Rafael MaldonadoUniversity of Puerto Rico at Ponce | UPRP · Department of Biology
Rafael Maldonado
Ph.D
About
11
Publications
365
Reads
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33
Citations
Citations since 2017
Introduction
Additional affiliations
August 2020 - May 2021
Position
- Professor (Assistant)
Description
- Courses taught include: Biology, Microbiology, Laboratory of Microbiology, Genetics, Laboratory of Genetics and education-training in microbiology to perform many roles within clinical nursing practice.
August 2020 - present
Molecular Sciences and Research Center at University of Puerto Rico Rio
Position
- Research Associate
Description
- Ion-Channel Structure and Molecular Biology
August 2016 - May 2017
Position
- Research Assistant
Description
- Courses taught include: Laboratory of General Microbiology.
Education
May 2021 - May 2021
April 2021 - May 2021
Cognitive class/IBM
Field of study
- Online certification - Python 101 for Data Science
March 2021 - March 2021
BioInteractive
Field of study
- Online certification - Certification hhmi/BioInteractive
Publications
Publications (11)
The main objective of the present study was to find detergents that can maintain the functionality and stability of the Torpedo californica nicotinic acetylcholine receptor (Tc-nAChR). We examined the functionality, stability, and purity analysis of affinity-purified Tc-nAChR solubilized in detergents from the Cyclofos (CF) family [cyclofoscholine...
Since their discovery, nicotinic acetylcholine receptors (nAChRs) have been extensively studied to understand their function, as well as the consequence of alterations leading to disease states. Importantly, these receptors represent pharmacological targets to treat a number of neurological and neurodegenerative disorders. Nevertheless, their thera...
Many pathogens, such as Pseudomonas aeruginosa and Escherichia coli bacteria can easily attach to surfaces and form stable biofilms. The formation of such biofilms in surfaces presents a problem in environmental, biomedical, and industrial processes, among many others. Aiming to provide a plausible solution to this issue, the anionic and hydrophobi...
Over the past 10 years we have been developing a multi-attribute analytical platform that allows for the preparation of milligram amounts of functional, high-pure, and stable Torpedo (muscle-type) nAChR detergent complexes for crystallization purpose. In the present work, we have been able to significantly improve and optimize the purity and yield...
For a long time, traditional purification and extraction methods for the native Torpedo californica nicotinic acetylcholine receptor in lipid-like detergent complex (nAChR-DC) have compromised its purity, functionality and X-ray structural studies possibility. The dataset presented in this article provide a characterization of the Torpedo californi...
Amphetamine-type stimulants (ATS) are the second most consumed illicit drug worldwide and lack good treatments for associated substance use disorders, lagging behind other addictive drugs. For this reason, a deeper understanding of the pharmacodynamics of ATS is required. The present study seeks to determine amphetamine (AMPH) enantiomers’ effects...
