Rafael Villa-Angulo

Autonomous University of Baja California | UABC · Bioinformatics and Biophotonics, Instituto de Ingeniería UABC

CdS, CdTe, Hg0.1Cd0.9Te, CdTe, and Ag films were progressively electrodeposited on ITO-coated soda–lime glass to manufacture a short- and mid-wavelength infrared photodetector. A distinctive feature of the applied electrodeposition method is the use of a non-aqueous solution containing ethylene glycol (EG) as the electrolyte in a traditional three-...

Type 2 diabetes (T2D) is a chronic systemic disease with a complex etiology, characterized by insulin resistance and mitochondrial dysfunction in various cell tissues. To explore this relationship, we conducted a secondary analysis of complete mtDNA sequences from 1261 T2D patients and 1105 control individuals. Our findings revealed significant ass...

Type 2 diabetes (T2D) is a chronic systemic disease with a complex etiology, characterized by insulin resistance and mitochondrial dysfunction in various cell tissues. To explore this relationship, we conducted a secondary analysis of complete mtDNA sequences from 1,261 T2D patients and 1,105 control individuals. Our findings revealed significant a...

Type 2 Diabetes Mellitus (DM2) is a complex and multifactorial disorder, it is currently classified as one of the epidemics of the 21st century due to the magnitude with which it is growing, as well as the cardiovascular effects it causes. This work presents an association study of base-pair positions of the human mitochondrial with Type 2 diabetes...

Controlling for genetic variables to managing conservation populations. Single nucleotide polymorphism (SNP) genetic markers were used to analyze genetic structure and variability in an American bison population in the state of Chihuahua, Mexico. A total of 174 individuals were sampled and analysis done of 42,366 SNP distributed in 29 chromosomes....

Zilpaterol hydrochloride (ZH) supplementation is marketed for cattle only, and its use has not been widely adopted as growth promoter in other species. The objective of this study was to assess the residual ZH in various tissues of feedlot hair lambs administered with this growth promoter. Forty Intact male lambs were randomly assigned to one of th...

Susceptibility to environmental factors, such as moisture, humidity, oxygen, heat, and ultraviolet (UV) light (photoinstability), has affected perovskite solar cell (PSC) stability in practical applications. To overcome the instability and performance degradation due to oxygen, humidity, and moisture, different strategies and encapsulation schemes...

Background Peripheral parenteral nutrition (PPN) is increasingly considered as an alternative to central parenteral nutrition (CPN) given the higher cost and more frequent clinical complications associated with the latter. However, the assessment of potential risks and benefits of PPN in critically ill pediatric canine patients has not been extensi...

Distance learning is a rapidly spreading form of education worldwide and it plays a crucial role to provide access to millions of people in developing countries. However, the benefits of online learning extend far beyond and became increasingly popular also in medical schools, including veterinary medicine [1, 2]. In these new teaching settings, hi...

Date palm pollen (DPP) plays a very important role in the fertilization process, since its viability and the pollination method influence on the quality, development, and yield of the fruit. In the present study, a broad review of its main characteristics, consumption, and DPP production are presented, as well as a description of its extraction met...

The goal of this study was to investigate the association of body composition components and to elucidate whether any of these components is a risk factor for Lumbar Disc Herniation (LDH). The group of study consisted of 90 adults involved in a physical activity program due to overweight and obesity. 19 adults with medical diagnostic through Magnet...

An intrinsic loss mechanism that limits quantum efficiency in cadmium-sulfide/cadmium-telluride (CdS/CdTe) p-in solar cells is governed by the inability to absorb energies less than the band-gap energy. Incorporating quantum wells (QWs) in the intrinsic region of a p-in solar cell to form a multi-quantum-well (p-i(MQW)-n) structure provides a means...

La comunidad de Ojos Negros está ubicada en el municipio de Ensenada Baja California, México. Desde 1930, los residentes locales fabrican un queso artesanal muy apreciado en la región; sin embargo, la leche cruda y el queso nunca han sido analizados por la calidad microbiológica y de higiene del producto final. El objetivo del presente estudio fue...

