administration of therapeutic agents through intact skin for systemic effects....

Sustained-release tablets have transformed the field of drug delivery by offering controlled and prolonged release of active pharmaceutical ingredients (APIs), resulting in improved patient compliance and therapeutic outcomes. This detailed article provides an in-depth exploration of the mechanisms underlying sustained release, various formulation...

A liposome is the drug delivery system used for the administration of various types of drugs or active substances essential for the treatment of various types of diseases. They play a major role in the target delivery of the drug to particular tissue without affecting the other body parts. Hence it is also called targeted drug delivery system. The...

Transdermal drug delivery system was presented to overcome the difficulties of drug delivery especially oral route. A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. It promotes healing to an injured area of the body. An advantage of a tra...

Oral administration of a variety of pharmaceutical dosage forms, such as tablets, capsules, syrup, suspension, and emulsion, is seen to be one of the more practical ways. Different fast-dissolving preparations, such as mouth dissolving film and MDT, have been produced by fast-dissolving drug delivery methods. The oral thin film is a brand-new dosag...

Over the past several years, treatment of infectious diseases and immunisation has undergone a revolutionary shift. With the advancement of biotechnology and genetic engineering, not only a large number of disease-specific biological have been developed, but also emphasis has been made to effectively deliver these biologicals. Niosomes are vesicles...

The microspheres are one of the novel drug delivery system in which effective therapeutic alternative to conventional or immediate release single-unit dosage forms. Microspheres can be characterized as solid, diameter having between 1-1000μm.there are different types of microsphere explained. These microspheres prepared and fill them in a hard gela...

The goal of targeted drug delivery is to elevate the medication's relative concentration in the target tissues while lowering it in the non-target tissues. The drug is thereby focused where it is needed. The drug therefore has no impact on the tissues surrounding. Therefore, carrier technology such microspheres, nanoparticles, liposomes, niosomes,...

The current study's objective is to develop and evaluate oral disintegrating tablets (ODT) for Vildagliptin. Vildagliptin, new class of oral hypoglycemic agent. It acts by inhibiting dipeptidyl peptidase-4. Conventional Vildagliptin tablets are (due to its first pass effect) unsuitable where quicker onset of action is required Hence, it is necessar...

The study focuses on enhancing Naproxen’s solubility and dissolution rate, a Biopharmaceutical Classification System (BCS) Class II drug characterized by low solubility and high permeability. The research explores the development of binary and ternary solid dispersions with aquaticsoluble carriers to improve these properties. The research involved...

This publication is based on peer-reviewed manuscripts from the 2022 Conference on Current Trends in Drug Discovery, Development and Delivery (CTD4-2022) held at KL University, India. Providing a wide range of up to date topics on the latest advancements in drug design and discovery technologies, this book ensures the reader receives a good underst...

Transdermal drug delivery system was presented to overcome the difficulties of drug delivery especially oral route. A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. It promotes healing to an injured area of the body. An advantage of a tra...

Over the past several years, treatment of infectious diseases and immunisation has undergone a revolutionary shift. With the advancement of biotechnology and genetic engineering, not only a large number of disease-specific biological have been developed, but also emphasis has been made to effectively deliver these biologicals. Niosomes are vesicles...

Over the past several years, treatment of infectious diseases and immunisation has undergone a revolutionary shift. With the advancement of biotechnology and genetic engineering, not only a large number of disease-specific biological have been developed, but also emphasis has been made to effectively deliver these biologicals. Niosomes are vesicles...

The purpose of the current experimental research was to optimize the quantities of macromolecules such as Eudragit L/100-55 and HPMC-K-100M for the development of extended release tablets of divalproex sodium, an anti-convulsant or epileptic agent used in the effective management of bipolar disorders, mania, seizures, convulsions, tremors/epilepsy....

Transdermal drug delivery system (TDDS) is an integral part of novel drug delivery system. The first transdermal system was approved by FDA in the year 1979 for the prevention of nausea, vomiting associated with travel (motion sickness). Transdermal drug delivery is the administration of therapeutic agents through intact skin for systemic effects....

The microspheres are one of the novel drug delivery system in which effective therapeutic alternative to conventional or immediate release single-unit dosage forms. Microspheres can be characterized as solid, diameter having between 1-1000μm.there are different types of microsphere explained. These microspheres prepared and fill them in a hard gela...

Sustained-release tablets have transformed the field of drug delivery by offering controlled and prolonged release of active pharmaceutical ingredients (APIs), resulting in improved patient compliance and therapeutic outcomes. This detailed article provides an in-depth exploration of the mechanisms underlying sustained release, various formulation...

