Purwantiningsih Sugita

Purwantiningsih Sugita
IPB University | IPB · Department of Chemistry

Professor

About

94
Publications
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348
Citations

Publications

Publications (94)
Article
Full-text available
Sugita P, Ustati MN, Kurniawanti, Syahbirin G, Dianhar H, Rahayu DUC. 2025. Phytochemical analysis and antioxidant activity of Araucaria spp. from Taman Bunga Nusantara, Cianjur, West Java, Indonesia. Biodiversitas 26: 118-126. Araucaria columnaris (AC) and Araucaria cunninghamii (ACu) are members of the Araucaria genus known for their various phar...
Article
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ABSRTACT The Araucariaceae family, a group of coniferous plants, has gained attention for its diverse bioactive compounds, particularly biflavonoids. These natural polyphenolic compounds have demonstrated significant anti-inflammatory properties, making them a promising target for pharmacological research. This review consolidates and critically an...
Article
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Objective: This study aimed to screen 23 biflavonoids (23 BF) from the Araucaria genus to identify the most promising compound for anti-dengue fever antivirus treatment using in silico techniques with yet another scientific artificial reality application (YASARA) Structure and the Protein-Ligand ANT System (PLANTS) programs. Methods: Predictions of...
Article
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The bromination of eugenol using molecular bromine (Br2) has been widely reported. However, the outcomes have been inconsistent, and as a result, the specific steps of the bromination process have not been definitively established. This research aims to synthesize various derivatives of bromo eugenol, incorporating bromine atoms either in the alken...
Article
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Objective: This study aimed to develop, characterize, and conduct stability evaluations to ensure compliance with intravenous administration for microemulsion ibuprofen injection. In addition, hematology assessment and profile of drug release kinetics were analyzed. Methods: The formulation process commenced by introducing various chitosan concentr...
Article
The present study synthesized baked hydrogels by crosslinking reactions from the sugar palm starch and modified chitosan using citric acid as a crosslinker and potassium persulfate as the free radical initiator. Sugar palm starch was derived from the sugar palm (Arenga pinnata) plant, extracted from the stem when it no longer produces sugar and fru...
Article
A ryltetralin and arylnaphthalene lignans consisting of methylenedioxy or trimethoxy groups, such as podophyllotoxin and phyllanthusmin C, are known to have effective anticancer properties. The synthesis of these compounds can be achieved through intramolecular Diels-Alder reactions on cinnamyl cinnamate ester derivatives. Furthermore, this ester i...
Article
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Antioxidants can prevent reactive oxygen-associated diseases, which trigger carcinogenesis, cardiovascular disease, and premature aging. India and Africa have mostly practiced sausage trees (Kigelia africana) as traditional medicine, whereas Indonesia is still limited. The research aims to determine the phytochemistry and bioactivity of the n-hexan...
Preprint
Full-text available
The present study synthesized baked hydrogels by crosslinking reactions from the sugar palm starch and modified chitosan using citric acid as a cross-linker and potassium persulfate as the free radical initiator. Sugar palm starch was derived from the sugar palm ( Arenga pinnata ) plant, extracted from the stem when it no longer produces sugar and...
Article
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Natural zeolite (NZ) from desilication and activation was prepared to support the Ni catalyst. The catalyst was utilized for the hydrodeoxygenation (HDO) of the palm fatty acid distillate (PFAD) into green diesel. Desilication using sodium hydroxide (NaOH) solution increases the porosity, surface area, and acidity of the natural zeolite, thus incre...
Article
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Sansevieria trifasciata (mother-in-law's tongue), an ornamental plant widely found in Indonesia, can absorb electromagnetic radiation in various electronic devices. This study aims to find the best S. trifasciata extract as an electromagnetic and thermal radiation reducer emitted from a smartphone. S. trifasciata leaves were macerated using ethanol...
Article
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Petroleum is the primary energy that is generally used throughout the world. Its non-renewable nature and exhaust gas emissions that can damage the environment are a concern for developing environmentally friendly renewable energy. Green diesel is an alternative energy to replace diesel fuel (diesel) from petroleum which has the potential to be dev...
Article
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The manufacture of vibration damping material from natural rubber (NR) required an increase in dynamic properties, thermal stability, and resistance to heat. Using the Carbon Black N990 as a filler in NR vulcanizates can potentially increase on these properties. This research aims to study the effect of using Carbon Black N990 on dynamic properties...
