Professor Sanjeev Singh

Professor Sanjeev Singh
Kwame Nkrumah University of Science and Technology | KNUST · Department of Anaesthesiology and Intensive Care

M.D, FA, FCA
Department of Anaesthesiology and Intensive Care

About

53
Publications
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Introduction
Prof. Sanjeev Singh is currently working in the Department of Anaesthesiology and Intensive Care at the Kwame Nkrumah University of Science and Technology. Sanjeev does research in critical care, anaesthesia, cardiothoracic surgery, cardiology, and advanced life support. Recent works are comparative studies of the antifibrinolytic and haemostatics effects on patients undergoing mitral valve replacement surgery, obstructed TAPVC repair with milrinone, and inhaled nitric oxide.

Publications

Publications (53)
Article
Full-text available
COPYRIGHT: ©2023 (Sanjeev Singh) et al. This is an open-access journal, and ar cles are distributed under the terms of the Crea ve Commons A ribu on License CC-BY 4.0. (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribu on, and reproduc on in any medium, provided the original authors and source are credited. ABST...
Article
Background Cardiopulmonary bypass (CPB) during open-heart surgery is associated with increased body fluids as a consequence of hemodilution due to the use of CPB. Ultrafiltration (UF) is a method used to decrease the body fluid volume on CPB. Aims and Objectives This study aimed to compare the effects of combined conventional UF (CUF) and modified...
Article
Background The objective of the study was to use docking and pharmacological research to explore phytochemicals as therapeutic candidates for the treatment of type 2 Diabetes Mellitus. Methods The 100 plant compounds for the study were selected after a thorough review of the most recent literature using PubMed and Google Scholar. Three-dimensional...
Article
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This study aimed to compare whether Bispectral Index (BIS) reduces the consumption of the anaesthetic drug and improves recovery time in coronary artery-bypass grafting off-pump (CABG-OP) surgery without awareness during surgery (ADS). The study was a single centre, prospective, randomised, and double-blind comparative research on ASA 3 patients bo...
Article
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Diabetes mellitus is a severe metabolic disorder, which consistently requires medical care and self-management to restrict complications, such as obesity, kidney damage and cardiovascular diseases. The subtype gestational diabetes mellitus (GDM) occurs during pregnancy, which severely affects both the mother and the growing foetus. Obesity, uncontr...
Article
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Objective The objective of the study is to evaluate the effectiveness and safety of epsilon-aminocaproic acid (EACA) and tranexamic acid (TXA) in reducing bleeding, re-exploration, and blood transfusion in patients who underwent a cardiac surgical procedure for mitral valve replacement on cardiopulmonary bypass. Methods A single-center, prospectiv...
Article
Background: Worldwide, 21% of deliveries are by elective cesarean sections (C/S) as a procedure to reduce maternal and neonatal mortality and morbidity. Blood loss during C/Ss is more than vaginal delivery. Therefore, reducing blood loss during the C/Ss is essential and challenging for anesthesiologists and obstetricians. This study aimed to assess...
Article
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Background: Protamine neutralises heparin after separation from cardiopulmonary bypass. This study aimed to evaluate the effects of lidocaine on protamine induced pulmonary vascular constriction in paediatric cardiothoracic surgery. Methods: This was a single-centre, prospective, double-blind and randomised study conducted among eighty pediatric pa...
Article
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Current practice for chemotherapy in most oncology departments is the use of dedicated venous access for the continuous and frequent delivery of drugs, fluids and blood products, and the monitoring of the effects of treatment. The frequent venipuncture of peripheral veins is associated with various complications and discomfort to the patients. Perm...
Article
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Introduction: Diaphragmatic injuries may be associated with thoracoabdominal blunt or penetrating traumas. The diagnosis is often delayed, despite the availability of several medical imaging modalities. The surgical management remains controversial, in terms of the choice of surgical approach and the surgical repair technique. Aim: To evaluate t...
Article
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Objective: Chest trauma, as blunt or penetrating injury, account for significant amount of all traumatic injuries. They are associated with high mortality of about 75% of all trauma-related deaths, either from direct or indirect consequence of the injury. Nearly 80-85 % of chest trauma is managed conservatively with only about 10-15 % needing emerg...
Article
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Background Infant mortality due to congenital malformations has an incident rate of 8 cases per 1000 live births. Due to Africa's inadequate health-care systems, congenital cardiac disease (CCD) remains a paediatric health-care issue. CCD patients undergo an open-heart operation (OHO) at the Komfo Anokye Teaching Hospital (KATH) in Kumasi. Aim Thi...
Article
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A high number of leucocytes reside in the human endometrium and are distributed differentially during the menstrual cycle and pregnancy. During early pregnancy, decidual natural killer (dNK) cells are the most common type of natural killer (NK) cells in the uterus. The increase in the number of uterine NK (uNK) cells during the mid-secretory phase...
Article
Background: In patients undergoing coronary artery bypass grafting off-pump (CABG-OP) surgery with limited haemodynamic reserve, achieving the ideal anaesthesia depth is challenging. The risk of awareness during surgery increases with light anaesthesia, too deep anaesthesia can cause hypotension, delayed awakening, and increased morbidity and morta...
