Radhakrishnan Narayanaswamy

• Doctor of Philosophy
• Professor (Full) at Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS)

Alkaline serine proteases (ASPs) and laccases (Lacs) have been reported to possess several industrial applications, particularly in the food, cosmetic, and leather industries. Thus, in the present study, eighteen natural biopolymers, including agar, agarose, alginate, kappa carrageenan, cellulose, chitosan pentamer, chitosan oligosaccharide, chondr...

Background: The purpose of our research was to find out how serum levels of leptin and adiponectin are connected with preeclampsia and whether they may be used as biomarkers for the illness. Materials and Methods: Thirty (30) normal-pregnant patients and sixty (60) preeclamptic patients were included. Additionally, we included thirty (30) age- and...

Background Human nephrin (hNeph) (podocyte protein) has been known to be involved in both the formation and maintenance of the slit diaphragm (SD) and also acts as a hub protein in the podocyte by modulating cell polarity, cell survival, cell adhesion, cytoskeletal organization, mechano-sensing, and SD turn-over. Methodology In the present investig...

Background Numerous reports have shown the role of human leukocyte antigen (HLA) alleles in the induction of cutaneous adverse drug reactions by moderating drug metabolism. We therefore aimed to investigate the docking patterns of four HLA alleles (HLA-B x 5101, HLA-B x 1501, HLA-A x 02:06 and HLA-B x 57:01) against four commercial drugs. Methodolo...

A BSTRACT A four-leaf water clover ( Marsilea species) has been reported to exhibit various biological activities. In the present study, we aimed to evaluate 23 selected constituents of a four-leaf water clover ( Marsilea species) as potent inhibitory agents of human acetyl cholinesterase (hAchE), carbonic anhydrase II (hCA-II), and protein tyrosin...

A BSTRACT Background Wood apple ( Limonia acidissima ) has been reported to possess various pharmacological activities. The present study aimed to evaluate the 11 selected constituents of Wood apple ( L. acidissima ) as potent anti-dandruff and anti-acne agents using a molecular docking approach. Materials and Methods The 11 selected constituents...

A BSTRACT Human intelectin-1 (hITL-1) has been known to be involved in diseases such as asthma, cancer, metabolic disorders, and inflammatory bowel disease. In the present study, we aimed to evaluate hITL-1 as modulator of metabolic syndrome (MetS) using an in silico approach. AQ2 - The eight selected human (h) proteins, namely tumor necrosis facto...

A BSTRACT Background Cancer rates continue to climb, owing largely to the world population’s aging and growth, as well as economically developing countries, a surge in cancer-causing behavior, particularly smoking. The third or fourth most prevalent type of cancer is colon cancer. Cancer of the large intestine (colon) is one of the primary causes...

Mosquitoes are vectors that can cause serious negative impacts, including disease transmission, and altered ecosystem dynamics. In this research, phytochemical screening and toxicity of the essential oil derived from Murraya koenigii (L.) Spreng. leaves (Mk-EO) were evaluated against Aedes aegypti (Linn.) and Culex quinquefasciatus Say. The Mk-EO p...

Background Sivelestat is a potent and specific neutrophil elastase inhibitor. It is clinically used in treating lung injury and respiratory distress syndrome. This engaged us to undertake the present study in which sivelestat was studied as an anti-inflammatory and anti-viral agent. Methodology The docking study of sivelestat on matrix metalloprote...

Background Numerous pharmacological activities have been reportedin Mikania species. In the present investigation, we aimed to evaluate 26 selected constituents of Mikania as potent inhibitory agents of human HMG-CoA reductase (hHMGR), human inducible nitric oxide synthase (hiNOS), and human squalene synthase (hSQS) using the in silico method. Meth...

Current vector control strategies based on synthetic chemicals are not eco-friendly against non-target organisms; hence, alternative approaches are highly required. Commercially purchased oil of Mentha spicata (Spearmint) and Eucalyptus citriodora (Citriodora) were examined against the medical pest Cx. quinquefasciatus (Say) and their non-toxicity...

