
Protus Arrey TarkangInstitute of Medical Research and Medicinal Plants Studies (IMPM) · Centre for Medicinal Plants and Traditional Medicine Research
Protus Arrey Tarkang
Ph.D
About
37
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Introduction
Additional affiliations
November 2019 - November 2019
Institute of Medical Research and Medicinal Plants Studies (IMPM)
Position
- Senior Researcher
Publications
Publications (37)
Female reproductive complications continue to be a major health challenge worldwide. Medicinal plants richer in secondary metabolites such as phytoestrogens have been used over decades for the treatment of reproductive health problems like infertility, with limited knowledge on their toxicities. The present study was designed to evaluate the estrog...
This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues. Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal,...
Chrysanthellum americanum is a medicinal plant widely used in the North region of Cameroon for the treatment of epilepsy and convulsion. This study aimed to investigate the acute and subacute toxicity of the aqueous extract of C. americanum using experimental rodent models. For the acute toxicity test, a single dose of 27.69, 69.22, 138.45, 276.9 a...
Previous studies suggest that 3′,5′-dihydro-2′H-spiro[indoline-3,1′-isoquinolin]-2-ones (DSIIQs [spiroquindolones]) are multitarget antiplasmodial agents that combine the actions of spiroindolone and naphthylisoquinoline antimalarial agents. In this study, 12 analogues of compound (±)-5 (moxiquindole), the prototypical spiroquindolone, were synthes...
Malaria was successfully treated with both natural and synthetic products. However , recent progress in battling malaria has stalled due to drug resistance. Therefore , the search of novel antimalarials capable of reversing or evading resistance is much needed and this could be achieved through ethnomedicinal approaches. Six medicinal plants were s...
Medicinal plants are efficient modulators of oxidative stress associated with diabetes mellitus. This study evaluated the cardio-, reno-, and hepato-antioxidant status of hydroethanolic extract of Costus afer on streptozotocin-intoxicated diabetic rats. Experimental animals were daily administered with hydroethanolic extract of C. afer by oral intu...
Harungana madagascariensis is a medicinal plant used for the treatment of diarrhoeal disease. The present
study evaluated the antidiarrhoeal, antibacterial and safe use of hydro-ethanolic extract of Harungana madagascariensis at acute and subacute administration. The antidiarrhoeal activity was characterized as inhibitor of Castor oil induced diarr...
Consumption of red wine has been associated with low motility rate from cardiovascular diseases. This phenomenon has over the years provoked an increase in wine consumption and its cost price. The present study tests the hypothesis that the cost of red wine is related to its total phenolic content and antioxidant capacity. Sixty seven red wines wer...
There is an urgent need for new anti-malaria drugs with broad therapeutic potential and novel mode of action, for effective treatment and to overcome emerging drug resistance. Plant-derived anti-malarials remain a significant source of bioactive molecules in this regard.
The multicomponent formulation forms the basis of phytotherapy. Mechanistic re...
Than antioxidant capacity of sixteen spices and five vegetables commonly consumed in the West region of Cameroon were evaluated in the study. The total phenolic content (TPC), Ferric Reducing Antioxidant Power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and ABTS⁺ characterized the antioxidant capacity. Samples with best...
Diabetes is commonly characterized by hyperglycemia related to different mechanisms. Many plants have been reported to possess antidiabetic actions in lowering blood sugar concentration and one of such is Costus afer. The present study hypothesis is that methanolic extract of C. afer (leaf, stem, and rhizome) control hyperglycemia by inhibiting glu...
Ethnopharmacological relevance: Epilepsy, called “Awa” in Bamileke tribe, is a neurogical
chronic affection more frequent in Cameroon and especially in Yaounde and its
neighborhoods. Several medicinal plants are used in Cameroon to treat epilepsy and
convulsions. So far, no studies have investigated the ethnomedical follow up epileptic
patients...
