Qi Wang

• Loughborough University

Legumes establish symbiosis with rhizobia by forming a symbiotic interface that enables cross‐kingdom exchanges of signaling molecules and nutrients. However, how host organelles interact with symbiosomes at the symbiotic interface remains elusive during rhizobia endosymbiosis. Here, symbiotic cells are reconstructed using 3D scanning electron micr...

Background To compare the performance between one-slice two-dimensional (2D) and whole-volume three-dimensional (3D) computed tomography (CT)-based radiomics models in the prediction of lymphovascular invasion (LVI) status in esophageal squamous cell carcinoma (ESCC). Methods Two hundred twenty-four patients with ESCC (158 LVI-absent and 66 LVI-pr...

Objective This study aimed to investigate whether contrast-enhanced computed tomography (CECT) based radiomics analysis could noninvasively predict the perineural invasion (PNI) in esophageal squamous cell carcinoma (ESCC). Methods 398 patients with ESCC who underwent resection between February 2016 and March 2020 were retrospectively enrolled in...

BACKGROUND The consistency of pancreatic apparent diffusion coefficient (ADC) values and intravoxel incoherent motion (IVIM) parameter values across different magnetic resonance imaging (MRI) devices significantly impacts the patient’s diagnosis and treatment. AIM To explore consistency in image quality, ADC values, and IVIM parameter values among...

Background Immunochemotherapy was an emerging neoadjuvant treatment mode that can potentially benefit patients with esophageal carcinoma, but its synergistic mechanism and impact on the tumor immune microenvironment were still unclear. The purpose of this study was to investigate the outcomes of neoadjuvant chemotherapy (nCT) and neoadjuvant immuno...

Objective To evaluate the feasibility, safety and efficacy of concurrent simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) combined with nimotuzumab in the treatment of locally advanced esophageal squamous cell cancer (ESCC). Methods Eligible patients were histologically proven to have locally advanced ESCC, and were unable...

Background With the continuous innovation of magnetic resonance imaging (MRI) hardware and software technology, amide proton transfer-weighted (APTw) imaging has been applied in liver cancer. However, to our knowledge, no study has evaluated the feasibility of a three-dimensional amide proton transfer-weighted (3D-APTw) imaging sequence for hepatoc...

Background: this study aimed to utilize various diffusion-weighted imaging (DWI) techniques, including mono-exponential DWI, intravoxel incoherent motion (IVIM), and diffusion kurtosis imaging (DKI), for the preoperative grading of rectal cancer. Methods: 85 patients with rectal cancer were enrolled in this study. Mann–Whitney U tests or independen...

Background To evaluate two-dimensional (2D) and three-dimensional (3D) computed tomography (CT) radiomics analysis for the T stage of esophageal squamous cell carcinoma (ESCC). Methods 398 patients with pathologically confirmed ESCC were divided into training and testing sets. All patients underwent chest CT scans preoperatively. For each tumor, b...

To investigate clinical data and computed tomographic (CT) imaging features in differentiating gastric schwannomas (GSs) from gastric stromal tumours (GISTs) in matched patients, 31 patients with GSs were matched with 62 patients with GISTs (1:2) in sex, age, and tumour site. The clinical and imaging data were analysed. A significant (P < 0.05) dif...

Introduction The image quality of continuously acquired free-breathing Dynamic Contrast-Enhanced (DCE) golden-angle radial Magnetic Resonance Imaging (MRI) of abdomen suffers from motion artifacts and motion-related blurring. We propose a scheme by minimizing patients’ motion status from breathing as well as optimizing the acquiring parameters to i...

Objective This study investigated the outcomes of neoadjuvant chemotherapy with and without immunotherapy in tumor microenvironment (TME) remodeling among patients with esophageal squamous cell carcinoma (ESCC) . Methods Retrospectively reviewed the data of patients with ESCC who received neoadjuvant chemotherapy, with or without immunotherapy (nCT...

Background Liver cancer is a highly lethal and aggressive form of cancer that poses a significant threat to patient survival. Within this category, liver hepatocellular carcinoma (LIHC) represents the most common subtype of liver cancer. Despite decades of research and treatment, the overall survival rate for LIHC has not significantly improved. Im...