Background Urtica dioica (Stinging nettle)has been reported to exhibit various pharmacological activities. In the present study, we aimed to evaluate 24 selected constituents of U. dioica as potent inhibitory agents of human carbonic anhydrase II (hCA-II), human 11 beta-hydroxysteroid dehydrogenases type 1 (h11beta-HSD1), and human dual specificity...

Background Glycyrrhiza glabra (Licorice) has been known for its various biological activities. In the current investigation, we aimed to evaluate 11 (10 natural and one synthetic) selected constituents of G. glabra as potent modulatory agents of human superoxide dismutase (hSOD), human phosphodiesterase-9 (hPDE 9) and human dipeptidyl peptidase-4 (...

22 Dec 2023): In-vitro and in-silico analysis of methanolic crude extracts of Mountain knotgrass Aerva lanta (L.) against two lepidopteran pests and non-target species, Toxin Reviews, ABSTRACT The present research investigates the toxicological screening of crude methanol extracts Avera lanata (Mx-Al) traditionally used for its medicinal properties...

Limonia acidissima has been known to possess various biological activities. In the present study, we aimed to study eleven selected constituents of Limonia acidissima as potent antibacterial agents using in silico approach. The eleven chosen constituents of Limonia acidissima was assessed on the docking behaviour of three bacterial enzymes namely E...

Introduction and Aim: Cissus rotundifolia has been reported to possess various pharmacological

Extracts of botanical origin naturally contain a complex mixture of chemicals considered effective in managing lepidopteran pests. Chemical screening of the ethanolic leaf extracts of two fig tree species, Ficus lyrata and Ficus auriculata , delivered 12 and 15 phyto‐compounds with relatively high peak area percentages in phytol and flavone, respec...

Background Bunch berry (Lantana camara) is primarily composed of flavonoids and vitamin C; therefore, it has been shown to possess various medical characteristics, including the ability to relieve fever, inflammation, and urinary tract infections. Objective In this study, we intended to assess twenty chosen constituents of Bunch berry as potent in...

A marine-derived red alga, along with their active constituents, were actively screened for their biocontrol potential against major insect pests. The current study explored the larvicidal activity of crude methanolic extracts of the red alga Halymenia dilatata (Mx-Hd) against Aedes aegypti (Linn.), and their enzyme inhibition, repellent activity,...

Nitrification inhibitors are recognized as a key approach that decreases the denitrification process to inhibit the loss of nitrogen to the atmosphere in the form of N2O. Targeting denitrification microbes directly could be one of the mitigation approaches. However, minimal attempts have been devoted towards the development of denitrification inhib...

Inflammation is a robust immune response against exogenous stimulation processes like microbial invasion and physical injury. Despite inflammation being an essential host-defence mechanism, their chronic stage is highly associated with severe inflammatory disorders such as cancer and heart diseases. Natural bioactive compounds have been contributin...

Phoenix pusilla (Arecaceae), commonly known as "small wild date palm", is regarded as one of the underutilized fruit crops in South India. Methanol extract of P. pusilla ripened fruits (PPRF) was analyzed for in vitro porcine pancreatic alpha-amylase (PPAA) and rat small intestine alpha-glucosidase (RIAG) inhibition activities, and through gas chro...

The Mikania genus has been known to possess numerous pharmacological activities. In the present study, we aimed to evaluate the interaction of 26 selected constituents of Mikania species with (i) cyclooxygenase 2 (COX 2), (ii) human neutrophil elastase (HNE), (iii) lipoxygenase (LOX), matrix metalloproteinase ((iv) MMP 2 and (v) MMP 9), and (vi) mi...

Insect pest control is one of the major issues facing the agriculture sector because of the need for new agrochemicals and biocontrol agents that are environmentally friendly, economically affordable, and safe for human health. Spodoptera frugiperda (fall armyworm) is one of the insect pests that causes huge damage to various crops around the globe...

