R Justin Davies

R Justin Davies
Cambridge University Hospitals NHS Foundation Trust · Cambridge Colorectal Unit (Addenbrooke's Hospital)

MA MB MChir LRCP FRCS FRCS (Gen Surg) FEBC FASCRS

About

200
Publications
50,219
Reads
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3,287
Citations
Introduction
Justin is a Consultant Colorectal Surgeon & Deputy Medical Director at Adddenbrooke's Hospital, Cambridge. He is a Fellow & Director of Studies at Downing College, Cambridge & Affiliated Assistant Professor at University of Cambridge. He is President Elect Designate at RSM Coloproctology Section & has previously served as UK National Representative for ESCP, as a member of ASCRS IBD Committee, as NICE Topic Advisor for CRC Guidelines and Chair of ACPGBI Education and Training & IBD Committees.
Additional affiliations
July 2006 - July 2007
University of Toronto
Position
  • Fellow
Description
  • Surgery for IBD, colorectal cancer, proctology
Education
October 2000 - October 2002
University of Cambridge
Field of study
  • Surgery
September 1989 - December 1994
University of Cambridge
Field of study
  • Medicine

Publications

Publications (200)
Article
Full-text available
Objective Observational studies have shown that fluorescence angiography (FA) decreases the incidence of anastomotic leak (AL) in colorectal surgery, but high-quality pooled evidence was lacking. Therefore, we aimed at confirming this preliminary finding using a systematic review and meta-analysis of randomised controlled trials (RCTs) in the field...
Article
Introduction Routine operative treatment of appendicitis was temporarily interrupted during the COVID-19 pandemic. Non-operative management in suspected appendicitis makes a definitive diagnosis difficult. This study investigated diagnostic outcomes of suspected appendicitis patients before and during COVID-19. Method A retrospective review of pat...
Article
Full-text available
Professional surgical societies recommend the identification and treatment of pre-operative anaemia in patients scheduled for abdominal surgery. Our aim was to determine if pre-operative iron allows correction of haemoglobin concentration and decreased incidence of peri-operative blood transfusion in patients undergoing major abdominal surgery. MED...
Article
Background: The aim of this study was to compare energy devices used for intraoperative hemostasis during colorectal surgery. Methods: A systematic literature review and Bayesian network meta-analysis performed. MEDLINE, EMBASE, Science Citation Index Expanded, and Cochrane were searched from inception to August 11th 2021. Intraoperative outcome...
Article
Full-text available
Acute left colonic diverticulitis (ALCD) in the elderly presents with unique epidemiological features when compared with younger patients. The clinical presentation is more nuanced in the elderly population, having higher in-hospital and postoperative mortality. Furthermore, geriatric comorbidities are a risk factor for complicated diverticulitis....
Article
Rectovaginal fistula (RVF) occurring during the course of Crohn's disease (CD) constitutes a therapeutic challenge and is characterized by a high rate of recurrence. To optimize the outcome of CD-related RVF repair, the best conditions for correct healing should be obtained. Remission of CD should be achieved with no active proctitis, the perianal...
Article
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PurposeThere is no consensus in the literature regarding the association between operative blood loss and postoperative outcomes in colorectal surgery, despite evidence suggesting a link. Therefore, this systematic review assesses the association between operative blood loss, perioperative and long-term outcomes after colorectal surgery.MethodsA li...
Article
Background This study aimed to determine the impact of pulmonary complications on death after surgery both before and during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Methods This was a patient-level, comparative analysis of two, international prospective cohort studies: one before the pandemic (January–October 201...
Article
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Objectives: Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients un...
Article
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The role of lateral lymph node dissection (LLND) during total mesorectal excision (TME) for rectal cancer is still controversial. Many reviews were published on prophylactic LLND in rectal cancer surgery, some biased by heterogeneity of overall associated treatments. The aim of this systematic review and meta-analysis is to perform a timeline analy...
Article
Aims The aim of this study was to determine the efficacy and outcomes of conservative versus surgical management of acute appendicitis (AA) during the pandemic. Methods We conducted an observational study in a tertiary centre. Data was collected from all patients (≥16 years) with a diagnosis of AA between 1st November 2019 to 10th March 2020 (pre-...
Article
A 67-years-old female presented with right lower abdominal pain and raised inflammatory markers. A computed tomography scan showed marked inflammatory changes with collections adjacent to terminal ileum. Patient was managed with intravenous antibiotics initially. Subsequent colonoscopy showed a bulky 8cm caecal pole tumour involving ileocaecal valv...
Article
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Background and Objective: During the COVID-19 pandemic, health systems worldwide made major changes to their organization, delaying diagnosis and treatment across a broad spectrum of pathologies. Concerning surgery, there was an evident reduction in all elective and emergency activities, particularly for benign pathologies such as acute diverticuli...
Article
Aim Several treatment strategies for post-operative ileus have been evaluated in randomised controlled trials. This network meta-analysis aimed to explore the relative effectiveness of these different therapies on their impact on ileus outcome measures. Method A systematic review was conducted to identify randomised controlled trials reported up t...
Article
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Background Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during the COVID-19 pandemic in periods of lockdown versus light restriction. Methods This internati...
