Prof. Imran Ali

Prof. Imran Ali
Jamia Millia Islamia · Department of Chemistry

Ph.D., C Chem, FRSC, Web of Science Highly Cited Researcher; Rank: 01 Indian & 24 Global (Anal. Chem.) as per Stanford University USA report

About

644
Publications
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Introduction
Prof. Imran Ali, PhD, C Chem, FRSC, London (UK), WoS Hi Ci Res., Ambassador of Bentham Science Publisher, currently works at the Department of Chemistry, Jamia Millia Islamia. His current research focus on nanotechnology for water treatment, anti-cancer drugs development and chiral chromatography. Editor-in-Chief: - Current Chromatography & Nanomedicine & Drugs Delivery **************************************************************** E. mails: drimran.chiral@gmail.com; drimran_ali@yahoo.com
Additional affiliations
September 2013 - present
King Saud University, Riyadh
Position
  • Professor
January 2013 - December 2020
King Saud University
Position
  • Professor
December 2006 - present
Jamia Millia Islamia, New Delhi, India
Position
  • Professor

Publications

Publications (644)
Article
WHO is searching most active antibiotics due to the bacterial resistance problem. The activities of the racemic antibiotics may be augment by preparing optically active antibiotics by the chiral separation. Chiral separation of potential antibiotics such as cefotaxime and ofloxacin was studied using amylose‐based packing chiral stationary phases (C...
Article
Ionic liquids are a very important class of compounds due to their remarkable properties and wide range of applications. On the other hand, capillary electrophoresis is also gaining importance in separation science because of its fast speed and inexpensive nature. The use of ionic liquids in capillary electrophoresis is gaining importance continuou...
Article
Full-text available
Amongst different water purification, sorption is the best one due to its unique features; especially universal and inexpensive. A large number of publications are appearing in the literature every year, confirming its importance. There is a great need to write a brief note on this method to keep aware of the researchers. The paper discusses the st...
Article
A novel antibacterial quinolone was prepared with two chiral centers. For medicinal safety purposes, the four stereoisomers of the molecule are separated by HPLC using a Chiral (+)-Crownpack column (25 cm × 0.46 cm, 5.0 μm) with an eluent of 50 mM H2SO4. The values of the retention, separation, and resolution factors of RR-, SS-, RS-, and SR-stereo...
Article
Full-text available
Magnetically active nanocomposite aerogels were prepared, characterized and used for water treatment. These materials were characterized by SEM, TEM, XRD, FT-IR and BET methods. These materials have ferromagnetic properties, facilitating the collection and removal of spent sorbent from the purified system for subsequent regeneration. The paper inve...
Article
The biological activities of flavanone and hesperetin were enhanced by synthesizing Schiff base types molecules (bis-imino-flavans; BHF4, BHF8 and BHF10) by combining flavanone and hesperetin. These molecules were characterized by spectroscopic studies. The four enantiomers of these molecules were separated by HPLC due to the presence of two chiral...
Article
Hospital wastewater is harmful to the environment and human health due to its complex chemical composition and high potency towards becoming a source of disease outbreaks. Due to these complexities, its treatment is neither efficient nor cost-effective. Instead, it is a challenging issue that requires immediate attention. In this direction, this ef...
Article
Chiral separation of β‐blockers is performed by utilizing the supercritical fluid chromatographic method. The chiral columns utilized were Chiralpak IG and Chiralpak IBN‐5. The finest mobile phase was CO2 −0.2% TEA in methanol (60:40). The values atenolol enantiomers retention factors were 6.39 and 8.98. These values for propranolol enantiomers wer...
Article
Full-text available
In recent years, major attention has been focused on microextraction procedures that allow high recovery of target analytes, regardless of the complexity of the sample matrices. The most used techniques included liquid-liquid extraction (LLE), solid-phase extraction (SPE), solid-phase microextraction (SPME), dispersive liquid-liquid microextraction...