The antifungal effects of Citrullus colocynthis extract (Hexane, chloroform, methanol, and water) were tested in vitro on Fusarium oxysporum f. sp. lycopersici (Sacc.) W. C. Snyder & H. N. Hans (FOL), the causal agent of Fusarium wilt. Of these, methanol and water extract at 10% showed the highest inhibition of mycelial growth of FOL by 12.32 and 2...

Mosquitoes are the potential vectors of several viral diseases such as filariasis, malaria, dengue, yellow fever, Zika fever and encephalitis in humans as well as other species. Dengue, the most common mosquito-borne disease in humans caused by the dengue virus is transmitted by the vector Ae. aegypti. Fever, chills, nausea and neurological disorde...

Kidney stone is a major global menace that demands research on non-surgical treatment involving biological compounds for the benefit of the patients. Among the biological extracts, Citric acid is traditionally used to dissolve kidney stones. The current research focuses on evaluating the in vitro anti-urolithiatic activity and in silico study of et...

In-vitro chemical characterization and mosquitocidal screening of essential oil derived from Mikania scandens (L.) Willd. (Asteraceae) (CVO-MS) against the malarial vector Anopheles gambiae was investigated. GC-MS analysis evidenced a total of 12 bio-active compounds, and maximum at α-bisabolol (39.34%) followed by stigmasterol (13.45%) respectivel...

Organic acids (OA) have been known to regulate both the availability and absorption of non-heme iron. Honey contains 0.57 % of organic acids (OA). These prompt us to carry out the present study, where fifty-three selected (honey) ligands were assessed on the docking behavior of human Ferritin, Transferrin, and Hepcidin using the PatchDock method. F...

Embelin has been reported to possess variety of pharmacological activities such as androgenic antagonists, antiangiogenic, antibacterial, anticancer, anticonvulsant, antidiabetic, antidepressant, antihelmintic, antifertility, antihyperlipidemic, anti-inflammatory, antimalarial, antimitotic, antiobesity and antioxidant properties. The current resear...

Cissus rotundifolia has been reported to possess various biological activities such as anti-diabetic, anti-fertility, anti-hyperlipidemic, anti-malarial, anti-osteoporotic, and anti-parasitic activities. Therefore in the present study, eleven selected constituents of Cissus rotundifolia which includes aconitic acid, astragalin, acteoside, aliospiro...

Cissus rotundifolia has been reported to possess various biological activities such as anti-diabetic, anti-fertility, anti-hyperlipidemic, anti-malarial, anti-osteoporotic, and anti-parasitic activities. Therefore in the present study, eleven selected constituents of Cissus rotundifolia which includes aconitic acid, astragalin, acteoside, aliospiro...

Spodoptera litura Fab. is a polyphagous pest causing damage to many agriculture crops leading to yield loss. Recurrent usage of synthetic pesticides to control this pest has resulted in resistance development. Plant-derived diterpenoid compound andrographolide was isolated from the leaves of Andrographis paniculata. It was analysed by gas chromatog...

The present research investigated the chemical characterization and insecticidal activity of n-Hexane extracts of Epaltes divaricata (NH-EDx) along with their chief derivatives n-Hexadecanoic acid (n-HDa) and n-Octadecanoic acid (n-ODa) against the dengue vector Aedes aegypti and lepidopteran pest Spodoptera litura. Chemical screening of NH-EDx thr...

Cissus rotundifolia is commonly used as food thickeners in rural Nigeria and in South Arabia. And moreover, this plant leaves are also consumed by local people as leafy vegetable. Ithas been reported to possess various biological activities such as anti-diabetic, anti-fertility, anti-hyperlipidemic, anti-malarial, anti-osteoporotic and anti-parasit...

In the present study, 18 selected Azadirachta indica constituents, which includes azadiractin, azadiron, epicatechin, epoxyazadiradione, gallic acid, gedunin, isomargolonone, kaempferol, mahmoodin, margolone, margolonone, myristinin A, nimbolide, nimocinolide, quercetin, quercitrin, rutin, and sugiol were assessed on the docking behavior of Aflatox...