Different materials have been used to fabricate summer (warm environment) clothing, such as cotton, nylon, neoprene, polyester and 100% synthetic fibers. However, due to mechanical and thermal properties, nylon and polyester cloth have a tendency to rot and chafe in damp conditions. In addition, close-fitting synthetic fibers and neoprene make some...

Herein, we apply theoretical models to characterize the transfer function and frequency response of a complex optoelectronic circuit that comprises a primary ultrafast sampling circuit followed by a cascade connection of N demultiplexing stages. The successive radio-frequency optoelectronic samplers were based on the cascade connection of positive-...

Hypoplasia and ovarian cysts are the most common ovarian pa-thologies in cattle. In this genome-wide study we analyzed the signal intensity of 648,315 Single Nucleotide Polymorphisms (SNPs) and identified 1338 genes differentiating cows with ovarian pathologies from healthy cows. The sample consisted of six cows presenting an ovarian pathology and...

We compared two techniques of machine learning for the identification of cows that will be good producers of milk based on their genome-wide information. Data from a genomewide genotyping panel, consisting of 164312 single nucleotide polymorphism markers (SNPs), within the 29 autosomal chromosomes, from 1092 Holstein cow samples were used for this...

Predictions for the photon absorption coefficient (α) and photoluminescence (PL) of quasitype II CdS/ZnS core/shell nanocrystals [quantum dots (QDs)] have been obtained using a straightforward developed procedure. The developed procedure begins by solving the threedimensional (3-D) Schrodinger equation written in spherical coordinates. Then, α is o...

The objective of the present work was to investigate the influence of pollen sources over chemical characteristics of the Medjool date cultivar. The study was conducted under conditions of the Northwest part of Mexico, during the year 2016 cultivation season. The content of nutrients (protein, lipids, fiber and ash), sugars (total, reducing, non-re...

Pollen from four date palm cultivars (Medjool, Zahidi, Khadrawy, and Deglet Noor) was selected to study the effect of pollenizers on Medjool female production and fruit characteristics. The study was conducted during the 2016 season in San Luis Rio Colorado, Mexico. Three bunches of each of the four selected female palms were pollinized by each sou...

Pollen from four date palm cultivars (Medjool, Zahidi, Khadrawy, and Deglet Noor) was selected to study the effect of pollenizers on Medjool female production and fruit characteristics. The study was conducted during the 2016 season in San Luis Rio Colorado, Mexico. Three bunches of each of the four selected female palms were pollinized by each sou...

Resumen y Abstract. El objetivo de este estudio fue evaluar el efecto del macho polinizante sobre la composición nutricional del dátil cultivar Medjool. Se seleccionó el polen de cuatro cultivares criollos (Medjool, Zahidi, Khadrawy y Deglet Noor). Se polinizaron cuatro grupos de tres racimos, en cada una de las palmas seleccionadas. Se evaluó el...

Hypoplasia and ovarian cysts are the most common ovarian pathologies in cattle. In this genome-wide study we analyzed the signal intensity of 648,315 Single Nucleotide Polymorphisms (SNPs) and identified 1338 genes differentiating cows with ovarian pathologies from healthy cows. The sample consisted of six cows presenting an ovarian pathology and s...

Date palm crop was introduced to Mexico by Spanish colonizers. The best climatic conditions for plant development were found in the San Luis Rio Colorado, Sonora and Mexicali, Baja California valleys. By 2015 both areas achieved the 97% of the national production. High quality Medjool variety is almost the only grown in the region, and is very dema...

Molecular markers have become a very important resource for genetic studies in crops. Due to their genome-wide abundance, it has increased its use for genetic studies in genomes of animals and plants. They have been used in the germplasm of the date palm to identify genetic diversity, sex determination and gene characterization. RAPD, RFLP, AFLP, I...

Different materials have been used to fabricate summer (warm environment) clothing, such as cotton, nylon, neoprene, polyester and 100% synthetic fibers. However, because of their mechanical and thermal properties, nylon and polyester cloth has a tendency to rot and chafe in damp conditions. In addition, close-fitting synthetic fibers and neoprene...

