Qunlin Chen

• Ph.D
• Associate Professor at Southwest University

Researchers and educators interested in creative writing need a reliable and efficient tool to score the creativity of narratives, such as short stories. Typically, human raters manually assess narrative creativity, but such subjective scoring is limited by labor costs and rater disagreement. Large language models (LLMs) have shown remarkable succe...

Creativity is hypothesized to arise from a mental state which balances spontaneous thought and cognitive control, corresponding to functional connectivity between the brain’s Default Mode (DMN) and Executive Control (ECN) Networks. Here, we conduct a large-scale, multi-center examination of this hypothesis. Employing a meta-analytic network neurosc...

Curiosity, an innate and intrinsic motivation to explore, makes vital contributions to learning in individuals of various ages. Epistemic curiosity centers on the drive to close information gaps and can be classified into joyous exploration and interest (I) and deprivation sensitivity (D) types. Each subtype is associated with different academic ac...

The relationship between bipolar disorder (BD) and creativity has long fascinated both the academic community and the public. However, empirical evidence and meta-analytic findings have remained ambiguous and complex. This meta-analysis systematically investigates the association between BD (including clinical and subclinical samples) and various d...

Creativity is typically operationalized as divergent thinking (DT) ability, a form of higher-order cognition which relies on memory, attention, and other component processes. Despite recent advances, creativity neuroscience lacks a unified framework to model its complexity across neural, genetic, and cognitive scales. Using task-based fMRI from two...

Semantic memory offers a rich repository of raw materials (e.g., various concepts and connections between concepts) for creative thinking, represented as a semantic network. Similar to other networks, the semantic network exhibits a modular structure characterized by modules with dense internal connections and sparse connections between them. This...

Creative thinking is a unique higher-order human capacity that leads to novel and appropriate products or ideas. Researchers have increasingly turned to transcranial direct current stimulation (tDCS), employing weak electrical stimulation to augment individual creative performance. Despite these efforts, the field grapples with inconsistent finding...

Researchers and educators interested in creative writing need a reliable and efficient tool to score the creativity of narratives, such as short stories. Typically, human raters manually assess narrative creativity, but such subjective scoring is limited by labor costs and rater disagreement. Large language models (LLMs) have shown remarkable succe...

Novelty and appropriateness are two fundamental components of creativity. However, the way in which novelty and appropriateness are separated at behavioral and neural levels remains poorly understood. In the present study, we aim to distinguish behavioral and neural bases of novelty and appropriateness of creative idea generation. In alignment with...

Creative idea generation plays an important role in promoting successful memory formation. Yet, its underlying neural correlates remain unclear. We investigated the self-generated learning of creative ideas motivated by the schema-linked interactions between medial prefrontal and medial temporal regions framework. This was achieved by having partic...

Curiosity, an innate and intrinsic motivation to explore, makes vital contributions to learning in individuals of various ages. Epistemic curiosity centers on the drive to close information gaps and can be classified a joyous exploration and interest (I) and deprivation sensitivity (D) types. Each subtype is associated with different academic achie...

Novelty and appropriateness are two fundamental components of creativity. However, the way in which novelty and appropriateness are separated at behavioral and neural levels remains poorly understood. In the present study we aimed to distinguish behavioral and neural bases of novelty and appropriateness of creative idea generation. In alignment wit...

Both psychological resilience and creativity are complex concepts that have positive effects on individual adaptation. Previous studies have shown overlaps between the key brain regions or brain functional networks related to psychological resilience and creativity. However, no direct experimental evidence has been provided to support the assumptio...

Complex cognitive processes, like creative thinking, rely on interactions among multiple neurocognitive processes to generate effective and innovative behaviors on demand, for which the brain’s connector hubs play a crucial role. However, the unique contribution of specific hub sets to creative thinking is unknown. Employing three functional magnet...

Creativity research commonly involves recruiting human raters to judge the originality of responses to divergent thinking tasks, such as the alternate uses task (AUT). These manual scoring practices have benefited the field, but they also have limitations, including labor-intensiveness and subjectivity, which can adversely impact the reliability an...