Objective: To differentiate gastric leiomyomas (GLs) and gastric stromal tumors (GSTs) based on preoperative enhanced computed tomography characteristics. Methods: Twenty-six pathologically confirmed GLs were propensity score-matched to 26 GSTs in a 1:1 ratio based on sex, age, tumor site, and tumor size. Tumor shape and contour, mucosal ulcerat...

Background: Chemotherapy plays an important role in definitive chemoradiotherapy strategies. However, the most optimal concurrent chemotherapy scheme is still controversial. This study aimed to systematically evaluate the efficacy and toxicity of paclitaxel/docetaxel combined with platinum (PTX) and fluorouracil combined with cisplatin (PF) in the...

Objective: In this study, we compared the enhancement of blood vessels and liver parenchyma on enhanced computed tomography (CT) of the upper abdomen with two concentrations of contrast media (400 and 300 mg I/mL) based on similar iodine delivery rate (IDR) of 0.88 and 0.9 g I/s and iodine load of 450 mg I/kg. Methods: We randomly assigned 160 pati...

Symbioses between legumes and rhizobia require establishment of the plant-derived symbiosome membrane, which surrounds the rhizobia and accommodates the symbionts by providing an interface for nutrient and signal exchange. The host cytoskeleton and endomembrane trafficking systems play central roles in the formation of a functional symbiotic interf...

Purpose To systematically evaluate the efficacy and toxicity of paclitaxel/docetaxel combined with platinum (PTX) and fluorouracil combined with cisplatin (PF) in concurrent chemoradiotherapy (CCRT) treatment of unresectable esophageal cancer. Methods PubMed, the CNKI database, and Google Scholar were searched by combining subject words and free w...

Endoplasmic reticulum (ER) homeostasis is essential for plants to manage responses under environmental stress. Plant immune activation requires the ER, but how ER homeostasis is associated with plant immune activation is largely unexplored. Here we find that transcription of an HVA22 family gene, OsHLP1 (HVA22-like protein 1), is induced by Magnapo...

Purpose The goal of current study was to introduce noninvasive and reproducible MRI methods for in vivo functional assessment of lung adenocarcinoma (LUAD). Methods Forty-four patients with pathologically confirmed LUAD were included in this study. All the lesions were classified as adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (...

Objective: To investigate feasibility of applying deep learning image reconstruction (DLIR) algorithm in a low-kilovolt enhanced scan of the upper abdomen. Methods: A total of 64 patients (BMI<28) are selected for the enhanced upper abdomen scan and divided evenly into two groups. The tube voltages in Group A are 100kV in arterial phase and 80kV...

Background Lung cancer screening revealed that people with small pulmonary nodules are mostly asymptomatic and that some of these people are at risk of developing lung cancer, so we intended to explore the repeatability of small lung nodule measurement in low-dose lung screening. Methods We scanned eight ground-glass nodules (GGNs) and solid nodul...

Purpose To predict multiple prognostic factors of HCC including histopathologic grade, the expression of Ki67 as well as capsule formation with intravoxel incoherent motions imaging by extracting the histogram metrics. Patients and Methods A total of 52 patients with HCC were recruited with the MR examinations undertaken at a 3T scanner. Histogram...

Root nodule symbiosis enables nitrogen fixation in legumes and, therefore, improves crop production for sustainable agriculture1,2. Environmental nitrate levels affect nodulation and nitrogen fixation, but the mechanisms by which legume plants modulate nitrate uptake to regulate nodule symbiosis remain unclear1. Here, we identify a member of the Me...

Legumes have evolved a symbiotic relationship with rhizobial bacteria and their roots form unique nitrogen-fixing organs called nodules. Studies have shown that abiotic and biotic stresses alter the profile of gene expression and transcript mobility in plants. However, little is known about the systemic transport of RNA between roots and shoots in...

Rationale: Pulmonary benign metastasizing leiomyoma (PBML) is rare, usually occurs in women who underwent hysterectomy during the reproductive years, and has no obvious clinical symptoms. A full understanding of the characteristics of PBML is important for its sequential treatment and prognosis. Patient concerns: In this report, a 36-year-old fe...

In plants, the actin cytoskeleton plays a central role in regulating intracellular transport and trafficking in the endomembrane system. Work in legumes suggested that during nodulation, the actin cytoskeleton coordinates numerous cellular processes in the development of nitrogen‐fixing nodules. However, we lacked live‐cell visualizations demonstra...

