Qiang Zhu

• Chinese Academy of Sciences

Background: Increased plasma copeptin concentrations are related to poor prognosis after aneurysmal subarachnoid hemorrhage (aSAH). The aim of this study was to assess prognostic significance of plasma copeptin detection compared with glial fibrillary astrocyte protein, myelin basic protein, S100B, phosphorylated axonal neurofilament subunit H, ne...

Background: Periostin, a neurite outgrowth-promoting factor, is increasingly expressed in rat brain tissues after cerebral ischemia or subarachnoid hemorrhage. However, periostin concentrations are undetermined in peripheral blood from patients with traumatic brain injury (TBI). Methods: In this prospective, observational study, serum periostin...

Background: Macrophage migration inhibitory factor (MIF) is a well-known pro-inflammatory cytokine. Serum MIF concentrations are associated with the severity and prognosis of ischemic stroke. Methods: In this prospective, observational study, white blood cell (WBC) count and serum concentrations of C-reactive protein (CRP), interleukin-6 (IL-6),...

Background: In-hospital major adverse events (IMAEs), mainly including acute lung injury, acute traumatic coagulopathy, progressive hemorrhagic injury and posttraumatic cerebral infarction, are associated with poor prognosis after traumatic brain injury (TBI). Thioredoxin, a potent anti-oxidant, has been identified as an oxidative stress marker. T...

Background: Angiogenesis is a fundamental process for brain development and repair. Thrombospondin-1 is the first identified endogenous angiogenesis inhibitor. Its expression in rat brain is upregulated after intracerebral hemorrhage (ICH). We determined whether plasma thrombospondin-1 concentrations are associated with injury severity and prognos...

Enhanced blood levels of copeptin correlate with poor clinical outcomes after acute critical illness. This study aimed to compare the prognostic performances of plasma concentrations of copeptin and other biomarkers like myelin basic protein, glial fibrillary astrocyte protein, S100B, neuron-specific enolase, phosphorylated axonal neurofilament sub...

Background: Higher plasma 8-iso-Prostaglandin F2α concentrations have been associated with poor outcome of severe traumatic brain injury. We further investigated the relationships between plasma 8-iso-Prostaglandin F2α concentrations and clinical outcomes in patients with acute intracerebral hemorrhage. Methods: Plasma 8-iso-Prostaglandin F2α co...

Higher plasma copeptin levels correlate with poor clinical outcomes after traumatic brain injury. Nevertheless, their links with acute traumatic coagulopathy and progressive hemorrhagic injury are unknown. Therefore, we aimed to investigate the relationship between plasma copeptin levels, acute traumatic coagulopathy and progressive hemorrhagic inj...

Most time series data mining algorithms use similarity search as a core subroutine, and thus the time taken for similarity search is the bottleneck for virtually all time series data mining algorithms, including classification, clustering, motif discovery, anomaly detection, and so on. The difficulty of scaling a search to large datasets explains t...

Most time series data mining algorithms use similarity search as a core subroutine, and thus the time taken for similarity search is the bottleneck for virtually all time series data mining algorithms, including classification, clustering, motif discovery, anomaly detection, and so on. The difficulty of scaling a search to large datasets explains t...

Most time series data mining algorithms use similarity search as a core subroutine, and thus the time taken for similarity search is the bottleneck for virtually all time series data mining algorithms, including classification, clustering, motif discovery, anomaly detection, and so on. The difficulty of scaling a search to large datasets explains t...

Most time series data mining algorithms use similarity search as a core subroutine, and thus the time taken for similarity search is the bottleneck for virtually all time series data mining algorithms. The difficulty of scaling search to large datasets largely explains why most academic work on time series data mining has plateaued at considering a...

Higher plasma leptin levels have been associated with poor clinical outcomes after intracerebral hemorrhage. Nevertheless, their links with hematoma growth and early neurological deterioration are unknown. Therefore, we aimed to investigate the relationship between plasma leptin levels, hematoma growth, and early neurological deterioration in patie...