Clitoria ternatea has been reported to possess various biological activities such as analgesic, anxiolyticanti-bacterial, anti-cancer, anti-convulsant, anti-depressant, anti-fungal, anti-helmintic, anti-inflammatory, anti-microbial, antioxidant, antipyretic, hypoglycemic, nephro-protective and sedative. Therefore the present study was aimed to eval...

Comparative baseline toxicity of chemical pesticides Temephos, along with the crude extracts of Swietenia mahagoni Jacq. (Meliaceae) (Mx-Sm) against the Laboratory strains (LS) and Wild Strains (WS) of Aedes aegypti Linn. and their non-target screening against the aquatic predator was analyzed. The larval mortality was significant in Temephos (0.5...

Recent scientific understanding of the cascade of inflammatory mediators from arachidonic acid, a precursor of prostanoids, has enabled researchers to adopt new test procedures and also apply these new methods for medicinal plant research. Whole crude extracts from plants have been widely investigated in the past few decades and several plants have...

Clitoriaternatea has been reported to possess various biological activities such as analgesic, anxiolyticanti-bacterial, anti-cancer, anti-convulsant, anti-depressant, anti-fungal, anti-helmintic, anti-inflammatory, anti-microbial, anti-oxidant, antipyretic, hypoglycemic, nephro-protective and sedative. Therefore the present study was aimed to eval...

The present study emphasizes the biochemical and bioinformatics insights of a fungal secondary metabolite identified as Asperyellone in detail. In brief, yellow color pigment, Asperyellone (AY) obtained from Aspergillus species...

Insect pest control is one of the major issues facing in agriculture sector because of the need for new agrochemicals/biocontrol agents which should to be more environmentally friendly, economically affordable and as well safe to human health. Spodoptera frugiperda (fall armyworm), is one of the insect pests which causes huge damage to various crop...

Anopheles gambiae is the insect vector for malaria. In recent years it evolved as a distinctive model system for the study of innate immunity, mostly due to latest advancements in the functional genomics of A. gambiae. In the present study, three selected EmbeliaribesBurm F (Myrsinaceae) constituents, which includes embelin, 5-O-methylembelin, vila...

The present investigation aimed to determine the fungal toxicity of Isaria tenuipes (My-It) against the dengue mosquito vector Aedes aegypti L. and its non-target impact against the aquatic predator Toxorhynchites splendens. Lethal concentrations (LC 50 and LC 90) of My-It were observed in 2.27 and 2.93 log ppm dosages, respectively. The sub-lethal...

The human diet and its nutritional content may benefit in preventing several health issues. The enrichment of natural compounds in foodstuffs, having health supporting qualities is the present-day attention of by dieticians to explore a healthy food. Capsicum spp., are amongst the enormously consumed fruits worldwide, due to their bioactive compoun...

Triazole analogues are well known to have desirable properties for medicinal chemistry such as hydrogen bonding capability, moderate dipole character, rigidity and stability under in vivo conditions etc. This prompts us to carry out the present study, we have selected 20 triazole analogues and evaluated on the docking behavior of four targeted enzy...

The aim of this work is to investigate the structural and chemical behavior of the novel N⁴,N4′-dimethyl-[1,1′-biphenyl]-3,3′,4,4′-tetraamine (NNDMTA) compound using experimental and computational method. The synthesized compound has been characterized by FT-IR, NMR and UV-Visible spectroscopy method. The geometry structure was optimized by means o...

The crude n-hexane extracts Epaltes pygmaea (NH-Epx) displayed a steady larval toxicity against Culex quinquefasciatus and Aedes aegypti at the maximum dosage of 125 ppm. The level of α- and β carboxylesterase activity was downregulated to the sub-lethal dosage of NH-EPx (75 ppm) in both vectors. The level of GST and CYP450 gets upregulated. The LC...

