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Introduction
Current institution
DIATROS
Current position
- Head of Department
Publications
Publications (162)
Objective
To evaluate the efficacy and safety of a non-hormonal vaginal moisturizer in alleviating the clinical symptoms of vulvovaginal atrophy (VVA).
Methods
This was an observational, single center, open label study in which the investigational product was applied to postmenopausal women (n = 36) with VVA symptoms three times per week for a per...
This narrative review explores the main surgical techniques for labiaplasty in the treatment of labial hypertrophy, focusing on their safety, efficacy, and recommendations according to the anatomical typology of the labia minora. Studies published between 2000 and 2023 were reviewed, selected according to predefined criteria, and reported clinical...
The increasing prevalence of obesity imposes significant health challenges, particularly in women undergoing menopause. Effective obesity management is essential to mitigate associated comorbidities and improve quality of life. The pillars of obesity treatment encompass lifestyle modifications, pharmacotherapy and surgical interventions. Pharmacoth...
Esta revisión narrativa explora el papel potencial del estetrol (E4), un esteroide estrogénico natural, en la anticoncepción, analizando sus propiedades farmacológicas, su efectividad y su seguridad. Se revisaron estudios preclínicos, ensayos clí-nicos y evaluaciones de seguridad del E4 como anticonceptivo oral combinado (AOC). Se investigó el impa...
Background
The prevalence and severity of perimenopausal symptoms are typically associated with multiple factors, including demographic characteristics. The sociodemographic characteristics of women living in rural areas differ from those residing in urban areas, and it has been suggested that these differences could potentially influence the preva...
Background
Vaginal dryness (VD) represents a significant concern affecting women across diverse life stages, encompassing both pre- and postmenopausal women at any age. Dyspareunia, defined by genital pain that can be experienced before, during, or after intercourse, is often associated with vaginal dryness.
Aim
This study aimed to evaluate the ef...
Este texto está disponible en la página Web de la Asociación Española de Especialistas en Medicina del Trabajo: (AEEMT) http://www.aeemt.com/web/2024/02/22/la-obesidad-en-la-salud-laboral/
Obesity is not a choice or a result of lack of willpower, but a multifactorial, chronic, progressive, and relapsing disease. During menopause, hormonal and body composition changes lead to greater visceral adiposity, that aggravates women’s health at a cardiometabolic, mechanic and mental level. Adiposity has been identified as an important modifie...
This study aimed to examine the relationship between menopause transition and mood disorders, specifically anxiety and depression. The authors conducted a narrative review of relevant literature on menopause transition and mood disorders. They reviewed studies that focused on the impact of hormonal changes during menopause on psychological well-bei...
Objectives
The objective is to assess the perception of gynecologists regarding patients’ adherence to vulvovaginal atrophy (VVA) treatments, to evaluate the gynecologists’ opinions on what their patients think about treatment adherence, and to compare the gynecologists’ opinions with the patients’ own perceptions within the CRETA study.
Methods
S...
Objectives: The purpose of this systematic review is to analyse all available evidence to validate if exist relation between the menopause status and periodontal health.
Methods: We searched the Institute of Scientific Information Web of Knowledge, MEDLINE, PubMed, Scopus, and Cochrane databases for all articles published in peer-reviewed journals...
Background: Sexual dysfunction is a common problem among postmenopausal women. Tibolone is a steroid hormone that is commonly used to alleviate symptoms of menopause, including sexual dysfunction. However, the evidence regarding the effect of tibolone on female sexual function is mixed.
Purpose: The aim of this systematic review is to examine the e...
Purpose: The aim of this systematic review is to evaluate the current evidence regarding the effectiveness of platelet-rich plasma (PRP) for the treatment of vulvar lichen sclerosus (VLS).
Methods: A comprehensive search was conducted using the Pubmed and Cochrane Library database to identify relevant studies published up to March 2023. The inclusi...
Objective: This study evaluates the effectiveness and side effects of direct current electrocauter therapy in the treatment of vaginal laxity. The improvement in vaginal laxity and sexual health were evaluated.
Materials and Methods: This is a prospective, controlled (single blind placebo) and randomized study evaluating the safety and efficacy of...
