
Rabea ParveenJamia Hamdard · Department of Pharmaceutics
Rabea Parveen
Doctor of Philosophy
About
127
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Publications (127)
Background
Traditional formulations are used extensively throughout the world due to their holistic approach to health and wellness with the fewest possible adverse effects. Itrifal Sana is a traditional unani polyherbal formulation, a unique combination that makes it synergistically potent, capable of providing dual benefits for health and well-be...
The importance of metabolomics in furthering the study of medicinal plants is discussed in this chapter. It clarifies the differences between primary and secondary metabolites; examines important metabolomics techniques such as LC-MS, GC-MS, and NMR; and highlights their uses in the identification of bioactive compounds, quality assurance, authenti...
The gut microbiota is a varied population of microorganisms that live in the human gastrointestinal system. Emerging research emphasizes the importance of this microbial ecology in general health and its influence on a variety of disorders. The review explores the synergy between herbal treatment and traditional medicine, emphasizing their cultural...
Background
Skin cancer continues to be an imperative global health issue, urging continuous exploration of treatment methodologies. Conventional treatments for skin cancer include surgical interventions, immunotherapy, targeted therapy, chemotherapy, and radiation therapy. However, these methods often present obstacles like treatment resistance, sy...
Infectious diseases, particularly fungal infections, continue to pose substantial challenges to global public health. This chapter explores the promising role of plant-based nanoparticles in addressing these challenges. Utilizing eco-friendly green synthesis methods, these nanoparticles, including silver, palladium, zinc oxide, selenium, copper and...
The objective of this study was to develop a nanoformulation of 5-fluorouracil (5-FU) combined with Andrographolide (AG) to synergize their anticancer activity, reduce the dose of 5-FU, and minimize the side effects of 5-FU. Solid lipid nanoparticles (SLNs) of 5-FU and AG were synthesized and characterized separately for average particle size, EE,...
Dengue fever has become a major public health concern. It is usually related to intravascular leaking, bleeding disorders, and thrombocytopenia and is recognized as a potent threat to humans. The scarcity of anti-dengue medication or vaccine for such a serious disease leads to an upsurge in the usage of traditional medicines for its proper manageme...
Cite this article: Parveen R, Samal M, Nafis, Mukhtar HM, Ahmad S. Development of solid lipid nanoparticle gel for transdermal delivery system of chaulmoogra oil. Abstract Aim: The main objective of the study was to formulate, evaluate and perform an optimization study of chaulmoogra oil-loaded solid lipid nanoparticles (SLNs) based gel. Methods: T...
Artificial Intelligence (AI) has emerged as a powerful tool in various domains, and the field of drug formulation and development is no exception. This review article aims to provide an overview of the applications of AI in drug formulation and development and explore its future prospects. The article begins by introducing the fundamental concepts...
Background:
Rubia cordifolia L., Rubiaceae, is globally reported to treat skin-related problems. The study aimed to assess the antityrosinase potential of RC and the development of gel formulation.
Methods:
AutoDock vina (version V.1.2.0) program package was used for molecular docking to check for the binding affinity of ligands with protein. Re...
Background
Herbal drugs when used in combination with chemotherapeutic drugs can reduce the side effects and increase the efficacy by acting on multiple targets. Andrographolide (AG), a diterpene lactone isolated from Andrographis paniculata Nees, is a bioactive compound with anticancer potential, and 5-fluorouracil (FU), a pyrimidine analogue, is...
Background:
Bioautography is a technique for the detection of biological activity that combines the elements of planar chromatography. Its hyphenated variants are widely used in the screening of natural products possessing biological activity. It can be used in the activity-based screening of phytochemical ingredients by employing various enzyme p...
Objectives:
The present study was conducted to investigate the phytochemical analysis and demonstrate the nephroprotective potential of root extract of Glycyrrhiza glabra L. against cisplatin (CP) -induced nephrotoxicity in vitro and in vivo.
Materials and methods:
The HPTLC analysis and UPLC-MS were carried out for standardizing and metabolite...
The lack of sufficient scientific evidence prompted the analytical investigation of nephroprotective potential of the silk extract of Zea mays L., which is traditionally and ethnomedicinally used for various disorders including kidney dysfunction. The present study was conducted to investigate the phytochemical analysis and demonstrate the nephropr...
