Professor Robert Kingsford-Adaboh

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• PhD (chemistry), MPhil (chemistry), BSc (chemistry, Dip.Sc.Ed
• Head of Department at University of Ghana

This study explores the metabolic profiling of secondary metabolites from the endophytic fungus Aspergillus niger associated with the medicinal plant Moringa oleifera for the discovery of anti-infective agents. Aspergillus niger was isolated and characterised based on morphological traits and molecular phylogenetic analysis, confirmed via nucleotid...

Ghana has recently renewed its commitment to build a strong Science, Technology, and Innovation (STI) base for improved socio-economic development. This commitment hinges on recognizing that the strength of the nation’s STI policy depends on the quality of pre-tertiary education and training in science and mathematics to produce a critical mass of...

The synthesis of two new star-shaped organic small molecules with a truxene core, molecules 11 and 12, were carried out. They varied in sidechain length with molecule 11 having hexahexyl and molecule 12 having hexadodecyl side chains. The physical and photovoltaic properties were measured and characterized. Both molecules showed activity in UV-visi...

Investigation of the efficient conversion of photon energy to electricity by newly synthesized well-ordered low band gap semiconducting polymers. Demand for carbon-free energy has grown over recent years as the world fights against climate change. It is estimated that by 2050, global demand for carbon-free energy will increase to roughly 20 terawat...

Three new semiconducting organic small molecules were synthesized and fully characterized. The Acceptor-Donor-Acceptor small molecules consisted of an electron-rich EDOT central core which was separately capped at the terminals by electron-deficient units such as 1, 3-Indanedione, 3-Ethylrhodanine, and ethyl cyanoacetate to form DIN-2TE, DRH-2TE, a...

The focus of this research is to synthesize and characterize 4-phenyldiazenylnapthalen-1-ol and analyse its optical properties as a sensitizer in Dye-Sensitized Solar Cells (DSSCs). The compound was synthesized and purified by recrystallization. The compound was characterized by an electrothermal melting point apparatus, TLC, UV-Vis Spectroscopy, a...

Single crystals of optoelectronic materials that respond to external stimuli, such as mechanical, light, or heat, are immensely attractive for next generation smart materials. Here we report single crystals of a green fluorescent protein (GFP) chromophore analogue with irreversible mechanical bending and associated unusual enhancement of the fluore...

We report a systematic study of the antibacterial inhibitory potential of isoflavone natural products isolated from the seeds extracts of Millettia thonningii . In an effort to gain bond topological information which may have consequences for the observed bioactivities, the crystal structure of robustic acid was solved and refined using the indepen...

Co-crystals have been used to produce new drugs and to improve the physical properties of drugs. Some disease causing germs have developed resistance to newer drugs, hence there is a general trend to take ‘old’ but efficacious drugs, improve their properties and use them to treat the conditions. This study used mechano-synthesis to produce a co-cry...

Monitoring of pesticide residues in food commodities of plant origin is part of the regular controls on food to safeguard consumer's health. This study reports for the first time in Ghana a 3-year (2010-2012) monitoring of pesticide contamination of fruits and vegetables and their health implications. A total of 3483 samples were purchased in notab...

Although the molluscicidal activity of crude dichloromethane extract of Millettia thonningii, known to be rich in alpinumisoflavones was attributed to its inhibition of isolated rat liver mitochondrial complex I activity, the effects of the constituent alpinuisoflavones on mitochondrial function have not been reported. The present study, therefore...

Fungal pathogens continue to pose challenges to humans and plants despite efforts to control them. Two coumarins, robustic acid and thonningine-C isolated from Millettia thonningii, show promising activity against the fungus Candida albicans with minimum fungicidal concentration of 1.0 and 0.5 mg/mL, respectively. Molecular modelling against the pu...

Pesticides are known to improve agriculture yield considerably leading to an increase in its application over the years. The use of pesticides has shown varying detrimental effects in humans as well as the environment. Presently, enough evidence is available to suggest their misuse and overuse in the last few decades in most developing nations prim...

Three simple semiconducting acceptor-donor-acceptor (A-D-A) small molecules based on an electron-rich (3,4-ethylenedioxythiophene) EDOT central core have been synthesised (DIN-2TE, DRH-2TE, DECA-2TE) and characterised. Organic photovoltaic (OPV) devices incorporating these materials have been prepared and evaluated. The physical properties of the m...