Sustained-release tablets have transformed the field of drug delivery by offering controlled and prolonged release of active pharmaceutical ingredients (APIs), resulting in improved patient compliance and therapeutic outcomes. This detailed article provides an in-depth exploration of the mechanisms underlying sustained release, various formulation...

A liposome is the drug delivery system used for the administration of various types of drugs or active substances essential for the treatment of various types of diseases. They play a major role in the target delivery of the drug to particular tissue without affecting the other body parts. Hence it is also called targeted drug delivery system. The...

Purpose: The main aim of current research investigation was develop and optimise the tablet formulation for Telmisartan with help of cyclic oligosaccharides (-cyclodextrins), super disintegrant (sodium starch glycolate; SSG) along with non-ionic surfactant (Tween-80) by utilizing 2 3 factorial design. Methods:Telmisartan formulations were developed...

Objective: The current study's objective is to develop and characterise fast-dissolving tablets (FDT) for felodipine. Felodipine an excellent calcium channel blocker. It is primarily used to effectively control angina pectoris and hypertension. It has a limited bioavailability after oral administration due to its extremely low solubility in GI flui...

Oral administration of a variety of pharmaceutical dosage forms, such as tablets, capsules, syrup, suspension, and emulsion, is seen to be one of the more practical ways. Different fast-dissolving preparations, such as mouth dissolving film and MDT, have been produced by fast-dissolving drug delivery methods. The oral thin film is a brand-new dosag...

The drug delivery industry is currently experiencing intense competition and quick evolution due to an ever-growing demand. One such novel and distinctive drug delivery method that is quickly gaining popularity in the realm of rapid dissolving technology is the fast-dissolving tablet (FDT). Because a large variety of medications are supplied throug...

The main objective of the current work isto study the effect of super disintegrants in combination for the drug release of Lansoprazole by developing fast disintegrating tablets (FDT). Lansoprazole, a proton pump inhibitor. It mainly used for the effective management of peptic ulcer. It shows poor dissolution and absorption properties. Mouth dissol...

Objective: The purpose of present investigation to formulate, characterize the fast dissolving tablets (FDT) for Lansoprazole. Lansoprazole, a proton pump inhibitor. It mainly used for the effective management of peptic ulcer. It is having very low solubility in GI fluid, which results in to poor bioavailability after oral administration. So there...

Herbal medicines were most widely used for various diseases and ailments from ancient period of time. Due to its less toxicity and less side effects patients showing interest than allopathic treatment. The main purpose of present investigation to screen the active constituents from Spilanthes acmella and to assess the hepatoprotective activity agai...

The goal of targeted drug delivery is to elevate the medication's relative concentration in the target tissues while lowering it in the non-target tissues. The drug is thereby focused where it is needed. The drug therefore has no impact on the tissues surrounding. Therefore, carrier technology such microspheres, nanoparticles, liposomes, niosomes,...

Objectives: The objective of the current study was to develop an extended release (XR) tablet formulation for ranolazine using Eudragit L 100-55 and hydroxypropylmethylcellulose (HPMC) K100M in an appropriate composition. Ranolazine, an anti-anginal agent, is mainly used for treating chronic stable angina pectoris. The main advantage of this drug...

The objective of current work is to study the effects of combination of macromolecules (polymers) of natural (Lannea coromandelica gum) and semi synthetic (HPMCK100M) origin on the drug release of Flavoxate.HCl from the Gastro retentive floating formulation.Flavoxate.HCl, an antispasmodic agent,Mainly used for treating urinary incontinence andurgen...

Purpose: The purpose of present investigation to assess the anti-depressant activity of methanolic extract of Areca catechu using Mice model. Methods: The methanolic extract was prepared using cold extraction process with the help of continuous hot percolator apparatus. The final extract was evaluated for preliminary phytochemical analysis, acute t...

The main objective of the current work is to study the effect of super disintegrants in combination for the drug release of Tolvaptan. HCl by developing Fast Disintegrating Tablets (FDT). Tolvaptan. HCl, a newer aquaretic sorvaptan. It mainly used for the effective management of Hyponatremia associated with Syndrome of Inappropriate Anti Diuretic H...

The objective of the current study was to develop gastro retentive formulation of moxifloxacin. HCl using various drug release modifiers and performing in vitro and in in vivo evaluations. Moxifloxacin is a novel synthetic fluoro quinolone antibacterial agent. Floating, muco adhesive tablets of moxifloxacin. HCl were prepared using variable amounts...

Objective: The purpose of present investigation to formulate, characterize the oral dissolving tablets (ODT) for Tolvaptan HCl. Tolvaptan HCl, a newer aquaretic sorvaptan. It mainly used for the effective management of Hyponatremia associated with Syndrome of inappropriate anti diuretic hormone (SIDAH), cardiac cirrhosis and congestive cardiac fail...

