Professor Dr. Naser A Al-Wabel

• DVM, MSc, Ph. D, Professor
• Professor at Qassim University

The current study is aimed at evaluating the potential health benefits of Salvia officinalis L. (sage) methanol extract on lead and nicotine hydrogen tartrate-induced sperm quality degeneration in male rats and also identifying some of the non-polar volatile bioactive compounds that might be attributed to the bioactivity of S. officinalis extract u...

The temperature sensitive liposomal formulations are a promising tool to improve the therapeutic index of the drugs with minimal toxicity. The aim of this study was to investigate the potential of concomitant delivery of cisplatin (Cis) and doxorubicin (Dox) containing thermosensitive liposomes (TSLs) with mild hyperthermia against cancer in vitro...

Thermosensitive liposomes loaded with cisplatin and doxorubicin composed of DPPC, DSPC, and DPPE-PEG5000 with different ratios were prepared by thin film hydration method. The Differential Scanning Calorimetry (DSC) curves showed that the liposomes composed of DPPC-DSPC-DPPE-PEG5000 with phospholipid ratio 95:5:0.05 w/w were a suitable formulation...

Ethnopharmacological relevance The use of herbal and medicinal plants to treat male infertility is well known in history. Tribulus terrestris L. (TT) belongs to the Zygophyllaceae family and it is used in folk medicine to vitalize and also improve both physical performance and sexual function in men in addition to the protective effect of the gross...

Folklore phytotherapy is a worldwide practice extensively used for the treatment of various conditions like wounds which are rising as one of the health care obstacles. This study was undertaken to evaluate wound healing effect of methanolic extracts of some plants native to Al-Qassim Region, Saudi Arabia. Wistar rats were used as an animal model f...

The purpose of the present study was to evaluate the antidiarrheal activity and the phytochemical constituents of methanol extracts of some plants native to Saudi Arabia. Castor oil–induced diarrhea and gastrointestinal motility test using charcoal meal method were examined. The methanolic extracts were initially assayed for their effects in castor...

Alzheimer's disease (AD) is the most frequent cause of dementia, especially in the elderly. AD is the most common progressive neurodegenerative disorder, which involves the loss of structure and function of cholinergic neurons. Moreover, if these neuronal changes cannot be compensated, this may ultimately lead to neurodegenerative processes. Theref...

 Aim is to find out the dispensing practices of community pharmacies in three cities of Saudi Arabia and to assess their attitude toward dispensing non-OTC drugs including analyze the causes of their malpractice.  Method: Between July 2014 and August 2014 retail pharmacies in Makkah, Tabuk and Madina (KSA) were visited randomly by a three volunta...

Objective: To evaluate activity of methanol extract of Achillea fragrantissima (meth) (A. fragrantissima) alone or in combination with diminazine aceturate (DA) against Trypanosoma evansi (T. evansi) in experimentally infected rats. Methods: Sixty adult male Wister albino rats were divided equally into 6 groups (A-F). Rats in groups A-E were exp...

Background: Black cumin oil is obtained from the seeds of Nigella sativa L. which belongs to family Ranunculaceae. The seed oil has been reported to possess antitumor, antioxidant, antibacterial, anti‑inflammatory, hypoglycemic, central nervous system depressant, antioxidant, and immunostimulatory activities. These bioactivities have been attribute...

Objective: The activity of methanol extract of Achillea fragrantissima (meth-A. fragrantissima) alone or in combination with diminazine aceturate (DA) against Trypanosoma evansi (T. evansi) in experimentally infected rats was evaluated. Methods: Sixty adult male Wister albino rats were divided equally into 6 groups (A-F). Rats in groups A-E were ex...

Based on the heterocyclic core of bendamustine, four series (4a-g, 5a-f, 8a-b and 9a-b) of benzimidazole derivatives were designed and synthesized starting from 4-(1H-benzo[d]imidazol-2-yl)-4-oxobutanehydrazide. In the rational design of target molecules, the benzimidazole ring of bendamustine was retained and the bis-(chloroethyl) amine group (mec...

Nowadays, use of alternative and complementary therapies with mainstream medicine has gained the momentum. Aromatherapy is one of the complementary therapies which use essential oils as the major therapeutic agents to treat several diseases. The essential or volatile oils are extracted from the flowers, barks, stem, leaves, roots, fruits and other...

http://www.sciencedirect.com/science/article/pii/S1319016415000821

Comparative evaluation of metered-dose inhaler technique demonstration among community pharmacists in Al Qassim and Al Ahsa regions, Saudi Arabia. Patients rely on the information about use of proper inhaler technique when dispensed by community pharmacists however; several studies have shown that patients are unable to show correct inhalation tech...

ABSTRACT The aim of this study was carried out to investigate, clarify the pancreatic regeneration, and recommend in different fractions of the ethanol extract Allium cepa (onion) L. Antidiabetic and antihyperlipidemic potentials were reported in streptozotocin – induced diabetic rats and its in vivo and in vitro antioxidant effects were studied. T...