Article
The present article considers a comparative analysis of two elastomers, polyurethane (PUС) and organosilicon (OSC), both modified with 1.0–9.0 wt.% multiwall carbon nanotubes (MWCNTs). The MWCNTs-1 and MWCNTs-2 were synthesized through CVD method using Co-Mo/Al2O3-MgO and Fe-Co/2,1Al2O3. The results obtained showed that the lowest bulk conductivity...
Article
Full-text available
Due to environmental pollution and climatic issues, hydrogen is considered a green fuel, which is an innovative area of research. Among various methods, water splitting is one of the best ways to produce hydrogen fuel. The optimization of water splitting is an important experimental factor to get a good yield of hydrogen at the economic level. Amon...
Article
Supercritical fluid chromatography and high-performance liquid chromatography techniques are popular for the chiral separations of different drugs and pharmaceuticals. Therefore, this article describes a comparative study of the chiral separation of some calcium channel antagonists such as verapamil, gallopamil, and nisoldipine. The columns used we...
Article
A comparative study of chiral separation of pantoprazole and rabeprazole is carried out using supercritical fluid chromatography and high‐performance liquid chromatography. The columns used were Chiralpak IA and Chiralpak IE. The best mobile phase in supercritical fluid chromatography was carbon dioxide‐0.2% triethylamine in methanol (60:40) and 0....
Article
Nano-anticancer drugs are gaining importance in cancer treatment due to their unique properties and wide range of applications. The efforts are made to synthesize silver nanoparticles by a green method and used as nano-carriers for curcumin. Green synthesis of the gum-stabilized AgNPs was monitored by UV–Vis spectrophotometry and the possible inter...
Article
Full-text available
This article describes a technique for the manufacturing of the composites MWCNTs-modified elastomers. The effect of the different MWCNTs mass contents in the elastomer on specific volume and surface electrical resistivity values was investigated. The results on the heaters based on the elastomers and altered with multi-walled carbon nanotubes (MWC...
Article
The supercritical fluid chromatography technique is one of the most promising and innovative technologies used in the analysis as well as the separation of various racemates. The various enantiomers have been separated using SFC due to its several merits over conventional HPLC methods such as low cost, wide polarity compatibility, higher column eff...
Article
Full-text available
For the first time, experimental and simulation studies were carried out to determine the mechanisms of catalyst formation for the targeted synthesis of carbon nanotubes. The geometry of the molecular system of a solution of the initial components of a Ni/MgO catalyst has been calculated and modeled using the molecular mechanics method. During the...
Chapter
Full-text available
The existence of the several pollutants in water resources has led the water unfit for consumption or reuse, and eventually becoming one of the greatest threats to the environment and human health. Pollutants in water are not desirable even if they have less toxicity, therefore, they must be either removed or degraded. Despite several materials rep...
Article
The removal of actinides and rare earth elements (REEs) in nitric acid solutions; produced in nuclear processes; is a challenging job. The present article describes the sorption behavior of oxidized multilayer graphene (o-MG) to actinides and rare earth elements (REEs) in nitric acid solutions (up to 3 mol L⁻¹ HNO3), including nitrogen and phosphor...
Article
With the advent of technologies in many countries, pharmaceutically active compounds (PhAC), personal care products (PPCPs), and other medicines have been treated by particular facilities. Although the overall rate of PhACs extraction from hospital wastewater (HWW) through different secondary wastewater treatment plants (WWTPs) has been high equal...
Article
The facile synthesis of the advanced cobalt-based materials [1.0Co/Al2O3 (A), 0.5Co/Al2O3 (B), 3.5CoNaY (C) and 0.4CoHY (D)] is reported. The characterization of the materials was carried out by X-ray photoelectronic, energy-dispersive X-ray, atomic absorption and low-temperature nitrogen adsorption methods. These materials were used for a comparat...