Objective: Our aim was to develop an updated systematic review to delineate the possible role of the Radiofrequency in the treatment of vaginal laxity and sexual health.
Methods: We searched the Institute of Scientific Information Web of Knowledge, MEDLINE, PubMed, Scopus, and Cochrane databases for all articles published in peer-reviewed journals...
El síndrome premenstrual es un trastorno común en mujeres en edad reproductiva y se caracteriza por al menos un síntoma físico, emocional o conductual, que aparece en la fase lútea del ciclo menstrual y se resuelve poco después del inicio de la menstruación. Los tratamientos convencionales para el dolor perimenstrual cíclico tienen inconvenientes q...
Objective: This study aimed to evaluate the self-reported satisfaction of Spanish postmenopausal women currently treated for vulvovaginal atrophy (VVA) symptoms.
Methods: The CRETA (CRoss sectional European sTudy on Adherence) is a multicenter cross-sectional study conducted in 29 public and private hospitals in Spain, which enrolled postmenopausa...
Cosmetic, aesthetic, and functional gynecology (gyn-aesthetics), a relatively new, dynamic, and expanding field, can be considered a functional area in which a multidisciplinary team of various medical specialties intervenes. However, this functional area has a unique peculiarity: the difficulties in medical training in this specific area are limit...
Los síntomas vasomotores (SVM) se encuentran entre los síntomas más comunes de la transición a la menopausia. Más del 70% de las mujeres de mediana edad informan SVM en algún momento durante la transición a la menopausia, y para un tercio de las mujeres los SVM son muy frecuentes o graves. Muchas mujeres recurren a terapias naturales para tratar lo...
Objective:
To assess the correlation of different vulvovaginal atrophy therapeutic options with the quality of life of postmenopausal women.
Study design:
The CRETA study is a descriptive, observational, cross-sectional, multicenter study designed to measure, besides treatment satisfaction and adherence, the quality of life of postmenopausal wom...
Resumen
Objetivo: conocer la opinión de usuarias de métodos anticonceptivos sobre el acceso sin prescripción médica a las píldoras de solo gestágenos (PSG) en España.
Material y métodos: estudio transversal, descriptivo, basado en encuestas online a 3.000 usuarias de métodos anticonceptivos en Alemania, Italia y España. La presente investigación s...
It is becoming increasingly common that patients’ preferences move towards non-surgical approaches, such as pulsed magnetic stimulation, for female stress urinary incontinence. Objective: We evaluated the efficacy and safety of a device that uses electromagnetic technology to treat urinary incontinence, with an emphasis on health-related quality of...
Introduction and hypothesis: This report aims to prospectively describe the effectiveness and safety of injected cross-linked hyaluronic acid (HA) for the treatment of chronic vulvar fissures.
Methods: A descriptive prospective case series design including 15 patients affected by chronic vulvar fissures who were treated with cross-linked HA filler...
Purpose:
To explore the perceived need and enthusiasm for over the counter (OTC) progestogen-only pills (POP).
Materials and methods:
A web-based survey of 1000 sexually active women (16-45) and 100 pharmacists in Germany, Italy and Spain.
Results:
Despite not wanting to conceive, 5-6% of women in each country were not using contraception and...
Ovarian cancer is one of the most common gynecologic cancers and has the highest mortality rate. The risk/protective factors of ovarian cancer suggest that its etiology is multifactorial. Several factors are involved in age-related increases in carcinogenesis, including the accumulation of senescent cells, inflammaging (a chronic inflammatory state...
This project aims to develop eligibility criteria for menopausal hormone therapy (MHT). The tool should be similar to those already established for contraception A consortium of scientific societies coordinated by the Spanish Menopause Society met to formulate recommendations for the use of MHT by women with medical conditions based on the best ava...
A comprehensive therapeutic approach to healthy aging in women has as its main objective to replenish the levels of hormones that decrease over the years.
In the present work, a review of the works published in the last two years about testosterone treatment in postmenopausal women is made.
Current evidence indicates the use of testosterone as a tr...
