Rachel Riera

Rachel Riera
Universidade Federal de São Paulo | UNIFESP · Departamento de Medicina

Phd

About

229
Publications
28,308
Reads
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2,433
Citations
Additional affiliations
January 2013 - February 2016
Universidade Federal de São Paulo
Position
  • Professor (Assistant)

Publications

Publications (229)
Article
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Background Traumatic brain injury (TBI) is one of the most important causes of acquired structural epilepsy, post-traumatic epilepsy (PTE), however, efficient preventative measures and treatment are still not available to patients. Preclinical studies indicated biperiden, an anticholinergic drug, as a potential drug to modify the epileptogenic proc...
Article
Objectives This study aimed to assess the cost-effectiveness of a remotely operated referral management system (RORMS) compared with a conventional referral management system (CRMS) in Brazil. Methods This is a model-based cost-effectiveness analysis under the perspective of the Unified Healthcare System (Sistema Único de Saúde [SUS]) in Brazil. A...
Article
Hematological malignancies represent defying clinical conditions, with high levels of morbidity and mortality, particularly considering patients who manifest multiple refractory disease. Recently, chimeric antigen receptor (CAR)‐T cell therapy has emerged as a potential treatment option for relapsed/refractory B cell malignancies, which have motiva...
Preprint
Health professionals are encouraged to attend a residency period of two to seven years after graduating. The typical demands of this in-service training modality have been associated with reduced sleep quality, decreased exercise frequency, and detachment from family and social relationships, leading to an increased diagnosis of anxiety, depression...
Article
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Background: The use of mechanical thrombectomy to restore intracranial blood flow after proximal large artery occlusion by a thrombus has increased over time and led to better outcomes than intravenous thrombolytic therapy alone. Currently, the type of anaesthetic technique during mechanical thrombectomy is under debate as having a relevant impact...
Article
Purpose: to critically appraise and synthesize the evidence on the effects of vitamin C-based regimens for patients with sepsis or septic shock. Methods: a broad search was performed on May 2021 to identify randomized clinical trials (RCTs) assessing vitamin C-based regimens as adjuvant therapy for adults with sepsis or septic shock. We used the...
Book
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Este é um estudo inovador, que caracterizou o perfil dos egressos das três edições dos cursos do projeto Apoio à Formulação e Implementação de Políticas Públicas de Saúde Informadas por Evidências (ESPIE). Os seus resultados são subsídios de alto valor para futuros esforços de institucionalização das Políticas Informadas por Evidências (PIE) no âmb...
Article
Objective: To identify, critically evaluate and synthesize the evidence obtained from systematic reviews on the association between genetic polymorphisms and osteoarthritis (OA) development. Methods: Considering gene polymorphisms associated with OA susceptibility (risk or protection), a comprehensive search was conducted in the following databa...
Article
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Background An increase in the use of automated systems has optimised the drug dispensing process in hospitals. Methods This case study describes the implementation of automated drug dispensing system and presents the preliminary results of automated pharmaceutical dispensing with robots (PillPick® and BoxPicker®, ©Swisslog Healthcare) at Hospital...
Article
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Referral of cases from primary to secondary care in the Brazilian public healthcare system is one of the most important issues to be tackled. Telehealth strategies have been shown effective in avoiding unnecessary referrals. The objective of this study was to estimate cost per referred case by a remotely operated referral management system to furth...
Article
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Introduction We provide a critical assessment regarding current evidence for the use of moderately hypofractionated irradiation for patients with breast cancer. The aim of the study was to summarize the available evidence regarding outcomes after moderately hypofractionated compared with conventional radiation doses in the post-operative treatment...
Article
The aim of this study was to identify, systematically assess and summarise the available evidence about the efficacy and safety of intravenous domiciliary antibiotic therapy. In this systematic review, we considered studies with adults with any kind of infection and recommended intravenous antibiotic therapy. We included studies comparing the thera...
Article
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Rationale, Aims, and Objectives: It is generally believed that evidence from low quality of evidence generate inaccurate estimates about treatment effects more often than evidence from high (certainty) quality evidence (CoE). As a result, we would expect that (a) estimates of effects of health interventions initially based on high CoE change less f...
Article
Background: Varicose veins are enlarged and tortuous veins, affecting up to one-third of the world's population. They can be a cause of chronic venous insufficiency, which is characterised by oedema, pigmentation, eczema, lipodermatosclerosis, atrophie blanche, and healed or active venous ulcers. Injection sclerotherapy (liquid or foam) is widely...
Preprint