The objective of current study is to develop gastro retentive formulation for Moxifloxacin. HCl using various drug release modifiers and performing In-vitro, In-vivo evaluations. Moxifloxacin, novel synthetic fluoro quinolone, antibacterial agent. Floating, Muco Adhesive tablets of Moxifloxacin. HCl were prepared using variable amounts of HPMCK100M...

Objectives: The objective of the current study was to formulate a sustained release (SR) formulation for pravastatin. Pravastatin is a lipid lowering, biopharmaceutical classification class-III agent. Materials and methods: SR tablets of pravastatin were prepared using variable amounts of hydroxy methyl propyl cellulose (HPMC) K4M and sodium car...

The purpose of present investigation to study the effect of various superdisintegrants on the dissolution characteristics of Lamotrigine by formulating oral disintegrating tablets (ODT). Lamotrigine, an antiepileptic agent, belongs to type-II as per Biopharmaceutical Classification System (BCS) exerts Low aqueous solubility and high permeability be...

Objective: The purpose of present investigation to formulate, characterize the oral dissolving tablets (ODT) for Lamotrigine. Lamotrigine, an antiepileptic agent, belongs to type –II as per Biopharmaceutical Classification System (BCS). Methods: ODT formulations of Lamotrigine were prepared using different quantities of Sodium Starch Glycolate & Cr...

Purpose: The objective of the present study is to assess the antimicrobial activity of gastroretentive formulation for moxifloxacin HCl and in vitro antimicrobial evaluation using the cup-plate method. Materials and Methods: Gastroretentive floating tablets of moxifloxacin HCl were prepared using variable amounts of hydroxypropyl methylcellulose (H...

The purpose of present research work is to develop gastro retentive formulation for Moxifloxacin using various release retardants. Moxifloxacin, that is a novel synthetic fluoro quinolone, is an iantibacterial agent. Floating tablets of Moxifloxacin. HCl were prepared using variable amounts of HPMCK4M, HPMCK15M and HPMCK100M with effervescent mixtu...

Purpose: The objective of the current study is to develop gastroretentive formulation for moxifloxacin HCl (hydrochloride) using various drug release modifiers and performing in vitro and in vivo evaluations. Moxifloxacin is a novel synthetic compound having antibacterial activity. Materials and Methods: Floating and mucoadhesive tablets of moxiflo...

Purpose: The objective of the current study is to develop gastroretentive formulation for moxifloxacin using various drug release modifiers, moxifloxacin, novel synthetic fluoroquinolone, and antibacterial agent. Materials and Methods: Floating tablets of moxifloxacin.HCl were prepared using variable amounts of hydroxypropyl methylcellulose (HPMC)...

Objective: The purpose of present research work is to develop gastro retentive formulation for Moxifloxacin using various drug release modifiers. Moxifloxacin, novel synthetic fluoro quinolone, antibacterial agent. Methods: SR granules were prepared by gastro retentive tablets of Moxifloxacin. HCl were prepared using variable amounts of HPMCK100M,...

Objective: The main objective of current research work is to formulate the Levetiracetam oral disintegrating tablets. Levetiracetam, a newer anti convulsant and used to treat epilepsy and chronic seizures. Methods: The oral disintegrating tablets of Levetiracetam were prepared employing various proportions of Crospovidone and Croscarmellose sodium...

Objective: The main objective of the current research work is to formulate the Levetiracetam oral disintegrating tablets. Levetiracetam, a newer anti convulsant and used to treat epilepsy and chronic seizures. Methods: The orally disintegrating tablets of Levetiracetam were prepared to employ various proportions of Crospovidone and Croscarmellose s...

Objective: The purpose of the present research study was to develop sustained release (SR) tablet formulations for Losartan Potassium using HPMCK100M as a release retardant. Methods: Losartan Potassium is an antihypertensive agent angiotensin-II receptor blocker belongs to BCS class-II agent. SR tablets for Losartan Potassium were formulated using...

Purpose: The main objective of present research investigation is to formulate the sustained release formulation of Rosuvastatin, BCS class-II agent. Methods: The SR tablets of Rosuvastatin were prepared employing HPMCK4M and SCMC in different compositions by Direct Compression.. The concentration of Polymers , HPMCK4M and SCMC required to achieve t...

Objective: The purpose of the current research work was to study effect of formulation variables in a statistical way for the SR formulations of Valsartan sodium. Methods: Valsartan sodium is an antihypertensive agent angiotensin‒II receptor blocker belongs to BCS class‒III agent. SR tablet formulations of Valsartan sodium were formulated using var...

Aim and Objective: The main objective of the present research investigation is to formulate the sustained release (SR) formulation of rosuvastatin. Rosuvastatin, an antihyperlipidemic agent, belongs to Biopharmaceutical Classification System class-II agent. Materials and Methods: The SR tablets of rosuvastatin were prepared by employing different c...