Article
Background The determination of enantio-separation, absolute configuration and chiral recognition mechanism of ofloxacin and flumequine was carried out by HPLC and modeling studies. The column used was Chiralcel® OD-H with normal and polar organic mobile phase modes. The exhaustive chiral separation was optimized through various HPLC parameters. R...
Article
γ-Cyclodextrin-graphene oxide nanocomposite was synthesized and characterized for sorption, kinetics, thermodynamics, and simulation studies of tetracycline and chlortetracycline antibiotics removal from water. The optimized sorption parameters were 400 mg/L concentration, 30 minutes contact time, pH 8.0, dose 1.0 g/L and 25 °C temperature. The sor...
Article
SnO2-CeO2 nanocomposite materials (0.1SnO2–0.9CeO2, 0.15SnO2–0.85CeO2, 0.2SnO2–0.8CeO2, and 0.3SnO2–0.7CeO2) were prepared by co-precipitation in a water-isopropanol solution followed by thermal treatment. The materials were characterized by EDX, TEM, XRD and low-temperature nitrogen adsorption and used for comparative removing dye azorubine in wat...
Article
In every section of the environment pharmaceuticals are now can be observed and detected. Hospitals are one of the major sources of pollution via either through environment or wastewater treatment plants (WWTPs). The treatment plants are not prepared for effective treatment of emerging contaminants (ECs). This paper further illustrates the lack of...
Article
Full-text available
2D-HPLC is an important development in chiral separations due to its excellent capability to resolve the enantiomers. This article describes the latest update in the chiral resolution of racemates using 2D-HPLC. The various aspects of the chiral resolution such as validation, optimization, and applications are discussed in both biological and envir...
Article
The current article describes the chiral separation of tioconazole, miconazole, isoconazole, sertaconazole and terconazole, with Lux i-Cellulose 5 and Lux i-Amylose-1 chiral columns under organic polar, normal and reversed mobile phases modes. The mobile phase flow rate was 1 mL/min with 230 nm detection at 25 ± 1 °C temperature. The polar organic...
Article
Metformin is the largest drug produced globally in metric tons. It has been reported in many water treatment plants and water resources. The analysis of metformin at trace level is important before supplying water to the communities. The present article describes solid-phase micromembrane tip extraction and capillary electrophoretic methods for the...
Article
(https://doi.org/10.1016/j.radphyschem.2021.109431) - Hydrogen generation by water splitting is reported in nano-ZrO2+H2Oabs. and nano-ZrO2+H2Oflu. systems using gamma radiation at different ZrO2 particle sizes (50-70 nm) and temperatures (300-673K). The rates of molecular hydrogen (H2) formation in radiolysis process were studied in radiation-chem...
Article
Full-text available
The current research is focused on studying the biological efficacy of flexirubin, a pigment extracted from Chryseobacterium artocarpi CECT 8497.Different methods such as DPPH, H2O2, NO•, O2•-, •OH, lipid peroxidation inhibition by FTC and TBA, ferric reducing and ferrous chelating activity were carried out to evaluate the antioxidant activity of f...
Article
Full-text available
Cobalt-doped TiO2 nanoparticles were prepared and characterized by FT-IR, TEM, SEM, and XRD. The surface morphology was sphere-shaped with ~ 26.46 nm of the size of the nanoparticles. Ninety percent atenolol photodegradation was obtained with 15 mg/L concentration, 40 min stirring time, 2 pH, 2.0 g/L dosage of nanoparticles, 200.0 nm irradiation UV...
Article
Nowadays, the removal of the rare-earth elements in water and hydrogeosystems is an urgent issue. Therefore, graphene oxide / polyhydroquinone nanocomposite was used to remove samarium ions (Sm³⁺) in aqueous solutions. The sorption and desorption of Sm³⁺ ions on the graphene oxide / polyhydroquinone nanocomposite from aqueous solutions are studied...
Article
An inexpensive nano-structured modified adsorbent was prepared from natural montmorillonite. The optimum and significant parameters were Al³⁺:Co²⁺(11:2) with ion exchange, drying and calcination temperatures, respectively 75, 85 and 450 °C. The material was characterized by EDX, SEM, TEM, XRD and low-temperature nitrogen adsorption. The adsorbent w...
