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Introduction
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Publications
Publications (18)
Exclusive enteral nutrition (EEN) is a first-line therapy for pediatric Crohn’s disease (CD), but protective mechanisms remain unknown. We established a prospective pediatric cohort to characterize the function of fecal microbiota and metabolite changes of treatment-naive CD patients in response to EEN (German Clinical Trials DRKS00013306). Integra...
Alternative splicing is crucial for increasing eukaryotic cell transcriptome and proteome diversity Changes in alternative splicing play a key role in cell differentiation and tissue development, and aberrations in this process have been associated with diseases Despite its importance, the exact mechanisms for regulating alternative splicing are po...
The amount of scientific literature available is overwhelming, especially in fast-evolving fields like drug repurposing. Researchers face a significant challenge: staying up-to-date is nearly impossible due to the sheer volume of publications, databases, and tools available. This situation creates an urgent need for more efficient ways to access an...
In recent decades, the development of new drugs has become increasingly expensive and inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly understood. In response, computational systems and network medicine tools have emerged to identify potential drug repurposing candidates. However, these tools often require complex ins...
Transcription factors (TFs) are essential players in orchestrating the regulatory landscape in cells. Still, their exact modes of action and dependencies on other regulatory aspects remain elusive. Since TFs act cell type‐specific and each TF has its own characteristics, untangling their regulatory interactions from an experimental point of view is...
In recent decades, the development of new drugs has become increasingly expensive and inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly understood. In response, computational systems and network medicine tools have emerged to identify potential drug repurposing candidates. However, these tools often require complex ins...
In recent decades, the development of new drugs has become increasingly expensive and inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly understood. In response, computational systems and network medicine tools have emerged to identify potential drug repurposing candidates. However, these tools often require complex ins...
Cytometry techniques are widely used to analyze cellular characteristics at single-cell resolution. This allows forstudying disease-specific mechanisms and potential drug targets, as well as pre-clinical therapy response indiseases such as atherosclerosis and breast cancer [1], [2].Many data analysis methods for cytometry data focus solely on ident...
Differential gene expression normalised to a single housekeeping (HK) is used to identify disease mechanisms and therapeutic targets. HK gene selection is often arbitrary, potentially introducing systematic error and discordant results. Here we examine these risks in a disease model of brain hypoxia. We first identified the eight most frequently us...
Funding Acknowledgements
Type of funding sources: Public grant(s) – National budget only. Main funding source(s): This work was supported by the German Center for Cardiovascular
Research (DZHK grant number Deutsches Zentrum für Herz-
Kreislaufforschung 81 × 3600606 to D.B.).
Abstract:
Background/Introduction
Reticulated platelets (RPs) are prothro...
Cytometry techniques are widely used to discover cellular characteristics at single-cell resolution. Many data analysis methods for cytometry data focus solely on identifying subpopulations via clustering and testing for differential cell abundance. For differential expression analysis of markers between conditions, only few tools exist. These tool...
Background
Reticulated platelets (RPs) are young, hyper-reactive thrombocytes that contain more RNA compared with mature platelets (MPs). The measurement of RPs level in peripheral blood with point-of-care systems is fast, reproducible, and inexpensive. Elevated RPs in peripheral blood predict adverse events in patients with acute and chronic coron...
Cytometry techniques are widely used to discover cellular characteristics at single-cell resolution. Many data analysis methods for cytometry data focus solely on identifying subpopulations via clustering and testing for differential cell abundance. For differential expression analysis of markers between conditions, only few tools exist. These tool...
A plethora of tools exist for RNA-Seq data analysis with a focus on alternative splicing (AS). However, appropriate data for their comparative evaluation is missing. The R package ASimulatoR simulates gold standard RNA-Seq datasets with fine-grained control over the distribution of AS events, which allow for evaluating alternative splicing tools, e...
