Qing Li

• Post doc at Fudan University

Dental morphology varies greatly throughout evolution, including in the human lineage, but little is known about the biology of this variation. Here, we use multiomics analyses to examine the genetics of variation in tooth crown dimensions. In a human cohort with mixed continental ancestry, we detected genome-wide significant associations at 18 gen...

We report a genome-wide association study of facial features in >6000 Latin Americans based on automatic landmarking of 2D portraits and testing for association with inter-landmark distances. We detected significant associations (P-value <5 × 10 −8) at 42 genome regions, nine of which have been previously reported. In follow-up analyses, 26 of the...

Dental size variation in modern humans has been assessed from regional to worldwide scales, especially under microevolutionary and forensic contexts. Despite this, populations of mixed continental ancestry such as contemporary Latin Americans remain unexplored. In the present study we investigated a large Latin American sample from Colombia (N = 80...

The CANDELA consortium has been focused on the genetic underpinnings of physical appearance in Latin American people for nearly 10 years. We have performed GWAS, admixture mapping, etc., using ~700,000 SNPs from ~7000 individuals using both quantitative and qualitative methods to assess the facial and dental phenotypes. First, we reported four geno...

During their dispersal across the globe, modern humans met and interbred with distinct archaic hominin lineages, including Neanderthals, Denisovans, and unknown hominin species [1]. This process is known as introgressive hybridization and is thought to play an important role in Middle/Late Pleistocene hominin evolution [2]. While these population i...

Among the most common and well-preserved elements within the hominin fossil record are the teeth which have been intensively used in evolutionary studies. In addition, much of the recent and contemporary human diversity has been assessed using dental morphological traits, including applications in forensic sciences. However, the genetic bases under...

We report a genome-wide association study for facial features in > 6,000 Latin Americans. We placed 106 landmarks on 2D frontal photographs using the cloud service platform Face++. After Procrustes superposition, genome-wide association testing was performed for 301 inter-landmark distances. We detected nominally significant association (P-value <...