Background
In the past decade, a rising trend has seen in the use of plant-based medicines because of fewer/no side effects. Plants are always the major source of traditional medicines in every culture. The main objective of this review is to shed a light on phytochemical composition and pharmacological research of Valeriana wallichii.
Methods
Ele...
Vitex negundo is a traditional herb known for its medicinal properties in Unani, Ayurveda, Siddha, Chinese, Roman, and other traditional systems of medicine. Traditionally, it is used as anthelminthic, antitoxin, aphrodisiac, contraceptive, antimalarial, analgesic, antiinflamatory, antiasthmatic, vermifuge, etc. All parts of V. negundo contain numb...
Tyrosinase is acopper-containing key substance in the pigmentation of mammalian hair and skin. Melanin synthesis is influenced by variety of extrinsic and internal variables, including hormone fluctuations, inflammation, ageing, and subsequent ultraviolet light exposure. Melasma, senile lentigines, freckles, and diminished colour are all undesirabl...
Background
Arq-e-Keora is a liquid formulation of the Unani system of medicine and used since long for the management of weakness of heart and palpitation etc.
Objective
The study was carried out to generate a scientific data for its metabolite profiling, stability testing, pharmacokinetics and pattern recognition analysis of Arq-e-Keora.
Method...
In addition to the classical functions of the musculoskeletal system and calcium homeostasis, the function of vitamin D as an immune modulator is well established. The vitamin D receptors and enzymes that metabolize vitamin D are ubiquitously expressed in most cells in the body, including T and B lymphocytes, antigen-presenting cells, monocytes, ma...
Solid tumor is one of the highly prevalent cancers among humans and the treatment is often restricted by drug resistance to chemotherapeutics. One of the main reasons might attribute to limited penetration ability of drugs through tumor tissues due to heterogeneity within the tumor microenvironment. Over the recent years, so much of research has be...
Nanoparticles have gained prominence in many areas and domains world-wide such as metallic NP, carbon-dots, quantum dots, polymeric NP, nano-suspension, nanocrystals, solid lipid nanoparticles (SLN), etc. and have been applied in the field of medicine as nanomedicine with promising results. Rise in global cancer mortality rate has been an issue sin...
Gut microbiota contributes to diverse mammalian processes including the metabolic functions of drugs. It is a potential new territory for drug targeting, especially for dietary natural compounds such as tannins, flavonoids, steroidal glycosides, anthocyanins, lignans, alkaloids, and others. Because most herbal medicines are orally administered, the...
Synergism among herbals or phytochemicals potentiates incredible biological effects thus mitigating several acute and chronic ailments. Boerhaavia diffusa (BD) and Tinospora cordifolia (TC) are well-known medicinal plants used as the folk medicinal regimen for treating various ailments. Due to lack of scientific evidence, the study is aimed to eval...
Background
Vitamin D deficiency is a global phenomenon and causes serious morbidities in people via fluctuation in ions homeostasis, oxidative and inflammatory stress. The fundamental goal of this review was to comprehend the growing awareness, biological impact, fortification and different resources of Vitamin D.
Methods
The purpose of the presen...
The use of herbal medicines and supplements in the last thirty years has increased enormously. Herbal medication has demonstrated promising and effective potential against various diseases. Herbal and phytoconstituent medications are gaining popularity globally and many people are adopting herbal remedies to deal with different health issues. The i...
Sharbat-e-Bazoori Motadil (SBM) is a traditional Unani syrupy formulation, widely used for the management of kidney diseases. Due to lack of scientific evidence, the present work prospective is aimed to evaluate the protective effect of sugar-free SBM against cisplatin (CP)-induced nephrotoxicity using in vitro and in vivo followed by phytochemical...
Ganoderma lucidum P. karst is an edible fungus that is used in traditional medicine and contains triterpenoids as the major phytoconstituents. Ganoderic acids are the most abundant triterpenoids that showed pharmacological activity. As Indian varieties contain ganoderic acid H (GA-H), we aimed to prepare GA-H-based triterpenoid enriched fraction (T...
The study was aimed to develop a characterized polyherbal combination as an immunomodulator containing Phyllanthus emblica L., Piper nigrum L., Withania somnifera (L.) Dunal, and Tinospora cordifolia (Willd.) Miers. Through response surface methodology (RSM), the ratio of aqueous extracts of four plant materials was optimized and comprised 49.76% o...