In arid and semi-arid zones, animal health and production are closely correlated with body conformation traits. These selected traits, in turn, allow livestock to adapt unfavorable soil and environmental conditions. The primary objective of this study was to perform a genome-wide association analysis for a set of sampled and imputed SNPs with 16 co...

An electrocardiogram (ECG) is a non-invasive technique that checks for problems with the electrical activity of a patient's heart. ECG is economical and extremely versatile. Some of its characteristics make it a very useful tool to detect cardiac pathologies. The ECG records a series of characteristic waves called PQRST; however, the QRS complex an...

In heterostructures for nanophotovoltaic (NPV) devices, a number of layers are concatenated in a multilayer configuration. In the analysis of a multilayer configuration, it is commonly assumed that the intensity of the optical field has an exponential decrease along the direction of propagation inside the structure. Effects such as reflections and...

The influence of the edge effect by using Neuro-fuzzy Wavelet hybrid models to forecast monthly time series of precipitation one month in advance is analyze in this study. In order to implement the models, data from climatologic station, located at Emilio Lopez Zamora dam in the city of Ensenada northwestern Baja California, Mexico, was used. In pa...

The influence of the edge effect by using Neuro-fuzzy Wavelet hybrid models to forecast monthly time series of precipitation one month in advance is analyze in this study. In order to implement the models, data from climatologic station, located at Emilio Lopez Zamora dam in the city of Ensenada northwestern Baja California, Mexico, was used. In pa...

The influence of the edge effect by using Neuro-fuzzy Wavelet hybrid models to forecast monthly time series of precipitation one month in advance is analyze in this study. In order to implement the models, data from climatologic station, located at Emilio Lopez Zamora dam in the city of Ensenada northwestern Baja California, Mexico, was used. In pa...

Recently, for copy number variation (CNV) analysis, bovine researchers have focused mainly on the use of genome-wide SNP genotyping arrays. One of the highest densities commercially available SNPchips for cattle is the Affymetrix axiom genome-wide Bos 1, which assays 648,315 informative SNPs across the whole bovine genome. Here, we describe the mic...

Copy number variations (CNVs) are an important source of genomic structural variation, and can be used as markers to investigate phenotypic and economic traits. CNVs also have functional effects on gene expression and can contribute to disease susceptibility in mammals. Currently, single nucleotide polymorphism genotyping arrays (SNP chips) are the...

The major challenge for semiconductors to achieve temperatures below 10 K by luminescence upconversion, is that at these lattice temperatures the acoustic phonon component dominates and the scattering rate becomes comparable to the band-to-band radiative transition rate. This problem can be significantly alleviated by employing quantum-confined sys...

La propuesta de esta norma mexicana para la interoperabilidad tiene como objetivo principal auxiliar a las instituciones de educación superior a la implementación de esquemas de colaboración interinstitucional mediante la interoperabilidad entre los sistemas de software destinados al almacenamiento y uso de objetos de aprendizaje. En el Volumen 1,...

La propuesta de esta norma mexicana para la interoperabilidad tiene como objetivo principal auxiliar a las instituciones de educación superior a la implementación de esquemas de colaboración interinstitucional mediante la interoperabilidad entre los sistemas de software destinados al almacenamiento y uso de objetos de aprendizaje. El volumen 2 de...

Exposición de Posters de Divulgación de la Biotecnología UPM

The nonlinear response of p-i-n photodiodes (PIN-PDs) has become a concern for circuit designers implementing PIN-PD-based switches because this response can significantly compromise systems performance. A major challenge with this implementation is the selection of an appropriate linear operation range from the (I) – (V) curve of the PIN-PD to red...

Genomic structural variations represent an important source of genetic variation in mammal genomes, thus, they are commonly related to phenotypic expressions. In this work, ∼770,000 single nucleotide polymorphism genotypes from 506 animals from 19 cattle breeds were analyzed. A simple LD-based structural variation was defined, and a genome-wide ana...

