About
64
Publications
5,968
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
1,037
Citations
Introduction
Current institution
Additional affiliations
January 2013 - December 2016
Publications
Publications (64)
Objective: To investigate a novel registration method for holographic navigation (HN) based on a laser crosshair simulator (LCS) and to evaluate its feasibility and accuracy using a mixed-reality display. Methods: A novel registration approach for HN in neurosurgery was introduced, utilizing two co-planar laser emitters and a computer-vision recogn...
Mixed reality navigation (MRN) technology is emerging as an increasingly significant and interesting topic in neurosurgery. MRN enables neurosurgeons to “see through” the head with an interactive, hybrid visualization environment that merges virtual- and physical-world elements. Offering immersive, intuitive, and reliable guidance for preoperative...
Objective：
To investigate a novel registration method for holographic navigation (HN) based on a laser crosshair simulator and to evaluate its feasibility and accuracy using a mixed-reality display.
Methods：
A novel registration approach for HN in neurosurgery was introduced, utilizing two coplanar laser emitters and a computer-vision recognizable...
Addressing conventional neurosurgical navigation systems’ high costs and complexity, this study explores the feasibility and accuracy of a simplified, cost-effective mixed reality navigation (MRN) system based on a laser crosshair simulator (LCS). A new automatic registration method was developed, featuring coplanar laser emitters and a recognizabl...
OBJECTIVE
Mixed-reality simulation is an emerging tool for creating anatomical models for preoperative planning. Its use in neurosurgical training (NT) has been limited because of the difficulty in real-time interactive teaching. This study describes the development of a patient-specific, interactive mixed-reality NT system. The authors took cases...
Mixed Reality Navigation (MRN) is pivotal in augmented reality-assisted intelligent neurosurgical interventions. However, existing MRN registration methods face challenges in concurrently achieving low user dependency, high accuracy, and clinical applicability. This study proposes and evaluates a novel registration method based on a laser crosshair...
Objectives
Infantile spasm (IS) is an epileptic encephalopathy with ongoing neurological damage due to seizures and epileptiform abnormalities. Epilepsy surgery is considered for children refractory to drug therapy, especially when there is a focal brain lesion. In this study, we investigated the feasibility and efficacy of intraventricular stereot...
Object:
Vertebrobasilar dissecting aneurysms (VBDAs) are known to have a poor natural history with high rates of re-bleeding and mortality. There is a strong relation between hyperhomocysteinemia (HHcy) and cerebrovascular disease; we perform a retrospective study within the male of Chinese Han population to explore the association between HHcy an...
Objective: To investigate the clinical feasibility of Mixed Reality Navigation (MRN) based on multimodal imaging for intracranial lesion resection.
Methods: A semi-automatic MRN system on the HoloLens smart glasses was developed and its accuracy and feasibility tested. 37 patients with intracranial lesions were prospectively enrolled, of which 15...
Objective
Endoscopic port surgery is a promising alternative for the surgical treatment of intracerebral hypertensive basal ganglia hemorrhage (HBGH). The precise location of hematoma is a crucial step for surgery. The authors developed a simple, low-cost navigation method using an Android smartphone for the localization of HBGH.
Methods
All patie...
OBJECTIVE
To increase access to health interventions and healthcare services for patients in resource-constrained settings, strategies such as telemedicine must be implemented for the allocation of medical resources across geographic boundaries. Telecollaboration is the dominant form of surgical telemedicine. In this study, the authors report and e...
Objectives
Ki67 is an important biomarker of pituitary adenoma (PA) aggressiveness. In this study, PA invasion of surrounding structures is investigated and deep learning (DL) models are established for preoperative prediction of Ki67 labeling index (Ki67LI) status using conventional magnetic resonance (MR) images.
Methods
We reviewed 362 consecut...
Purpose: This study aimed to evaluate the accuracy of a mixed reality neuronavigation (MRN) system for 3D objects observation and insertion of puncture needles, simulating the neurosurgical puncture procedures such as hematoma aspiration and external ventricular drainage.