We aimed to develop a chromatographic method for scientific validation of water extract of some important Indian traditional plants used in AYUSH-based formulation as immunomodulator and to evaluate their bioactive potential. Fruits of Phyllanthus emblica L. and Piper nigrum L., stem of Tinospora cordifolia (Willd.) Miers, rhizome of Curcuma longa...
Didymocarpous pedicellata R.Br. (Gesneriaceae), also known as stone flower, is a valuable medicinal plant growing in the subtropical Himalayas (India). It is traditionally used for treating kidney and bladder stones and is the main ingredient of herbal formulations used to treat kidney stones, such as Cystone and Safoof-e-Pathr Phori (SPP). The pre...
Ethnopharmacological relevance
Kidney disease (KD) is one of the serious health issues, which causes worrisome morbidity and economic burden. Therapeutic strategies are available however majority of them are associated with severe adverse effects and poor patient compliance and adherence. This explorative article was undertaken to provide a holisti...
Diabetes is a metabolic disorder increasing at an alarming rate in the current era. Medicinal plants and their supplements have shown protective effects against metabolic dysregulation and oxidative damage. The present study is aimed to explore the antidiabetic potential of hydroalcoholic extract of Picrorhiza kurroa (HAE-PK). The UPLC/MS analysis...
The biomedical survey reports edible plant Aegle marmelos has been utilized for centuries by tribal communities in India as a dietary supplement for the management of diabetes. Herein, we have investigated cytotoxicity, cytoprotective and antidiabetic activity of characterized alkaloid-free hydroalcoholic extract of A. marmelos (AFEAM; 200 and 400...
Chronic Kidney Disease (CKD) is a major health problem characterized by kidney dysfunction with progressive segmental glomerulosclerosis to end-stage renal disease (ESRD). Due to lack of scientific data and comprehensive reports, the current systematic review provides an inclusive understanding and prospective associated with phytopharmacology of N...
The cases of COVID-19 are still increasing day-by-day worldwide, even after a year of its first occurrence in Wuhan city of China. The spreading of SARS-CoV-2 infection is very fast and different from other SARS-CoV infections possibly due to structural differences in S proteins. The patients with severe diseases may die due to acute respiratory di...
Mulberry is a fast growing deciduous plant found in wide variety of climatic, topographical and soil conditions, and is widely distributed from temperate to subtropical regions. Due to presence of valuable phytochemical constituents, mulberry as a whole plant has been utilized as a functional food since long time. Mulberry fruits are difficult to p...
Ethnopharmacological relevance
Synthetic drugs used for cancer treatment have side effects that may be immunosupressive, can cause liver, kidney and cardiac toxicity, and infertility and ovarian failure, among others. Thus, herbal drugs could be used in the cancer treatment as an adjuvant therapy. Andrographis paniculata (Burm.f.) Nees (AP) is one...
The biomedical survey reports edible plant Aegle marmelos has been utilized for centuries by tribal communities in India as a dietary supplement for the management of diabetes. Herein, we have investigated cytotoxicity, cytoprotective and antidiabetic activity of characterized alkaloid-free hydroalcoholic extract of A. marmelos (AFEAM; 200 and 400...
BGR-34 is a polyherbal formulation frequently used to combat diabetes around the globe especially in Asian countries. It provides an attractive treatment option to prediabetics, diabetics, and in metabolic disorders by controlling the altered blood glucose level. The lack of phytopharmacological studies on BGR-34 prompted as to reveal the compounds...
Ethnopharmacological relevance
Withania somnifera (Family: Solanaceae), commonly known as Ashwagandha or Indian ginseng is distributed widely in India, Nepal, China and Yemen. The roots of plant consist of active phytoconstituents mainly withanolides, alkaloids and sitoindosides and are conventionally used for the treatment of multiple brain disord...
As per the definition approved by the World Health Organization (WHO), the term herbal medicine applies to all those medicines that occur in the form of plants, plant parts (such as roots, rhizomes, stem, bark, wood, leaves, flowers, fruits, seeds or their active ingredients), herbal preparations, or the finished products containing these materials...
