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Publications (83)
Pantoprazole is a model substance that requires dosage form adjustments to meet the needs of all patients. Pediatric pantoprazole formulations in Serbia are mostly compounded as capsules (divided powders), while in Western Europe liquid formulations are more common. The aim of this work was to examine and compare the characteristics of compounded l...
Contact lens care solutions are necessary for proper hygiene of contact lenses. Numerous microorganisms can be transmitted through them, leading to serious eye infections, while blindness can occur in particularly severe cases. A direct link between ocular infections and contact lens care solutions has been proven. Commercial preparations must meet...
The development of anthelmintic resistance in sheep gastrointestinal nematodes (GINs) requires novel strategies for the sustainable control of these parasites. This study aimed to evaluate the anthelmintic efficacy of the Origanum vulgare (L.) essential oil (EO) against sheep GINs and to evaluate the possibility of its use in control practice. The...
Gastrointestinal nematodes (GINs) nowadays present a
serious threat to sustainable sheep breeding. Various classes of
commercial anthelmintics were used to control these parasites.
However, due to the development of anthelmintic resistance
(AR), the efficacy of these drugs has decreased, which in turn
resulted in high economic losses. For thes...
Herbal products such as essential oils may play a promising role in the treatment of infections caused by gastrointestinal nematodes (GINs). The aim of this study was to evaluate the in vitro potential of 11 essential oils (EOs) and one binary combination of isolated EO compounds, as well as the in vivo anthelmintic efficacy of two EO formulations....
For the living world, in the existing ecosystem, for the reproduction,
production and spread of plant species, bees are one of the most important
parts of nature. In the pollination of certain field and fruit-vegetable
plant species, bees participate with almost 100%. Any factor that
contributes to reducing the presence of bees in nature, directly...
In this pilot study, a method for the determination of phthalates in honey was developed. The following phthalates are included: diethyl phthalate, di-isobutyl phthalate, di-n-butyl phthalate, bis (2-Ethylhexyl) phthalate, and di- (n-octyl) phthalate. For the preparation of the samples, the method of liquid-liquid extraction with hexane with an ult...
This paper will discuss the most common causes of poisoning of honey bees and other pollinating insects that occur in the Republic of Serbia and the world as well. Some potential ways of pollinator exposure to different poisons and their intake will be described. The paper will also deal with the methods of testing and assessing toxicity of newly s...
Honey is a very popular food that is often consumed by immunocompromised people, so it is crucial that it is safe. The safety of honey is determined by numerous hazards- the chemical ones like residues of sulfonamides, lindane and PAHs. Honey from our country contains high concentrations of banned antimicrobial substances such as sulfonamides (3.9%...
Nosemosis is a bee disease practically present in all countries of the world. Control of the presence of Nosema apis and Nosema ceranae is of great importance. The consequences for bees will depend on the degree of infection of the bees colony.Weakening of bee colonies, reduction of production possibilities, contamination with bee feces of hives, d...
American foulbrood (AFB) is one of the most important contagious honey bee diseases. In Serbia, it is mandatory to report AFB, and this disease is registered in our country every year. Starting from 2018, active surveillance of the presence of the AFB has been conducted throughout the country. The paper analyzes the data on the occurrence of AFB du...
The objective of this study was to analyse the content of OHCs and NDL-PCBs in wild boar population living in densely populated flatland region with intensive agricultural production. A total of 82 liver samples were analysed by GC-MS method, revealing the presence of minimum one residue in the liver of the majority of animals (92.7%). Most commonl...
The development of resistance to commercial anthelmintics, particularly in different species of gastrointestinal nematodes (GINs), requires the search for alternatives. Within that context, the aim of this study was to evaluate the in vitro ovicidal activity of five different essential oils (EOs): Origanum vulgare, Satureja hortensis, Thymus vulgar...
Essential oils have numerous medicinal properties which include antiseptic, anti-inflammatory, anticancer but also antiviral, antimicrobial and antiparasitic effects. Although researches have highlighted different possible application of these oils, little is known about their use in animals including dogs and cats. Specifically, essential oils sho...
