
Radoslaw MaksymCentrum Medyczne Kształcenia Podyplomowego
Radoslaw Maksym
MD PhD Ob&G
About
63
Publications
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Introduction
Adjunct at Ist Dept of Ob&G, Centre of Postgraduate Medical Education. Consultant in Obstetrics, Gynecology and Reproductive Surgery at St. Sophia Hospital, Warsaw. Clinical Andrologist. Pioneer in implementation of Us-guided-HIFU treatment for uterine fibroids. Member of Polish Societies of Gynecology, Andrology and Endocrinology, International Society of Gynecological Endocrinology and ISUOG. A graduate of School of Molecular Medicine of Medical University of Warsaw.
Skills and Expertise
Additional affiliations
Education
November 2019 - January 2022
February 2011 - August 2017
Military Institut of Medicine
Field of study
- Obstetrics and Gynecology
October 2009 - June 2016
Publications
Publications (63)
Background
Endometriosis, due to its ambiguous symptoms, still remains one of the most difficult female diseases to treat, with an average diagnosis time of 7–9 years. The changing level of hypoxia plays an important role in a healthy endometrium during menstruation and an elevated expression of the hypoxia-inducible factor 1-alpha (HIF-1α) has bee...
Endometriosis is a common chronic disorder characterized by the growth of endometrium-like tissue outside the uterine cavity. The disease is associated with chronic inflammation and pelvic pain and may have an impact on the patient’s fertility. The causative factors and pathophysiology of the disease are still poorly recognized. The dysregulation o...
Context The basal body temperature (BBT) undergoes fluctuations, experiencing a rise of 0.2-0.5°C due to an increase in progesterone level. Traditionally, morning internal temperature were used as surrogates for BBT, but potential disruptions from body movements and sleep phases results in significant deviations. Assessing the lowest resting temper...
Endometriosis is a complex condition causing surgical challenges, sometimes leading to urogynecological complications, the diagnosis and treatment of which are not always obvious. We present a case of a 46-year-old woman with a history of severe endometriosis and adenomyosis who developed an oligosymptomatic vesicovaginal fistula (VVF) as a complic...
Infertility has been recognized as a civilizational disease. One of the most common causes of infertility is polycystic ovary syndrome (PCOS). Closely interrelated immunometabolic mechanisms underlie the development of this complex syndrome and lead to infertility. The direct cause of infertility in PCOS is ovulation and implantation disorders caus...
Citation: Stefaniak, M.; Dmoch-Gajzlerska, E.; Jankowska, K.; Rogowski, A.; Kajdy, A.; Maksym, R.B. Progesterone and Its Metabolites Play a Beneficial Role in Affect Regulation in the Female Brain. Pharmaceuticals 2023, 16, 520. Abstract: Premenstrual dysphoric disorder is a female affective disorder that is defined by mood symptoms. The condition...
Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility. Absent, impaired, or rare ovulation induces progesterone deficiency in the luteal phase, which is a critical problem in PCOS. A usual pattern of progesterone administration from a fixed and arbitrary predetermined day of a menstrual cycle may preserve infertility...
Pomimo wprowadzania licznych nowatorskich metod terapeutycznych leczenie mięśniaków macicy pozostaje istotnym problemem współczesnej medycyny. Zasadniczo działania powinniśmy ograniczyć do guzów powodujących istotne dolegliwości lub sytuacji podejrzenia onkologicznego. Wśród typowych objawów można wymienić: nieprawidłowe krwawienia, objawy uciskowe...
Planning a treatment strategy tailored to the needs and expectations of patients remains a major clinical challenge for fibroids. In addition to the medical indications, the provider should consider the patient's needs and concerns. Radical surgery is highly effective but is associated with the risk of complications and the need for rehabilitation....
Biochemical markers of spermatogenesis and fertility assessment are important in the practical management of infertile males and the determination of an individual's prognosis. We performed an analysis on 100 males with a male infertility factor. The following study inclusion parameters were analyzed: seminogram, FSH, LH, testosterone, estradiol, p...
The surgical removal of endometriosis lesions is a method of treatment with proven effectiveness in reducing pain and improving fertility in patients with endometriosis. Although one of the most effective forms of treating pain in endometriosis is hormonal treatment, it cannot be used in patients trying to become pregnant because it does not improv...