Method: A semi-automatic registration MRN system on HoloLens smart glasses wa...
OBJECTIVE A clear, stable, suitably located vision field is essential for port surgery. A scope is usually held by hand or
a fixing device. The former yields fatigue and requires lengthy training, while the latter increases inconvenience because
of needing to adjust the scope. Thus, the authors innovated a novel robotic system that can recognize th...
Purpose: This study aimed to evaluate the accuracy of a mixed reality neuronavigation (MRN) system for 3D objects observation and insertion of puncture needles, simulating the neurosurgical puncture procedures such as hematoma aspiration and external ventricular drainage.
Method: A semi-automatic registration MRN system on HoloLens smart glasses wa...
Objective
Cavernomas at Foramen of Monroe (FoM) are rare cases among the intracranial cavernomas. Pure ventriculoscopic removal of cavernoma at FoM through a single burr hole is challenging and rarely reported.
Methods
We herein introduced the virtual endoscopy (VE) assisted ventriculoscopic resection to treat the cavernomas at FoM. Two cases diag...
Objective:
The authors aimed to evaluate the technical feasibility of a mixed-reality neuronavigation (MRN) system with a wearable head-mounted device (HMD) and to determine its clinical application and accuracy.
Methods:
A semiautomatic registration MRN system on HoloLens smart glasses was developed and tested for accuracy and feasibility. Thir...
Objective
Proton magnetic resonance spectroscopy (¹H—MRS) can benefit the differentiation of gliomas preoperative grading and facilitate guiding biopsy. This study was to investigate the optimal metabolite or metabolic ratios of MRS for the biopsy target delineating by using the technique of MRS imaging guided frame-less stereotactic biopsy.
Metho...
Objectives
Spontaneous intracerebral hemorrhage remains a major cause of death and disability throughout the world. We tried to establish accurate long‐term outcome prediction models for hypertensive intracerebral hemorrhage (HICH) using CT radiomics and machine learning.
Methods
In a retrospective study of 270 patients with HICH between June 2013...
Intracranial aneurysms (IAs) are common lesions in the brain. There is a strong relation between hyperhomocysteinemia (HHcy) and cerebrovascular disease; we perform a retrospective study within the Chinese Han population to explore the association between HHcy and IAs. Two hundred six patients with IAs and 206 control subjects were evaluated for th...
Objective:
To shed light on the association between hyperhomocysteinemia (HHcy) and thoracoabdominal aortic aneurysms (TAAAs).
Methods:
From July 2013 to March 2017, we conducted a matched case-control study involving individuals who presented to the Chinese People's Liberation Army General Hospital and underwent thoracoabdominal magnetic resona...
Rationale and Objectives
The classification of patients based on pathology and molecular features is important for improving WHO grade II glioma patient prognosis, especially for the initially diagnosed patients. Less invasive and more convenient methods for the prediction of the pathological type and gene status are desired.
Materials and Methods...
Purpose:
The aim of this study was to develop a method to delineate the lethally frozen-tissue region (temperature less than -40°C) arising from interventional cryoablation procedures using a short tau inversion-recovery ultrashort echo-time (STIR-UTE) magnetic resonance (MR) imaging sequence. This method could serve as an intraprocedural validati...
Background
Glioblastoma (GBM), the most malignant form of gliomas, is a relatively common primary brain tumor in adults. Preoperative identification of isocitrate dehydrogenase 1 (IDH1) mutations in GBM is of critical prognostic importance. The aim of the present study was to explore the feasibility and diagnostic performance of basic patient infor...
Background:
The incidences of premature coronary heart disease present a rising trend worldwide. The possible risk factors that may predict the incidence of repeat percutaneous coronary intervention (PCI) in premature acute coronary syndrome (ACS) remains unclear.
Methods:
A total of 203 patients ≤45 years with ACS from Chinese PLA General Hospi...
The aunt's brain magnetic resonance imaging (MRI) obtained at 43 years old. Axial images of the brain were obtained during her second hospitalization [Panels (A–E), respectively]. (A–E) The T2-weighted fluid-attenuated inversion recovery images showed high-intensity areas in the left frontal lobe, bilateral parietal lobes, bilateral temporal lobes,...