The economic losses caused by gastrointestinal nematodes of small ruminants are increasing today due to the development of anthelmintic resistance. Therefore, researchers from different parts of the world are searching for new, alternative strategies to control these parasites. As a valuable natural resource, medicinal plants and their products hav...
Modern livestock production inevitably involves the use of antimicrobial drugs. Adequate application thereof depends on the application of appropriate biosafety measures as well as timely and accurate diagnostics of the diseases. Administration of antimicrobial drugs without previous identification of “zootechnical errors” or relevant laboratory an...
Th ermophilic Campylobacter spp. are the leading cause of zoonotic enteric disease in Europe and USA. In Serbia, it has an upward trend in human population. Th e disease is usually indirectly transmitted to humans through the consumption of food contaminated by the faeces of infected animals. Th e aim of this paper was to analyze data on the preval...
Este ectoparásito provoca grandes pérdidas en el sector, pero su erradicación es posible si se aplica una combinación de productos y se mejora la bioseguridad. INTRODUCCIÓN Desde un punto de vista económico y de salud animal, el ácaro rojo o Dermanyssus gallinae es el ectoparásito de mayor importancia para la industria avícola (De Geer, 1978). La i...
Th e irrational control of Dermanyssus gallinae ectoparasites (De Geer, 1778) in intensive livestock can cause health problems, economic damage, and can also toxicologically harm the health of humans and the environment. Formulation P 547/17 (Pulcap) is a new generation of inert matter (an oil). In Pulcap formulation and technology, the fulfi lment...
The general insecticidal effects of diatomaceous earth (DE) SiOz and petroleumderived spray oils are widely known. The seleded formulations based on SiOz and the new oil formulation (PU7l17) for the control of red poultry mite (Dermanyssus gallinae) are recommended because of their toxicological cfraraderistics. Their efficiency for D. gallinae has...
Laboratory trials of the preparations give limited, preliminary efficacy information to Dermanyyus gallinae (De Geer, 1778). It is only under the realistic conditions of clinical trials that it is possible to obtain a final picture of the effectiveness of D. gallinae control. We recommend the following elements of clinical trials: 1. basic farm and...
Trichinellosis is one of the most important foodborne diseases in the Eastern European countries. The main objective of this study was to investigate the epidemiological patterns of trichinellosis outbreaks that occurred between 2005 and 2016 in Vojvodina, a northern province of the Republic of Serbia. The average incidence was 3.5 per 100,000 inha...
Technological solutions and environmental conditions have a significant impact on infestation intensity and the problems around D. gallinae control. Changes in keeping laying hens in EU, in terms of D. gallinae influence, have not led to the welfare of the layers. On the contrary, they have contributed to the spreading of disease, have worsened con...
Maximum limits for PAHs content in honey and bee products are not set. The objective of this study was to conduct a market survey of honey for the presence of PAH16 with the aim of detecting potential contamination and health risks for consumers. A total number of 61 honey samples produced in the territory of Serbia were examined. The content of PA...
Maximum limits for PAHs content in honey and bee products are not set. The objective of this study was to conduct a market survey of honey for the presence of PAH16 with the aim of detecting potential contamination and health risks for consumers. A total number of 61 honey samples produced in the territory of Serbia were examined. The content of PA...
The usage of microbiological screening tests is widespread in control of presence of antimicrobial drug residues in meat samples. Screening tests must be capable to detect antimicrobial drug residue of interest and detection limits must comply with MRL (Maximum Residue Limit). The aim of this study was to examine the performance of a microbiologica...
Enteritis campylobacterialis has an increasing trend in Serbia. Human illness
usually appears as sporadic case, most commonly in children with obvious
seasonality. In registered outbreaks, incriminated food was most frequently
poultry meat. Campylobacter is one of the most important food borne
pathogens, commonly underreported, mostly because isola...
Dermanyssus gallinae control has so far been predominantly based on acaricides (insecticides) and their efficacy has been decreasing in time due to the development of resistance. D. gallinae is a species that has developed resistance to all current acaricides. Considering this, we can assume that the new acaricide - fluralaner with its evident effi...