Metacognitive experience, measured by processing fluency, contributes to divergent thinking performance; however, whether it exhibits varying effects on insight problem-solving remains unknown. Additionally, as individuals’ interpretation of metacognitive experience is influenced by their creative mindset, whether creative mindset plays a role in t...

Recent studies and reviews suggest that creative thinking is at least partly a domain-general cognitive ability, dependent on consistent patterns of brain activity including co-activation of the executive control and default mode networks. However, the degree to which the generation of ideas in different creative tasks relies on common brain activi...

Existing research has consistently supported a relationship between creative achievement and specific personality traits (e.g., openness to experience). However, such work has largely focused on univariate associations, potentially obscuring complex interactions among multiple personality factors, rendering an incomplete picture of the creative per...

Enhancing creative problem solving with neuromodulatory approaches is gaining increased interest. However, inconsistent findings of the success in such approaches emphasize the need for a comprehensive overview of the effect of using non-invasive brain stimulation (NIBS) on creative thinking. The current meta-analysis aimed to investigate whether c...

Poetry composition is an ecologically valid approach for investigating creative processes. However, little is known about how the brain creates poetry and about the role of knowledge during poetry composition. Here, we identified patterns of task-based functional connectivity during poetry composition by experts and novices under two experimental c...

Phrases-guessing is one of the essential reasoning abilities in problem solving for human beings. However, it is still an open question about why individuals perform differently during the same reasoning task. In this study, we utilized a bilingual phrase-guessing task to explore the neural activities under the individually different performances w...

Everyday creativity is the basic ability of human survival and penetrates every aspect of life. Nevertheless, the neural mechanisms underlying everyday creativity was largely unexplored. In this study, seventy-five participants completed the creative behaviour inventory, a tool for assessing creative behaviour in daily life. The participants also c...

Research indicates that creative cognition depends on both associative and controlled processes, corresponding to the brain’s default mode (DMN) and executive control (ECN) networks. However, outstanding questions include how the DMN and ECN operate over time during creative task performance, and whether creative cognition involves distinct generat...

Positive risk‐taking is a crucial element of individual creativity and social development. However, little is known regarding the relation between individual neural differences and positive risk‐taking. In addition, critical thinking (CT) and gender have been proven to be two important individual‐specific factors associated with risk‐taking behavio...

Stressful life events are significant risk factors for depression, and increases in depressive symptoms have been observed during the COVID-19 pandemic. The aim of this study is to explore the neural makers for individuals’ depression during COVID-19, using connectome-based predictive modeling (CPM). Then we tested whether these neural markers coul...

Creative problem solving (CPS) in real-world contexts often relies on reorganization of existing knowledge to serve new, problem-relevant functions. However, classic creativity paradigms that minimize knowledge content are generally used to investigate creativity, including CPS. We argue that CPS research should expand consideration of knowledge-ri...

Malevolent creativity, as one dark side of creativity, refers to manifestations people propose to harm themselves or others materially, mentally, or physically in an innovative way. This study aimed to explore the neural correlates of malevolent creative idea generation using task-based static and dynamic functional connectivity (FC) analysis acros...

Introduction Human brain network is organized as a hierarchical organization, exhibiting various connectome gradients. The principal gradient is anchored by the modality-specific primary areas and the transmodal regions. Previous studies have suggested that the unimodal-transmodal gradient in the functional connectome may offer an overarching frame...

Self-efficacy is a subjective belief that depends on self-related past experience, and is a strong predictor for individual future performance. To the aim of promoting one’s future performance, it is necessary to gain better knowledge of it’s cognitive process and brain mechanism. The present research sought to investigate the functional connectivi...

Recent neuroimaging studies demonstrate that creativity is related to brain regions across both hemispheres, and the corpus callosum forms the structural basis of inter-hemispheric information exchange. However, the findings regarding the relationship between inter-hemispheric interaction and creativity remain inconsistent, which may be caused by d...

Daydreaming and creativity have similar cognitive processes and neural basis. However, few empirical studies have examined the relationship between daydreaming and creativity using cognitive neuroscience methods. The present study explored the relationship between different types of daydreaming and creativity and their common neural basis. The beha...

Neuroticism is one of the main endophenotypes of major depressive disorder (MDD) and is closely related to the negative effect systems of Research Domain Criteria (RDoC) domains. The relationship between neuroticism and aging is dynamic and complex. Moreover, reduced hippocampal volumes are probably the most frequently reported structural neuroimag...