Background: Ultra-performance LC (UPLC)-tandem MS (MS/MS) and high-performance TLC (HPTLC) assay methods were developed for chemical fingerprinting and quantitative analysis of bioactive constituents of a certain "Itrifal formulation," a traditional kind of Unani medicine. Objective: In the present investigation, HPTLC and UPLC-MS/MS methods were d...
Background:
Ultra-performance LC (UPLC)-tandem MS (MS/MS) and high-performance TLC (HPTLC) assay methods were developed for chemical fingerprinting and quantitative analysis of bioactive constituents of a certain "Itrifal formulation," a traditional kind of Unani medicine.
Objective:
In the present investigation, HPTLC and UPLC-MS/MS methods wer...
Background: Standardization of Unani formulations is essential to assess the quality and safety of drugs to establish their acceptance internationally as well as in nationally. Safoof-e-Pathar phori is a polyherbomineral formulation that contains six different plant and mineral constituents: Didymocarpus pedicellata, Dolichos biflorus, Rheum emodi,...
Background:
Standardization of Unani formulations is essential to assess the quality and safety of drugs to establish their acceptance internationally as well as in nationally. Safoof-e-Pathar phori is a polyherbomineral formulation that contains six different plant and mineral constituents: Didymocarpus pedicellata, Dolichos biflorus, Rheum emodi...
Background:
Interest in the antioxidant and antidiabetic activity of natural products are growing vastly in the modern world. Thin layer chromatography-bioautography-mass spectroscopy (TLC-bioautography-MS) plays an important role in chemico-biological screening of natural sources. TLC combined with 2, 2-Diphenyl-1-picrylhydrazyl (DPPH) free radic...
Background:
One of the most precious systems of traditional medicine is the Unani system of medicine. A wide variety of formulations indigenous to the Unani medicine have been preserved over the years. These formulations are potent and effective even after ages of postformulation. Rose petals are an example of such an herb, which is extensively an...
Unani medicine, based largely on herbs, is practiced as a traditional system of medicine in the Indian subcontinent. It owes its origination to the Greek philosopher Hippocrates (460-377 BC) and his associates. However, it progressed and got established under the patronage of Persian and Arab empires and later came to the Indian sub-continent aroun...
Gymnema sylvestre , popularly known as gurmar, is extensively used in traditional systems of medicine for diabetes, stomach ailments, liver diseases, and cardiac disorders. Dried leaf powder of G. sylvestre was extracted through soxhlation using 70% (v/v) alcohol. The hydroalcoholic extract was concentrated to 1/4th of its volume and basified to is...
Introduction
The absence of microbial growth and resistance to oxidative deterioration in fruits of Musa × paradisiaca L. (bananas) is an indication of the presence of antimicrobial and antioxidant metabolites.
Objective
In order to investigate the secondary metabolomic spectrum as well as the active antimicrobial and antioxidants present in essen...
Andrographis paniculata (family: Acanthaceae) is used in the Indian, Thai, and Chinese traditional system of medicines since the ancient times to cure fever, common cold, inflammation, upper respiratory tract infection, pharyngitis, laryngitis, tonsillitis, pneumonia, tuberculosis, hepatic impairment, and pyelonephritis. Andrographolide (a diterpen...
Higher plants are the major source of crude drugs used in herbal therapy. Adulteration in crude-drug material has necessitated scientific characterization of plant drugs, which is based primarily on morphological, anatomical and physico-chemical characters studied through microscopy and some analytical techniques. These criteria are helpful in isol...
Background:
Bacopa monnieri (BM) is a herbaceous plant traditionally used from time immemorial in Ayurvedic and folklore medicines. We hypothesized that the extract of the whole plant might contain numerous molecules with having antitumor activities that could be very effective in killing of human cancer cells.
Objectives:
This work investigated...
Moringa oleifera Lam. (family; Moringaceae), commonly known as drumstick, have been used for centuries as a part of the Ayurvedic system for several diseases without having any scientific data. Demineralized water was used to prepare aqueous extract by maceration for 24 h and complete metabolic profiling was performed using GC-MS and HPLC. Hypoglyc...
List of polar metabolites identified by GC-MS analysis.
List of lipophilic metabolites identified by GC-MS analysis.
Proposed mechanism of action of AEMOL.