Single and multiple quantum well QW nanophotonic devices, such as detectors and solar cells, are often fabricated by the concatenation of low-dimensional heterojunctions of different semiconductors. Quantum effects dominate the well structure, with dimensions of the order of several nanometers. At this width regime, even small variations in the fun...

This paper presents the simulation and thermodynamic analysis of an absorption cooling advanced system of the type air-cooled GAX. The study of the system is focused on the thermal conditioning of residential spaces located in regions with extreme hot weather. The mathematical model of the system is solved using a computational algorithm called bac...

In this paper we present the practical implementation of a high-speed polyphase sampling and demultiplexing architecture for optoelectronics analog-to-digital converters (OADCs). The architecture consists of a one-stage divide-by-eight decimator circuit where optically-triggered samplers are cascaded to sample an analog input signal, and demultiple...

The dependence of photon absorption by a low-dimensional cadmium-sulfide/cadmium-telluride (CdS/CdTe) heterostructured absorber on the thickness and number of CdTe active layers is investigated. The equation for the photon absorption coefficient (α) used is based on the partial momentum k-selection approach. Theoretical results show that absorption...

In this paper we present a procedure for the selection of the minimal dc reverse bias voltage of a high-speed optically triggered sampling circuit. The optically triggered sampling circuit is based on a PIN photodiode. A set of expressions that includes the optical power dependence of the current passing through the PIN photodiode is derived. Theor...

In this paper, we present an experimental method demonstrating an improvement in the resolution of optically sampled time-interleaved analog-to-digital converters (ADCs) by applying a data averaging technique. We implemented two experiments for oversampling four times the bandwidth of an analog input signal using a multichannel time-interleaved arr...

Selection for specific phenotypes leaves a genetic signature in the underlying DNA that can be detected by various analysis methods. In this study, we measured the amount of population differentiation among 12 Bos taurus breeds of cattle using Wright's FST index to reveal signatures of divergent selection. To begin characterization of clusters of S...

In gene-phenotype association studies, identification of loci whose allelic variation is related to a quantitative trait is of enormous importance. The present work describes, in a general manner, the most used methods for QTL mapping, which are related to phenotypic traits in bovine yielding. So far, we have implemented two methodologies for the a...

The imprints of domestication and breed development on the genomes of livestock likely differ from those of companion animals. A deep draft sequence assembly of shotgun reads from a single Hereford female and comparative sequences sampled from six additional breeds were used to develop probes to interrogate 37,470 single-nucleotide polymorphisms (S...

The Bovine HapMap Consortium has generated assay panels to genotype ~30,000 single nucleotide polymorphisms (SNPs) from 501 animals sampled from 19 worldwide taurine and indicine breeds, plus two outgroup species (Anoa and Water Buffalo). Within the larger set of SNPs we targeted 101 high density regions spanning up to 7.6 Mb with an average densit...

MAF distribution. Average proportions of SNPs of various frequencies by breed in high-density regions (intervals' upper limit inclusive).

Average minor allele frequencies (MAF) per breed across the high density regions in this study.

Total average of r2 per breed across high density regions.

Haplotype block structure across high-density regions in all breeds.

Effective population size for each breed, estimated from r2.

This paper describes a work related to the design and implementation of a communication tool for persons with speech and hearing disabilities. This tool provides to the user a Human-Computer interface capable of the capture and recognition of gestures belonging to the Mexican Spanish Sign Alphabet. To capture the manual expressions, a data-glove co...

In a second generation of high resolution haplotype block and LD analysis in the Cattle genome, 503 samples from 20 different breeds where genotyped with the BovineHD Beadchip, which interrogates 777,000 SNPs. The analysis focused on chromosomes 1, 6, 14, and 25, containing 46492, 35512, 24774, and 12931 SNPs, respectively. Haplotype blocks were es...

SNPs are the most recurrent polymorphisms at the genome and they appear about one per each kilobase between both chromosomes of an individual. A principal approach of research investigation is the use of SNPs to identify genomic variation of diverse phenotypic traits. A method for identifying nsSNPs for any given organism, based on genotypes obtain...