Abstract Objective: The aims of this study were to evaluate the students’ knowledge, awareness and the reasons behind self medication in two higher education institutions in Al Qassim region of Saudi Arabia. Subjects and method: This pre-validated anonymous questionnaire was used in English and Arabic language that contained both open ended and clo...

Objective: The aims of this study were to evaluate the students’ knowledge, awareness and the reasons behind self medication in two higher education institutions in Al Qassim region of Saudi Arabia. Subjects and method: This pre-validated anonymous questionnaire was used in English and Arabic language that contained both open ended and close ended...

Aim is to find out the dispensing practices of community pharmacies buraydah city and to assess their attitude toward dispensing non-OTC drugs including analyze the causes of their malpractice. Method: Between July 2014 and August 2014 retail pharmacies in Buraydah – Al Qassim (KSA) were visited randomly by a two voluntary collaborators who played...

Abstract Introduction: Fenugreek is a folklore medicine prescribed for treatment of renal stones in Sudan. There has been many studies evaluating the effect of fenugreek seeds and leaves in renal stones. These studies have used the aqueous, methanolic extracts of seed and/or whole seed to establish the effect in nephrolithiasis. In the current stud...

Objective: The aims of this study were to evaluate the students' knowledge, awareness and the reasons behind self medication in two higher education institutions in Al Qassim region of Saudi Arabia. Subjects and method: This pre-validated anonymous questionnaire was used in English and Arabic language that contained both open ended and close ended...

The pedagogic approaches used in the different educational system such as medical sciences and pharmacy have been changing and new teaching strategies are used to promote active learning. Team-based learning (TBL) is one of the approaches of innovative teaching methodology which is based on a structured or student centred but instructor-led method...

Adnan, Karim, Khan and Al-Wabel et al assessed community pharmacists’ knowledge of and skills pertaining to metered dose inhaler demonstration in five cities in the Al-Qassim region of Saudi Arabia. It was found that the majority of pharmacists (93.7%) were unable to demonstrate the appropriate inhalation technique to be used with metered dose inha...

Aim is to assess the drug adherence profiles of Saudi patients prescribed antihypertensive agents, and to examine the factors associated with antihypertensive drug adherence among Saudi patients. This study is a cross-sectional survey of 20 hypertensive patients and the data were collected primarily by self-administered questionnaires. In conclus...

The animals were treated with ethanolic extract, methanolic fraction and isolated compound. The nootropic and anxiolytic activity was assessed in rats using cook’s pole climb apparatus and elevated plus maze respectively. The methanolic fraction has shown significant nootropic and anxiolytic activity. However the isolated compound has not shown s...

Medicinal plants have been used traditionally worldwide for the prevention and treatment of liver disease. Thymus Capitatus and Salvia Officinal are used frequently as spices. The present investigation aimed to investigate the possible potential protective effect of Thymus and Salvia essential oils against Paracetamol induced hepatotoxicy. Administ...

Spices and herbs have been long used for thousands of centuries by many cultures to enhance the flavor and aroma of foods. Ancient societies recognized the value of using spices and herbs in preserving foods and for their medicinal value. During the 19th century, scientific experiments have documented the antimicrobial properties of some spices, he...

Spices and herbs have been long used for thousands of centuries by many cultures to enhance the flavor and aroma of foods. Ancient societies recognized the value of using spices and herbs in preserving foods and for their medicinal value. During the 19th century, scientific experiments have documented the antimicrobial properties of some spices, he...

Sensitivity and fatality of salinomycin to Saudi dromedary camels (Camelus dromedarius) was studied. The clinical symptoms and analysis of feed content pointed at salinomycin as the possible causative agent. In a small trial (n=7), we tested the effect of doses of salinomycin, 15mg/kg every second day on dromedary camels of local strain. We observe...

The present study was designed to monitor tetracycline residues in table eggs collected from different regions located in Al-Qassim region from January 2006 to October 2006 using HPLC with UV detection and compare them with internationally acceptable maximum residue limits (MRLs) and assessing proper implementation of the proper withdrawal times. H...

The present work was carried out to investigate the hepatoprotective effect of ginger, chicory and their mixture against carbon tetrachloride intoxication in rats. Carbon tetrachloride treatment significantly elevated the alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma glutamyltransferase activities and the seru...

The present study aimed to evaluate the diuretic effects of methanol extracts of Conyza dioscorides and Alhagi maurorum in a single or repeated (1 × 5 days) oral dose of 500 or 1000 mg kg-1 and compared to furosemide 20 mg kg-1, orally administered in albino rats. Oral administration of Conyza dioscorides significantly (P < 0.05) decreased serum an...

Cardiovascular disease is the main cause of mortality in the industrialized world. The Mediterranean diet is common among people in countries around the Mediterranean Sea which consists of a high intake of olive oil as an important fat source, resulting in a high intake of monounsaturated fatty acids (MUFA) and a low intake of saturated fatty acids...