Objectives Pulmonary nodules have become common incidental findings with the widespread use of computed tomography (CT) technology. Such nodules have the potential to become early lung cancer lesions, so understanding more about factors that may be associated with them is important. Materials and methods The present work was based on a large prosp...

The microtubule (MT)-severing enzyme katanin triggers dynamic reorientation of cortical MT arrays that play crucial functions during plant cell morphogenesis, such as cell elongation, cell wall biosynthesis, and hormonal signaling. MT severing specifically occurs at crossover or branching nucleation sites in living Arabidopsis cells. This differs f...

Purpose: To investigate the predictive value of serial diffusion-weighted MRI (DWI) on tumor response of the concurrent chemoradiotherapy (CCRT) for esophageal squamous cell carcinoma (ESCC) and to determine the optimal time point of DWI measurements. Methods and materials: From June 2010 to October 2011, 38 ESCC patients were consecutively enro...

Objective To assess the usefulness of the spectral curve slope of dual-energy CT (DECT) for differentiating between hepatocellular carcinoma (HCC), hepatic metastasis, hemangioma (HH) and cysts. Methods In total, 121 patients were imaged in the portal venous phase using dual-energy mode. Of these patients, 23 patients had HH, 28 patients had HCC,...

Objective: To investigate the use of non-linear-blending and monochromatic dual-energy CT (DECT) images to improve the image quality of hepatic venography. Methods: 82 patients undergoing abdominal DECT in the portal venous phase were enrolled. For each patient, 31 data sets of monochromatic images and 7 data sets of non-linear-blending images w...

The aim of the present study was to evaluate the clinical value of magnetic resonance imaging (MRI) in the preoperative T staging of gastric cancer and in the postoperative pathological diagnosis. In total, 30 patients with gastric cancer were investigated, including 19 males and 11 females (age, 50-69 years; mean age, 60 years). The preoperative d...

Aim: To explore the associations of diffusion-weighted magnetic resonance imaging (DWI) measurements with the therapeutic effect (TE) on and survival of esophageal carcinoma patients treated with chemoradiotherapy (CRT). Methods: From March 2010 to December 2011, 77 patients were prospectively enrolled into a cohort study. DWI was performed at t...

Objective: This study evaluated the feasibility of CT perfusion parameters for the early efficacy prediction of sorafenib in the treatment of hepatocellular carcinoma (HCC) in rats. Methods: CT hepatic perfusion measurements were performed in the livers of 40 rats implanted with rat HCC. The rats in the experimental group (n = 28) were treated b...

PURPOSE To investigate the possibility of using dual-energy CT keV spectrum to differentiate hepatic carcinoma (HCC), liver metastasis, hemangioma and cysts. METHOD AND MATERIALS Eighty-one patients with liver diseases were enrolled. The dual-energy CT was performed at the portal venous phase with tube voltage 100/Sn140 kV, tube current 230/178 mA...

Objective: The objective of this study was to evaluate image quality of computed tomography (CT) portal venography using nonlinear blending technique of dual-energy CT (DECT) in portal phase. Methods: Fifty patients underwent contrast-enhanced abdominal scan with DECT at portal venous phase. The images of 2 energy levels were mixed by a nonlinea...

To probe the blood supply of liver metastasis by celiac arteriography, proper hepatic arteriogaphy, pure portal vein perfusion CT. Fifty patients with liver metastasis were examined prospectively by plain CT scan, multiphase enhanced CT scan, celiac arteriography and proper hepatic arteriography, of whom, 23 were examined by pure portal vein perfus...

The blood supply of liver metastatic tumors affects the selection of administration approach and target vessels of interventional therapy. This study was to investigate the blood supply of liver metastatic tumors with both CT arterial portography (CTAP) via the superior mesenterica arterial (SMA) and multi-slice spiral CT perfusion imaging. Twenty...

Hepatic metastases are common for patients with malignant tumors, especially for the gastrointestinal malignancies. Early diagnosis confers better prognosis. This study was designed to investigate the hepatic hemodynamic changes by multi-slice helical perfusion CT in rats with liver micrometastatases of Walker-256 tumor cells. Liver micrometastatas...