Rafal Sokolowski

Rafal Sokolowski
Wojskowy Instytut Medyczny · Intensive Care Unit

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17
Publications
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Introduction
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Publications

Publications (17)
Article
Full-text available
Lymphocytes play a leading role in regulation of the immune system in lung cancer patients. The recognition of T cells profile may help in prediction of effectiveness of anticancer immunotherapy. The aim of the study was to determine the dominant subpopulation of CD4+ and CD8+ lymphocytes in metastatic and non-metastatic lymph nodes (LNs) of lung c...
Article
Full-text available
Dendritic cells (DCs) play a pivotal role in the homeostasis of the immune system. The tumor microenvironment impairs the proper function of DCs. The immunomodulatory properties of DCs in lung cancer are of interest. In the present study, we analysed DCs subsets and immune cells with the expression of immunomodulatory molecules: PD-1 and PD-L1 and...
Article
Full-text available
Sarcoidosis (SA) is a systemic granulomatous disorder of unknown etiology with lung and mediastinal lymph nodes (LNs) as the main location. T lymphocytes play important role in the formation of granulomas in SA, but still little is known about the role of maturation profile in the development of inflammatory changes. The aim of this study was to de...
Article
Full-text available
In 2019, a pandemic began due to infection with a novel coronavirus, SARS-CoV-2. In many cases, this coronavirus leads to the development of the COVID-19 disease. Lung damage in the course of this disease often leads to acute hypoxic respiratory failure and may eventually lead to acute respiratory distress syndrome (ARDS). Respiratory failure as a...
Article
Full-text available
Over the past decade, immune checkpoint inhibitors have revolutionized the treatment of non-small cell lung cancer (NSCLC). Unfortunately, not all patients benefit from PD-(L)1 blockade, yet, the PD-L1 tumor cell expression is the only approved biomarker, and other biomarkers have been investigated. In the present study, we analyzed the presence of...
Article
Organophosphates are stable cholinesterases inhibitors (AChE). Inhibition of AChE activity leads to the accumulation of large amounts of acetylcholine and hyperactivity of the cholinergic system by stimulating acetylcholine receptors - muscarinic and nicotinic. This group included tabun, sarin, soman and VX gases. Exposure to gaseous form causes sy...
Article
Sarcoidosis is a granulomatous disease of generalized unknown etiology, which usually manifests itself pulmonary lymphadenopathy and interstitial changes in the lungs. In 11-83% of cases may occupy the organ of vision. In addition, 0.1 %-0.2% of patients with chronic HCV infection have been observed sarcoidal granulomas in various organs. A 74 year...
Article
Nosocomial infections are a growing public health problem. Special hazards are bacteria classified to alert-pathogens. In the recent years, there is an increase of gastrointestinal infections caused by falling within this group of Clostridium difficile anaerobic rod. Treatment with first-infection may not be effective. In approximately 20% of cases...
Article
Sarcoidosis is a multiorgan, granulomatosis disease about unknown etiology and predilection for the respiratory system. Lesions are mainly localized in the hilar lymph nodes and lung parenchyma. Sometimes abnormalities appear in the different organs like liver, spleen, kidney, salivary glands, organ of sight, brain, skin, bones. The case of 31 year...

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