Article
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Background: Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during the COVID-19 pandemic in periods of lockdown versus light restriction. Methods: This internati...
Article
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Background: Various sites are used for specimen extraction in oncological minimally invasive colorectal surgery. The objective is to determine if the choice of extraction site modulates the incidence of incisional hernia (IH). Methods/design: A systematic review will be performed in accordance to the Preferred Reporting Items for Systematic Revi...
Article
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Anorectal emergencies comprise a wide variety of diseases that share common symptoms, i.e., anorectal pain or bleeding and might require immediate management. While most of the underlying conditions do not need inpatient management, some of them could be life-threatening and need prompt recognition and treatment. It is well known that an incorrect...
Article
Low Anterior Resection Syndrome (LARS) groups together bowel dysfunction symptoms which occur after rectal resection, such as fecal incontinence, urgency, frequent bowel movements and clustering of stool. For adequate surgical outcome reporting, as well as to encompass all aspects of the condition, optimal syndrome definition and clinical scoring a...
Article
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We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which pati...
Article
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Background Dissection with subsequent ligation and resection of arteries at their origin (central vascular ligation, CVL) is essential for adequate oncological resection during right hemicolectomy (RH) with complete mesocolic excision (CME). This technique is technically demanding due to the highly variable arterial pattern of the right colon. Ther...
Article
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Purpose The aim of this study was to compare the outcomes of right hemicolectomy with CME performed with laparoscopic and open surgery. Methods PubMed, Scopus, Web of Science, China National Knowledge Infrastructure, Wanfang Data, Google Scholar and the ClinicalTrials.gov register were searched. Primary outcome was the overall number of harvested...
Chapter
Pelvic exenteration is associated with major psychological, psychosexual, physiological, and functional implications for patients. Many surgical techniques are used in exenteration surgery, requiring the expertise of a range of specialists including colorectal surgery, urology, gynecological oncology, reconstructive plastic surgery, interventional...
Article
Full-text available
Background and aims Although rectal cancer is predominantly a disease of older patients, current guidelines do not incorporate optimal treatment recommendations for the elderly and address only partially the associated specific challenges encountered in this population. This results in a wide variation and disparity in delivering a standard of care...
Article
Importance The incidence of early-onset colorectal cancer (younger than 50 years) is rising globally, the reasons for which are unclear. It appears to represent a unique disease process with different clinical, pathological, and molecular characteristics compared with late-onset colorectal cancer. Data on oncological outcomes are limited, and sensi...
Article
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Background The introduction of complete mesocolic excision (CME) for right colon cancer has raised an important discussion in relation to the extent of colic and mesenteric resection, and the impact this may have on lymph node yield. As uncertainty remains regarding the usefulness of and indications for right hemicolectomy with CME and the benefits...
Article
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Peri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS-CoV-2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Su...
Article
Background Several treatment strategies for avoiding post-operative ileus have been evaluated in randomised controlled trials. This network meta-analysis aimed to explore the relative effectiveness of these different therapeutic interventions on ileus outcome measures. Methods A systematic literature review was performed to identify randomized con...
Article
Objective Professional surgical societies recommend the identification and treatment of pre-operative anaemia in patients scheduled for abdominal surgery. However, the evidence supporting this recommendation has been of poor quality until the recent release of several randomized controlled trials (RCT) addressing the question. Our aim was to determ...
Conference Paper
Full-text available
Εισαγωγή: Η τεχνική της ενδοσκοπικής έξω-περιτοναϊκής πλαστικής και η τεχνική κατά Lichtenstein είναι δύο από τις πιο συχνά χρησιμοποιούμενες τεχνικές δια την αποκατάσταση της βουβωνοκήλης. Η τρέχουσα επιστημονική τεκμηρίωση βασιζόμενη σε μετα-αναλύσεις συμβατικής μεθοδολογίας δεν δύναται να αποτανθεί για τα πλεονεκτήματα της μιας τεχνικής έναντι τ...
Conference Paper
Full-text available
Embase, Pubmed, Google scholar, και Cochrane library. Εδιενεργήθη πρώτα μετα-ανάλυσις συμβατικής μεθοδολογίας και ακολούθως των δικτύων. Αποτελέσματα: Η θνητότητα 90-ημερών ήτο στατιστικώς σημαντική μικρότερη στην ομάδα της αποσυμφορητικής κολοστομίας εν συγκρίσει με τις ομάδες της επειγούσης κολεκτομής και ενδοσκοπικής ενδοαυλικής προθέσεως. Επιπλ...
Article
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Background Despite the current therapeutic options for the treatment of inflammatory bowel disease, surgery is still frequently required in the emergency setting, although the number of cases performed seems to have decreased in recent years. The World Society of Emergency Surgery decided to debate in a consensus conference of experts, the main per...
Article
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Background A resection with clear margins (R0 resection) is the most important prognostic factor in patients with locally recurrent rectal cancer (LRRC). However, this is achieved in only 60 per cent of patients. The aim of this study is to investigate whether the addition of induction chemotherapy to neoadjuvant chemo(re)irradiation improves the R...