In this study, "Quick, Easy, Cheap, Effective, Rugged and Safe" 'QuEChERS' method was modified for the determination of 36 pesticides fortified at (0.01-1.0) mg kg(-1) in three vegetables and a fruit (lettuce, carrot, tomatoes and pineapples respectively) from Ghana. The method involved extraction with acetonitrile, phase separation with primary se...

Antimony (Sb) is a regulated drinking water contaminant that has been found to leach from polyethylene terephthalate (PET) plastic containers into the waters stored in them. The common inorganic species of antimony in water are Sb(III) and Sb(V), with the former being more toxic and the latter being more soluble. In order to assess the extent to wh...

Legume related foods of cowpea and bambara beans rich in protein are notable diets of most Ghanaians. These legumes because of pest and insect infestation are preserved with pesticides by farmers and vendors. Therefore the study monitored pesticide residues in cowpea and Bambara beans from some open markets in the Accra Metropolis for 24 months and...

Legume related foods of cowpea and bambara beans rich in protein are notable diets of most Ghanaians. These legumes because of pest and insect infestation are preserved with pesticides by farmers and vendors. Therefore the study monitored pesticide residues in cowpea and Bambara beans from some open markets in the Accra Metropolis for 24 months and...

The aim of this study was to assess nitrate, chloride and calcium contamination in hand-dug well water as a result of effluent infiltration from household pit-latrine. The study also compared wet and dry season effluent contamination levels. The results were compared to the natural background levels, Ghana Standard Board (GSB) and World Health Orga...

The study monitored the concentrations of pesticide residues in vegetables arriving at Agbogbloshie, a central market in the Accra Metropolis from different parts of Ghana and beyond. A total of 810 samples of 5 different vegetables from Central, Volta, Greater Accra, Ashanti, Eastern Regions, and neighboring country (Togo) were collected from Janu...

The three N-phenylphthalimide derivatives, 2-(3,4-dichlorophenyl)isoindoline-1,3-dione (I), 2-(2,4-dichlorophenyl)isoindoline-1,3-dione (II) and 2-(2,4,5-trichlorophenyl)isoindoline-1,3-dione (III), were synthesized by the condensation of equimolar amounts of phthalic anhydride and 3,4-dichloroaniline, 2,4-dichloroaniline, 2,4,5-trichloroaniline, r...

Pycnanthus angolensis (also known as African/false nutmeg) is native to the forest zones of West Central Africa. Its use in folklore for the cure of diseases is well documented. Data collected from several references from various research groups in the literature confirm its wide spread use in folk medicine. Among the ailments purported to be cured...

Crystal structures of 2-methylmalonic acid, 2-ethylmalonic acid and 2-phenylmalonic acid, which are derivatives of malonic acid and have found usefulness in diagnostics and biochemical evaluations as markers and organic synthesis, are reported. 2-Methylmalonic acid and 2-ethylmalonic acid both crystallize in triclinic P-1 space group with cell para...

This review discusses the potential applications of isoflavonoids from Millettia thonningii and M. pachycarpa in developing new pharmaceutical agents based on folkloric anecdotes and evidences from pharmacological and biochemical assays and to encourage further research into their pharmacological applications. Millettia thonningii is a deciduous pl...

In the asymmetric unit of the title compound, 2C7H9ClN+·C9H6O42−·2H2O, there are two crystallographically independent cations, one dianion and two water molecules. The dihedral angle between the two carboxylate groups of the dianion is 78.1 (2)°. In the crystal, the components are held together by N—H...O, O—H...O and C—H...O hydrogen bonds, formin...

In the asymmetric unit of the title compound, 2C7H9ClN⁺·C9H6O4²⁻·2H2O, there are two crystallographically independent cations, one dianion and two water mol­ecules. The dihedral angle between the two carboxyl­ate groups of the dianion is 78.1 (2)°. In the crystal, the components are held together by N—H⋯O, O—H⋯O and C—H⋯O hydrogen bonds, forming a...

Surface water samples from seven streams on the Akwapim Ridge were analysed over a period of 1 year for various water quality parameters following standard methods prescribed in APHA, AWWA, WEF and AOAC. The study was carried out in order to assess the suitability of the streams for drinking and other domestic purposes. Additionally, the effect of...

Single crystals of alpinumisoflavone, C20H16O5, {systematic name: 5-hydroxy-7-(4 hydroxyphenyl)-2, 2-dimethyl-2H, 6H-benzo [1, 2-b: 5, 4-b′]-dipyran-6-one}, solvated with water, methanol, and ethanol, have been obtained. The incorporation of the solvent molecules into the crystal structure creates a new short inter-molecular O–H···O and C–H···O con...