Physical control, especially inert substances are an alternative to insecticides in the control of Dermanyssus gallinae (De Geer, 1778). The use of SiO2 formulations is technically demanding. SiO2 formulations have a number of limiting characteristics. However, if the formulation is selected appropriately and the facility hygienically prepared, the...
The control of D. gallinae has thus far been predominately based on acaricides (insecticides), the efficacy of which has decreased over time due to the development of resistance. D. gallinae is a species which has developed resistance to all acaricides used so far. From this point of view, it is possible to assume that the new acaricide fluralaner...
Cases of deliberate, illegal animal poisoning are widely documented in the literature. Recently, there has been an increase in number of cases of poisoning of domestic and wild animals with highly toxic pesticides in the Republic of Serbia. During the two-year period (2016-2017), in total 40 autopsies of dogs and 2 cats from the territory of the So...
Cases of deliberate, illegal animal poisoning are widely documented in the literature. Recently, there has been an increase in number of cases of poisoning of domestic and wild animals with highly toxic pesticides in the Republic of Serbia. During the two-year period (2016-2017), in total 40 autopsies of dogs and 2 cats from the territory of the So...
Clinical examinations of the preparations and methods are an important source of information for the practical control of D. gallinae. The contribution of this information to practice determines the accuracy, integrity, usability, and availability.
Important factors to the assessment of clinical examination are: 1. basic informations on the farm an...
The generally accepted approach to D. gallinae control is based on the control of infestations. The reduction of D. gallinae infection to an acceptable level can temporarily prevent its harmful effects on the health status ofpoultry. However, the reduced number of D. gallinae continues to persist in poultry environment resulting in an intensive inc...
Monitoring antibiotics residues in honey and honey products helps to assess the potential risk of these products to human health. These data provide an insight in the extent of antibiotic treatment that has been used during the beekeeping and enable the evaluation of potential environment pollution with antibiotic residues. This article offers an o...
The treatment of reproductive disorders is based on the use of the available antibiotics or antiseptic agents. Prolonged or inadequate antibiotic treatment contributes to the development of antimicrobial resistances, while the use of antiseptics, particularly in high concentrations, leads to endometrial lesions and prolonging of the service period....
The aim of our study was to determine whether and to what extent certain species of helminths and protozoa are present in the wild boar population living in hunting grounds in Vojvodina. For this purpose, 52 faecal samples of hunted wild boars (aged 6 months to 2 years) were examined. Examination of the faeces was performed using classical coprosco...
The past decades of clinical practice in poultry farming are character-ized by inadequate control of one of the most important poultry ectopara-site, the red poultry mite (Dermanyssus gallinae). Therefore, the program for control of D. gallinae based exclusively ona physical mechanisms of action of acaricides has been developed in Serbia since 2012...
The quality of drinking water depends on the water sources, but also on the
quality of the water distribution system which supplies the water on to the
final user. In addition, the possibility of contamination of water used for
watering animals in the farm buildings depends on the hygienic conditions on
farms. Microbiological quality of water on fa...
The study encompassed collecting of honey samples from diverse honey producers from the territory of Vojvodina Province and the analysis thereof for the presence of antibiotic and sulfonamide residues. Having in mind the actual clinical information and epizootical situation, it is most likely that antibiotics are still in use in apiaries. In this r...
High-performance liquid chromatography (HPLC) method with diode array detection (DAD) were optimized and validated for separation and determination of tetramethrin in an antiparasitic human shampoo. In order to optimize separation conditions, two different columns, different column oven temperatures, as well as mobile phase composition and ratio, w...
The aim of our study was to compare the effect of various proportions of popped amaranth grain (Amaranthus cruentus) in piglet diets on selected blood indicators, such as red blood cell count (RBC), haematocrit (HCT), haemoglobin concentration (HB) and mean corpuscular haemoglobin concentration (MCHC), but also growth efficiency (daily weight gain)...
In order to evaluate the efficacy of inactivated oil-emulsion Newcastle disease vaccine (commercially available on market in Serbia) we carried out the potency test in chickens, using hemagglutination inhibition (HI) test for detection of antibodies. Th e values of HI titers in the serum before and three weeks aft er vaccination revealed immunoconv...