Article
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Background: In recent years, smartphone applications (apps) have generated an increasing interest worldwide. Anaesthesia, as a profession, has been one of the first to adopt new technologies. Aims and Objectives: This study aimed to assess the pattern of smartphone use in anaesthesia practice (duration, frequency and purpose of use), determine the...
Article
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The extracellular matrix (ECM) plays an important role in the evolution of early metazoans, as it provides structural and biochemical support to the surrounding cells through the cell–cell and cell–matrix interactions. In multi-cellular organisms, ECM plays a pivotal role in the differentiation of tissues and in the development of organs. Fibulins...
Article
Background: Cancellation of elective surgery is a worldwide problem. The situations where patients' surgical appointments are cancelled are an unfortunate occurrence within medical practice. The main objective of this study was to survey the frequency of cancellation, reasons, and its psychological effect on patients at Komfo Anokye Teaching Hospit...
Article
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Arteriovenous malformation (AVM) are vascular anomalies that arise due to abnormal connection with shunting of blood from arteries to veins without an intervening capillary network. They are mostly found intracranially but extracranially, the scalp AVM cases are also well reported. However, arterio-venous malformation (AVM) of the scalp is a rare l...
Article
Abstract Background Bispectral index (BIS) monitoring reduces the utilisation of anaesthetic agents during general anaesthesia during surgery. This study was designed to test whether the use of BIS monitoring reduces the anaesthetic requirements during off-pump (OP) coronary artery bypass grafting (CABG) and its effect on the clinical outcome. Mate...
Article
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Abstract: Tracheal webs are rare anomalies that can be either congenital (Legasto, A. C. et al., 2004) or acquired (Yin, Y., & Zhang, L. 2010) due to prolonged or traumatic endotracheal intubation (Linna, O. et al., 2002). Patients with tracheal webs present with shortness of breath especially during exertion, stridor, and recurrent chest infection...
Article
Abstract: Sinus of Valsalva aneurysm (SOVA) is not only a rare anomaly but also not commonly associated with Tetralogy of Fallot (TOF) patients. The incidence of the SOVA is 0.09% in the general population and it is associated with only 2% of TOF patients. This combination of unruptured SOVA with TOF makes it unique. We present this case of a 4½- y...
Article
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The durability of artificial bioprosthestic or tissue heart valves is limited by structural valve deterioration (SVD) due to long-term calcification especially in young patients and in Africa. A novel bioprosthestic valve, the Resilia Inspiris Aortic Tissue Valve has been developed which, in preclinical studies, has shown reduced calcification thus...
Article
Background: Cancellation of elective surgery is a worldwide problem. The situations where patients' surgical appointments are cancelled are an unfortunate occurrence within medical practice. The main objective of this study was to survey the frequency of cancellation, reasons, and its psychological effect on patients at Komfo Anokye Teaching Hospit...
Article
Full-text available
Background: Cardiopulmonary bypass (CPB) is associated with increased fluid accumulation in body and ultrafiltration is a method used to decrease body fluid volume and tissue oedema as the consequences of haemodilution after cardiac surgery with CPB. This study aimed to compare the effects of modified ultrafiltration (MUF) versus combined conventio...
Article
Background and objectives Educational initiatives are a sustainable means to address provider shortages in resource-limited settings (RLS), yet few regional anesthesia curricula for RLS have been described. We sought to design a reproducible training model for RLS called Global Regional Anesthesia Curricular Engagement (GRACE), implement GRACE at a...
Article
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Email address: To cite this article: Sanjeev Singh. A Comparative Clinical Study of Oral Clonidine Versus Intravenous Clonidine on Haemodynamic Changes due to Laryngoscopy and Endotracheal Intubation. Abstract: Laryngoscopy with or without endotracheal intubation amounts to a highly noxious stimulus to the haemodynamics of a patient and various eff...
Article
Full-text available
Abstract Gastric perforation into the thoracic cavity through a diaphragmatic rupture is rare but, when it occurs, patients present in severe distress, with mortality approaching 50%. We present our experience of two rare and unusual cases of traumatic diaphragmatic rupture from penetrating chest injury associated with herniated intrathoracic gastr...
Article
Full-text available
Abstract Background: Ultrafiltration is a method used to decrease body fluid volume and tissue oedema as the consequences of hemodilution after cardiac surgery with cardiopulmonary bypass (CPB). Combined conventional (CUF) and modified ultrafiltration (MUF) may offer advantages in comparison with conventional ultrafiltration. We conducted a prospec...
Article
Smartphones are used in many areas of anaesthesia practice. However, recent studies have expressed concerns about smartphone uses in the operating room. It is hoped that this study might serve as a modest beginning to the assessment smartphone's future in the operating room in developing countries. We performed a survey to learn about the smartphon...
Article
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Liver transplant centers often establish hemoglobin A1c (HbA1C) criteria for candidates with type 2 diabetes mellitus (T2DM) based on data from other surgical specialties showing worse outcomes in patients with poor glycemic control. However, because of the reduced reliability of HbA1C in cirrhosis, it is unclear whether pretransplant HbA1C values...
