Qianbin Zhao

Qianbin Zhao
Nanyang Technological University | ntu · School of Electrical and Electronic Engineering

Doctor of Engineering

About

54
Publications
12,203
Reads
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1,279
Citations
Introduction
Microfluidics, Inertial microfluidics, Particle manipulation, Organ-on-a-chip, Microfluidic wearables.

Publications

Publications (54)
Article
Full-text available
Organ-on-a-chip (OOC) uses the microfluidic 3D cell culture principle to reproduce organ- or tissue-level functionality at a small scale instead of replicating the entire human organ. This provides an alternative to animal models for drug development and environmental toxicology screening. In addition to the biomimetic 3D microarchitecture and cell...
Article
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Portability and low-cost analytic ability are desirable for point-of-care (POC) diagnostics; however, current POC testing platforms often require time-consuming multiple microfabrication steps and rely on bulky and costly equipment. This hinders the capability of microfluidics to prove its power outside of laboratories and narrows the range of appl...
Article
Correction for ‘Modular off-chip emulsion generator enabled by a revolving needle’ by Yuxin Zhang et al. , Lab Chip , 2020, 20 , 4592–4599, DOI: 10.1039/D0LC00939C.
Article
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Current outbreak of COVID‐19 pandemics worldwide has caused millions of fatalities and imposed a severe impact on our daily lives. Thus, the global healthcare system urgently calls for rapid, affordable and reliable detection toolkits. Although the gold standard nucleic acid amplification tests have been widely accepted and utilized, they are time‐...
Article
Nanoparticles of gallium-based liquid metal alloys have presented applications in flexible electronics, drug delivery, and molecular imaging. They can be readily produced using top-down methods such as sonication. However, sonication process generates heat that can cause dealloying of nanoparticles through hydrolysis and oxidation of gallium. This...
Article
Anisotropic elastic composites—that is, elastomers containing aligned fillers—often have enhanced properties in the direction of alignment. Depending on the fillers, these composites can have desirable electrical, thermal, or mechanical properties. Here, a silicone composite filled with both solid magnetic metal microparticles and liquid metal micr...
Article
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Inertial microfluidic technology, which can manipulate the target particle entirely relying on the microchannel characteristic geometry and intrinsic hydrodynamic effect, has attracted great attention due to its fascinating advantages of high throughput, simplicity, high resolution and low cost. As a passive microfluidic technology, inertial microf...
Article
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Microalgae cells have been recognized as a promising sustainable resource to meet worldwide growing demands for renewable energy, food, livestock feed, water, cosmetics, pharmaceuticals, and materials. In order to ensure high-efficiency and high-quality production of biomass, biofuel, or bio-based products, purification procedures prior to the stor...
Article
Microdroplets of gallium-based liquid metal alloys have enabled various applications in the fields of biomedicine, electronics, and chemistry. However, due to the high surface tension of liquid metal, high-throughput production of uniformly sized liquid metal microdroplets is challenging using conventional acoustic or microfluidic methods. Here, ad...
Article
Nanoparticles produced from gallium-based liquid metal alloys have been explored for developing applications in the fields of electronics, catalysis, and biomedicine. Nonetheless, physical properties, such as phase behavior at micro-/nanosize scale, are still significantly underexplored for such nanoparticles. Here, we conduct an in situ investigat...
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Conductive elastic composites have been used widely in soft electronics and soft robotics. These composites are typically a mixture of conductive fillers within elastomeric substrates. They can sense strain via changes in resistance resulting from separation of the fillers during elongation. Thus, most elastic composites exhibit a negative piezocon...
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This work investigates particle focusing under Dean-flow-coupled elasto-inertial effects in symmetric serpentine microchannels. A small amount of polymers were added to the sample solution to tune the fluid elasticity, and allow particles to migrate laterally and reach their equilibriums at the centerline of a symmetric serpentine channel under the...
Article
Despite that droplet-based microfluidics has been broadly used as a versatile tool in biology, chemistry and nanotechnology, its rather complicated microfabrication process and the requirement of specialized hardware and operating skills hinder researchers to fully unleash the potential of this powerful platform. Here, we develop an integrated micr...
Article
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Focusing and separation of particles such as cells at a high throughput are extremely attractive for biomedical applications. Particle manipulation based on inertial effects requires a high flow speed, and thus suits well to high-throughput applications. Recently, inertial focusing and separation using curvilinear microchannels have been attracting...
Article
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In the regime of inertial microfluidics, the secondary flow is widely adopted to reduce the number of the equilibrium position and improve the focusing performance of particles. At the same time, secondary flow can also enhance the mixing effect and may deteriorate particle focusing due to the induced rotating streams, especially for the particle w...
Article
Functional liquid metal nanoparticles (NPs), produced from eutectic alloys of gallium, promise new horizons in the fields of sensors, microfluidics, flexible electronics, catalysis, and biomedicine. Here, the development of a vapor cavity generating ultrasonic platform for nebulizing liquid metal within aqueous media for the one‐step production of...
Article
Functional nanoparticles comprised of liquid metals, such as eutectic gallium indium (EGaIn) and Galinstan, present exciting opportunities in the fields of flexible electronics, sensors, catalysts, and drug delivery systems. Methods used currently for producing liquid metal nanoparticles have significant disadvantages as they rely on both bulky and...
Data
Supplemenary information for <Tunable particle separation in a dielectrophoresis (DEP)- inertial microfluidic device>
Article
Full-text available
Particle separation is indispensable in many microfluidic systems and holds a broad range of biomedical applications. Inertial microfluidic devices that work solely on intrinsic hydrodynamic forces and inertial effects can offer label-free, high throughput and high efficiency separation performance. However, the working range of the current inertia...
Article
This work presents a simple, low-cost method to fabricate semi-circular channels using solder paste, which can amalgamate the cooper surface to form a half-cylinder mould using the surface tension of Sn-Pd alloy (the main component in solder paste). This technique enables semi-circular channels to be manufactured with different dimensions. These se...