The illegal use of antibiotics in honey production has recently been focused and the presence of antibiotic residues in honey is a critical parameter for its quality as it affects the safety of honey for human population. The need for simple test methods for determination of the presence of antibiotic residues in honey certainly exists. A modified...
The aim of this study was to investigate the effi cacy of the subunit vaccine against
virulent CSF infection in piglets deriving from sows vaccinated with China strain.
The experimental research included 34 piglets aged 45 days (13 naïve and 21 piglets
originating from sows immunized with China strain CSFV). Three experimental groups
consisting of...
Reproductive failure in swine is often a difficult diagnostic problem. If diagnoses of infectious disease or management related problems are not obtained, feed quality and safety may be questioned. Mycotoxins are often present in swine feed in the amount that can have detrimental impact on production and reproduction. Problems are expressed only as...
A clinical form of sepsis induced by cecal ligation and puncture (CLP) was caused in order to monitor the concentration of enzymes (alanine aminotransferase - ALT, aspartate aminotransferase - AST, lactate dehydrogenase - LDH, amylase and creatine kinase - CK) in the rat blood. Experiments were performed on male Wistar rats, weighing on average 215...
Reproductive failure in swine is often a difficult diagnostic problem. If diagnoses of infectious disease or management related problems are not obtained, feed quality and safety may be questioned. Mycotoxins are often present in swine feed in the amount that can have detrimental impact on production and reproduction. Problems are expressed only as...
Current most important side effects of antimicrobial drugs usage are veterinary drug residues in edible animal tissues and development of resistance in food borne pathogens. Enrofloxacine and flumequine are fluoroquinolone antimicrobials licensed in Serbia for use in poultry treatment. Elimination of health risk for consumers is usually made by exa...
The pharmaceutical properties of aromatic plants are partially attributed to essential oils (EOs) which are widely used to prevent and treat human diseases [1]. However, little is known about the control of infective animal diseases with EOs.
Arcanobacterium pyogenes (AP) is one of the important opportunistic pathogens of the upper respiratory and...
Bacteria Escherichia coli (E.coli) is a ubiquitous microorganism with a different serotypes, that cause septicemia in neonatal piglets, diarrhea in suckling piglets, diarrhea and edemic disease in weaned piglets. Vaccination and antibiotic treatment are less effective ways in solving the problem, especially when the category of pig is not taken int...
Skin lesions caused by dermatophytes are classified depending on the infected skin structure: surface layer of cutis, fur layer, clutches or nails. Surface mycoses are caused by dermatophytes: Epidermophyton, Microsporum and Trichophyton species (also important are Malassezia spp., Candida spp., and Trichosporon). Skin is the target tissue for fung...
Mycotoxins are secondary metabolites of fungi that can contaminate animal feeds at all stages of food production chain. Consumption of feed contaminated with mycotoxins may result in immunosuppression, which represents a predisposing factor for occurence of infectious diseases in livestock. The influence on immune system is of special interest in s...
In the paper are presented the results of investigating protective effect of attenuated live vaccine against classical swine fever (CSF) under experimental conditions. The vaccine contains C-strain of CSF. In the Republic of Serbia it is used for systemic immunoprophylaxis. Potency testing was performed according to the guidelines of the European P...
Wide application of antimicorbial agents forces bacteria to utilize specific genes and rearrange genomic structure in order to survive in the environment. In this article lateral gene transfer, mobile genetic elements, plasmid mediated resistance and spontaneous mutators in bacteria are briefly described. This resourceful means, by which microorgan...
Aeromonas hydrophila is a microorganism widely distributed in nature: in water, soil, food. It is also part of the normal bacterial flora of many animals. As an opportune microorganism it is a secondary biological agent that contributes to the occurrence of a fish disease and its deterioration. Frequently, its presence is an indication of bad zoohy...
Quinolone antibiotics have been widely used in human and veterinary medicine. This has caused the development of resistance and difficulties in the treatment of complicated bacterial infections in humans. The resistance to quinolones develops due to chromosome mutations and it can also be transferred by plasmids. The target enzyme for quinolones in...