Accumulating evidence indicates that structural and functional abnormalities in hippocampal formation are linked to major depressive disorder (MDD). However, the resting-state functional connectivity (RSFC) of hippocampal subfields in MDD remains unclear. This cross-sectional study aimed to investigate the RSFC of hippocampal subfields in a large s...

Backgrounds and aims Internet addiction (IA) is a common internet-related addictive behavior. An enormous amount of previous research on IA disorders (IADs) have paid attention to the neural basis of abnormalities, while few studies have elucidated the neural distinctions of IA tendency in general population. Methods The current study examined the...

The self-defeating humor style is characterized by the excessive use of self-mockery, fawning over others and ineffective denial of negative emotions. The differences in brain structures responsible for self-defeating humor and the role of divergent thinking (DT) in this relationship have not been directly investigated in a large sample. Using voxe...

Objective: Increased anxiety in response to the COVID-19 pandemic has been widely noted. The purpose of this study was to test whether the prepandemic functional connectome predicted individual anxiety induced by the pandemic. Methods: Anxiety scores from healthy undergraduate students were collected during the severe and remission periods of th...

Although the unity and diversity model of executive functions (EFs) has been replicated, there are some studies questioning the validity of the EFs construct. This debate can be partially resolved by directly combining the brain activity pattern in different executive control processes. Previous univariate activation studies have suggested that the...

Memory suppression (MS) is essential for mental well-being. However, no studies have explored how intrinsic resting-state functional connectivity (rs-FC) predicts this ability. Here, we adopted the connectome-based predictive modeling (CPM) based on the resting-state fMRI data to investigate whether and how rs-FC profiles in predefined brain networ...

Prior studies have illustrated that a superior memory exists for self-access ideas compared with comprehension in close-ended problems. For example, an aha! experience followed by sudden solutions for insight problems can enhance the later long-term memory for such solutions. However, whether there is a superior memory of ideas generated in open-en...

While a recent upsurge in the application of neuroimaging methods to creative cognition has yielded encouraging progress toward understanding the neural underpinnings of creativity, the neural basis of barriers to creativity are as yet unexplored. Here, we report the first investigation into the neural correlates of one such recently identified bar...

Creative thinking is a hallmark of human cognition, which enables us to generate novel and useful ideas. Nevertheless, its emergence within the macro-scale neurocognitive circuitry remains largely unknown. Using resting-state fMRI data from two large population samples and a novel “travelling pattern prediction analysis”, here we identified the mod...

Stress-related psychosomatic responses are viewed as important risks to our physical health. Growing evidence from structural imaging studies has implicated that stress and trauma exposures have negative effects on brain structural alterations. However, whether stress-related emotional distress and somatic symptoms are related to the structure of b...

Mind wandering (MW) refers to a drift of attention away from the ongoing events to internal concerns and activates brain regions in the default mode network (DMN) and the frontoparietal control network (FPCN). Although a number of studies using rest-fMRI data have shown that static and dynamic functional connectivity within the DMN were related to...

Are intelligence and creativity distinct abilities, or do they rely on the same cognitive and neural systems? We sought to quantify the extent to which intelligence and creative cognition overlap in brain and behavior by combining machine learning of fMRI data and latent variable modeling of cognitive ability data in a sample of young adults (N = 1...

Creativity is very important and is linked to almost all areas of our everyday life. Improving creativity brings great benefits. Various strategies and training paradigms have been used to stimulate creative thinking. These training approaches have been confirmed to be effective. However, whether or not training can reshape the resting-state brain...

During nociceptive processing of pain, activated regions, specified as the 'pain matrix', have been proven not selectively or preferentially tied to pain. Counterintuitively, the deactivated regions, especially the default mode network (DMN), are recently revealed to be simultaneously and functionally involved. In this study, we searched for pain-s...

Functional imaging studies have indicated that divergent thinking involves the cooperation between episodic memory and mental imagery. Moreover, divergent thinking was also demonstrated to rely on inhibition to suppress inappropriate information. Here, a mediation analysis was used to investigate the comprehensive associations between volumetric di...

