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Citations since 2016
9 Research Items
Overall success in launching discovered drugs is tightly restricted to the high rate of late‐stage failures that ultimately inhibits medicines distribution in markets. As a result, it is imperative that methods that can reliably predict the effectiveness and, more critically, the toxicity of medicine early in the drug development process before cli...
The targeting nano carriers have been promptly proposed to overcome the current obstacles in conventional chemotherapy approaches for cancer. Currently, PMBN (poly[MPC-co-(BMA)-co-(MEONP)]), is considered as a promising amphiphilic polymer that could be easily targeted and conjugated to hydrophobic substances with low bioavailability. To target bre...
Introduction Paclitaxel (PTX) is an antineoplastic chemotherapeutic drug and is used for the treatment of many types of cancers including breast, ovarian, lung, bladder, prostate, melanoma, esophageal, AIDS-related Kaposi's sarcoma, as well as other types of solid tumor cancers. It can damage the microtubules structure induces apoptosis through a J...
Background: Copper is a pollutant compound which can cause earnest toxicity in human and some organisms. Bioreporters are frugal and non-toxic detectors for pollution compounds. Precedent designed recombinant Escherichia coli copper bioreporters with the lux gene of Vibrio fischeri or Aequorin luciferase of Jellyfish does not provide a high sensiti...
Objective Poly [2-methacryloyloxyethyl phosphoryl choline (MPC)-co-n-buthyl methacrylate (BMA)-co-p-nitrophenyl-oxycrabonyl poly ethylene glycol-methacrylate (ME- ONP)] (PMBN), a biocompatible terpolymer, is a unique polymer with applications that range from drug delivery systems (DDS) to scaffolds and biomedical devices. In this research, we have...
Usually, conventional chemotherapy of leukemia is not successful, as hematopoietic stem cells change to cancer type. So, it seems designing a new targeting system is necessary to overcome this problem. A nano smart polymer, PMBN conjugated with interleukin 3 as a ligand of the CD123 receptor, which is overexpressed on leukemia stem cells, was used...
Today, various polymer nanoparticles have been prepared and utilized successfully in different biomedical applications such as drug delivery systems (DDS). In this research, we have synthesized poly [2-methacryloyloxyethyl phosphorylcholine (MPC)-co-nbutyl methacrylate (BMA)-cop -nitrophenyloxycarbonyl poly(ethylene glycol) methacrylate (MEONP)] (P...
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