Article
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Biflavonoids are dimers of flavonoids created by a covalent connection of C-C or C-O-C between two flavonoids and have been found to have a variety of pharmacological effects, including the ability to treat diabetes mellitus (DM). In the current investigation, the inhibitory effect of biflavonoids extracted from Araucaria hunsteinii K. Schum toward...
Conference Paper
Rice husk (RH) is one of Indonesia's abundant rice processing wastes. It is produced in large quantities, but its usefulness is not optimal. RH can be used as raw material for various silica-based. The silica can be synthesized by the sol-gel method. The precursor solution that becomes the based principle of the sol-gel method is then hydrolyzed an...
Article
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The purpose of this research was to characterize the volatile compounds, texture, and color profile of meatballs made from beef, rat, wild boar, and their combinations. Volatile compounds were analyzed using SPME/GC-MS and multivariate data analysis (PCA, PLS-DA). Additionally, several textural features such as hardness, gumminess, chewiness, cohes...
Article
The high beef price triggers adulteration of beef and other non-halal animal meat, such as wild boar and rats. An appropriate and effective analytical method is needed to differentiate halal and non-halal animal meat. The SPME/GC-MS method could authenticate meat based on specific volatile compounds in each meat. The objective of this study was to...
Article
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Plants are like the pharmaceutical industry that provides products that have the potential as active medicinal ingredients. In order to search for compounds useful for health, the purpose of this study was to identify secondary metabolites of Curcuma mango (temu mango) growing in the experimental garden of Biopharmaca LPPM IPB and review its activi...
Article
Natural rubber (NR) is a biopolymer with low vibration damping capacity. NR requires modification of its viscoelastic properties through crosslink in NR vulcanizates molecular chains as vibration damping. This study is the first to report a correlation between crosslink density and dynamic shear properties of NR vulcanizates, including hysteresis l...
Article
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This study reports the optimization of the preparation of etoricoxib (ETX)-loaded low molecular weight of chitosan (LMWC) nanoparticles (ETX-LMWC-NPs) by ionic gelation method with sodium tripolyphosphate (TPP) as cross-linking agent. The independent variables (LMWC/TPP mass ratio, LMWC, and poloxamer 188 concentration) were formulated and optimize...
Article
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Araucaria genera consist of 19 species, and three of them are grown in Botanical Garden, Bogor, Indonesia. These plants were reported to contain biflavonoids and are primarily found in leaves. Biflavonoids display an extensive range of biological properties such as anti-inflammatory, anti-oxidant, anti-tumor, antivirus, anti-microbial, anti-fungal,...
Article
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Injectable ibuprofen has been formulated as nanoemulsion, prodrug microemulsion, and freeze-dried. However, its application is limited because of solubility, high dosing, and complex formulation. Microemulsion ibuprofen injection is an alternative dosage form that increases solubility and bioavailability. The study aimed to formulate an ibuprofen m...
Article
Numerous uses of silica nanoparticles include medication delivery, lightweight aggregates, and energy storage. This work synthesized SiO2-NPs from rice husk (RH) by a sol-gel extraction method. Fourier transform infrared (FTIR), Raman spectroscopy, X-ray diffraction (XRD), X-ray fluorescence (XRF), and scanning electron microscopy (SEM) with energy...
Article
Global infections, such as diarrhea and acute respiratory disease, have urged the researchers in this area to discover coumarin-scaffold antibacterial agents, most widely used therapeutic drugs worldwide. This research aims to synthesize 3-substituted coumarins using microwave-assisted and evaluate their antibacterial activities against Escherichia...
Article
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Coumarins are heterocyclic compounds naturally found in plants. Coumarin-derived compounds have been commonly synthesized and some have exhibited a wide range of bioactivities. In searching for coumarins-based antioxidants and antibacterial, in this study, various 4-methyl coumarins have been synthesized by reacting ethyl acetoacetate with several...
Conference Paper
Electrochemical biosensor based on Bacillus licheniformis whole-cell can detect urea level in a urea solution. The level was indirectly monitored through the ammonia oxidation reaction using B. licheniformis microorganism on an electrode surface. The working electrode was a screen-printed carbon electrode (SPCE). B. licheniformis pellet was placed...
Conference Paper
The synthesis of C-heptylcalix[4]resorcinarene octabenzoate and octacinnamate had been conducted. The activity test as sunscreen compound has also been carried out. The first step of synthesis of C-heptylcalix[4]resorcinarene was the reaction between resorcinol with octanal using HCl catalyst in ethanol at 78 °C for 24 hours to yield C-heptylcalix[...
