R. Correia de Abreu

Hospital Pedro Hispano · Department of Medicine

Background Lyme disease (LD), caused by Borrelia burgdorferi sensu lato’s species, has a wide presentation and severity and is often a neglected diagnosis. Neuroborreliosis (NB) occurs in 10-15% of patients (pts). This study evaluate NB (clinical manifestations, treatment and evolution) in a district acute hospital in Portugal. Methods Pts with Bo...

Introduction: Non-AIDS comorbidities, metabolic, renal and bone toxicities associated to combined antiretroviral therapy (cART), namely NRTIs, led to dual therapy (NUC sparing regimens). Tenofovir Alafenamide Fumarate (TAF) demonstrated improved renal and bone safety profile over TDF even with mild to moderate renal impairment. Objectives: Evaluate...

Objective To describe and analyze transmitted drug resistance (TDR) between 2014 and 2019 in newly infected patients with HIV-1 in Portugal and to characterize its transmission networks. Methods Clinical, socioepidemiological, and risk behavior data were collected from 820 newly diagnosed patients in Portugal between September 2014 and December 20...

Introduction: Although raltegravir has been available since 2007, data are lacking on the Portuguese population living with HIV who initiated this antiretroviral therapy. Hence, this study aimed to characterize the patients who initiated raltegravir-based regimens between January 2015 and December 2017, on sociodemographics, clinical features, and...

Background: Portugal has one of the highest incidence rates of HIV and AIDS and one of the highest percentages of late diagnosis in the European Union. Objectives: Evaluation of late diagnoses between 1998-2018. Comparison of demographic, epidemiological and mortality data. Identification of risk factors to very late presentation. Methods: Retrospe...

Pilot study, 48weeks, about the usage of TAF/FTC/BIC in patients previously with free nucs therapy recovered after TDF induced renal failure. - Introdução - O desenvolvimento de comorbidades não-SIDA (diabetes, HTA, dislipidemia, etc), os sindromes metabólicos e as alterações renais e ósseas associadas aos ITRNs, incluindo a toxicidade renal induz...

With the advent of high-potency antiretroviral treatment introduced in 1996, HIV infection ceased to be an acute and deadly disease to become chronic and controllable. However, the early aging of this population, which according to some authors and cohorts, is 10 years less than in the "normal" population, has been studied. Although the realities o...

Background: Portugal has one of the highest incidence rates of HIV and AIDS and one of the highest percentages of late diagnosis in the European Union.

HIV and SARS-CoV-2

Objectives Nocardiosis is a rare infection caused by Nocardia spp., a gram-positive bacteria non-commensal of the human flora. Nocardiosis usually presents with lung infection but may disseminate to other organs, most frequently the brain. The major risk factor is immunosuppression, but lung diseases also increase the risk of infection. Treatment w...

Introduction: Actinomycosis is a chronic bacterial infection that rarely affects the respiratory system. Lung infection usually develops after aspiration of oropharyngeal or gastrointestinal secretions. Typically, it presents with pneumonia, lung abscess or empyema, and the most common radiologic presentation is a pulmonary mass, simulating a tumou...

Introduction: Actinomycosis is a chronic bacterial infection that rarely affects the respiratory system. Lung infection usually develops after aspiration of oropharyngeal or gastrointestinal secretions. Typically, it presents with pneumonia, lung abscess or empyema, and the most common radiologic presentation is a pulmonary mass, simulating a tumou...

Therapeutic armory for HIV-2 infected patients is limited when compared to the one available to HIV-1. Evidence on the use of integrase inhibitors for HIV-2 is still narrow outside clinical trials. The authors present a case report showing the success of a single-tabled regimen containing elvitegravir in an HIV-2 infected patient.

Human Immunodeficiency Virus (HIV) was first related with Acquired Immunodeficiency Syndrome (AIDS) in 1983, and since then many attempts have been made to treat, control and in the last couple of years several studies have been conducted with the intention of achieve a cure or at least a functional cure. The understanding of the replication of the...

Objective: To characterize the profile of non-AIDS-related comorbidities (NARC) in the older HIV-1-infected population and to explore the factors associated with multiple NARC. Methods: This was a multicentre, cross-sectional study including HIV-1-infected patients aged ≥50 years, who were virologically suppressed and had been on a stable antiretro...

Spearing nucs-regime with Raltegravir and Etravirine in real world

Antibiotic stewardship promotes adequate antibiotics use and can reduce the costs in these drugs by 10-30%. We present a multimodal strategy applied in an acute care hospital, with impact on reduction and cost after 2 years.

Background: Since 2015, with the approval of 2nd and 3rd generation direct antiviral agents (DAA) the treatment for hepatitis C virus (HCV) in Portugal improved substantially. Few information is available about the evolution of inflammatory markers during HCV-infection treatment with these new agents. Methods: An analysis of 29 co-infected patient...

BEST HOPE is a project to construct a cohort of newly diagnosed HIV patients in Portugal: BEST HOPE aims are: 1) to analyze the prevalence and characteristics of TDR in newly diagnosed HIV patients, and 2) to describe and analyze risk factors associated with HIV infection and transmission of drug resistance in Portugal.

BEST HOPE is a project to construct a cohort of newly diagnosed HIV patients in Portugal: BEST HOPE aims are: 1) to analyze the prevalence and characteristics of TDR in newly diagnosed HIV patients, and 2) to describe and analyze risk factors associated with HIV infection and transmission of drug resistance in Portugal.

BEST HOPE is a project to construct a cohort of newly diagnosed HIV patients in Portugal: BEST HOPE aims are: 1) to analyze the prevalence and characteristics of TDR in newly diagnosed HIV patients, and 2) to describe and analyze risk factors associated with HIV infection and transmission of drug resistance in Portugal.

Evaluation of HAART Therapy above 100000 cps/mL in naives

Introduction: Today NRTI (nucs) are the basis of ART, however toxicities and acquired resistance are a serious burden. Efficacy of nucs-sparing regimes was observed in several studies, however real world data is still needed.

Introduction: Today NRTI (nucs) are the basis of ART, however toxicities and acquired resistance are a serious burden. Efficacy of nucs-sparing regimes was observed in several studies, however real world data is still needed.

Purpose: Very scarce information has been published to date with the combination of ABC/3TC/NVP but it is currently being used in clinical practice in Spain and Portugal. Our aim was to present the clinical experience with this regimen in a cohort of adult HIV-infected antiretroviral (ARV)-naïve patients. Methods: Retrospective, multicentre, coh...

Introduction: TDF is "gold standard" of HAART and is associated with RF. According to the EuroSIDA RF occurs after 2-3 years of continuous use, so we discuss the early markers to use. Objective: Determine early predictors of RF using the 24h urine (Cockcroft-Gault equation), occasional urine samples and blood analysis (glomerular filtration rate (G...

Introdução: A leucoencefalopatia multifocal progressiva (LMP) é uma doença desmielinizante infecciosa do sistema nervoso central com uma prevalência de 0,7 a 11% em doentes com síndrome da imunodeficiência adquirida humana (SIDA). A doença é por regra multifocal, bilateral, assimétrica e cursa com lesões da substância branca subcortical mais freque...