In the present study, five gossypol analogues such as gossypol, gossypol acetic acid, gossypol polyvinyl pyrrolidine, diamino gossypol and ethyl gossypol were assessed on the docking behaviour of Human neutrophil elastase (HNE), Matrix metalloproteinases (MMP 2 & 9) and tyrosinase by utilizing PatchDock method. Furthermore, Molecular physicochemica...

Larval toxicity of ethanolic extract of C. parvula (Ex-Cp) was prominent in the second and the third instars at the maximum lethal dosage of 100 ppm with 98 and 97% mortality rate respectively. The LC50 and LC90 was displayed at 43 ppm and 88 ppm dosage respectively. Correspondingly, the sub-lethal dosage (65 ppm) of Ex-Cp significantly alters the...

Demand for a new anti-cancer drug has been dramatically increasing in the recent years. The Wnt/β catenin pathway acts as significant modulator of colon cancer and now serve as a new drug target for the development of anti-cancer/anti-tumour molecules. In the present study, five compounds namely apigenin, galangin, luteolin, proanthocyanidin and si...

Aflatoxins are secondary metabolites of certain fungi like Aspergillus flavus, Aspergillus niger, Aspergillus nomius and Aspergillus parasiticus. Food products like cereals, milk, milk products, nuts, oilseeds and spices are reported for aflatoxins contamination. Among the fourteen aflatoxin types reported so far, aflatoxins B1, B2, G1, G2, M1, and...

Herein, we have meticulously derived the nanosized fluorescent aggregates from pyrene Schiff base (PS) in DMSO:water (10:90) ratio. The aggregation property of PS molecule was characterized by SEM and TEM measurements, revealed the aggregated particles are in spherical shape with ~3 nm in size. Moreover, aggregates exhibit a high fluorescence quant...

Molecular docking is a computational method to study the formation of intermolecular complexes of one small molecule ligand (drug lead) with a macromolecule, which usually is a protein (drug target) of known three dimensional structure. Four different types of interactions between the molecules can be distinguished such as 1) protein-protein; 2) pr...

Objectives: D-proline is an isomer of L-proline, naturally occurring amino acid. Apart from this, several proline homologs and analogs are available in nature. For instance, hydroxyproline one of proline analog plays a key role in collagen function. Inhibition of collagenase activity plays a significant role in protecting the unbalanced turnover of...

Objectives: D-proline is an isomer of L-proline, naturally occurring amino acid. Apart from this, several proline homologs and analogs are available in nature. For instance, hydroxyproline one of proline analog plays a key role in collagen function. Inhibition of collagenase activity plays a significant role in protecting the unbalanced turnover of...

The current study explores the photo‐protective effect of asperyellone (AY) (a fungal secondary metabolite), assessed under in vitro condition using human dermal fibroblast cell line. AY was isolated from Aspergillus sp. during the resting phase and purified. The initial cytocompatibility assessment on concentrations of AY and the duration of expos...

At present, UV irradiation is a serious public health concern, as results of global warming and other environmental factors. UVA and UVB radiation plays a vital role in cutaneous damage in humans. Compounds that can protect against harmful UV radiation could be ideal photoprotective agents. Though chemical sunscreening agents are commercially avail...

Phytic acid (myo-inositol hexaphosphate) has gained much attention among researchers for its therapeutic value. This review focuses on pharmacological activities of phytic acid, which have been demonstrated by pre-clinical studies. Anti-carcinogenic, antioxidant, antidiabetic, hypolipidemic, anti-angiogenic, and immunomodulation are the most extens...

Objectives: Ionotropic glutamate receptors (iGluRs) play a key role in the development and function of the nervous system. They also play an important in memory and learning process. They are implicated in various pathological conditions such as Alzheimer’s, Epilepsy, Huntington’s, and Parkinson’s diseases. This prompted us to carry out the present...