Chapter
Even after almost 30 years of documented investigations in the field of chiral environmental pollutants, enantiomers are often still considered as two halves of one chiral pollutant, although they behave differently in homo-chiral biological environments. Thus, the below citations still need to be highlighted in order to initiate a special sensitiv...
Chapter
Nowadays, the environment is being continuously contaminated by different pollutants, including many organic pollutants that are chiral. It is well known that several toxic pollutants enter into the human body via the food chain. Well-known toxic chiral contaminants include pesticides, plasticisers phenols, biphenyls, polycyclic aromatic hydrocarbo...
Chapter
The analytical separation technologies with most applications to enantiomer-selective chromatographic separations are high-performance liquid chromatography (HPLC) and the more advanced ultrahigh-performance liquid chromatography (UHPLC) based on stationary phases with particles <3 μm of size. Enhanced chromatographic resolutions by applying ultraf...
Chapter
In a non-chiral environment, the enantiomers of a racemate possess the same physical and chemical properties. By contrast, metabolic and regulatory processes mediated by biological systems are sensitive to stereochemistry and different responses can often be observed when comparing the activities of a pair of enantiomers (Ali and Aboul-Enein 2004;...
Chapter
As outlined earlier, the notorious lack of well-validated standards of highest optical purity is still a considerable drawback for reliable peak assignments and quantitation (Landagaray et al. 2016; Naile et al. 2016; Hasan et al. 2017; Ulrich et al. 2018). Furthermore, enantioselective analyses today are an integrated part of toxicological and mec...
Chapter
For the quantification of trace amounts of pollutants, complex validation protocols for method validation and quality control (QC) are required today in order to provide reliable results suitable for further statistical treatment in national and international surveys and pollutant monitoring programmes. National and international protocols today ar...
Chapter
During the past two decades and after the first edition of this monograph was published in 2001, tremendous progress has been made with respect to sensitivity and selectivity in scientific technology for ultra-trace analysis. Today, chromatographic separation and modern mass-selective detection have been significantly improved as compared with the...
Chapter
The economic growth of a nation raises the claim for a healthy eco-friendly environment. Therefore, to avoid any disease and problems due to the adverse effect of chiral pollutants, it is essential to monitor the chiral pollutants in our environment. In spite of the advancement of science and technology, data on the chirality of the different pollu...
Chapter
Enantioselective separations by capillary electrophoresis (CE) have rapidly attracted attention in the early 1980s as a promising field of pharmaceutical sciences after the innovative work of Jorgenson (1988) and by the group of Terabe (Nishi et al. 1990a, b). In 1987, CE instruments became commercially available, largely stimulated by pharmaceutic...
Chapter
Capillary gas chromatography (cG) has been an important separation technique for enantioselective chromatography from the early beginning of this research field in analytical chemistry. A number of early reports illustrate the importance of this separation technology for enantiomer separation. The relevance of enantioselective high resolution gas c...
Article
The enantiomers of quinolone racemates were resolved using chiral crown ether within 8 minutes. Thermodynamics data and modeling results were used to determine chiral recognition mechanism. The column used was (+)-Crownpack column (250 mm × 4.6 mm, 5 µm) with three mobile phases I: ACN:Water (80:20) + 10 mM H2SO4 and 10 mM CH3COONH4, II: ACN:Water...
Article
Full-text available
The present work describes the synthesis of new click products with a 2-mercapto-benzothiazole basic structure supporting the different functionalized side chains linked to the 1,2,3-triazole ring at position N-1 via Cu(I)-mediated click chemistry under both thermal and microwave irradiation (MWI). MWI led to higher yields in much less time than cl...