Role of electromagnetism therapy for urinary Incontinence after Radical Prostatectomy
Introducción: Más allá de la salud reproductiva de la mujer, el síndrome del ovario poliquístico (SOP) afecta a medio y largo plazo a otros parámetros de su salud, aumentando significativamente el riesgo de padecer síndrome metabólico, diabetes mellitus tipo 2, cardiopatías, hepatopatías o cáncer de endometrio, además de tener un impacto importante...
The aim of this study was to determine the efficacy of focused electromagnetic therapy, a minimally invasive option for stress urinary incontinence
Introduction: The aim of this study was to determine the efficacy of focused electromagnetic therapy, a minimally invasive technique, to treat stress urinary incontinence in terms of symptom resolution and to assess the impact of this technique on health-related quality of life (HRQoL). Method: Twenty-seven women suffering from urinary incontinence...
La toxina botulínica tiene dos efectos, relajación de fibra muscular y analgesia, que se pueden aplicar para tratar patologías ginecológicas tales como vulvodinia, vaginismo, dolor pélvico crónico, trastorno de excitación sexual persistente e hiperhidrosis. Estas indicaciones no están reconocidas en ficha técnica y se consideran “uso compasivo”.
Se...
Objective
To study knowledge regarding genitourinary syndrome of menopause (GSM) and the treatments for it and to analyze treatment adherence during the COVID-19 confinement.
Methods
Multi-center observational study including women between 35 and 75 years. An extension study of treatment adherence was conducted during the coronavirus pandemic betw...
Abstract
Labia minora Hypertrophy is multifactorial but in general terms is a normal variation of anatomy. The demand for surgical
treatment is increasing exponentially year after year. Labiaplasty is a surgical option whic haims to improve functional
and aesthetic concerns. Unfortunately, most of the surgeons lack of enough experience, in order to...
Objective
To know the contraceptive behaviour of Spanish women who use combined oral contraception (COC) during the period of lockdown due to COVID-19.
Methods
Cross-sectional, descriptive study of a sample of Spanish women who use COC based on a survey conducted through social networks using the online platform Survey Monkey. The survey was condu...
Non-invasive radiofrequency acts through an electromagnetic field that generates a thermal effect on adipose tissue without contact with the skin. The temperature in the subcutaneous reaches between 44°C to 45°C, which after 45 minutes of intervention causes apoptosis of adipocytes. The objective of this study is investigate the impact of non-invas...
Purpose
To examine the prevalence of depressive and anxiety symptoms and the corresponding risk factors among pregnant women during the confinement due to the COVID-19 outbreak in Spain.
Materials and methods
Between 15 April and 14 May 2020, a multicentre cross-sectional survey was performed to study depression, anxiety and resilience in a sample...
Objectives
To develop the population-based norms for the Cervantes-SF scale, which measures the impact of menopause on the health-related quality of life (HRQOL) of women in Spain.
Methods
We used a sample obtained from representative studies of the Spanish population according to geographic density and autonomous community. This sample was compos...
The objective of this study was to investigate whether the BC tumor biology in women with larger breast volume, in obese women and especially in women with central adiposity at the moment of diagnosis of BC is more aggressive than in those women without these characteristics. 347 pre- and postmenopausal women with a recent diagnosis of BC were anal...
Objective: Ovarian cancer (OvCa) is the deadliest gynaecologic malignancy. Knowing that OvCa, as a disease, has different origins has allowed us to relate them to the mechanisms of action of different contraceptive methods with the aim of evaluating the possibility of their use in reducing risk.
Study design: This commentary review article will in...
In the post-COVID-19 era, it will be important to better understand the host response to severe acute respiratory syndrome related to coronaviurus-2 (SARS-CoV-2) infection and the pathology of disease in genital tissue. A better understanding of how SARS-CoV-2 causes disease and how the host responds can help direct new therapeutic targets. With th...
Introduction:
The aim of this study was to investigate whether postmenopausal women with breast cancer (BC) on adjuvant aromatase inhibitor (AI) therapy have a higher prevalence of female sexual dysfunction (FSD). Second, the aim was to determine the quality of life (QoL) and level of anxiety depending on whether or not they are AI users.
Methods...