Endometriosis is one of the most common gynecological and systemic diseases, with a remarkable immune background. Patients suffer from pain and fertility reduction. Due to the distinct immune component, an immunotherapeutic approach may gain importance in the future. In endometriosis, shifts in the cell fractions of the immune system are well known...
One of the leading health conditions associated with female infertility is endometriosis, which is the presence of endometrial-like tissue outside the uterine cavity. It is estimated that endometriosis can be demonstrated in up to half of infertile patients, but this does not mean that in all cases, it is the only cause that reduces fertility. Apar...
Ze względu na wzrost wagi problemów prokreacyjnych we współczesnym społeczeństwie, coraz istotniejszym zagadnieniem staje się wdrożenie optymalnego postępowania obejmującego również aspekt dietetyczny. Zmiana diety lub suplementacja gotowymi preparatami może być prostą, ekonomiczną i bezpieczną metodą postępowania, która dość istotnie poprawia ogól...
Endometriosis is an inflammatory condition manifested by the presence of endometrial-like tissue outside of the uterine cavity. The most common clinical presentations of endometriosis are dysmenorrhea, infertility, and severe pelvic pain. Few hypotheses attempt to explain the pathogenesis of endometriosis; however, none of the theories have been fu...
Endometriosis involvement of the urological tract may lead to significant disabilities. The involvement of the urological tract gives rise to severe complications that burden patient health and quality of life. Two cases of patients with severe urogynecological complications after surgery of deep infiltrating endometriosis were analyzed. Last resor...
Endometriosis is a chronic gynecological disorder that affects 2-10% of women of childbearing age. Despite many years of research, the pathogenesis of endometriosis is not fully understood, and the treatment of endometriosis is associated with numerous controversies. Endometriosis runs in families and is associated with other diseases. In the group...
The pathogenesis of endometriosis depends on the interaction of environmental and genetic factors. Due to its high prevalence and major impact on quality of life and health, identifying important causative agents of endometriosis is a major public health concern. One of the interesting phenomena that undoubtedly influences the risk of endometriosis...
Endometriosis is a disease that manifests itself as a complex set of clinical symptoms. Due to the diverse course and different expectations of patients, it requires comprehensive and interdisciplinary medical care. The statement that “endometriosis is the occurrence of endometrial-like tissue outside the uterine cavity” does not reflect the comple...
Dehydroepiandrosterone (DHEA) concentration decreases with age, therefore, DHEA has been considered a hormone that reduces the symptoms associated with aging, so the usefulness of DHEA in premenopausal and postmenopausal women, and the options of hormone therapy have received a large amount of attention. The effectiveness of DHEA in the premenopaus...
Endometriosis is a relatively common disorder affecting women of reproductive age. Due to the significant impairment of quality of life and fertility it causes, endometriosis is considered an important challenge to present-day health care. Much effort has been taken to understand the etiology and pathogenesis of endometriosis as better understandin...
Efektywne i bezpieczne leczenie mięśniaków macicy pozostaje istotnym problemem współczesnej ginekologii. Mięśniaki powodują szereg objawów: nieprawidłowe krwawienia, objawy uciskowe, niepłodność oraz niepowodzenia położnicze (poronienia i przedwczesne porody). Mięśniaki macicy są stwierdzane są nawet u 40% kobiet w wieku reprodukcyjnym a zapadalnoś...
Inhibitors of 5α-steroid reductase are drugs used to treat androgen-dependent conditions including prostate diseases and androgenic alopecia. Finasteride was the first on the market and is currently the most widely used inhibitor. Dutasteride was the second inhibitor to be approved and has a similar safety profile. Common adverse events of treatmen...
Abstrakt: Narastający problem niepłodności małżeńskiej wraz ze złożonym tłem patogenetycznym powoduje wiele kontrowersji dotyczących leczenia. Podstawą efektywnego leczenia jest właściwa diagnostyka i postępowanie. Nie bez znaczenia pozostaje efektywność kosztowa i bezpieczeństwo, zarówno dla pacjentów jak i ich potomstwa. Zarówno diagnostyka jak i...