Introduction: Intracranial aneurysms (IAs) are common lesions in the brain. There is a strong relation between hyperhomocysteinaemia (HHcy) and cerebrovascular disease, we perform a retrospective study within the Chinese Han population to investigate the association between HHcy and IAs.
Methods: 206 patients with IAs and 206 control subjects was e...
Lu C, Chen X, Wang Q, Xu X, Xu B. Onco Targets Ther. 2018;11:7213–7227.
We, the Editors and Publisher of OncoTargets and Therapy, have retracted the following article.
Following publication of the article, concerns were raised about the duplication of images from Figures 1, 2, 3, 4, 5, and 6 with images from other unrelated articles. Specifically,...
This study was to evaluate the diagnostic performance of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) parameters derived from diffusion tensor imaging in the differentiation between grade II and III gliomas. The records of 60 patients (30 women, 30 men; mean age, 45.4 years) suspected of having gliomas who underwent an ADC im...
Background:
Spot sign on computed tomography angiography (CTA) has been reported as a risk factor for hematoma expansion (HE) and poor outcome after intracerebral hemorrhage (ICH). We performed a meta-analysis to investigate the predictive accuracy of spot sign for HE, mortality risk, and poor outcome.
Methods:
We searched PubMed, Embase, and th...
Background:
Several monoclonal antibodies have been licensed for relapsing remitting multiple sclerosis (RRMS). It is still unclear which treatment regimen should be recommended due to the lack of head-to-head randomized controlled trials (RCTs). This study aims to investigate the relative efficacy and safety of existing monoclonal antibody therap...
The pituitary stalk (PS) is crucial to endocrine function and water-electrolyte equilibrium. Preservation of the PS during craniopharyngioma (CP) surgery is critical; however, in a pathological state, it is difficult to identify. The hypothalamo-hypophyseal tract (HHT) connects the hypothalamus and the posterior pituitary gland and projects through...
Normal aging has been linked with the decline of cognitive functions, such as memory and executive skills. One of the prominent approaches to investigate the age-related alterations in the brain is by examining the cortical brain connectome. IBASPM is a toolkit to realize individual atlas-based volume measurement. Hence, this study seeks to determi...
Objective:
To investigate the clinical value of multimodal navigation-based virtual reality (MNVR) in the needle biopsy of intracranial eloquent lesions.Methods:From January 2016 to January 2017, 20 patients with intracranial deep-seated lesions involving eloquent brain areas underwent MNVR-aided needle biopsy at Department of Neurosurgery, People'...
Increasing evidence indicates that neuroinflammation plays a crucial role in the pathogenesis of temporal lobe epilepsy (TLE). However, it is unclear how the perpetuate inflammation develops. Some recent studies have suggested the possible involvement of microRNA-146a (miR-146a) in the modulation of inflammatory signaling occurring in TLE. To under...
Background: For stereotactic brain biopsy involving motor eloquent regions, the surgical objective is to enhance diagnostic yield and preserve neurological function. To achieve this aim, we implemented functional neuro-navigation and intraoperative magnetic resonance imaging (iMRI) into the biopsy procedure. The impact of this integrated technique...
Objective To investigate the impact and value of multimodal navigation and intraoperative magnetic resonance imaging (iMRI) on the biopsy of intracranial lesions. Methods From February, 2009 to December, 2016, this study enrolled 156 patients, who underwent multimodal navigation and iMRI-guided brain biopsy in the Neurosurgery Department of PLA Gen...
TO THE EDITOR: We committed an error while compiling a table in our recent article (Xu X, Chen X, Li F, et al: Effectiveness of endoscopic surgery for supratentorial hypertensive intracerebral hemorrhage: a comparison with craniotomy. J Neurosurg [epub ahead of print April 7, 2017. DOI: 10.3171/2016.10.JNS161589]). We misinterpreted the article by...