Oxymatrine, a potent monosomic alkaloid extracted from Chinese herb Sophora japonica (Sophora flavescens Ait.). possesses anti-inflammatory activittyes. This study was designed to investigate the effects of oxymatrine on nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK)-dependent inflammatory responses in lipopolysaccharide...

Most time series data mining algorithms use similarity search as a core subroutine, and thus the time taken for similarity search is the bottleneck for virtually all time series data mining algorithms. The difficulty of scaling search to large datasets largely explains why most academic work on time series data mining has plateaued at considering a...

Given the ubiquity of time series data, the data mining community has spent significant time investigating the best time series similarity measure to use for various tasks and domains. After more than a decade of extensive efforts, there is increasing evidence that Dynamic Time Warping (DTW) is very difficult to beat. Given that, recent efforts hav...

The increasing interest in archiving all of humankind's cultural artifacts has resulted in the digitization of millions of books, and soon a significant fraction of the world's books will be online. Most of the data in historical manuscripts is text, but there is also a significant fraction devoted to images. This fact has driven much of the recent...

Initiatives such as the Google Print Library Project and the Million Book Project have already archived more than twelve million books in digital format, and within the next decade, the majority of world’s books will be online. Although most of the data will naturally be text, there will also be tens of millions of pages of images, many in color. W...

The increasing interest in archiving all of humankind's cultural artifacts has resulted in the digitization of millions of books, and soon a significant fraction of the world's books will be online. Most of the data in historical manuscripts is text, but there is also a significant fraction devoted to images. This fact has driven much of the recent...

In the next decade a majority of all the books ever published will be digitized and online. Naturally, most of the data in historical manuscripts is text, but there is also a large amount devoted to images. This observation is responsible for the dramatic increase in interest in query-by-content systems for historical documents. While querying/inde...

Rock art is an archaeological term for human-made markings on stone, including carved markings, known as petroglyphs, and painted markings, known as pictographs. It is believed that there are millions of petroglyphs in North America alone, and the study of this valued cultural resource has implications even beyond anthropology and history. Surprisi...

High plasma copeptin levels are associated with mortality after intracerebral hemorrhage (ICH). However, there is a paucity of data available on whether copeptin is an independent prognostic marker of mortality. Thus, we sought to furthermore evaluate this relation. Thirty healthy controls and 86 patients with acute ICH were included. Plasma sample...

Time series motifs are sets of very similar subsequences of a long time series. They are of interest in their own right, and are also used as inputs in several higher-level data mining algorithms including classification, clustering, rule-discovery and summarization. In spite of extensive research in recent years, finding time series motifs exactly...

Initiatives such as the Google Print Library Project and the Million Book Project have already archived more than ten million books in digital format, and within the next decade the majority of world's books will be online. Although most of the data will naturally be text, there will also be tens of millions of pages of images, many in color. While...

Multivariate Time-Series (MTS) are ubiquitous, and are generated in areas as disparate as sensor recordings in aerospace systems, music and video streams, medical monitoring, and financial systems. Domain experts are often interested in searching for interesting multivariate patterns from these MTS databases which can contain up to several gigabyte...

Rock art, human-made markings on stone, is an important cultural artifact and the earliest expression of abstract thinking. While there are tens of millions of photographs of rock art in existence, there have been no large-scale attempts to organize, classify or cluster them. This omission is not due to a lack of interest, but reflects the extraord...

Time series motifs are pairs of individual time series, or subsequences of a longer time series, which are very similar to each other. As with their discrete analogues in computational biology, this similarity hints at structure which has been conserved for some reason and may therefore be of interest. Since the formalism of time series motifs in 2...

Rock art is an archaeological term for human-made markings on stone. It is believed that there are millions of petroglyphs in North America alone, and the study of this valued cultural resource has implications even beyond anthropology and history. Surprisingly, although image processing, information retrieval and data mining have had large impacts...

Rock art is an archaeological term for human-made markings on stone, including carved markings, known as petroglyphs, and painted markings, known as pictographs. It is believed that there are millions of petroglyphs in North America alone, and the study of this valued cultural resource has implications even beyond anthropology and history. Surprisi...