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Rationale, aims and objectives 39 Evidence-based medicine (EBM) holds that estimates of effects of health interventions based on 40 high-certainty evidence (CoE) are expected to change less frequently than the effects generated 41 in low CoE studies. However, this foundational principle of EBM has never been empirically 42 tested. 43 Methods 44 We...
Article
The debate on the use of cannabinoids for therapeutic purposes is constantly on the rise. This overview aimed to map the evidence on the therapeutic effects of cannabis derivatives and their synthetic analogs. Systematic reviews (SRs) of randomized trials were identified through a comprehensive search in several databases, and their methodological...
Article
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Objective To evaluate different hypofractionated radiotherapy (HRT) regimens for newly diagnosed elderly glioblastoma (GBM) patients. Methods We performed a systematic review with network meta-analysis (NMA), including searches on CENTRAL, Medline, EMBASE, CINAHL, clinical trial databases and manual search. Only randomized clinical trials (RCTs) w...
Preprint
Evidence-based health information is provided by evidence synthesis and health technology assessments. Nevertheless, this information is complex for public understanding, pointing to the need to disseminate clearly. This scoping review aims to identify different strategies for communicating health evidence to policymakers and the general population...
Article
Background: The development of severe coronavirus disease 2019 (COVID-19) and poor clinical outcomes are associated with hyperinflammation and a complex dysregulation of the immune response. Colchicine is an anti-inflammatory medicine and is thought to improve disease outcomes in COVID-19 through a wide range of anti-inflammatory mechanisms. Patie...
Article
Background Obstructive sleep apnoea syndrome (OSAS) is associated with several chronic diseases, including erectile dysfunction (ED). The association of OSAS and ED is far more common than might be found by chance; the treatment of OSAS with non‐invasive positive airway pressure therapy is associated with improvement of respiratory symptoms, and ma...
Article
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Objectives Assess the effects of different routes of prophylactic oxytocin administration for preventing blood loss at caesarean section (CS). Design Systematic review and meta-analysis. Methods Medline, EMBASE, CINAHL, Cochrane Library, BVS, SciELO and Global Index Medicus were searched through 24 May 2020 for randomised controlled trials (RCTs)...
Article
Objective : To investigate the frequency and perform a qualitative analysis of spin bias in publications of controlled trials assessing the therapeutic use of cannabis derivatives and their synthetic analogues. Study Design and Setting : Meta-epidemiologic study carried out at the Universidade Federal de São Paulo, Brazil. Results : 65 publicatio...
Article
Background: Botulinum toxin type A (BontA) is the most frequent treatment for facial wrinkles, but its effectiveness and safety have not previously been assessed in a Cochrane Review. Objectives: To assess the effects of all commercially available botulinum toxin type A products for the treatment of any type of facial wrinkles. Search methods:...
Article
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Background There is no consensus on the best timing for prophylactic oxytocin administration during cesarean section (CS) to prevent post-partum hemorrhage (PPH). Objectives Assess the effects of administrating prophylactic oxytocin at different times during CS. Methods We searched nine databases to identify relevant randomized controlled trials...
Article
Cochrane devolves most editorial governance of the Cochrane Database of Systematic Reviews (CDSR), including title prioritization, protocol registration, peer-review, editorial oversight and subsequent review deposition, to specific Cochrane Review Group (CRG) editorial boards. Current Cochrane policy stipulates authors of reviews who are also memb...
Article
Introdução: O plasma rico em plaquetas (PRP) é uma tecnologia com potencial aplicação em diversas áreas da medicina e odontologia. A alta variabilidade no processo de produção desta tecnologia e de tecnologias relacionadas desafiam a regulamentação de sua produção, do controle de qualidade e do uso. Objetivo: Avaliar práticas de produção, armazenam...
Article
Aims to identify, systematically evaluate and summarise the best available evidence on the frequency of long COVID (post‐acute COVID‐19 syndrome), its clinical manifestations and the criteria used for diagnosis. Methods Systematic review conducted with a comprehensive search including formal databases, COVID‐19 or SARS‐CoV‐2 data sources, grey lit...
Article
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Background: Numerous systematic reviews on coronavirus disease-19 (COVID-19) treatment have been developed to provide syntheses of the large volume of primary studies. However, the methodological quality of most of these reviews is questionable and the results provided may therefore present bias. Objective: To investigate how many systematic rev...
Article
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Objective: To describe and critically appraise the economic evaluations of antineoplastic drugs submitted to the ANS during the process of updating its 2020’ list of procedures. Methods: Cross-sectional study of critical analysis of the economic evaluation studies included in the documentation submitted to the ANS with the aim of incorporating them...
Article
A alocação de recursos em saúde é contingenciada pela desproporção entre as numerosas demandas da população e a relativa insuficiência de recursos para atendê-las. Esta desproporção faz com que processos decisórios sobre incorporação ou desinvestimento de tecnologias tenham que ser conduzidos, visando a garantir a eficiência dos sistemas de saúde....