Article
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Open heart surgeries under cardiopulmonary bypass are associated with excessive perioperative bleeding that often requires re-exploration. Antifibrinolytics like epsilon aminocaproic acid and tranexamic acid are widely used to control bleeding. There is paucity of literature on studies to reduce blood loss and blood transfusion following mitral val...
Article
Full-text available
Introduction: Anaesthesia for these patients undergoing for interventional procedures in paediatric patients with congenital cardiac anomalies remains a challenge for the anaesthesiologist. There are no specific techniques to follow and anaesthetic procedure is modified according to the cardiac anomalies, clinical condition of the patients and the...
Article
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Abstract: Transposition of the great arteries with an intact ventricular septum and aortopulmonary window is an extremely rare anatomic combination associated with high morbidity and mortality. We report a case of a 24days neonate with dextro-transposition of the great arteries with intact ventricular septum and a large aortopulmonary window as a m...
Article
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Pheochromocytoma is a neuroendocrine tumour of chromaffin cells, though rare but a known cause of paroxysmal hypertension with a triad of headache, diaphoresis and palpitation. The biochemical diagnosis of pheochromocytoma is based on estimation of plasma nor-adrenaline, adrenaline and their metabolites in plasma or urine. Clonidine suppression tes...
Conference Paper
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Anaphylactic reactions occurring during anaesthesia remain a major cause of concern for anaesthesiologists. Serious and occasionally fatal anaphylactic reaction may occur when a patient is exposed to a drug for the first time. On time prompt recognition and treatment of the acute event by the attending anaesthesiologist and subsequent determination...
Article
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Background and objectives: Different adjuvants have been used to prolong intrathecal spinal anesthesia, with the possible advantages of delayed onset of post-operative pain, delayed and reduced analgesic requirements. The aim of this study was to evaluate the effect ofintravenous dexmedetomidine on prolongation of intrathecal spinal anesthesia, lev...
Article
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Abstract: Background: Tachycardia and hypertension are well documented sequels of laryngoscopy and endotracheal intubation; they are transient, highly variable and are generally well tolerated in healthy patients. In hypertensive patients with coronary artery disease (CAD) these cardiovascular responses to laryngoscopy and intubation is exaggerated...
Article
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Abstract Nanotechnology is a multidisciplinary field that covers a vast and diverse array of devices derived from physics, biology, engineering, and chemistry. Applications of nanotechnology to medicine and physiology imply materials and devices designed to interact with the body at subcellular (i.e., molecular) scales with a high degree of specifi...
Article
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Background: Laryngeal, tracheal and bronchial receptors are stimulated by mechanical and chemical irritants during laryngoscopy and endotracheal intubation. That almost always triggers powerful cardiovascular responses. Various attempts have been made to attenuate these responses. The aim of this study was to compare the efficacy and safety of card...
Article
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Background: The specialty of anaesthesiology has undergone considerable development over the last 30 years. Once a technical specialty confined primarily to the operating room, the scope of anesthetic involvement in hospital practice has expanded considerably. Clinically, Anaesthesiologists are experts in fields as diverse as intensive care, obstet...
Article
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Abstract Background: Direct laryngoscopy and endotracheal intubation always trigger powerful cardiovascular responses. Various attempts have been made to attenuate these responses. The aim of this study was to compare the efficacy and safety of esmolol and lidocaine for suppressing cardiovascular response to laryngoscopy and tracheal intubation in...
Article
Background: Direct laryngoscopy and endotracheal intubation always trigger powerful cardiovascular responses. Various attempts have been made to attenuate these responses. The aim of this study was to compare the efficacy and safety of esmolol and lidocaine for suppressing cardiovascular response to laryngoscopy and tracheal intubation in a normote...
Article
Full-text available
Cardiovascular responses to laryngoscopy and intubation have long been recognized and various efforts have been made to attenuate this response. The aim of this study was to evaluate the effica-cy and safety of ß-blocker esmolol in attenuating cardiovascular response to laryngoscopy and tra-cheal intubation in the Ghanaian population. After obtaini...
Article
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Abstract: Background: Propofol is a commonly used induction agent. Propofol does not possess any strong analgesic effect, when used alone for induction of anaesthesia. In dose of more than 2 mg/kg bolus known to cause hypotension even requiring vasopressors. Nitrous oxide (N2O) has been in use for more than 150 years. Although N2O reduces the requi...
Article
Nasotracheal intubation typically comprises three distinct stages: (i) nasopharyngeal intubation; (ii) direct laryngoscopy to identify the vocal cords; and (iii) the passage of the tracheal tube into the trachea. The aim of this study was to identify and compare the cardiovascular responses associated with each of these stages. Seventy-five ASA I o...
Article
Ciprofloxacin resistance among multidrug resistant strains of Salmonella senftenberg in India N C Sharma, Y Dhar, S Kumar, P C John, S Singh PMID: 7735073

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