Whether creativity is a domain-general or domain-specific ability has been a topic of intense speculation. Although previous studies have examined domain-specific mechanisms of creative performance, little is known about commonalities and distinctions in neural correlates across different domains. We applied activation likelihood estimation (ALE) m...

Cognitive and neuroimaging evidence suggests that episodic and semantic memory—memory for autobiographical events and conceptual meaning, respectively—support different facets of creative thinking, with a growing number of studies reporting activation of brain regions within the default network during performance on creative thinking tasks. The pre...

Creativity is the ability to produce something novel and useful. Various tasks have been used to explore the neural bases of creativity. However, studies exploring the relationship between the brain regions during divergent thinking are still rare. Given that the brain works in networks, exploring the functional connectivity (FC) patterns during di...

Normal aging is known to be accompanied by decreased segregation across the whole-brain functional network, which is associated with cognitive decline. Although compelling evidence supports reduced segregation and increased integration in whole-brain functional connectivity with aging, the age effect on the reorganization of large-scale functional...

Are intelligence and creativity distinct abilities, or do they rely on the same cognitive and neural systems? We sought to quantify the extent to which intelligence and creative cognition overlap in brain and behavior by combining machine learning of fMRI data and latent variable modeling of cognitive ability data in a sample of young adults (N = 1...

Hemispheric lateralization for creative thinking remains a controversial topic. Early behavioral and neuroimaging research supported right hemisphere dominance in creative thinking, but more recent evidence suggests the left hemisphere plays an equally important role. In addition, the extent to which hemispheric lateralization in specific brain reg...

Advances in graph-theoretic models of networks have made it possible to investigate the topological properties of the human brain across time and space. Brain flexibility is defined as the frequency with which brain regions switch between different functional modules over time and has been shown to correlate with higher-order cognitive functions. N...

Mind popping is the phenomenon of a word, sentence, image, or melody suddenly coming into the conscious mind. It occurs without any conscious memories, also known as unconscious semantic memory. So far, little is known about the neural basis of this phenomenon. Using the Mind-Popping Questionnaire, we examined the frequency of daily mind popping of...

Creativity is the ability to generate original and useful products, and it is considered central to the progression of human civilization. As a non-inherited emerging process, creativity may stem from temporally dynamic brain activity, which, however, has not been well studied. The purpose of this study was to measure brain dynamics using entropy a...

Evidence from a range of fields shows that representation-connection (RC) is the key step towards the solution of a real-world insight problem. However, no study has focused on the inter-individual variability in RC, and little is known about whether structural and resting-state functional signals can account for inter-individual differences in RC....

Background Imaging studies have shown that the subcallosal region (SCR) volume was decreased in patients with major depressive disorder (MDD). However, whether the volumetric reductions in the SCR are due to thinning of the cortex or a loss of surface area (SA) remains unclear. In addition, the relationship between cortical measurements of the SCR...

Mind wandering is a phenomenon that involves thoughts shifting away from a primary task to the process of dealing with other personal goals. A large number of studies have found that mind wandering can predict negative emotions, but researchers have seldom focused on the positive role of mind wandering. The current study aimed to explore the relati...

The transition from early adulthood to the elder is marked by functional and structural brain transformations. Many previous studies examined the correlation between the functional connectivity (FC) and aging using resting‐state fMRI. Results showed that the changes in FC are linked to aging as well as the cognitive ability changes. However, some r...

High-level cognitive constructs, such as creativity and intelligence, entail complex and multiple processes, including cognitive control processes. Recent neurocognitive research on these constructs highlight the importance of dynamic interaction across neural network systems and the role of cognitive control processes in guiding such a dynamic int...

Recently, the field of developmental neuroscience has aimed to uncover the developmental trajectory of the human brain and to understand the changes that occur as a function of ageing. Here, we present a dataset of functional magnetic resonance imaging (fMRI) data covering the adult lifespan that includes structural MRI and resting-state functional...

Subjective well-being (SWB) reflects the cognitive and emotional evaluations of an individual's life and plays an important role in individual's success in health, work, and social relationships. Although previous studies have revealed the spontaneous brain activity underlying SWB, little is known about the relationship between brain network intera...