The title compound, C20H16O5, {systematic name: 5-hydr­oxy-7-(4-hydroxy­phen­yl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b′]dipyran-6-one}, was obtained by demethyl­ation of the biologically active related compound, 4-O-methyl­alpinum­iso­flavone. The mol­ecular structure of the title compound is characterized by a fused tricyclic system that contains a...

The accurate X-ray single-crystal structures of the isoflavone compounds 4-O-methylalpinumisoflavone, O,O-dimethylalpinumisoflavone and 5-O-methyl-4-O-(3-methylbut-2-en-1-yl)alpinumisoflavone {alpinumisoflavone = 5-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b′]dipyran-6-one} from data sets measured at cryogenic temperature have...

4′-O-Methylalpinumisoflavone crystals which hitherto had been difficult to crystallize for X-ray diffraction analyses have been obtained from a demethylated product of O, O-dimethylalpinumisoflavone. The structural and conformational features of the crystal measured at 90 K are reported and compared with previously reported work of O,O-dimethylalpi...

The charge density of DL-arginine monohydrate has been extracted from a synchrotron data set of 212121 reflections collected at 100 K with a Bruker CCD area detector up to a resolution of sin theta/lambda = 1.40 Angstrom(-1) (d = 0.36 Angstrom). DL-arginine monohydrate is characterised by a neutral alpha-amino group and a notable different hydrogen...

The petrol extract of the rootbark of Milletia Thonningii obtained by column chromatography afforded sixteen different crystalline samples to be isolated. The crystal structures of two of these compounds, O,O-Dimethylalpinumisoflavone (I) and 5-O-Methyl-4'-O-(3-methyl-but-2-en-1-yl)alpinumisoflavone (II) are being reported here. (II) has two indepe...

The petrol extract of the rootbark of Milletia Thonningii obtained by column chromatography afforded sixteen different crystalline samples to be isolated. The crystal structures of two of these compounds, O,O-Dimethylalpinumisoflavone (I) and 5-O-Methyl-4'-O-(3-methyl-but-2-en-1-yl)alpinumisoflavone (II) are being reported here. (II) has two indepe...

In the title compound, C6H14N4O2·H2O, the α-amino group is neutral. The molecular side chain including the guanidinium group is not fully extended, having a near gauche–gauche conformation [χ³ = 59.0 (1)°; χ⁴ = 72.8 (1)°]. The network of hydrogen bonds stabilizing the crystal lattice includes those formed between the deprotonated and negatively cha...

X-ray structure analyses of Smiles rearrangement and further cyclization products of 2-[3-cyanopropylthio-(and oxy)]pyridine-3-carbonitriles revealed the structures of 5-amino-8-methyl-1,2-dihydrothieno[2,3-h][1,6]-naphthyridine, C11H11N3S, and 5-amino-8-methyl-1,2-dihydrofuro[2,3-h][1,6]naphthyridine, C11H11N3O. The crystals of both compounds are...

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and...

Crystals of the title compound, C15H10O2, are monoclinic, space group P2(1)/c. The molecules are disordered around a centre of symmetry. Packing considerations and the calculation of the intermolecular interaction energies show that the disordered structure has occurred by random packing of structures with space groups P2(1) and Pc, the maximal sub...

The conformational analysis of a group of carcinogenic cyclopenta[a]phenanthren-17-ones has been done using quenched molecular dynamics to simulate built models. Optimum energy conformers have been searched within 300 to 600 K. The results are presented and compared to structures derived from X-ray experiments. While the pattern of distortion is si...

The crystal structures of racemic form of isoprenaline hydrochloride (I) and (S)-isoprenaline hydrogen (2R,3R)-tartrate (II) were determined by X-ray diffraction method. Among the related compounds I has the least extended phenethylamine chain with a gauche-gauche conformation. The side chain of II has the usually observed perpendicular-trans confo...

The crystal structure of a derivative of β-D-ribofuranose has been determined by X-ray diffraction method in order to characterize the molecular conformation. The phase angle P and the degree of puckering τm of the sugar ring are −7.6 and 34.3° respectively. The ring shows C(3′)-endo-C(2′)-exo puckering () as found in sucrose and 1,2,3,5-tetra-O-ac...