Quinten Beirinckx

Quinten Beirinckx
University of Antwerp | UA · Department of Physics

Doctor of Science: Physics

About

27
Publications
2,213
Reads
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34
Citations
Introduction
My current research interests: Quantitative Magnetic Resonance Imaging with specific focus on MR Relaxometry, Development of model-based super-resolution reconstruction with integrated motion estimation, Parameter estimation and optimal experiment design.
Additional affiliations
January 2017 - present
University of Antwerp
Position
  • Research Assistant
Description
  • Exercises for the course `Physics for Biomedical Research', 1st Bachelor Biomedical Sciences, tutor: Prof. Dr. Jan Sijbers.
January 2017 - present
University of Antwerp
Position
  • Research Assistant
Description
  • Exercises for the course `Physics incl. Mathematics', 1st Bachelor Biomedical Sciences & 1st Bachelor Pharmaceutical Sciences, tutor: Prof. Dr. Jan Sijbers
January 2017 - present
University of Antwerp
Position
  • PhD Student
Education
September 2014 - January 2015
Uppsala University
Field of study
  • Physics (Erasmus Exchange)
September 2012 - September 2016
University of Antwerp
Field of study
  • Biophysics & Medical Physics
September 2009 - June 2013
University of Antwerp
Field of study
  • Physics