The increasing number of infertile couples in modern societies have now become a pressing medical problem. It is estimated that even 8% of the male population can be affected by infertility. Many cases of impaired spermatogenesis are caused by increased scrotal and testicular temperature. Abnormal overheating can be a result of a scrotal varicocele...
Fibroids are the most common human tumors affecting approximately 40% of women of reproductive age. The prevalence rises with age, and pregnancy seems to have a protective effect. Fibroids change uterine anatomy and function, thus, can be a cause of infertility. Since reproductive plans are shifted to the fourth decade of life in developed countrie...
We present an improved approach for the preparation of highly selective and homogeneous molecular cavities in molecularly imprinted polymers (MIP) via the combination of surface imprinting and semi-covalent imprinting. Towards that, first a colloidal crystal mold was prepared via the Langmuir-Blodgett technique. Then, human chorionic gonadotropin (...
nhibitors of 5α-steroid reductase are drugs used to treat androgen-dependent conditions including prostate diseases and androgenic alopecia. Finasteride was the first on the market and is currently the most widely used inhibitor. Dutasteride was the second inhibitor to be approved and has a similar safety profile. Common adverse events of treatment...
Introduction: We studied the impact of dehydroepiandrosterone (DHEA) supplementation in women with diminished ovarian reserve and very low DHEA-S in the blood. Aim: In vivo study. The paper also presents a review of the literature regarding diminished ovarian reserve and the use of dehydroepiandrosterone. Material and methods: The paper presents a...
The infertility emerges as an epidemic problem of the modern civilization. Unintended lack of the offspring have a negative impact for individual couples and the society. Therapy is characterized by low cost effectiveness and possible adverse events. Complex substratum of infertility and their proven relation to nutrition and life style indicate a...
Infertility is defined as the lack of pregnancy in a 1-year period of unprotected regular intercourse, and should be always considered as a specific trait of a couple. It is very clear that infertility is the result of disorders that affect only one partner, therefore, is important to always optimize the fertility potential in both partners in the...
The aim of this study was to compare health-related quality of life (HRQoL) between men with prediabetes (PD) and a control group as well as to investigate the relationship between HRQoL and anabolic hormones. The analysis was carried out in 176 middle-aged (40–59 years) and elderly (60 80 years) men with PD, and 184 control peers. PD was defined a...
Aberrant regulation of matrix metalloproteinases (MMPs) may be the primary cause of endometrial lesion formation in a group of predisposed women. Prospect for the genuine origin of endometriosis is ongoing, since retrograde menstruation leads to presence of endometrial debris in peritoneal cavity of many women, which do not experience endometriosis...
Introduction: Prostate cancer is one of three most commonly diagnosed malignancies among males in Central and Southern-Eastern Europe. Early and accurate diagnosis increases survival rate and even gives a chance for complete cure of the disease. Thus, finding new markers of prostate cancer that would stratify the risks of metastasis became a matter...
The aim of this study was to report the clinical, histopathological, and molecular findings in a patient with late-onset lattice corneal dystrophy (LCD) without typical lattice lines and a novel mutation in the TGFBI gene.
Corneal lesions were visualized by slit-lamp examination and by in vivo confocal microscopy. Histopathological examination was...
Introduction: Doxorubicin, a well-known cytostatic agent, is limited by its cardiotoxicity. This, shortcoming could be overcame by modifying drug distribution. The new form of the drug, synthetized by the group of Prof. Tomasz Ciach from the Warsaw University of Technology was tested in this work. This novel molecule is doxorubicin conjugated to po...
Study question:
Is endometriosis associated with changes in CD4⁺ CD25⁺ FOXP3⁺ regulatory T cells (Treg cells)?
Summary answer:
Endometriosis is associated with disturbed compartmentalization of CD25(high) FOXP3⁺ Treg cells.
What is known already:
Endometriosis is associated with an abrogated immune response and displays some features of an aut...
Purpose To report the clinical and molecular findings in a patient with late‐onset lattice corneal dystrophy and a novel Leu565Pro mutation in the TGFBI gene.
Methods The diagnosis of lattice corneal dystrophy (LCD) was performed by visualization of characteristic lesions with slit‐lamp examination and by in vivo confocal microscopy. Mutation scree...