The present research evaluated the antidiabetic and antioxidant properties of M. lucida stem bark (50 and 500mg/kg) and glibenclamide (25mg/kg, standard drug) in acute (Oral glucose tolerance test) and sub-acute (Streptozotocin 60mg/kg, i.p. diabetic model) administration. A group of healthy rats constituted the normal control. The sub-acute experi...
Diabetes mellitus is a metabolic disorder of glucose metabolism which correlates with postprandial hyperglycemia and oxidative stress. Control of blood glucose level is imperative in the management of diabetes. The present study tested the hypothesis that
Costus afer
, an antihyperglycemic medicinal plant, possesses inhibitory activity against carb...
Diabetes mellitus is a metabolic disorder of glucose metabolism which correlates with postprandial hyperglycemia and oxidative stress. Control of blood glucose level is imperative in the management of diabetes. The present study tested the hypothesis that Costus afer, an antihyperglycemic medicinal plant, possesses inhibitory activity against carbo...
Nefang is a polyherbal anti-malarial composed of Mangifera indica ( MiB and MiL; bark and leaf), Psidium guajava ( Pg ), Carica papaya ( Cp ), Cymbopogon citratus ( Cc ), Citrus sinensis ( Cs ) and Ocimum gratissimum ( Og ) (leaves). Previous studies have demonstrated its in vitro and in vivo antiplasmodial activities, antioxidant properties and sa...
Nefang is a polyherbal product composed of Mangifera indica (bark and leaf), Psidium guajava, Carica papaya, Cymbopogon citratus, Citrus sinensis and Ocimum gratissimum (leaves). It is often used in Cameroon traditional medicine as an antimalarial. Previous studies have demonstrated its in vitro antiplasmodial activity, synergistic interactions bet...
Nefang is a polyherbal product composed of Mangifera indica (bark and leaf), Psidium guajava, Carica papaya, Cymbopogon citratus, Citrus sinensis and Ocimum gratissimum (leaves). It is often used in
Cameroon traditional medicine as an antimalarial. Previous studies have demonstrated its in vitro antiplasmodial activity, synergistic interactions bet...
The present study evaluates the protective effect of Morinda lucida (M. lucida) stem bark extract for protection of the liver against paracetamol induced toxicity. The experimental design constituted of 4 groups of 5 animals each serving as normal control (received distilled water), pathology control (received paracetamol, 2.5 g/kg p.o) and the rem...
The present study was designed to evaluate R. heudelotii, S. zenkeri, A lepidophyllus, I. gabonensis and T. vulgaris, common Cameroonian spices for radical scavenging activity. This was carried out by analysing their methanolic extracts against different assays such as DPPH, superoxide radical, hydroxyl radical, and nitric oxide and their reducing...
Background
The emerging resistance of Plasmodium species to currently available anti-malarials remains a public health concern, hence the need for new effective, safe and affordable drugs. Natural products remain a reliable source of drugs. Nefang is a polyherbal anti-malarial of the Cameroonian folklore medicine with demonstrated in vitro antiplas...
Nefang, a polyherbal product composed of Mangifera indica (bark and leaf), Psidium guajava, Carica papaya, Cymbopogon citratus, Citrus sinensis, and Ocimum gratissimum (leaves), is a potential therapy against P. falciparum malaria. In vitro antiplasmodial activities of its constituent solvent extracts were analyzed on CQ-sensitive (3D7) and multidr...
Content:
Justicia hypocrateriformis Vahl (Acanthaceae) is used as an herbal remedy for diarrhea in Cameroon folk medicine.
Objective:
This study evaluates the antidiarrheal and antioxidant properties of the aqueous extract of J. hypocrateriformis (JH).
Materials and methods:
Preliminary phytochemical screening and an acute toxicity testing of...
Background
The ancient tradition of sourcing treatment from herbs has resulted into traditional medicine being the first point of healthcare for many people who lack access to modern medical facilities [1] as evidenced by the indigenous knowledge and folk use of Nefang, a polyherbal product composed of Mangifera indica (bark and leaf), Psidium guaj...
