Professor Ruchi Tiwari

Professor Ruchi Tiwari
Pranveer Singh Institute of Technology | psit · Department of Pharmacy

M. Pharm. (Pharmaceutics), Ph.D. Nanotechnology

About

132
Publications
152,731
Reads
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2,377
Citations
Citations since 2017
69 Research Items
1864 Citations
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Introduction
Dr. Ruchi Tiwari is Professor in Department of Pharmaceutics at the Pranveer Singh Institute of Technology, Kanpur. She completed her PhD from JNU in 2013. She completed A1 Level course of French Language by Lingua Franca Institute in 2018. She is Life member of “Foundation for Health & Environment Research”. Her biography features in Marquis 'Who's Who in Medicine and Healthcare' and invited for Great Minds of the 21st Century, Sixth Edn. https://scholar.google.com/citations?user

Publications

Publications (132)
Article
The present study aims at the development and evaluation of dental gel containing metronidazole non-biodegradable polymers for targeted delivery of drug and thus prolonging the action. Hot Method was used for the preparation of gel. Natural polymers like, Guar gum, Sodium alginate, Chitosan, Xanthan gum, Gellan gum were used in the formulations of...
Article
Cancer can be described as the abnormal cell division which is uncontrolled and involves the destruction of neighbour cells and tissues. This condition is significantly holds up a fact that 18 million fresh cases were detected during 2018 and the prevalence rate of cancer within 0 to 74 years is 20.2%. WHO stated that 9.6 million deaths worldwide o...
Article
Background Diabetes foot ulcers (DFU) are among the most common complications in diabetic patients, leading to amputation and psychological distress. This mini-review covers the general physiology of ulcer healing as well as the pathophysiology of DFU and its therapies. Only a few treatments have been sanctioned and numerous compounds from various...
Article
Background: Herbal preparations with low oral bioavailability have a fast first-pass metabolism in the gut and liver. To offset these effects, a method to improve absorption and, as a result, bioavailability must be devised. Objective: The goal of this study was to design, develop, and assess the in vivo toxicity of polyherbal phytosomes for ova...
Article
To look into the ethics of using computers in pharmaceutical research, as well as the issues that come with it and start by looking at how philosophers think about computer ethics. With regard to computer ethics, the philosophical community is unsure whether or not it is confronted with a whole new topic of study. We identify the issues and areas i...
Article
Diabetic wound healing is a complicated procedure because hyperglycemia changes the various stages of wound healing. In type 2 diabetes mellitus (T2DM), oxidative stress is proven to be a critical factor in causing non-healing wounds and aggravating the inflammatory phase, resulting in the amputation of lower limbs in T2DM patients. This makes scie...
Article
Full-text available
This article will provide information about pharmaceutical robots used in industry, as well as assemble and analyse data from previous years on the market's deploy only few micro or nanotechnology robots are now available for distribution of medicines. These robots have use in sterile production, laboratories, packaging, 3D printing, and other area...
Article
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Artificial Intelligence (AI) aims to create intelligent modelling that aids in imagining information, solving problems, and making decisions. In recent years, AI has become increasingly relevant in areas of pharmacy such as drug discovery, drug delivery formulation development, polypharmacology, hospital pharmacy, and so on. Artificial Neural Netwo...
Article
Purpose The goal of the present research was to isolate a biopolymer from Phaseolus vulgaris (P. vulgaris) and Zea mays (Z. mays) plants and used it to construct Resveratrol (RES)-loaded translabial films. Methods Biopolymers were extracted from P. vulgaris and Z. mays seeds using a simple process. Separated biopolymers, sodium carboxy methylcellu...
Article
Background Biochanin-A (5,7 dihydroxy 4 methoxy isoflavone), a phytochemical phytoestrogen that serves as a protector/saviour of humans against various diseases. Biochanin-A is a nutritional and dietary isoflavonoid naturally present in red clover, chickpea, soybeans, etc, and various other herbs. The biochanin A possesses numerous biological activ...
Article
The idea of employing natural cell membranes as a coating medium for nanoparticles (NPs) endows man-made vectors with natural capabilities and benefits. In addition to retaining the physicochemical characteristics of the NPs, the biomimetic NPs also have the functionality of source cell membranes. It has emerged as a promising approach to enhancing...