Conference Paper
Belonging to Zingiberaceae family, temu mangga (Curcuma manga Val) are could be easily found in South East Asian countries including Indonesia. Traditionally, temu mangga have been used to cure many diseases. This research focused to isolate terpenoid compounds from C. mangga Val. rhizomes cultivated in Trop BRC garden LPPM-IPB, West Java, Indonesi...
Article
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Gelatin has been widely used as an additive in food industry pharmaceutical, and cosmetic. The similar physical appearance between bovine and porcine gelatin causes an issue for some communities like a Muslim due to awareness of halal food. This study aims to produce gelatin from femur bones of bovines with acid hydrolysis and their characteristics...
Article
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Electrochemical biosensor based on Bacillus licheniformis whole cell can detect urea level in a synthetic urine. We employed a synthetic urine solution as the urea source, and the level was indirectly monitored through the ammonia oxidation reaction using B. licheniformis microorganism on an electrode surface. The working electrode was a screen-pri...
Article
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White turmeric ( Curcuma zedoaria ) is one of plant species belongs to Zingiberaceae from Himalaya, India. Previous research showed that the rhizomes of this plant contained several secondary metabolites such as alkaloid, phenolic, and terpenoid which commonly known to have antibacterial activities. This study aims to investigate the phytochemical...
Article
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Coumarin derivatives from natural and synthetic sources are an important class of heterocyclic compounds that displayed a broad spectrum of pharmacological properties. Among all coumarin derivatives, 4-methyl coumarin has been essentially used as a building block to afford various chemical structures. In this study, the effect of various phenolics...
Article
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Objective: The aim of the present study is to isolate phenolic compounds from Curcuma zedoaria rhizomes grown in Bogor, West Java, Indonesia, which will enrich phytochemical information from this plant. Methods: C. zedoaria rhizomes were macerated in methanol then followed by increasing polarity partitions with n-hexane, ethyl acetate (EtOAc), and...
Article
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Objective: Phytochemicals are naturally present in every part of plants range from leaves, stem bark, and fruits to roots. The use of plant-based medicine is popular among individuals and communities in developing countries. This study evaluated that the phytochemical profile of Duranta repens fruits was collected from Jombang, East Java, Indonesia...
Conference Paper
Sausage tree (Kigelia africana) is a medicinal plant of Bignoniaceae family which can be used as anticancer. Study on K. africana as an anticancer activity is still restricted to its crude extract while the structure of its active compound is still limited. On the other hand, K. africana in Indonesia has not been used as a medicine. It is only used...
Conference Paper
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Chitosan film has good mechanical properties and can be utilized as biodegradable food packaging. However, its antioxidant activity is low. In this research, ®-carotene and butylated (BHT) was added into chitosan film and their effects on the physico-chemical and antioxidant properties of the film were studied. Glycerol was used as plasticizer. Chi...
Conference Paper
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Phoenix dactylifera L. (date palm) has been used in traditional medicine to treat illnesses. Extracts of P. dactylifera are reported to possess valuable pharmacological attributes. Date seeds are part of the palm trees that have not been widely used, based on previous studies that date seeds contain secondary metabolites such as phenolic acids comp...
Article
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The Melon fly, Zeugodacus cucurbitae (Diptera: Tephritidae), is one of the important pests on vegetables and fruits of Cucurbitaceae family. This study aims to observe population dynamics of fruit fly in three kinds of fruits based on altitude and the phenology of bitter gourd ( Momordica charantia ), angled luffa ( Luffa acutangula ) and cucumber...
Article
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Hepatocellular carcinoma (HCC) accounts for up to 90% of all primary liver cancers worldwide. Cinobufagin is recognized to inhibit miR-494 as the HCC target. Increased expression of TNF-α results in an inadequate response to liver anticancer drugs. The models in this study were cinobufagin, cycloartenol, and ethyl acetate fractions of Ganoderma luc...
Article
Full-text available
An eco-friendly phenol biosensor from Bacillus biofilm was prepared and investigated. The biofilm, which produced tyrosinase enzyme, was successfully immobilized on a screen-printed carbon electrode surface. A total of 72 Bacillus isolates were utilized because of their capability to produce tyrosinase enzyme in tyrosine media. Among them, Bacillus...
Article
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Date seeds are waste from palm fruit processing that has not been utilized optimally. Date seeds contain flavonoids which are known to act as antioxidants. The aim of this study was to determine the antioxidant activity and flavonoid of methanol extract which was carried out by soxhletation and its fractionation results. Date seeds are made into si...