Ricinodendron heudelotii is a valuable multipurpose tree from Africa that is lacking an efficient and inexpensive vegetative propagation method. To improve multiplication, a series of nursery experiments were conducted to assess the effect of propagation media, plant growth regulators (NAA and IBA), accession source harvest timing, cutting type, an...
Following the ethnopharmacological justification of the use of Nefang, a polyherbal product composed of Mangifera indica (bark and leaf), Psidium guajava, Carica papaya, Cymbopogon citratus, Citrus sinensis, Ocimum gratissimum (leaves), for the management of malaria [1], the antioxidant potential was evaluated for its therapeutic value. In vitro an...
Ethnopharmacological evidence of the folk use of Nefang, a polyherbal product composed of Mangifera indica (bark and leaf), Psidium guajava, Carica papaya, Cymbopogon citratus, Citrus sinensis, Ocimum gratissimum (leaves), for the treatment of malaria has been reported previously [1]. In vitro antiplasmodial activities of the constituent plant extr...
Nefang is a polyherbal product composed of Mangifera indica (bark and leaf), Psidium guajava, Carica papaya, Cymbopogon citratus, Citrus sinensis, and Ocimum gratissimum (leaves), used for the treatment of malaria. Compounds with antioxidant activity are believed to modulate plasmodial infection. Antioxidant activity of the constituent aqueous plan...
Cymbopgon citratus is well known for its extensive use in folk medicine. Its essential oils and extracts have been shown to have antimalarial, antileshmanial, hypolipidemic, hypoglycemic, antioxidant, anti-inflammatory, antifungal and antibacterial activities amongst others. This study was carried out to assess the effect of long-term oral administ...
Nefang is a polyherbal preparation constituted of the leavesof six plants and the bark of one of these,used
traditionally for the treatment of malaria by the Bayang community, South West Region of Cameroon. Since no ethnopharmacological survey has been carried out on this preparation, this study aims at obtaining indigenous and folkloric informatio...
Ethnopharmacological evidence of the folk use of Nefang, a polyherbal product composed of Mangifera indica (bark and leaf), Psidium guajava, Carica papaya, Cymbopogon citratus, Citrus sinensis, Ocimum gratissimum (leaves), for the treatment of malaria has been reported previously [1]. In vitro antiplasmodial activities of the constituent plant extr...
Morinda lucida is used as a remedy for diabetes and some other diseases in African folk medicine. In an acute toxicity study, Morinda lucida extract was administered orally at doses ranging between 2-20 g kg -1 to experimental mice and observed for any toxic symptoms up to 14 days. In the sub-acute toxicity, Morinda lucida stem bark extract was tes...
Momordica charantia(MC) commonly called balsam pear or bitter melon has been implicated in hypoglycemia and other pharmacological activities. Aqueous extract of the leaves of Momordica charantia(MC) was tested for hypoglycemic activity by oral administration to both normal rats and alloxan-induced diabetic rats for 28 days. Wistar rats were divided...
Due to the decreasing efficacy and increasing contraindications of synthetic drugs, the use of natural drugs is on the rise and as a result, self-medication is very frequent. Citrus sinensis, of Asian and Indian origin is cultivated all around the world and use of its fruits as food and other parts for treatment of various illnesses is frequent in...
In an attempt to mobilize indigenous healthcare knowledge, we carried out an acute and chronic oral toxicity study on the aqueous and ethanol leaf extracts of Carica papaya (CP) in Wistar rats. Pawpaw (Carica papaya L.)is a popular fruit tree of tropical origin. The fruits serve as fruits and vegetables worldwide. Its reported ethnomedical uses inc...
Morinda lucida is used as a remedy for diabetes and some other diseases in African folk medicine. In an acute toxicity study, Morinda lucida extract was administered orally at doses ranging between 2-20 g kg-1 to experimental mice and observed for any toxic symptoms up to 14 days. In the sub-acute toxicity, Morinda lucida stem bark extract was test...