Article
Context Caffeine is 1 of the most popular supplements consumed by athletes, and the evidence for improving soccer performance remains limited. Objective To investigate and update the effects (benefits and harms) of caffeine to improve performance on soccer players. Data Sources Electronic search in Medline (via PubMed), CENTRAL, Embase, SPORTDisc...
Article
PURPOSE There has been noteworthy concern about the impact of COVID-19 pandemic on health services including the management of cancer. In addition to being considered at higher risk for worse outcomes from COVID-19, people with cancer may also experience disruptions or delays in health services. This systematic review aimed to identify the delays a...
Article
Purpose: Delays and disruptions in health systems because of the COVID-19 pandemic were identified by a previous systematic review from our group. For improving the knowledge about the pandemic consequences for cancer care, this article aims to identify the effects of mitigation strategies developed to reduce the impact of such delays and disrupti...
Article
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Background: The World Health Organization (WHO) and the International Labour Organization (ILO) are developing Joint Estimates of the work-related burden of disease and injury (WHO/ILO Joint Estimates), with contributions from a large network of experts. Evidence from mechanistic data suggests that exposure to long working hours may increase alcoh...
Article
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Introduction Platelet-rich plasma is widely used for different types of clinical situations, but universal standardization of procedures for its preparation is still lacking. Methods Scoping review of comparative studies that have assessed at least two alternatives in one or more stages of preparation, storage and/or administration of PRP or its r...
Book
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A primeira publicação da América Latina e Caribe que se propõe a reunir diferentes conhecimentos científicos sobre o processo de elaboração de Sínteses de Evidências para Políticas em um único documento. Acredita-se que, dessa forma, o Decit/SCTIE/MS contribuirá para padronização, qualificação e avaliação de Sínteses de Evidências para Políticas de...
Article
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effectiveness and safety of proton pump inhibitor‐ and clarithromycin‐based triple therapies for Helicobacter pylori (H,pylori) eradication.
Article
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A better understanding of the SARS-CoV-2 virus behavior and possible risk factors implicated in poor outcome has become an urgent need. We performed a systematic review in order to investigate a possible association between body weight and prognosis among patients diagnosed with COVID-19. We searched in Cochrane Library, EMBASE, MEDLINE, WHO-Global...
Article
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Glioblastoma (GBM) is one of the most malignant primary intracranial neoplasms. This review aims to summarize the treatment of elderly patients with newly diagnosed GBM, with a focus on the radiation therapy (RT) approach. The available literature was reviewed, and we describe the most significant results relating to the post-operative approach of...
Article
Full-text available
Objectives This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of different types of anaesthesia for endovascular interventions in patients with acute ischaemic stroke.
Article
Background Even with a universal public health system, the Brazilian population faces inequalities on access to healthcare. Long queues for medical appointments, caused by lack of professionals, space and equipment, are barriers for those who cannot pay for treatments. However, health professionals working in the private sector may have free hours...
Article
Objective This systematic review and meta-analysis aimed to investigate the effectiveness and safety of ozone therapy for treating dental caries. Methods We searched for randomized controlled trials (RCTs) in eight databases, from inception to April 4, 2020 (MEDLINE, EMBASE, CENTRAL, LILACS, BBO, ClinicalTrials.gov, WHO and OpenGrey). Primary outc...
Article
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Objective We performed a systematic review to assess the effectiveness and safety of Tribulus terrestris to treat female sexual dysfunction (FSD). Data sources We performed unrestricted electronic searches in the MEDLINE, CENTRAL, EMBASE, LILACS, CINAHL, PsycINFO, WHO-ICTR, Clinicaltrials.gov and OpenGrey databases. Selection of studies We included...
Article
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Introduction: Different therapies are currently used, considered, or proposed for the treatment of COVID-19; for many of those therapies, no appropriate assessment of effectiveness and safety was performed. This document aims to provide scientifically available evidence-based information in a transparent interpretation, to subsidize decisions rela...
Article
Full-text available
We conducted a systematic review to compare the effectiveness and safety of exercise versus no exercise for patients with asymptomatic aortic aneurysm. We followed the guidelines set out in the Cochrane systematic review handbook. We searched Medline, Embase, CENTRAL, LILACS, PeDRO, CINAHL, clinicaltrials.gov, ICTRP, and OpenGrey using the MeSH ter...
Technical Report
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A elaboração das Diretrizes para Diagnóstico e Tratamento da COVID-19 é uma resposta rápida para o enfrentamento da COVID-19, diante da declaração de pandemia pela Organização Mundial de Saúde e as iniciativas do Ministério da Saúde para enfrentamento dessa nova situação no Brasil. A produção de evidência sobre o assunto nos últimos meses faz desta...