Article
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From the fruit of Kigelia africana three fractions of secondary metabolites were isolated. Fraction 1 (CD-1) was characterized by using UV-Vis, FTIR, 1D and 2D NMR and MS, meanwhile fraction 2 (CD-2) and 3 (B-1) were characterized by LCMS and compared with literature. All these fractions were screened for anticancer activity by using (3-(4,5-dimeth...
Article
Penelitian ini bertujuan untuk membandingkan aktivitas antioksidan, antibakteri, dan uji toksisitas dari berbagai jenis ekstrak kulit batang pohon kesambi (Schleichera oleosa (Lour)Oken). Tahapan penelitian meliputi proses esktraksi kulit batang kesambi dari kecamatan Mancak Serang dengan teknik maserasi bertingkat menggunakan 3 pelarut : Metanol,...
Article
p>Studi mengenai elektrokatalis untuk reaksi evolusi hidrogen (HER) dan evolusi oksigen (OER) sangat diperlukan terkait aplikasinya dalam pengembangan energi terbarukan berbasis hidrogen. Komposit perak nanowires (AgNWs) dengan polianilina (PANI) disiapkan dengan metode polimerisasi radikal dalam larutan matriks kitosan untuk menurunkan ukuran part...
Article
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Red Sayer is one of the date varieties from the United Arab Emirates. This variety is one type of dates that is imported into Indonesia and used as processed date palm juice producing waste, namely date seeds. Date seeds can be made into some coffee that is rich in antioxidants and does not contain caffeine. The purpose of this study is to determin...
Article
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It has been reported that the lidah mertua plant (Sansevieria trifasciata) can absorb electromagnetic radiation from various electronic equipment. The current study aimed to make a film layer from polyvinyl alcohol (PVA) and a dichloromethane (DCM) fraction of S. trifasciata to reduce heat radiation from smartphones. S. trifasciata leaves were mace...
Article
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This study aims to determine the effect of the methanol extract of sea water clams ( Meretrix meretrix ) against blood chemistry profile in vivo in Sprague Dawley rats. After three months fed by two different methanol extract concentration i.e. 0.1 g. kg ⁻¹ body weight (M/0.1) and 1 g. kg ⁻¹ body weight (M/1), blood serum has been taken prior for t...
Article
Malaria masih menjadi salah satu masalah kesehatan di dunia dan Indonesia. Cengkeh (Syzygium aromaticum (L.) Merry & Perry) adalah tanaman asli Indonesia yang berpotensi sebagai fitofarmaka. Tujuan penelitian ini adalah untuk menganalisis aktivitas antimalaria in vitro, uji toksisitas, dan uji penghambatan secara in vivo ekstrak metanol cengkeh var...
Article
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Indonesia adalah salah satu negara penghasil minyak sawit terbesar di dunia. Ketersediaan batang sawit sebagai limbah dari proses panen akhir tanaman sawit sangat besar, murah dan dapat menjadi sumber kayu alternatif yang berkelanjutan untuk berbagai aplikasi jika dapat dimanfaatkan dengan baik. Kelemahan batang sawit adalah berat jenis, sifat fisi...
Article
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Mangosteen peel extract contains xanthone compound having phenol basic structure. Because xanthone is insoluble in water, therefore mangosteen peel extract encapsulated by polymer substance through encapsulation technology is necessity. Mangosteen peel were powdered to 3 sizes. The nanomangosteen peel ethanol extract was encapsulated in various of...
Article
Meretrix meretrix was one of gastropods seawater has been used by people as a food. These shells are still categorized of bycatch and have not explored the benefits. This study aimed to characterize and analyze the content of bioactive Meretrix meretrix. This research was conducted morphological characterization shellfish sensory, measurement of yi...
Article
(-)-Robidanol 1 is a tetrahydroxyflavan-3-ol that has been isolated from Indonesian merbau hardwood (Intsia palembanica). Several bioactivities have been reported as a skin-whitening, anti-acne, and antioxidant agent. However, to isolate this compound from natural sources with reasonable yield requires a tedious work. This study aims to synthesize(...
Article
The rhizomes of Curcuma aeruginosa (Zingiberaceae), locally known as Temu Hitam, is usually used as a traditional medicine. The bioactive compounds in this plant were known to have antibacterial activities. However, information regarding bioactive compounds on antibacterial activity contained in C. aeruginosa rhizomes is still limited. In continuin...
Article
Full-text available
Batang sawit memiliki stabilitas dimensi, kerapatan, sifat fisik, dan mekanik lebih rendah daripada jenis kayu lainnya. Upaya mengatasi kelemahan sifat batang sawit dapat dilakukan melalui pemadatan (densifikasi) menggunakan kempa panas dan penambahan bahan kimia atau perekat. Tujuan penelitian ini adalah untuk mendapatkan komposisi optimal tanin r...