Article
The present paper describes the efficiency of the synthesis of multi-walled carbon nanotubes (MWCNTs), which is achieved through the implementation of a non-standard approach to the preparation of a Ni/MgO catalyst. The catalyst required for MWCNTs synthesis was obtained through chemical vapor deposition method. At the same time, the pre-catalyst w...
Book
Now in its updated second edition, this book describes emerging chiral environmental pollutants and their importance in environmental and human toxicology, as well as enantiomer selective separation and analytical methods. Compared to the first edition from 2001, the book has been completely restructured and a wealth of new material has been added...
Article
Full-text available
Hydrogen generation by water splitting is reported in nano-ZrO 2 +H 2 O abs. and nano-ZrO 2 +H 2 O flu. systems using gamma radiation at different ZrO 2 particle sizes (50-70 nm) and temperatures (300-673K). The rates of molecular hydrogen (H 2) formation in radiolysis process were studied in radiation-chemical process using γ-quanta (60 Co, D = 0....
Article
Background: Cancer is a very dangerous disease, whose treatment can be improved by removing the factors that cause side effects, if the drugs prescribed for cancer, are chiral in nature. Objectives: A computational evaluation for the most biologically active enantiomeric form of chiral drugs attacking on DNA of the cell, was done for the first tim...
Article
Copper nanoparticles were synthesized following their characterization by XRD, SEM-EDX and TEM techniques. These nanoparticles were used to remove new generation pollutant ketoprofen up to 89% at optimal conditions of 50 mg/L concentration, 50 min, 5.0 pH, 1.0 g/L dose and 25 °C. The adsorption followed the Langmuir, Temkin and Dubinin - Radushkevi...
Article
Full-text available
The Kingdom of Saudi Arabia (KSA) is one of the rising countries in the Gulf region but always scared of water; being present in the arid desert. Among some water resources groundwater is one of the most significant ones in this country but unfortunately is being contaminated by the toxic metal ions. The present article describes the status of grou...
Article
Full-text available
Copper carboxymethyl cellulose nanoparticles were prepared and characterized by FT-IR, XRD, SEM, TEM, and EDX techniques. Removal of tetracycline was obtained at 90% with optimized parameters of 500 μg/L concentration, 40 min contact time, 7.5 pH, 1.5 g/L dose, and 298 K temp. The adsorption followed Freundlich model very well in comparison to Lang...
Article
Full-text available
This article describes a technique for the manufacturing of the composites MWCNTs-modified elastomers. The effect of the different MWCNTs mass contents in the elastomer on specific volume and surface electrical resistivity values was investigated. The results on the heaters based on the elastomers and altered with multi-walled carbon nanotubes (MWC...
Article
Full-text available
This article describes a technique for the manufacturing of the composites MWCNTs-modified elastomers. The effect of the different MWCNTs mass contents in the elastomer on specific volume and surface electrical resistivity values was investigated. The results on the heaters based on the elastomers and altered with multi-walled carbon nanotubes (MWC...
Article
Full-text available
In this study, two novel conjugated polymers, poly(4,5,9,10-tetrakis((2-ethylhexyl)oxy]pyrene-alt-2,3-bis(3-(octyloxy)phenyl)-5,8-di(2-thienyl)-6,7-difluoroquinoxaline) (PPyQxff) and poly(4,5,9,10-tetrakis((2-ethylhexyl)oxy)pyren-alt-2,3-bis(3-(octyloxy)phenyl)-5,8-di(2-thienyl)quinoxaline) (PPyQx), consisting of quinoxaline units with and without...
Article
Inexpensive functionalized porous carbon (PC-KF) as a sorbent was prepared from less useful petroleum matrix leftover and characterized by several analytical and spectroscopic methods. The sorbent is used for the removing Co2+ metal ion in water. The optimized conditions were applied: concentration 0.5 mg/L, contact duration 6 min, a dose of adsorb...
Article
Hospital effluents are the sources for complex high percentage of micropollutants and till date no specific treatment have been investigated for the removal of pollutants. These effluents and their complex characteristics pose resistance to unit operation which undergoes in hospital wastewater treatment plants (WWTPs). In other words such complex c...