The main aim of present research study is to formulate the floating tablets of Labetalol HCl using 3 2 factorial design. Labetalol HCl, non selective α,-β-adreno receptor antagonist, Indicated for treatment of Hypertension/moderate Heart Failure. The Floating tablets of Labetalol HCl were prepared employing different concentrations of HPMCK4M and s...

Objective: The purpose of present research work is to develop the sustained release formulation for Telmisartan using 3 2 factorial design. Telmisartan an Antihypertensive agent, nonpeptide angiotensin-II receptor (type AT1) antagonist and BCS class-II agent. Methods: Sustained Release tablet formulations of Telmisartan were prepared using differen...

Abstract Objective: The purpose of present research work is to develop the sustained release formulation for Olmesartan medoxomil using 32 factorial design. Olmesartan an Antihypertensive agent, angiotensin‒II receptor (type AT1) blocker and BCS class‒II agent. Methods: Sustained Release tablets of Olmesartan medoxomil were prepared using differen...

Objective: The main objective of present research investigation is to formulate the Pravastatin Fast Dissolving tablets. Pravastatin, a newer antihyperlipidemic agent, belongs BCS class-III agent and used to treat hypercholesterolemia and to reduce the risk of Cardiovascular disease. Methods: The Fast Dissolving tablets of Pravastatin were prepared...

Objective: The purpose of the present research investigation was to formulate sustained release (SR) formulations for losartan potassium using 32 factorial designs. Methods: Losartan potassium is an antihypertensive agent, non-peptide angiotensin-II receptor (type AT1) blocker, and BCS class-III agent. SR tablet formulations of losartan potassium w...

The main objective of current research work was to formulate Amisulpride fast dissolving tablets. Amisulpride, a second generation antipsychotic agent, belongs to BCS class-II drug and used to treat psychoses, paranoid, productive schizophrenias, dysthymia. Fast dissolving tablets of amisulpride were prepared employing different concentrations of c...

Purpose: The main objective of present research investigation is to formulate the sustained release tablet of Simvastatin using 32 factorial design. Simvastatin, an antihyperlipidemic agent, belongs BCS class-II agent. Methods: The SR tablets of Simvastatin were prepared employing different concentrations of HPMCK4M and SCMC in different combinatio...

The main objective of present research investigation is to formulate the Moxifloxacin.HCl Fast Dissolving tablets. Moxifloxacin.HCl, a synthetic fluoroquinolone antibacterial agent, and used to treatacute bacterial sinusitis, acute bacterial exacerbation of chronic bronchitis. The Fast Dissolving tablets of Moxifloxacin.HCl were prepared employing...

The main objective of present research work is to formulate the sustained drug delivery systems of Simvastatin using 32 factorial design. Simvastatin, an antihyperlipidemic and BCS class-II agent. Sustained Release tablets of Simvastatin were prepared employing different concentrations of HydroxyPropylMethylCelluloseK4M and Sodium Carboxy Methyl Ce...

The main objective of present research work is to formulate the sustained drug delivery systems of Simvastatin using 32 factorial design. Simvastatin, an antihyperlipidemic and BCS class-II agent. Sustained Release tablets of Simvastatin were prepared employing different concentrations of HydroxyPropylMethylCelluloseK4M and Sodium Carboxy Methyl Ce...

The main objective of present research investigation is to formulate the sustained release tablet of Doxofylline using 3 2 factorial design. Doxofylline, an anti-Asthmatic agent, belongs BCS class-III agent. The SR tablets of Doxofylline were prepared employing different concentrations of HPMC K100M and Chitosan in different combinations by Direct...

Objective: Stroke is one of the leading causes of death and disabilities worldwide. Cost-effectiveness analysis helps identify neglected opportunities by highlighting interventions that are relatively inexpensive, yet have the potential to reduce the disease burden substantially. In India, there are wide social and economic disparities. Socioeconom...

In recent years many advancement has been made in research and development of Oral Drug Delivery System. Concept of Novel Drug Delivery System arose to overcome the certain aspect related to physicochemical properties of drug molecule and the related formulations. Purpose of this review is to compile the recent literature with special focus on Gast...

RATIONAL USE OF ANTIBIOTICS FROM HISTORY TO MARKET

Concepts, Formulation Approaches and Marketed Formulations Available and Evaluation Tests for Osmotic Delivery systems were explained with neat sketches

DRUG INTERACTIONS AND ADVERSE DRUG REACTIONS AWARENESS WITH SUITABLE EXAMPLES

Concepts, Formulation Approaches and Marketed Formulations Available and Evaluation Tests for RECTAL DRUG Delivery systems were explained with neat sketches