Vulvovaginal atrophy (VVA) is a frequent, underreported and underdiagnosed condition. Ospemifene is a third-generation Selective Estrogen Receptor Modulator (SERM) that has been shown to be effective in women with VVA and dyspareunia, vaginal dryness and vulvar vestibular symptoms. Some of the possible side effects included by FDA and EMA are hot f...
The prevalence of endometrial polyps is estimated between 7.8 and 35% of women, being more prevalent in postmenopausal women. Endometrial polyps are associated with endometrial hyperplasia and carcinogenesis, with an informed prevalence of malignant and premalignant lesions that may reach 13%. The detection of endometrial polyps in peri-or postmeno...
To evaluate numerous publications that question the bone and extraosseous benefits of vitamin D diet supplementation based on results, which often transcend to public opinion, but are not well interpreted. This may have negative consequences on compliance of patients under vitamin D supplementation. Critical appraisal of several articles on vitamin...
The most efficient approach for relief of the vasomotor symptoms of the menopause at any age comprises MHT based on estrogens (alone or in combination with progestogens), tibolone, and the combination of conjugated estrogens and bazedoxifene. Randomized placebo-controlled trials have demonstrated that low-dose vaginal estrogen, intravaginal dehydro...
To alert patients and health care providers about the use of energy-based devices to perform a vaginal “rejuvenation,” cosmetic vaginal procedures, or nonsurgical vaginal procedures to treat symptoms related to menopause, urinary incontinence, or sexual function, the US Food and Drug Administration (FDA) has issued a warning about the effectiveness...
Introduction
The prevalence of menopausal women with confirmed vulvovaginal atrophy (VVA) oscillates between 67–98%.
Aim
To assess the prevalence of postmenopausal women with VVA confirmed by gynecologic clinical assessment among all women attending menopause centers in Spain, as well as to describe the impact of VVA on quality of life and sexual...
Objective: To estimate the differences in unintended pregnancies avoided using either levonorgestrel (LNG) or ulipristal acetate (UPA) emergency contraception (EC).
Design: Cross-sectional study.
Setting: Survey carried out in Spain.
Participants: 1000 Spanish women reporting unprotected sex in 2017.
Main measurements: EC use, reasons for not using...
Objective: Oral combined hormonal contraceptives (CHCs) are available that limit the number of menses when used in a flexible extended regimen. Our aim was to investigate the decision-making processes of women presented with a flexible extended CHC option.
Methods: The FLEXO study is an epidemiological, cross-sectional, multicentre study conducted...
Tissue-selective estrogen complex (TSEC) is projected as a progestogen-free option for the treatment of estrogen deficiency symptoms in postmenopausal, non-hysterectomized women. TSEC combines the benefits of estrogen with a selective estrogen receptor modulator (SERM), in this case bazedoxifene acetate (BZA), which has an antagonistic effect on th...
OBJECTIVE: To describe the benefits and safety of using Carbon Dioxide Laser in multi-pulse modalities when performing labiaplasty and anatomical variants approach for functional and cosmetic indications.
DESIGN: This is a prospective, descriptive case series study.
SETTING: Private Practice Quirofano Calculaser Megacentro Pinares Pereira Colombia....
The objective of this study was to evaluate oral supplements with antioxidants in oocyte and embryonic quality in patients undergoing assisted reproductive treatments. A cohort of 120 patients was included in the study: 60 patients were included in the control group and 60 in the Seidivid group. The medication contained folic acid, myo-inositol, me...
The consumption of long-chain omega-3 polyunsaturated fatty acids (LCO3-PUFAs) has shown a great variety of beneficial effects, including cardiovascular, metabolic and inflammatory effects, which make them interesting for the postmenopausal woman. Because LCO3-PUFAs could be effective and safe during this period, a panel of experts from the Spanish...
Objectives:
To gain a deeper comprehension of current vulvovaginal atrophy (VVA) knowledge among Spanish postmenopausal women.
Methods:
An online survey (REVIVE) was conducted in four European countries with an overall sample of 768 participants included in Spain. Perceptions, experiences and needs of Spanish postmenopausal women in terms of sex...
Objectives:
This observational, multicentre, prospective phase IV study examined change in health-related quality of life (QOL) from baseline to 6 months in women initiating combined oral contraception (COC) based on natural estrogen.