Article
Full-text available
In present research, the activated carbon was prepared by a green approach from pomegranate peel coated with zero-valent iron nanoparticles (AC-nZVI) and developed as adsorbent for the removal of amoxicillin from aqueous solution. The physicochemical properties of the AC-nZVI were investigated using XRD, FTIR, and FESEM techniques. The optimal valu...
Article
A comparison of high-performance liquid chromatography (HPLC) and solid-phase extraction (SPE) methods is carried out for the simultaneous analysis of indoxyl sulfate and sodium butyrate in plasma using Phenyl (250 x 4.6 mm; 5 µm) and SunShell (150 x 4.6 mm, 2.6 µm) columns with mobile phases ammonium acetate (20 mM)-ACN (95:5, v/v) and water-ACN (...
Article
Despite the availability of some drugs, there is an urgent need for effective anti-cancer medication. It is due to various side effects and non-functionality of the present drugs; especially at the late stage of cancer. Therefore, three series (4a-e, 6a-e and 8a-j; 21 compounds) of benzotriazole-1,2,3-triazole hybrids (carrying different pharmacoph...
Article
Due to a great demand of new anticancer agents, novel series of phtalonitrile‐bis(1,2,3‐triazoles) appended with different functionalities were synthesized and characterized by FTIR, 1H NMR, 13C NMR and mass spectroscopy techniques. These were also screened for DNA binding, docking and anticancer activities. The DNA binding constants were in the ra...
Article
Full-text available
Analysis of 4-cyanophenol and 3-nitrophenol was carried out using multi-walled carbon nanotubes-based solid-phase extraction (SPE) and capillary electrophoresis (CE) methods. Capillary electrophoresis was carried out with 18 kV voltage, 214 nm detection, and phosphate buffer (pH 7.0, 15 mM) as background electrolyte at 25 ± 1 °C temperature with 15...
Article
A new HPLC method was developed for the enantio-separation and chiral recognition mechanism of quinolones (lomefloxacine, ofloxacine, primaquine and quinacrine) on Vancomycin CSP. The column used was Chirabiotic V column (150 x 4.6 mm, 5.0 μm) with two mobile phases i.e. (I) MeOH:ACN:H2O:TEA (50:30:20:0.1%) and (II) MeOH:ACN: H2O:TEA (70:10:20:0.1%...
Article
In an attempt to design and prepare a new library of anticancer candidates, focused thiopropargylated benzothiazole was reacted with ethyl azidoacetate and/or ethyl azidobenzoate to yield newer 1,2,3-triazole-benzothiazole conjugates bearing ester functionality through click chemistry approach. The hydrazinolysis of the obtained ester-based triazol...
Article
Background Diabetes mellitus type-II is a major health problem characterized by hypo-insulinemia and insulin resistance; leading to hyperglycemia and its complications. In Unani medicine, it is known as ziyābetus. Several drugs are prescribed in Unani medicine as single and compound formulations for this disease. Most of these drugs have been studi...
Article
An eco-friendly preparation method for the novel bioactive imidazolium ionic liquids halides (ILs) was developed under microwave-assisted conditions. Synthesized ILs were characterized by spectroscopic techniques. Selected ILs were investigated for their antimicrobial activity against highly resistant Gram-positive and Gram-negative bacterial strai...
Article
Full-text available
In regards to the Cannizzaro reaction and its peculiar mechanism, some researchers have presented a free radical mechanism for the Cannizzaro reaction, while others have found that it is feasible through an ionic mechanism, but the actual mechanism has not been finalized yet. The researchers have given the proof of both the mechanisms through their...
Article
Full-text available
p class="abstrakinggris">Waste released from sugar factories has a huge amount of inorganic and organic matter whose effect on plant is different when used in different concentrations. Hence, the effects of sugar factory effluent on the morphological and biochemical parameters of chickpeas ( Cicer arietinum Linn.) were studied by using the differen...