Life satisfaction reflects an individual's general evaluation of their overall quality of life. It has been hypothesized that relationship status (i.e. state of intimate relationship such as marriage, unmarried cohabiting, dating with others, single or divorce) may influence individual life satisfaction. However, there is little accessible empirica...

Critical thinking enables people to form sound beliefs and provides a basis for emotional life. Research has indicated that individuals with better critical thinking disposition can better recognize and regulate their emotions, though the neuroanatomical mechanisms involved in this process remain to be elucidated. Further, the influence of emotiona...

Creative thinking plays a vital role in almost all aspects of human life. However, little is known about the neural and genetic mechanisms underlying creative thinking. Based on a cross-validation based predictive framework, we searched from the whole-brain connectome (34,716 functional connectivities) and whole genome data (309,996 SNPs) in two da...

Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here the ENIGMA consortium presents the largest ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed...

Creativity is the ability to see the world in new ways. Creative individuals exhibit the ability to switch between different modes of thinking and shift their mental focus. This suggests a connection between creativity and dynamic interactions of brain networks. We report here the first investigation into the relationship between the reconfiguratio...

How déjà vu works has long been a mystery, partially because of its characteristics of unpredictable occurrences and quick disappearances, which make it difficult to be explored. Previous studies have described the anatomical structures underlying déjà vu in healthy subjects; however, the functional mechanism of déjà vu remains unclear. Therefore,...

Recently, the field of developmental neuroscience has aimed to uncover the developmental trajectory of the human brain and understand the changes that occur as a function of aging. Here we present an adult lifespan dataset of functional magnetic resonance imaging (fMRI) data including structural MRI and resting-state functional MRI. 494 healthy adu...

People’s ability to think creatively is a primary means of technological and cultural progress, yet the neural architecture of the highly creative brain remains largely undefined. Here, we employed a recently developed method in functional brain imaging analysis—connectome-based predictive modeling—to identify a brain network associated with high-c...

Tendency to forgive refers to one’s global dispositional level of forgiveness across situations and relationships. Brain imaging studies examined activation patterns underlying forgiving response, yet focal differences in brain structures related to tendency to forgive have never been investigated. In this study, voxel-based morphometry was used to...

The most widely used measurements of mindfulness are the Mindful Attention Awareness Scale (MAAS) and the Five Facet Mindfulness Questionnaire (FFMQ). However, controversies exist regarding the application of these scales. Additionally, the neural mechanisms of dispositional mindfulness havebecome a topic of interest. In the current study, we used...

The transition from early adulthood to older is marked by pronounced functional and structural brain transformations that impact cognition and behaviour. Here, we use dynamic functional network connectivity method to examine resting state functional network changes over aging process. In general, the features of dynamic functional states are genera...

Imagination and creative cognition are often associated with the brain’s default network. Recent evidence has also linked cognitive control systems to performance on tasks involving imagination and creativity, with a growing number of studies reporting functional interactions between cognitive control and default network regions. We sought to exten...

As a high-level cognitive activity, humor comprehension requires incongruity detection and incongruity resolution, which then elicits an insight moment. The purpose of the study was to explore the neural basis of humor comprehension, particularly the moment of insight, by using both characters and language-free cartoons in a functional magnetic res...

Middle childhood is an important period for individual trait shaping, during which children are likely to generate and own their distinct neuromechanism of creative-related traits. This study used voxel-based morphometry (VBM) to identify the brain structures that underlie trait creativity (as measured by the Williams Creativity Aptitude Test) in a...

The explanation for why significant sex differences are found in creativity has become an increasingly important topic. The current study applied a cognitive neuroscience perspective and voxel-based morphometry to investigate the sex differences for the association between verbal creativity and gray matter volume (GMV) in a large sample of healthy...

Creativity is the ability to produce original and valuable ideas or behaviors. In real life, artistic and scientific creativity promoted the development of human civilization; however, to date, no studies have systematically investigated differences in the brain structures responsible for artistic and scientific creativity in a large sample. Using...

Multimodal magnetic resonance imaging (mMRI) has been widely used to map the structure and function of the human brain, as well as its behavioral associations. However, to date, a large sample with a long-term longitudinal design and a narrow age-span has been lacking for the assessment of test-retest reliability and reproducibility of brain-behavi...