Methods:
Eligible women attending a baseline and 6-month gynaecology appointment belonged to one of three groups...
Recent reported studies have demonstrated that non-invasive fractional laser is a valid, safe, effective and well tolerated therapeutic option, without adverse events to treat the Menopause Genitourinary Syndrome. The heat shock effect induces the increase of vaginal epithelium thickness, the new glycogen content and the vascular changes, improving...
Physical inactivity not only places women's health at risk during menopause, but also increases menopausal problems. Abundant evidence links habitual physical exercise (PE) to a better status on numerous health indicators and better quality of life and to the prevention and treatment of the ailments that typically occur from mid-life onwards. We ca...
Although age is the most important predictor of a woman's reproductive capacity, there is still a risk of pregnancy during the menopause transition as occasional, spontaneous ovulation can occur. Therefore, we are facing a complex dilemma: ageing is accompanied by changes that can increase the risks associated with combined hormonal contraceptive (...
Recent reported studies have demonstrated that non-invasive fractional CO2 laser is a valid, safe, effective and well tolerated therapeutic option, without adverse events to treat the genitourinary syndrome of menopause. The heat shock effect induces the increase of vaginal epithelium thickness, the new glycogen content and the vascular changes, im...
BackgroundDT56a (Femarelle (R)) is a natural medication that contains a variety of phytoestrogens derived from tofu. Treatment with DT56a affects bones, vascular tissues and the nervous system in a manner similar to that of estrogen but DT56a acts as an estrogen antagonist in breast and uterine tissues.AimThe objective of this study was to analyze...
Introduction: The consequences of vulvar disorders in terms of health, sexuality, and quality of life are usually undervalued, with disparities in the conceptual, diagnosis and treatment criteria. Aim: The objective of this guide will be to analyse the factors associated with the diagnosis and treatment of vulvar disorders and to provide recommenda...
A total of 309 out of 317 peri/post-menopausal women [mean (SD) age of 55.7 (5.3) years (range: 45-71)], of whom 71.1% were active workers, were included in the analysis. Observed severity on VMS symptoms was distributed as: 79 (25.6%) without VMS, 74 (24.0%) mild, 95 (30.8%) moderate, and 60 (19.5%) severe. No significant differences were observ...
While we recognise that the term premature menopause is more accepted by most non-specialist health care providers and by the general population, 'primary ovarian insufficiency' (POI) is currently considered the most apposite term to explain the loss of ovarian function, because it better explains the variability of the clinical picture, does not s...
ABSTRACT In this review, we analyse the efficacy and safety of DT56a in the treatment of postmenopausal symptoms. Similar to all selective oestrogen receptor modulators (SERMs), DT56a demonstrates dual agonistic and antagonistic effects due to the synergy between its components. DT56a is referred to as a plant-origin SERM (phyto-SERM), and for this...
Objective:
The Cervantes Scale is a specific health-related quality of life questionnaire that was originally developed in Spanish to be used in Spain for women through and beyond menopause. It contains 31 items and is time-consuming. The aim of this study was to produce an abridged version with the same dimensional structure and with similar psyc...
Denosumab is a new drug developed for the treatment of osteoporosis. Moreover, increasing evidences link denosumab with benefits in cancer, an area of interest for those in charge of the postmenopausal health. Denosumab has shown efficacy in the control of bone loss associated with hypogonadic states created by chemotherapy in breast and other canc...
Objective To assess whether continuous and extended regimens (CRs/ERs) of combined hormonal contraceptives (CHCs) improve symptoms related to withdrawal bleeding or the hormone-free interval and to compare the efficacy, safety, and cost of CRs/ERs to those of conventional 28-day regimens. Study design A literature search of the PubMed database was...
Sexual health has been defined as “the state of physical, emotional and social wellbeing related to sexuality. However, there are medical, psychological and social reasons that complicate full sexual health that are frequently not attended to sufficiently. The objective of this guide will be to analyze the factors that impact the sexual health of m...
Vaginal health, defined as the vaginal state in which the physiological condition remains stable, being protected from the onset of symptoms and facilitating a satisfying sex life, is one of the most common and less valued concerns in postmenopausal women. Many of the conditions that affect the vagina are related to its trophism and susceptibility...