Article
The idea of employing natural cell membranes as a coating medium for nanoparticles (NPs) endows man-made vectors with natural capabilities and benefits. In addition to retaining the physicochemical characteristics of the NPs, the biomimetic NPs also have the functionality of source cell membranes. It has emerged as a promising approach to enhancing...
Article
Background Migraine is a common neurological condition marked by frequent mild to extreme headaches that last 4 to 72 hours. A migraine headache may cause a pulsing or concentrated throbbing pain in one part of the brain. Nausea, vomiting, excessive sensitivity to light and sound, smell, feeling sick, vomiting, painful headache, and blurred vision...
Preprint
Full-text available
Purpose Daidzein (DZ) is an isoflavone derived from soy plants that has a wide range of nutritional benefits. The cardioprotective effect of DZ on isoproterenol-induced myocardial infarction (MI) injury in rats was investigated in this work. Methods DZ (10 and 20 mg/kg) was given to adult male Wistar Albino rats on a daily basis for 6 weeks. After...
Article
Full-text available
Background Hair loss is a relatively common occurrence that causes concern in people of all ages. In most cases, hair loss is permanent, but it can lead to alopecia. Hair root activation is necessary to improve hair development and prevent hair loss. Herbal cosmetics are increasingly widely used by the general public due to the concept of fewer adv...
Article
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Background In this paper, the influence of the Ramberg-Osgood exponent on the ultimate behaviour of the H-shaped (or I-shaped) aluminium beams subjected to non-uniform bending moment is investigated. Methods In particular, the results of a wide parametric analysis recently carried out by the authors are herein exploited to point out the influence...
Article
Full-text available
In medicine, the expansion of artificial intelligence (AI)-based technologies is accelerating briskly. Deep neural networks, natural language processing, machine learning, robotics, and medical imaging have all been developed in a fresh year as part of a major artificial intelligence program. Many of the health services currently delivered by clini...
Article
The present study assessed the topical potential of nanofibers loaded with Mupirocin (MUP) for the treatment of burns. Nanofibers of MUP were composed of Polyvinyl Pyrrolidone (PVP), Gelatin Type-A, and Ethanol using two methods: Solvent casting and Electrospinning. Nanofibers were characterized for Fourier transform infrared spectroscopy (FTIR), s...
Article
Background: In the mammalian system, the hair follicle is known to be the most significant organ that determines appearance, gender distinction, provides intense temperature protection, and plays a role in self-defense. The younger generations have begun to suffer from extreme hair loss problems due to many lifestyle-related changes such as fatigue...
Article
Full-text available
Resveratrol (RSV), the most effective stilbene phytoalexin synthesized naturally or induced in plants as part of their defense mechanism, is a key component of natural phenolic compounds and is being considered as a treatment option for a variety of diseases. RSV was discovered in the skin of red grapes, mulberries, peanuts, pines, and Polygonum cu...
Article
Full-text available
Background In the mammalian system, the hair follicle is known to be the most significant organ that determines appearance, gender distinction, provides intense temperature protection, and plays a role in self-defense. The younger generations have begun to suffer from extreme hair loss problems due to many lifestyle-related changes such as fatigue,...
Article
Full-text available
Suggested cell entry mechanisms of SARS-CoV-2 are binding of S1 protein present on spikes of SARS-CoV-2 with the cell surface of hACE2 and S-protein priming by the serine protease, Transmembrane Serine Protease 2 (TMPRSS2) and cysteine protease, Cathepsin B and L (Cat B/L). Melittin is the primary constituent of Apis mellifera, the European honeybe...
Research
Background: Apis mellifera, European honey bee venom (BV) is a complex combination of chemical compounds comprising proteins, peptides, enzymes, and other small molecules. Melittin (MEL), which is the key component of BV is considered as an alternative for treatment of various infections. MEL is an amphipathic, cell-penetrating, 26-residue, ahelica...
Research
https://www.youtube.com/watch?v=45WXZ7WVg1Y&t=200s
Article
Full-text available
The topical delivery offers numerous benefits, such as the ability to deliver drugs specifically on site selectively, prevents fluctuations in the levels of the drug, improved compliance, and improved self-medication capacity. Skin is the main route of the administration of the drug delivery system (DDS) and burns mainly cause skin damage. A burn i...