Publications

Publications (27)
Article
Objectives The aim of this study was to evaluate the use of a multicontrast deep learning (DL)–reconstructed 4-fold accelerated 2-dimensional (2D) turbo spin echo (TSE) protocol and the feasibility of 3-dimensional (3D) superresolution reconstruction (SRR) of DL-enhanced 6-fold accelerated 2D Dixon TSE magnetic resonance imaging (MRI) for comprehen...
Thesis
Full-text available
Magnetic resonance imaging (MRI) is one of the most widely used neuroimaging techniques, thanks to its exceptional soft tissue contrast and intrinsic safety for patients. Unfortunately, signal intensities in conventional MRI images are expressed in relative units that depend on scanner hardware and software. While this poses no issue for visual ins...
Article
Full-text available
Arterial spin labeling (ASL) is a promising, non-invasive perfusion magnetic resonance imaging technique for quantifying cerebral blood flow (CBF). Unfortunately, ASL suffers from an inherently low signal-to-noise ratio (SNR) and spatial resolution, undermining its potential. Increasing spatial resolution without significantly sacrificing SNR or sc...
Conference Paper
Due to acquisition time constraints, T2-w FLAIR MRI of Multiple Sclerosis (MS) patients is often acquired with multi-slice 2D protocols with a low through-plane resolution rather than with high-resolution 3D protocols. Automated lesion segmentation on such low-resolution (LR) images, however, performs poorly and leads to inaccurate lesion volume es...
Article
Out of the 34 globins in Caenorhabditis elegans, GLB-33 is a putative globin-coupled transmembrane receptor with a yet unknown function. The globin domain (GD) contains a particularly hydrophobic haem pocket, that rapidly oxidizes to a low-spin hydroxide ligated haem state at physiological pH. Moreover, the GD has one of the fastest nitrite reducta...
Article
Full-text available
Multi-slice (MS) super-resolution reconstruction (SRR) methods have been proposed to improve the trade-off between resolution, signal-to-noise ratio and scan time in magnetic resonance imaging. MS-SRR consists in the estimation of an isotropic high-resolution image from a series of anisotropic MS images with a low through-plane resolution, where th...
Article
Full-text available
Quantitative Magnetic Resonance (MR) imaging provides reproducible measurements of biophysical parameters, and has become an essential tool in clinical MR studies. Unfortunately, 3D isotropic high resolution (HR) parameter mapping is hardly feasible in clinical practice due to prohibitively long acquisition times. Moreover, accurate and precise est...
Data
This document includes supplementary material that complements the main body of the paper. In Section 1, we provide analytical derivations of the Jacobian and Hessian of the alternating minimization scheme which was used to obtain the joint Maximum a Posteriori estimates of the tissue and motion parameters. Next, Section 2 elaborates on the impleme...
Conference Paper
Full-text available
In clinical MRI, direct acquisition at isotropic high resolution (HR) and with high signal-to-noise ratio (SNR) is often infeasible due to the long scan time required. Multi-slice super-resolution reconstruction (MS-SRR) can reduce this limitation by reconstructing an HR 3D isotropic image from a series of MS images with an anisotropy factor (AF, d...
Conference Paper
Full-text available
T2* mapping using ultra-short echo time (UTE) MRI enables quantitative evaluation of knee structures with short transverse relaxation times. However, acquisitions with low through-plane resolution are commonly used to obtain T2* maps within reasonable scan time, affecting the estimation accuracy due to partial volume effect. In this work, a model-b...
Conference Paper
Full-text available
T2* mapping using ultrashort echo time (UTE) MRI allows for quantitative evaluation of collagen-rich knee structures with short mean transverse relaxation times. However, acquisitions with low through-plane resolution are commonly used to obtain T2* maps within reasonable scan times, affecting the accuracy of the estimations because of partial volu...
Conference Paper
Full-text available
Super-resolution reconstruction (SRR) allows for high-resolution image reconstruction from a set of low-resolution multi-slice images with different orientations. Arterial spin labeling (ASL) is an interesting albeit complicated candidate for SRR, as it relies on subtraction. SRR-ASL can be performed on low-SNR subtracted or on low-contrast unsubtr...
Poster
Full-text available
Super-resolution reconstruction (SRR) allows for high-resolution image reconstruction from a set of low-resolution multi-slice images with different orientations. Arterial spin labeling (ASL) is an interesting albeit complicated candidate for SRR, as it relies on subtraction. SRR-ASL can be performed on low-SNR subtracted or on low-contrast unsubtr...
Article
Full-text available
Magnetic resonance imaging (MRI) based T1 mapping allows spatially resolved quantification of the tissue-dependent spin-lattice relaxation time constant T1, which is a potential biomarker of various neurodegenerative diseases, including Multiple Sclerosis, Alzheimer disease, and Parkinson’s disease. In conventional T1 MR relaxometry, a quantitative...
Conference Paper
Full-text available
Super-resolution reconstruction (SRR) allows for 3D high-resolution image reconstruction from a set of low-resolution multi-slice images with different orientations. Arterial spin labeling (ASL) is an interesting albeit complicated candidate for SRR, as it relies on subtraction. SRR-ASL can be performed on low-SNR subtracted or on low-contrast unsu...
Conference Paper
Full-text available
Model-based Super Resolution Reconstruction (SRR) methods have recently been applied in MR relaxometry to address the need for an improved trade-off between spatial resolution, precision, and acquisition time. In this work, an optimal experimental design framework is proposed to identify acquisition settings for T1-SRR that maximize the precision o...
Conference Paper
Full-text available
Quantitative MRI aims to measure biophysical tissue parameters through the analysis of the MR signal 1. Conventional parameter estimation methods, which often rely on a voxel-wise mapping, ignores spatial redundancies. In this work, a deep learning method for T1 mapping is proposed to overcome this limitation.
Conference Paper
Full-text available
To date, 3D high resolution (HR) quantitative T1 mapping is not feasible in clinical practice due to prohibitively long acquisition times. Recent work has shown that super-resolution reconstruction (SRR), in which a 3D HR T1 map is directly estimated from a set of low through-plane resolution (LR) multi-slice (ms) T1-weighted (T1w) images with diff...
Poster
Full-text available
Quantitative T1 mapping allows spatially resolved quantification of the tissue-dependent spin-lattice relaxation time constant T1. Prohibitively long acquisition times impede the introduction of 3D high resolution (HR) quantitative T1 mapping in clinical practice. Model-based super-resolution reconstruction (SRR), in which a 3D HR T1 map is directl...
Conference Paper
Full-text available
In this educational poster, we emphasize the critical role that statistical parameter estimation plays in turning MRI relaxometry into an accurate and precise qMRI modality. In this longstanding goal, most of the efforts have been made on deriving more accurate physical models, but, to the authors’ knowledge, the importance of using modern statisti...
Poster
Full-text available
MRI relaxometry holds the promise of providing biomarkers for monitoring, staging and follow up of diseases. Imperative to meet minimum standards for objective, reproducible, and reliable biomarkers is the need for accurate, precise, quantitative parameters maps such as T1 or T2. While unrealistic physical modelling is often argued as the main caus...
Conference Paper
Full-text available
MRI relaxometry holds the promise of providing biomarkers for monitoring, staging and follow up of diseases. Imperative to meet minimum standards for objective, reproducible and reliable biomarkers is the need for accurate, precise, quantitative parameters maps, such as T1 or T2 maps. While unrealistic physical modeling is often argued as the main...
Conference Paper
Full-text available
Cerebral blood flow (CBF) can be estimated non-invasively with arterial spin labeling (ASL). Multi-post-labeling-delay (PLD) pseudo-continuous ASL (PCASL) allows for accurate CBF estimation by sampling the dynamic perfusion signal at different PLDs and fitting a model to the perfusion data. Unfortunately, ASL difference images have a low SNR. There...
Thesis
The genome of the nematode Caenorhabditis elegans contains 33 putative globin genes that are all transcribed. Two globins, GLB-33GD and GLB-12, are closely examined. GLB-33 belongs to the nervous system of the C. elegans and consists of a transmembrane domain, GLB-33 7TM, which is covalently coupled with a globin domain, GLB-33GD, only the latter i...
Article
1,2-diolato ligands, such as carbohydrates and glycoproteins, tend to stabilize chromium(V), thus forming important intermediates that have been implicated in the genotoxicity of Cr(VI). Since many years, room-temperature continuous-wave electron paramagnetic resonance (EPR) at X-band microwave frequencies has been used as a standard characterizati...

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