Status epilepticus (SE) is a severe medical condition. To determine its epidemiology and outcome of SE, we performed a meta-analysis to investigate the etiology, incidence and mortality of SE. We searched PubMed and Embase between Jan 1, 2000, and Oct 31, 2016, with no regional restrictions, for observational studies of the etiology, incidence and...
This study is to measure the diagnostic examination quality of magnetic resonance spectroscopy in differentiating high-grade gliomas from metastases. PubMed, Embase, and Chinese Biomedical databases were systematically searched for relevant studies published through 10 July 2016. Based on the data from eligible studies, heterogeneity and threshold...
In recent years, researchers have increased attentions to the morphological brain network, which is generally constructed by measuring the mathematical correlation across regions using a certain morphometric feature, such as regional cortical thickness and voxel intensity. However, cerebral structure can be characterized by various factors, such as...
OBJECTIVE
The goal of this study was to investigate the effectiveness and practicality of endoscopic surgery for treatment of supratentorial hypertensive intracerebral hemorrhage (HICH) compared with traditional craniotomy.
METHODS
The authors retrospectively analyzed 151 consecutive patients who were operated on for treatment of supratentorial HI...
It is always a great challenge to distinguish high-grade glioma (HGG) from primary central nervous system lymphoma (PCNSL). We conducted a meta-analysis to assess the performance of MR perfusion-weighted imaging (PWI) in differentiating HGG from PCNSL. The heterogeneity and threshold effect were evaluated, and the sensitivity (SEN), specificity (SP...
Detailed description of the studies included.
(DOCX)
The association between the MDR1 gene C3435T polymorphism and childhood intractable epilepsy remains controversial. In this study, we performed a meta-analysis to clarify this issue. We searched the PubMed, Medline, Embase and CNKI databases for studies published through October 2016 that evaluated the association between the MDR1 C3435T polymorphi...
Central neurocytoma (CN) is a rare benign neuronal tumor of the ventricular system. Microsurgical resection is considered to be the mainstay of treatment for intraventricular CN, and the extent of resection is the most important prognostic factor. We describe our initial experience in the management of intraventricular CN with intraoperative MRI to...
Background:
Thalamic gliomas are rare tumors that constitute 1%-5% of all central nervous system tumors. Despite advanced techniques and equipment, surgical resection remains challenging because of the vital structures adjacent to the tumor. Intraoperative magnetic resonance imaging (MRI) might play an active role during brain tumor surgery becaus...
Objective:
To investigate the feasibility and reliability of virtual endoscopy (VE) as a rapid, low-cost and interactive tool for suprasellar arachnoid cysts (SACs) diagnosis and surgical planning.
Methods:
18 SACs patients treated with endoscopic ventriculocystostomy were recruited, and same number of endoscopic third ventriculostomy treated pa...
Anterior temporal lobe resection (ATLR) is often complicated by superior quadrant visual field deficits (VFDs) because of damage to the anterior portion of the optic radiation (Meyer's loop). This study reports the evaluation of optic radiation mapping in protecting against VFDs in the ATLR. We retrospectively analyzed 52 patients with medically re...
Objective:
Magnetic resonance spectroscopy (MRS) is a powerful tool for preoperative grading of gliomas. We performed a meta-analysis to evaluate the diagnostic performance of MRS in differentiating high-grade gliomas (HGGs) from low-grade gliomas (LGGs).
Methods:
PubMed and Embase databases were systematically searched for relevant studies of g...
Objective: To explore the clinical value of optic radiation reconstruction in protecting against visual field deficits (VFDs) in anterior temporal lobectomy (ATL). Methods: We retrospectively analyzed 24 patients with medically refractory temporal lobe epilepsy undergoing ATL between January 2013 and June 2014. The surgical operations were aided by...
- [...]
Purpose
Differentiating glioma recurrence from radiation necrosis remains a great challenge. We conducted a meta-analysis to evaluate the diagnostic quality of magnetic resonance spectroscopy (MRS) in differentiating glioma recurrence from radiation necrosis.
Methods
Studies about evaluation of MRS for the differential diagnosis of glioma recurren...