Article
Background: Chronic hyperglycaemia and related complications involving peripheral nerves in diabetes are one of the most severe microvascular complications with an average prevalence of 50-60%. Diabetic neuropathy is among the vascular disorders of diabetes, the most debilitating and crippled, lethal condition impacting patients's quality of life....
Presentation
Webinar was about Nanotechnological Aspects of Materials.
Article
Full-text available
Background The present study assessed the transdermal potential of transferosomes loaded with allopurinol for the treatment of gout. Methods Transferosomes of allopurinol were composed of different ratios of tween-80, soya lecithin and solvent using a thin-film hydration method. Transferosomes were characterized for scanning electron microscopy (S...
Article
Background: Clinically, melatonin (MLT) has variable oral absorption and extensive first-pass effect, making its oral mode less preferable. Ethosomes are able to permeate intact through the human skin due to its high deformability. Aim: Present study assessed topical potential of ethosomes loaded with MLT for the prevention of UV radiation. Met...
Article
Full-text available
Background: Tretinoin and 5-fluorouracil are indicated for treatment of various skin disorders and actinic keratosis respectively. Objective: Present study was focused to design liposomes containing 5- fluorouracil and tretinoin. Design was further optimized by 3² full factorial design. Methods: Liposomes were prepared by ethanol injection method...
Book
Full-text available
"Intellectual Property Rights And Drug Regulatory Affairs" authored by Dr Ruchi Tiwari, Dr Gaurav Tiwari (Publisher: NIRALI PUBLICATIONS) consists of 24 Chapters including focus on Current Good Manufacturing Practices (cGMPs), Good Clinical Practices (GCPs), intellectual property rights, trade marks, different schedules, regulatory requirement for...
Article
Full-text available
Objective: The neuropharmacological activities of ethanolic extract derivatives of lupeol are being screened on rats. Prepared derivatives are evaluated for their locomotor, anxiolytic and stereotype activities. The present investigation was designed to evaluate the antipsychotic effect of semisynthetic derivatives of lupeol using rat models of ele...
Article
Objective: The neuropharmacological activities of ethanolic extract derivatives of lupeol are being screened on rats. Prepared derivatives are evaluated for their locomotor, anxiolytic and stereotype activities. The present investigation was designed to evaluate the antipsychotic effect of semisynthetic derivatives of lupeol using rat models of ele...
Article
Tretinoin (TTN), acne vulgaris, melasma, fotoyaşlanma, foliküler keratoz ve keratinizasyon bozukluklarının tedavisinde kullanılır. 5-Florourasil (5FU) kanser tedavisinde kullanılan bir ilaçtır ve antimetabolitler sınıfında yer almaktadır. Araştırmanın amacı yeni 5FU ve TTN içeren lipozomların tasarımlanması olarak belirlenmiş ve 32 tam faktöriyel t...
Article
Full-text available
In designing of Prodrugs, targeting can be achieved in two ways: site-specified drug delivery and site-specific drug bioactivation. Prodrugs can be designed to target specific enzymes or carriers by considering enzyme-substrate specificity or carrier-substrate specificity in order to overcome various undesirable drug properties. There are certain t...
Article
Introduction Transferosomes also known as ultra-deformable liposomes were introduced by Gregor Cevc in 1990. These are deformable vesicles that transport drug across the skin, which is the best route of drug delivery because skin is the largest human organ with 3 kg total weight and a surface area of 1.5-2.0 m2. Methods Transferosomes are able to...
Article
Total Quality Management (TQM) is an approach that seeks to improve quality and performance which will meet or exceed customer expectations. This can be achieved by integrating all quality-related functions and processes throughout the company. TQM looks at the overall quality measures used by a company including managing quality design and develop...
Article
Full-text available
Objective: The objective of the current study was to assess the knowledge, attitude, and practices (KAPs) regarding diabetes and foot care in diabetic and non-diabetic participants as well as to detect the efficiency of nerve heed herbal oil (NHHO) prepared by Diabport Pvt. Ltd. on pain associated with nerves.Methods: A statistical analysis of soci...
Article
Full-text available
Background and Objective Applying Ethosomal Gels (EGs) in transdermal drug delivery systems has evoked considerable interest because of their good water-solubility and biocompatibility. The aim of present study was to prepare and characterize ethosomes of antileprotic drug Dapsone (DAP) together with an antibiotic Cloxacillin Sodium (CLXS) which ma...