Rhabdomyosarcomas (RMS) express CXCR4 and CXCR7 receptors that bind prometastatic alpha-chemokine stromal-derived factor-1 (SDF-1). In this report, we analyzed the activity of both promoters in a model of less metastatic human embryonal-RMS cell line (RD) and more metastatic alveolar-like RMS (RD cells transduced with paired box gene 3/forkhead hom...
The papillomavirus life cycle parallels keratinocyte differentiation in stratifying epithelia. We have previously shown that the human papillomavirus type 8 (HPV8) E2 protein downregulates beta4-integrin expression in normal human keratinocytes, which may trigger subsequent differentiation steps. Here, we demonstrate that the DNA binding domain of...
Cancer metastasis is a major clinical problem that contributes to unsuccessful therapy. Augmenting evidence indicates that metastasizing cancer cells employ several mechanisms that are involved in developmental trafficking of normal stem cells. Stromal-derived factor-1 (SDF-1) is an important alpha-chemokine that binds to the G-protein-coupled seve...
Multidrug resistance-associated proteins may play crucial roles in the protection of internal organs, particularly the kidneys and liver, from various toxic agents. Little is known about their significance in transplanted organ function and survival. The aim of the present study was to evaluate the frequency of functional ABCC2 4544A>G polymorphism...
Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma of adolescents and children that frequently infiltrates the bone marrow (BM). We have demonstrated that the a-chemokine stromal-derived factor (SDF)-1-CXCR4 axis (Blood2002;100:2597, Cancer Res. 2003;63:7926, Cancer Res.2007;67:2131) plays an important role in RMS metastases. With the re...
Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma of adolescents and children that frequently infiltrates bone marrow (BM). RMS is divided in two sub-types, alveolar-RMS (ARMS) and embryonal-RMS (ERMS). The ARMS subtype is often associated with a more aggressive phenotype, poorer clinical prognosis, and expression of Pax3-FKHR and Pax7-...
Juvenile epithelial corneal dystrophy of Meesmann (MCD, OMIM 122100) is a dominantly inherited disorder characterized by fragility of the anterior corneal epithelium and intraepithelial microcyst formation. Although the disease is generally mild and affected individuals are often asymptomatic, some suffer from recurrent erosions leading to lacrimat...
Purpose To report the clinical and molecular findings in Polish patients with stromal corneal dystrophies caused by TGFBI gene mutations.
Methods Patients with clinically diagnosed granular (n=14; 9 unrelated families) and lattice (n=2; 2 unrelated families) corneal dystrophies participated in the study. Corneal phenotypes were assessed by slit lam...
Purpose Age‐related macular degeneration (AMD) is a leading cause of visual impairment in developed countries, particularly in the Caucasian population above 65 years. It is a complex disorder with both genetic and environmental factors playing a role. Variants of HTRA serine peptidase 1 gene (HTRA1), particularly a single nucleotide polymorphism (...
Tuberous sclerosis (TS), neurological disorder manifesting with the formation of tumors in numerous organ systems, is a disease associated with the upregulation of mammalian target of rapamycin (mTOR) pathway. It has been found that in healthy individuals two tumor suppressor genes, TSC1 and TSC2, encoding proteins called hamartin and tuberin, resp...
Tuberous sclerosis (TS), autosomal dominant disorder manifested by the formation of usually benign tumors in the brain, heart, kidneys and skin, results from an inactivating mutation in one of two tumor suppressor genes TSC1 or TSC2. Protein products of these genes, hamartin and tuberin, respectively, have been shown to participate in the mTOR path...
Introduction: Arachidonic acid release has been reported to play a significant role in TNF-induced cytotoxicity. However, the role of this signalling cascade in CD178-(CD95 ligand)mediated cytotoxicity remains unclear. The aim of the study was to investigate the role of arachidonic acid metabolism in TNF- and CD95-mediated cytotoxicity. Material an...
Integrin beta4 is a transmembrane protein expressed predominantly on epithelial cells. In human epidermis integrin beta4 associates with integrin beta6. Integrin alpha6beta4 is concentrated at the basement membrane zone, where it localizes to specialized adhesion structures called hemidesmosomes. In addition to its adhesive functions, keratinocyte...