N⁴, N⁴′-dibutyl-3,3′-diaminobenzidine target molecules were fashioned and characterized using analytical (UV, NMR, FT-IR, Mass, and CHNS analysis) methods. Optimized molecular geometry, NMR chemical shift value and vibrational frequencies of the N⁴, N⁴′-dibutyl-3,3′-diaminobenzidine in the pulverized state were computed using the density functional...

Phytic acid (myo-inositol hexaphosphate) has gained much attention among researchers for its therapeutic value. This review focuses on pharmacological activities of phytic acid, which have been demonstrated by pre-clinical studies. Anti-carcinogenic, antioxidant, antidiabetic, hypolipidemic, anti-angiogenic, and immunomodulation are the most extens...

Vitiligo is a depigmentation disorder with complex causes. Nonetheless, recent progress has been made to unravel the pathophysiology of vitiligo. In this review, we provide an overview of the currently known herbal medicine for vitiligo treatment and also highlighted the herbs that have been used in clinical trials. In view of traditional uses, her...

Cancer is one of the noncommunicable diseases which is the second leading cause of deaths throughout the world. Chemotherapy is the major treatment approach, however, with a limited success rate accompanied by secondary adverse health effects. Moreover, in recent years, about 30–80% of cancer patients are developing resistance to chemotherapeutic d...

Plants have been an integral part of our ancient culture. And they have been used as drugs for thousands of years ago by our native peoples and tribes in various parts of the world. Even today, documentations on traditional knowledge of medicinal plants and practices are still on-going throughout the world. Numerous therapeutic agents have been eme...

Endophytic fungi are unique microbes that reside in the plant tissues and cause no harm or any symptoms of diseases. Although plants are the major source of modern drugs, there is a continuous search for new sources to obtain new lead molecules, with higher biological properties, for treating various diseases. Many plants are associated with severa...

Mentha piperita has been well known for its hypolipidemic activity. This prompted the present study to be carried out on a selected 12 phyto-constituents of Mentha piperita which are naringin, eriodictyol, eriodictyol 7-glucuronide, eriocitrin, hesperidin, isorohifolin, luteolin 7-glucoside, diosmin, rosmarinic acid, piperitoside, menthoside and ca...

Biodegradation pathway of substituted imidazole ring compounds has been reported to have close analogue to the histidine degradation pathway. The present study carried out on four different types of polybenzimidazole (PBI) analogs such as m-PBI (where n= 1, 2 & 3), p-PBI (where n= 1, 2 & 3), pyridine-m-PBI (where n= 1, 2 & 3) and alkylated-m-PBI (w...

Objectives: The biodegradation pathway of substituted imidazole ring compounds has been reported to have close analogy to the histidine degradation pathway. This prompted the present study to be carried out on 12 selected imidazole and its derivatives which are 1-imidazole, 1, 2-dimethylimidazole, 1-ethyl imidazole, 2-ethyl-4-methylimidazole, 2-iso...

Background: The phytoconstituents phytic acid and 4-hydroxyisoleucine have been reported to posses various biological properties. Objective: This prompted us to carry out the docking study on these two ligands (phytic acid & 4-hydroxyisoleucine) against eleven targeted enzymes. Materials and methods: Phytic acid & 4-hydroxyisoleucine were eval...

Carica papaya (papaya) fruits are available throughout the world and it is well accepted as food or as a quasi-drug. Aqueous papaya leaves extract have been used as treatment for dengue fever. This prompted us to carry out the docking study on these nine selected ligands (phyto-constituents of papaya) which are carpaine, dehydrocarpaine I and II, c...

The present study describes, molecular docking analysis of Imidazole derivatives and Polybenzimidazole (PBI) analogs as inhibitors of Superoxide dismutase (SOD) and Xanthine oxidase (XO). Twelve imidazole derivatives and twelve PBI analogs were evaluated on the docking behaviour of SOD and XO using PatchDock. Docking studies revealed that 1-Ethylim...