Garlic (Allium sativum), a member of the family Liliaceae, contains an abundance of chemical compounds that have been shown to possess beneficial effects to protect against several diseases, including cancer. Evidence supports the protective effects of garlic in stomach, colorectal, breast cancer in humans. The protective effects appear to be relat...

To evaluate the use of xylazine/ketamine and isoflurane for the induction and maintenance of anesthesia in adult ostriches (Struthio camelus), 7 healthy adult ostriches (weight 100-130 kg) were deprived of food for 12 hours and then given an injection of xylazine (4 mg/kg IM), followed 20 minutes later by an injection of ketamine (8 mg/kg IV). Afte...

Milk samples were obtained during the second month of lactation from cattle, camels, sheep and goats for analysis of their essential mineral content. The Mean±SD concentrations of Zn, Mn, Cu, Fe, Ca, Na and K in the milk of cattle were calculated as mg kg-1 on dry matter basis and were as follows: 2.0±0.28, 1.291±2.43, 1.80±1.10, 4.214±1.78, 661.0±...

The aim of the present study was to investigate the biological effects of aqueous herbal extracts mixed with stirred yoghurt filtrate against alloxan-induced oxidative stress and diabetes in rats. Aqueous extracts of six medicinal plants: fenugreek, greater burdock, goat`s rue, colocynth, chicory and lupine were mixed with stirred yoghurt filtrate...

Semicarbazide-sensitive amine oxidase (SSAO) activity was measured spectrophotometrically using benzylamine as a substrate, in the serum of healthy males and females of horses, camels, cattle, sheep and goats. The animals were born and raised in the same area, and the blood collection was made on the same day to avoid variations. Also the concentra...

Sensitivity and fatality of salinomycin to Saudi dromedary camels (Camelus dromedarius) was studied. The clinical symptoms and analysis of feed content pointed at salinomycin as the possible causative agent. In a small trial (n=7), we tested the effect of doses of salinomycin, 15mg/kg every second day on dromedary camels of local strain. We observe...

E. coli transmitted from under-cooked hamburger may cause life threatening conditiosn including hemorrhagic colitis, hemolytic uremic syndrome and thrombotic-thrombocytopaenic purpurea. Unfortunately, the emergence of resistance has become increased Therefore, the antimicrobial susceptibility of the causative strain E. coli "O-157:H-7" was determin...

Summary The objective of this study was to evaluate kinetics and the residual decline of tylosin in milk and plasma of lactating Najdi ewes following single intramuscular injection of tylosin at the dose of 10 mg/kg. Blood and milk samples were collected from the ewes before and at different time intervals after treatment. Tylosin concentrations we...

The present study investigated some biological effects of synbiotic fermented milk in rats receiving lead acetate in drinking water. Synbiotic fermented milk was prepared by mixing probiotic fermented milk with honey, garlic, ginseng, cod liver oil and chicory inulin. Glutathione-S-transferase (GST), alanine aminotransferase (ALT) and aspartate ami...

This article presents a brief summary about the possible antimicrobial and antioxidant properties of some well known and widely used species. The author emphasizes on the previously reported studies which were carried out to reveal the antimicrobial and antioxidant properties of species commonly used throughout the world In addition, the usefulness...

The antioxidant status of rats experimentally infected with Trypanosoma evansi isolated from a camel was studied using established parasitological, haematological and biochemical methods. The results indicated that infections in all rats resulted in a fulminating parasitaemia. Changes in blood parameters in T. evansi-infected rats indicated leukocy...

In this study, we measured the concentration of some antioxidant substances in erythrocytes hemolysate, liver, kidney and brain in young and adult camels. It has been found that the activity of the antioxidant enzymes glutathione peroxidase (GSH-Px), catalase (CAT), superoxide dismutase (SOD) and the concentration of glutathione, ascorbic acid and...

Generation of free radicals in kidney cortex plays an important role in the pathogenesis of gentamicin (GM) nephrotoxicity, and curcumin, the yellow curry pigment isolated from turmeric, has been confirmed to have a strong antioxidant action. Therefore, in the present work, we aimed at testing the possible protective or palliative effect of curcumi...

This article reviews the reported phytochemical, pharmacological and toxicological properties of Hibiscus sabdariffa L. (English: roselle, red sorrel; Arabic: karkade), the calyces of which are used in many parts of the world to make cold and hot drinks. Nutritionally, these contain ascorbic acid (vitamin C). In folk medicine, the calyx extracts ar...

The cardiovascular effects of cisapride administered intravenously at escalating doses with and without pretreatment with erythromycin were evaluated in morphine/chloralose anesthetized dogs. Dogs were instrumented to permit simultaneous recording of ECGs, left ventricular (LVP) and aortic (AoP) pressures, as well as programmed electrical stimulati...

Thesis (M.S.)--Ohio State University, 1998. Includes bibliographical references (leaves 37-39). Advisor: S. Mark Strauch, College of Veterinary Medicine.