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In this work, a novel double-layer microfluidic device for enhancing particle focusing was presented. The double-layer device consists of a channel with expansion-contraction array and periodical slanted grooves. The secondary flows induced by the grooves modulate the flow patterns in the expansion-contraction-array (ECA) channel, further affecting...
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Numerous lab-on-a-chip applications benefit from channels with complex structures and configurations in the areas of tissue engineering and clinical diagnostics. The current fabrication approaches require time-consuming, complicated processes and bulky, expensive facilities. In this work, we propose a novel method for fabrication of complex channel...
Article
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Recently, research on particle migration in non-Newtonian viscoelastic fluids has gained considerable attention. In a viscoelastic fluid, three dimensional (3D) particle focusing can be easily realized in simple channels without the need of any external force fields or complex microchannel structure compared with that in a Newtonian fluid. Due to i...
Article
Proteinuria is an established risk marker for progressive renal function loss and patients would significantly benefit from a point-of-care testing. Although extensive work has been done to develop the microfluidic devices for the detection of urinary protein, they need the complicated operation and bulky peripherals. Here, we present a rapid, mask...
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Microfluidic systems enable rapid diagnosis of diseases, biological analysis, drug screening, and high-precision materials synthesis. In spite of these remarkable abilities, conventional microfluidic systems are microfabricated monolithically on a single platform and their operations rely on bulky expensive external equipment. This restricts their...
Article
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Manually hand-powered portable microfluidic devices are cheap alternatives for point-of-care diagnostics. Currently, on-field tests are limited by the use of bulky syringe pumps, pressure controller and equipment. In this work, we present a manually operated microfluidic device incorporated with a groove-based channel. We show that the device is ca...
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In the capillary venules, blood cells auto-separate with red blood cells aggregating near the centre of vessel and the nucleated cells marginating toward the wall of vessel. In this experiment, we used cell margination to help enrich the Jurkat cells via a groove-based channel which provides a vertical expansion-contraction structure, wherein the r...
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In this paper, we proposed a microparticle manipulation approach, by which particles are able to be guided to different equilibrium positions through modulating the Reynolds number. In the microchannel with arc-shaped groove arrays, secondary flow vortex arisen due to the pressure gradient varies in the aspects of both magnitude and shape with the...
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This work investigates the on-chip washing process of microparticles and cells using co-flow configuration of viscoelastic fluid and Newtonian fluid in a straight microchannel. By adding a small amount of biocompatible polymers into the particle medium or cell culture medium, the induced viscoelasticity can push particles and cells laterally from t...
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White blood cells (WBCs) constitute only about 0.1% of human blood cells, yet contain rich information about the immune status of the body, thus separation of WBCs from the whole blood is an indispensable and critical sample preparation step in many scientific, clinical and diagnostic applications. In this work, we developed a continuous and high-t...
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Inertial microfluidics can separate microparticles in a continuous and high-throughput manner, and is very promising for a wide range of industrial, biomedical and clinical applications. However, most of the proposed inertial microfluidic devices only work effectively at a limited and narrow flow rate range because the performance of inertial parti...
Article
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Sheathless particle focusing which utilises the secondary flow with a high throughput has great potential for use in microfluidic applications. In this work, an innovative particle focusing method was proposed. This method makes use of a mechanism that takes advantage of secondary flow and inertial migration. The device was a straight channel with...
Article
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In this paper, a novel microfluidic device for sheathless particle focusing and separation in viscoelastic fluid is proposed. The device consists of two stages: a straight channel section with asymmetrical expansion–contraction cavity arrays (ECCA section) for sheathless Dean-flow-coupled elasto-inertial particle focusing (1st stage), and a straigh...
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The separation of target objects conjugated with magnetic particles is a significant application in biomedicine and clinical diagnosis. Conventional magnetophoresis-based devices use a sheath flow to pre-focus the particles into a single stream and typically operate at a low flow rate. We demonstrate in this work a high-throughput, sheathless, magn...
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In this work, a novel microfluidic platform for tunable particle focusing in a straight channel with symmetric semicircle obstacle arrays using electrophoresis (EP)-modified inertial effects was presented. By exerting an EP force on the charged microparticles, a relative velocity gap between microspheres and fluid in a straight channel with symmetr...
Article
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In this paper, continuous plasma extraction under viscoelastic fluid in a straight channel with asymmetrical expansion-contraction cavity arrays (ECCA channel) is demonstrated by exploiting the Dean-flow-coupled elasto-inertial effects. First, the forces experienced by particles in the ECCA channel were discussed. Then, 4.8 μm diameter particles, w...
Article
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Separation of microparticles has found broad applications in biomedicine, industry and clinical diagnosis. In a conventional aqueous ferrofluid, separation of microparticles usually employs a sheath flow or two offset magnets to confine particle streams for downstream particle sorting. This complicates the fluid control, device fabrication, and dil...
Article
In this work, particle lateral migration in sample-sheath flow of viscoelastic fluid and Newtonian fluid was experimentally investigated. The 4.8 μm micro-particles were dispersed in a PEO (polyethylene oxide) viscoelastic solution, then the solution was injected into a straight rectangular channel with a DI (deionised) water Newtonian sheath flow....
Article
Dynamic characteristics of a rotor rubbing with circular stator and four pin shape stators are studied based on contact dynamics theory. Based on finite element (FE) method, the rotor system attached with two disks and pin shape stators are simulated by Timoshenko beam. The circular stator is simulated by a lumped mass model, and the rotor and stat...

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