About
9
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Introduction
Quanfa (Frank) is currently a PhD student in the Clinical Psychology program at UW-Madison, advised by Dr. James Li.
His primary research interest is testing the utility and generalizability of the hierarchical taxonomy of psychopathology (HiTOP) across racial-ethnic boundaries, in addition to testing the utility of polygenic scores in studies of neurodevelopmental disorders.
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Current institution
Publications
Publications (9)
Background
There is converging evidence that mental disorders are more optimally conceptualized in a hierarchical framework (i.e., the Hierarchical Taxonomy of Psychopathology, HiTOP) that transcends the categorical boundaries of the Diagnostic and Statistical Manual of Mental Disorders (DSM). However, the majority of this evidence comes from studi...
This study explored whether maltreatment moderates the association of polygenic risk for ADHD. Because individuals with low polygenic scores (PGS) for ADHD were previously shown to have better than expected functional outcomes (i.e., cognitive, mental health, social-emotional) than individuals with middle or high ADHD PGS, we hypothesized low ADHD...
Background
ADHD polygenic scores (PGSs) have been previously shown to predict ADHD outcomes in several studies. However, ADHD PGSs are typically correlated with ADHD but not necessarily reflective of causal mechanisms. More research is needed to elucidate the neurobiological mechanisms underlying ADHD. We leveraged functional annotation information...
Background
ADHD polygenic scores (PGS) are reliably predictive of ADHD outcomes across studies. However, traditional PGS are statistical indices of genetic liability – predictive of ADHD but uninformed by biological information. The objective of our study was to determine whether a novel, biologically-informed, functionally annotated ADHD PGS can r...
Background: ADHD polygenic scores (PGS) are reliably predictive of ADHD outcomes across studies. However, traditional PGS are statisticalindices of genetic liability – predictive of ADHD but uninformed by biologicalinformation. The objective of our study was to determine whether a novel, biologically-informed, functionally annotated ADHD PGS can re...
Objective
Polygenic scores (PGS) are widely used in psychiatric genetic associations studies due to their impressive power to predict focal outcomes. However, they lack in discriminatory power, in part due to the high degree of genetic overlap between psychiatric disorders. The lack of prediction specificity limits the clinical utility of psychiatr...
Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder that is known to have a polygenic (i.e., many genes of individually small effects) architecture. Polygenic scores (PGS), which characterize this polygenicity as a single score for a given individual, are considered the state-of-the-art in psychiatric g...
Background. Childhood exposure to interpersonal violence (IPV) may be linked to distinct
manifestations of mental illness, yet the nature of this change remains poorly understood.
Network analysis can provide unique insights by contrasting the interrelatedness of symptoms underlying psychopathology across exposed and non-exposed youth, with potenti...