Background: The phytoconstituents phytic acid and 4-hydroxyisoleucine have been reported to posses various biological properties. Objective: This prompted us to carry out the docking study on these two ligands (phytic acid & 4-hydroxyisoleucine) against eleven targeted enzymes. Materials and Methods: Phytic acid & 4-hydroxyisoleucine were evaluated...

Demand for a new anti-malarial drug has been dramatically increasing in the recent years. Plasmodium falciparum enoyl-acyl carrier protein reductase (PfENR) plays a vital role in fatty acid elongation process, which now emerged as a new important target for the development of anti-microbial and anti-parasitic molecules. In the present study, 19 com...

The recent applications of nanobiomaterials and functionalized nano-devices are now impacting the global market and show the great promise that this technology holds for the rest of this century. The changes in nanotechnology have provided new insights for material schemes that are centered on the structural switch of atoms and molecules. This tech...

Collagen plays a vital role in the maintenance of structure and function of a human body. It has been widely applied in various fields including biomedical, cosmeceutical, food, pharmaceutical and tissue engineering. In the present study, the docking behaviour of type I collagen with 15 different ligands namely hydroxymethylfurfural, methylglyoxal,...

Cancer remains one of the most devastating diseases in the world amid epidemiologic studies suggesting that cancer will be the number one disease in prevalence by 2020. It is described as an abnormal growth of cells triggered by numerous alterations in the expression of crucial genes that leads to the dysregulated balance of cell proliferation and...

Background: Clinacanthus nutans (Burm. f.) Lindau has gained popularity among Malaysians as a traditional plant for anti-inflammatory activity. Objective: This prompted us to carry out the present study on a selected 11 constituents of C. nutans which are clinacoside A-C, cycloclinacoside A1, shaftoside, vitexin, orientin, isovitexin, isoorienti...

Herbs and spices have been used in retaining and boosting human beauty since time immemorial. Herbal cosmetic has growing demand in the worldwide market and is an invaluable gift of Mother Nature. In the present review, the focus is on the cosmetic herbs of Southeast Asian countries namely Malaysia, Cambodia, Laos, Myanmar [Burma], Thailand, Vietna...

In the present study twelve constituents of honeywere evaluated on the docking behaviour of human neutrophil elastase (HNE) and matrix metalloproteinases (MMP 2 & MMP 9) using Discovery Studio. In addition molecular physicochemical, bioactivity, ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) and TOPKAT (Toxicity Prediction by...

In recent year's anti-angiogenesis agents have been recognized as effective drugs for the treatment of solid tumors, this prompted us to conduct the present study. The anti-angiogenic activity of dimeric form of embelin (vilangin) was evaluated using endothelial cell (in vitro) and chorioallantoic membrane (CAM) egg yolk angiogenesis model (in vivo...

We demonstrate refractive index sensors based on single mode tapered fiber and its application as a biosensor. We utilize this tapered fiber optic biosensor, operating at 1550 nm, for the detection of protein (gelatin) concentration in water. The sensor is based on the spectroscopy of mode coupling based on core modes-fiber cladding modes excited b...

The natural product molecule 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) isolated from the medicinal plant Melicope ptelefolia was shown to exhibit potent lipoxygenase (LOX) inhibitory activity. It is known that LOX plays an important role in inflammatory response as it catalyzes the oxidation of unsaturated fatty acids, such as linoleic acid to...

In recent years regulation of the enzymatic activity of human aldose reductase (HAR) has been the main focus of investigation, due to its potential therapeutic application in Diabetes mellitus (DM). In the present study, the docking behaviour of human aldose reductase (HAR) with seven different ligands namely embelin, copper-embelin complex, zinc-e...

In recent years regulation of the enzymatic activity of human neutrophil elastase (HNE) has been the main focus of investigation, due to its potential therapeutic application in medicinal field. In the present study, the docking behaviour of human neutrophil elastase (HNE) with 14 different ligands namely Chrotacumines-A, B, C, Grandols- B, D, G, R...