Rachel Hunt

Purpose Laser interstitial thermal therapy (LITT) is a minimally invasive, image-guided, cytoreductive procedure to treat recurrent glioblastoma. This study implemented dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) methods and employed a model selection paradigm to localize and quantify post-LITT blood-brain barrier (BBB) permeabil...

Background: Early ambulation is considered a key element to Enhanced Recovery After Surgery protocol after spine surgery. Objective: To investigate whether ambulation less than 8 hours after elective spine surgery is associated with improved outcome. Methods: The Michigan Spine Surgery Improvement Collaborative database was queried to track al...

Background 5-aminolevulinic acid (5-ALA) is a valuable surgical adjuvant used for the resection of glioblastoma multiforme (GBM). Since Food and Drug Administration approval in 2017, 5-ALA has been used in over 37,000 cases. The current recommendation for peak efficacy and intraoperative fluorescence is within 4 h after administration. This narrow...

Introduction: Symptomatic vasospasm (SV) is a complication of aneurysmal subarachnoid hemorrhage (aSAH) and can lead to cerebral infarction. Changes in vital trends, such as heart rate (HR) and mean arterial blood pressure (MAP), have been associated with SV in aSAH. Real-time assessment of instantaneous vital sign waveform data could improve detec...

INTRODUCTION Developing and advancing patient-centered care within neuro-oncology is an essential element of any tertiary brain tumor center. Patient-centered care of neuro-oncology patients requires a holistic approach that integrates oncologic treatment with social and psychological support. OBJECTIVE The aim of this study is to evaluate how a P...

Multidisciplinary oncology care requires a team of experts which should include patient stakeholders. The Henry Ford Health System (HFHS) Hermelin Brain Tumor Center (BTC) patient and family advisory council (PFAC) recommended a focus group of patient stakeholders newly diagnosed with glioblastoma(GBM) to better understand this experience. Our PFAC...

The neurological ICU (neuro ICU) often suffers from significant limitations due to scarce resource availability for their neurocritical care patients. Neuro ICU patients require frequent neurological evaluations, continuous monitoring of various physiological parameters, frequent imaging, and routine lab testing. This amasses large amounts of data...

INTRODUCTION In patients with newly diagnosed intracerebral lesions, gliomas are often suspected. However, other conditions such as multiple sclerosis, abscess or lymphoma are possible, as well. Furthermore, biopsy can be challenging due to eloquent and/or deep location within the brain. In this prospective, blinded study, analysis of plasma isolat...

INTRODUCTION Surgical site infections (SSI) after lumbar spine surgery is costly and potentially preventable. A number of studies have shown the efficacy of vancomycin powder in preventing SSI, but there are few studies that have examined all the available perioperative antibiotics. We sought to examine associations between intraoperative antibioti...

INTRODUCTION The Michigan Spine Surgery Improvement Collaborative (MSSIC) is a prospective, longitudinal, multicenter, quality improvement collaborative. Using MSSIC, we sought to identify the relationship between a positive PHQ-2, which is predictive of depression, and patient satisfaction, return to work, and achieving ODI MCID up to 2-yr after l...

INTRODUCTION The Michigan Spine Surgery Improvement Collaborative (MSSIC) is a multicenter quality-improvement collaborative. Using MSSIC, we sought to identify the relationship between ambulation on the day of surgery (POD#0) and 90-d adverse events after lumbar surgery, specifically length of stay (LOS), urinary retention (UR), urinary tract infe...

Background: The mesial prefrontal cortex, cingulate cortex, and the ventral striatum are key nodes of the human mesial fronto-striatal circuit involved in decision-making and executive function and pathological disorders. Here we ask whether deep wide-field repetitive transcranial magnetic stimulation (rTMS) targeting the mesial prefrontal cortex (...

The mesial prefrontal cortex, cingulate cortex and the ventral striatum are key nodes of the human mesial fronto-striatal circuit involved in decision-making and executive function and pathological disorders. Here we ask whether deep wide-field repetitive transcranial magnetic stimulation (rTMS) targeting the mesial prefrontal cortex (MPFC) influen...

Introduction Voluntary actions are characterized by a feeling that the self is the cause of action (sense of agency, SoA). SoA is created from efferent indicators (action prediction, body scheme) and afferent indicators (visual feedback, proprioception). In case of congruency between indicators, experience of SoA develops; in case of incongruence,...

Improving scheduling methods in manufacturing environments such as job shops offers the potential to increase throughput, decrease costs, and therefore increase profit. This makes scheduling an important aspect in the manufacturing industry. Job shop scheduling has been widely studied in the academic literature because of its real-world applicabili...

Job Shop Scheduling (JSS) involves determining a schedule for processing jobs on machines to optimise some measure of delivery speed or customer satisfaction. We investigate a genetic programming based hyper-heuristic (GPHH) approach to evolving dispatching rules for a two-machine job shop in both static and dynamic environments. In the static case...

Job Shop Scheduling (JSS) is a complex real-world problem aiming to optimise a measure of delivery speed or customer satisfaction by determining a schedule for processing jobs on machines. A major disadvantage of using a dispatching rule (DR) approach to solving JSS problems is their lack of a global perspective of the current and potential future...

Feature selection is the task of finding a subset of original features which is as small as possible yet still sufficiently describes the target concepts. Feature selection has been approached through both heuristic and meta-heuristic approaches. Hyper-heuristics are search methods for choosing or generating heuristics or components of heuristics,...

Genetic programming (GP) has been used extensively for classification due to its flexibility, interpretability and implicit feature manipulation. There are also disadvantages to the use of GP for classification, including computational cost, bloating and parameter determination. This work analyses how GP-based classifier learning scales with respec...

Object detection in images is inherently imbalanced and prone to overfitting on the training set. This work investigates the use of a validation set and sampling methods in Multi-Objective Genetic Programming (MOGP) to improve the effectiveness and robustness of object detection in images. Results show that sampling methods decrease runtimes substa...

This work investigates the use of sampling methods in Genetic Programming (GP) to improve the classification accuracy in binary classification problems in which the datasets have a class imbalance. Class imbalance occurs when there are more data instances in one class than the other. As a consequence of this imbalance, when overall classification r...