Article
Warts clinically are skin infections caused by Human Papilloma Virus (HPV). Some warts are painful while others cause frustration in patients. Warts are contagious and need to be diagnosed clinically from the outgrowth of skin. Topical retinoids have clinical use for treatment of chronic skin conditions. Topical retinoids for treatment of skin canc...
Article
Full-text available
In present study, matrix tablets of Omeprazole (OPZ) were formulated by wet granulation technique using a combination of hydroxyl propyl methyl cellulose (HPMC K15M) and ethyl cellulose (EC) in varying ratios and the effect of polymer ratio as well as their concentration on drug release profile was investigated. Response surface methodology (RSM) w...
Article
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Social media are now providing a space to discuss medical conditions outside of the healthcare providers’ office. Patients and their families use social media technologies to share their experiences and their findings and educate others with similar conditions. Social media provides a forum for reporting personal experiences, asking questions, and...
Book
Full-text available
This book consists of 24 chapters. A topic includes and focuses on Current Good Manufacturing Practices (cGMPs), Good Clinical Practices (GCPs), intellectual property rights, trade marks, different schedules, regulatory requirement for packaging material, ICH Guidelines for stability and safety, specifications for clinical trials and the correspond...
Article
Novel drug delivery system aims to deliver the drug at a rate directed by the needs of the body during the period of treatment, and target the active entity to the site of action. A number of novel drug delivery systems have emerged encompassing various routes of administration, to achieve controlled and targeted drug delivery, dendrimer carriers b...
Article
Full-text available
Introduction: The work was aimed to develop an enteric-coated hydroxypropyl methylcellulose (HPMC) capsules (ECHC) plugged with 5-fluorouracil (5-FU)-loaded microsponges in combination with calcium pectinate beads. Materials and methods: The modified quasi-emulsion solvent diffusion method was used to prepare microsponges. A 3(2) factorial desig...
Article
Full-text available
The work was aimed at developing novel enteric coated HPMC capsules (ECHC) plugged with 5 Florouracil (5-FU) loaded Microsponges in combination with calcium pectinate beads. Modified quasiemulsion solvent diffusion method was used to formulate microsponges based on 32 factorial design and the effects of independent variables (volume of organic solv...
Article
Full-text available
Unlabelled: The present investigation studied a novel bilayer tablet having an extended release system of metformin HCl with Eudragit RS 100 and RL 100 and an immediate release system of acarbose with polyvinylpyrrolidone K30 (PVP K30) and polyethylene glycol 6000 (PEG 6000) in different ratios using solvent evaporation and cogrinding techniques....
Article
Full-text available
The present investigation studied a novel Bilayer tablet having extended release (ER) system of metformin HCl (M.HCl) with Eudragit RS 100 and RL 100 and immediate release (IR) system of Acarbose with PVP K30 and PEG 6000 in different ratios using solvent evaporation technique. Solid dispersions (SDs) were characterized by Fourier Transform-Infra R...
Article
Full-text available
Solid dispersions are one of the most promising strategies to improve the oral bioavailability of poorly water soluble drugs. By reducing drug particle size to the absolute minimum, and hence improving drug wettability, bioavailability may be significantly improved. This article reviews the various preparation techniques for solid dispersion and co...
Article
Full-text available
The aim of this study is to screen the polyherbal preparation for antidiabetic activity in rats. The blood glucose lowering activity of the polyherbal preparation-I (1:1:1 of wheat germ oil, Coraidrum sativum, and Aloe vera) was studied in normal rats after oral administration at doses of 1.0 ml/kg and 2.0 ml/kg and polyherbal preparation-I, II (wh...
Article
Full-text available
Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. For the treatment of human diseases, nasal and pulmonary routes of drug delivery are gaining increasing importance. These routes provide promising alternatives to parenteral drug delivery particularly for peptide a...
Article
Investigation on binary and ternary systems of β-cyclodextrin (β-CD) and hydroxypropyl-β cyclodextrin (HPβ-CD) with Polyvinylpyrrolidone (PVP) on the solubility of Meloxicam (MX) was studied. Phase solubility analysis with PVP K-30 v was used to investigate interactions in aqueous solution between MX and the carrier, either alone or in combination....