Article
Aim: Herbal plants are widely used to promote and rehabilitate health and to prevent and cure disease. One of the herbal plants that have been used is Curcuma aeruginosa Roxb. (Zingiberaceae), which is commonly called "Temu hitam" in Indonesia. The rhizome of C. aeruginosa has been reported to possess many interesting pharmacological activities suc...
Presentation
Full-text available
(–)-Robidanol 1 is a tetrahydroxyflavan-3-ol that has been isolated from Indonesian merbau hardwood (Intsia palembanica). Several bioactivities have been reported as a skin-whitening, anti-acne, and antioxidant agent. However, to isolate this compound from natural sources with reasonable yield requires a tedious work. This study aims to synthesize(...
Article
Full-text available
Synthesis of glutaraldehyde cross-linked chitosan (chitosan-GA) has been done and characterized by using FTIR and TGA. Adsorption of Fe(III) ion by glutaraldehyde cross-linked chitosan (chitosan-GA) has been studied by using batch method. The objectives of this research are to know optimum adsorption condition of Fe(III) ion by chitosan-GA, then st...
Conference Paper
Separation of Cu (II) ion from a mixture containing Zn (II) ion was conducted by solid-liquid extraction method through column chromatography. The column was filled with FHA-ZEO resin. This resin is the result of immobilized fatty hydroxamic acid (FHA) into activated natural zeolite (ZEO) involving as solid phase. Parameters becoming variable were...
Article
The difference of crude size was reported to give impact over magosteen pericarp nanosized extract (ME) antibacterial and antioxidant activity. Nano-sized ME (213,6 nm) showed the best antibacterial activity in inhibiting the growth of bacteria compared to extract from crude with a particle size of 20 mesh and 40 mesh. In the other hand, its antiox...
Article
Full-text available
Synthesis of glutaraldehyde cross-linked chitosan (chitosan-GA) has been done and characterized by using FTIR and TGA. Adsorption of Fe(III) ion by glutaraldehyde cross-linked chitosan (chitosan-GA) has been studied by using batch method. The objectives of this research are to know optimum adsorption condition of Fe(III) ion by chitosan-GA, then st...
Article
Full-text available
Meretrix meretrix is one of the shells of sea water are widely utilized by people as food. This clam also has many properties and benefits, so in this study tested the effect of the water extract of Meretrix meretrix against blood chemistry profile Sprague Dawley rats with the method (OECD 413: 2009). Based on observations obtained growth, feed int...
Article
Full-text available
Chitosan-glycerophosphate hydrogel can be used as dental scaffold due to its thermosensitivity, gelation performance at body temperature, suitable acidity for body condition, biocompatibility, and ability to provide good environment for cell proliferation and differentiation. Previous study showed that glucose addition to the chitosan solution befo...
Article
Objective: The aim of this study was to evaluate the acute effect of the Kepel leaves extract (Stelechocarpus burahol [Bl.] Hook. F. and Th.) after a single dose oral treatment on the body weight and the organ of Sprague-Dawley (SD) rats. Methods: This experiment was conducted based on the OECD-guideline 401-1999. A single oral dose of the Kepel le...
Article
Full-text available
Biodegradable starch film has potential applications in agriculture, food, and pharmacy. However, film made solely of starch posses poor water resistence, mechanical properties, and antimicrobial activity. In this experiment, some films were prepared by combining starch, chitosan, and lauric acid in various ratios in order to improve those properti...
Article
Kecapi is many contains secondary metabolites that can prevent a variety of diseases. The aims of this study were to obtain active compounds from the kecapi leaves through a purification, which includes vacuum liquid chromatography, gravity column chromatography, radial chromatography and preparative thin layer chromatography as well as the determi...
Article
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Ketoprofen-loaded chitosan was made by modifying poloxamer 188 and also varying time and amplitude of ultrasonication condition. Preliminary tests were carried out by optimizing ultrasonication condition including amplitude and sonication time. Nanoparticles characterization was carried out by using PSA, SEM, FTIR, and XRD. Optimum condition of son...
Article
Full-text available
Aims: To isolate and to characterize the chemical constituents in sinyo nakal (Duranta repens) fruits' methanol extract. The fruits were collected from Jombang, East Java, Indonesia. Methodology: The fruits have been extracted with n-hexane in previous study to separate the nonpolar components. Fractionation of the methanol extract was done by usin...