Article
Modulation of the microbiota of patients suffering from inflammatory bowel disease (IBD) with probiotics was suggested to avoid active disease and/or to lower the intensity of the active phase. Considering that the ecological niche of Bifidobacterium spp and Lactobacillus spp includes fermented dairy products, and that countries with highest dairy...
Article
Full-text available
Background: Functional outcomes after ileoanal pouch creation have been studied; however, there is great variability in how relevant outcomes are defined and reported. More importantly, the perspective of patients has not been represented in deciding which outcomes should be the focus of research. Objective: The primary aim was to create a patie...
Article
Full-text available
Introduction: Diverticular disease is one of the most frequent reasons for attending emergency departments and surgical causes of hospital admission. In the past decade, many surgical and gastroenterological societies have published guidelines for the management of diverticular disease. The aim of the present study was to appraise the methodologic...
Article
Full-text available
Background During the Covid-19 pandemic, non-operative management for acute appendicitis (AA) was implemented in the UK. Aim of this study was to determine the efficacy and outcomes of conservative versus surgical management of AA during the pandemic. Materials & Methods We conducted an observational study in a tertiary referral centre. Data was c...
Article
Full-text available
Objective Patients with suspected appendicitis remain a diagnostic challenge. This study aims to validate risk prediction models and to investigate diagnostic accuracy of ultrasonography (US) and computed tomography (CT) in adults undergoing an appendicectomy. Materials and Methods A retrospective case review of patients aged 16-45 undergoing an a...
Data
Supplementary Data from the publication entitled: "SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study"
Article
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Introduction: Colorectal cancer (CRC) is the fourth leading cause of death with 1.4 million new cases occurring annually worldwide. High-quality clinical practice guidelines are needed to tailor high-quality individualized treatment. The aim of the present study was to evaluate the methodological quality of the current guidelines for the managemen...
Article
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Background: Surgical resection of splenic flexure cancers (SFC) is technically demanding due to the complex regional anatomy, characterized by the presence of embryological adhesions, close proximity to the pancreas and spleen, and a highly heterogenous arterial supply and lymphatic drainage. The accessory middle colic artery (AMCA) is increasingly...
Article
collaboration Abstract Purpose. The primary aim of the study was to review the existing literature about patient-reported outcome measures (PROMs) in colorectal cancer and IBD. The secondary aim was to present a road map to develop a core outcome set via opinion gathering using social media. Method. This study is the first step of a three-step proj...
Article
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Introduction: The debate on the best surgical management strategy for acute malignant left-sided colonic obstruction is ongoing. Decompressing colostomy (DC) and stenting as a bridge to surgery (SBTS) are the currently proposed alternative approaches to emergency colectomy (EC). However, the results of a traditional meta-analysis were inconclusive...
Article
Introduction: Patients with suspected appendicitis remain a diagnostic challenge. The aim of this study was to validate risk prediction models, and to investigate diagnostic accuracy of ultrasonography and computed tomography (CT) in adults undergoing appendicectomy. Methods: A retrospective case review was performed of patients aged 16-45 years...
Article
Full-text available
Introduction: Quality in medical care must be measured in order to be improved. Trauma management is part of health care, and by definition, it must be checked constantly. The only way to measure quality and outcomes is to systematically accrue data and analyze them. Material and methods: A systematic revision of the literature about quality indica...
Article
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Background: Surgical services are preparing to scale up in areas affected by COVID-19. This study aimed to evaluate the association between preoperative SARS-CoV-2 testing and postoperative pulmonary complications in patients undergoing elective cancer surgery. Methods: This international cohort study included adult patients undergoing elective sur...
Article
Background During the Covid-19 pandemic, non‐operative management for acute appendicitis (AA) was implemented in the UK. The aim of this study was to determine the efficacy and outcomes of conservative versus surgical management of AA during the pandemic. Materials & Methods: We conducted an observational study in a tertiary referral centre. Data w...
Article
Full-text available
Background The multidisciplinary perioperative and anaesthetic management of patients undergoing pelvic exenteration is essential for good surgical outcomes. No clear guidelines have been established, and there is wide variation in clinical practice internationally. This consensus statement consolidates clinical experience and best practice collect...
Preprint
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Introduction Recent evidence has shown the importance of the microbiome in the development and maintenance of obesity. Probiotics were proposed for modulating the microbiome in order to achieve weight loss. Methods Data related to consumption of dairy food in European countries were obtained from the Global Dairy Consumption Report of the European...
Article
Full-text available
Background The purpose of this systematic review and meta-analysis was to determine the prevalence of the number of sigmoid arteries (SA) and variations in their origins. Methods A thorough systematic search of literature through February 2020 was conducted on major electronic databases to identify eligible studies. Data were extracted and pooled...