Prof. Gheita

Prof. Gheita
Cairo University | CU · Rheumatology and Clinical Immunology

MD

About

260
Publications
45,607
Reads
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2,984
Citations
Introduction
Prof. Gheita is a Rheumatology Consultant and EULAR Certified Rheumatologist; Editor In-Chief the Egyptian Rheumatologist (Elsevier) and Editorial Board Member African J (AFLAR), Eur JR, IJRD (APLAR), APR, Rheumatology International, Clinical Rheumatology (ILAR) and Medicine *ex-Director of Research Affair, CU; ex-Head of Scientific Research and Ethics Committee (SReC) Rheumatology Department; SCU member for Rheumatology University Staff promotion in Egypt (2019-22), Member of EULAR Task Force.
Additional affiliations
January 1994 - present
Cairo University
Position
  • Professor
Education
January 1986 - June 1987
University of London
Field of study
January 1981 - January 1985
Horreya Language School - Dokki - Egypt
Field of study
January 1974 - January 1981
Park Walk School - London UK
Field of study

Publications

Publications (260)
Presentation
Full-text available
The current P.P.P. is based and adapted from the original article entitled; " Coronavirus disease 2019 ( COVID-19) an emerging trigger for primary fibromyalgia syndrome: A tale of three cases POST COVID-19." Int. J. Clin. Rheummatol. 2021; 16(4): 123- 135.
Article
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Objective We investigated prolonged COVID-19 symptom duration, defined as lasting 28 days or longer, among people with systemic autoimmune rheumatic diseases (SARDs). Methods We analysed data from the COVID-19 Global Rheumatology Alliance Vaccine Survey (2 April 2021–15 October 2021) to identify people with SARDs reporting test-confirmed COVID-19....
Article
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Vaccine hesitancy is considered a major barrier to achieving herd immunity against COVID-19. While multiple alternative and synergistic approaches including heterologous vaccination, booster doses, and antiviral drugs have been developed, equitable vaccine uptake remains the foremost strategy to manage pandemic. Although none of the currently appro...
Article
Objectives The assessment of physical function is fundamental in the management of patients with idiopathic inflammatory myopathies (IIMs). We aimed to investigate the physical function of patients with IIMs compared with those with non-IIM autoimmune rheumatic diseases (AIRDs) utilizing Patient-Reported Outcome Measurement Information System (PROM...
Article
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Introduction/aims: We studied COVID-19 vaccination-related adverse events (ADEs) 7-days post-vaccination in patients with idiopathic inflammatory myopathies (IIMs) and other systemic autoimmune and inflammatory disorders (SAIDs). Methods: 7-day vaccine ADEs were collected in an international patient self-reported e-survey. Descriptive statistics...
Article
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Objectives COVID-19 vaccines have been proven to be safe in the healthy population. However, gaps remain in the evidence of their safety in patients with systemic autoimmune and inflammatory disorders (SAIDs). COVID-19 vaccination related adverse events (ADEs) in patients with SAIDs and healthy controls (HC) seven days post-vaccination were assesse...
Article
Objectives COVID-19 vaccines have been proven to be safe in the healthy population. However, gaps remain in the evidence of their safety in patients with systemic autoimmune and inflammatory disorders (SAIDs). COVID-19 vaccination related adverse events (ADEs) in patients with SAIDs and healthy controls (HC) seven days post-vaccination were assesse...
Article
Background Metabolic syndrome (MetS) is characterized by insulin resistance, high blood pressure/sugar, dyslipidemia, and obesity. Whether MetS and its components affect the development of Behçet's Disease (BD) remains unclear. Aims The aim was to determine the frequency of MetS among BD patients and to study its relation to the disease characteri...
Article
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The study aimed to explore the experience of coronavirus disease-2019 (COVID-19) infection and vaccine adverse events (AEs) among rheumatologists. A validated questionnaire was distributed as a Google form to rheumatologists across the country via social networking sites from late December 2021 till early January 2022. The questionnaire included qu...
Conference Paper
Full-text available
Background: Evaluation of physical function is fundamental in the management of idiopathic inflammatory myopathies (IIMs). Patient-Reported Outcome Measurement Information System (PROMIS) is a National Institute of Health initiative established in 2004 to develop patient-reported outcome measures (PROMs) with improved validity and efficacy. PROMIS...
Article
Full-text available
Background Polymyalgia rheumatica (PMR) is diagnosed and treated by both general practitioners (GP) and rheumatologists. How rheumatologists around the world manage the referral process of patients with PMR from GP’s has not been described. EULAR/ACR guidelines recommend initial prednisolone doses between 12.5 and 25 mg, but it is unknown if guidel...
Article
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Background Significant gaps are present in the evidence of the spectrum and severity of COVID-19 infection in idiopathic inflammatory myopathies (IIM). IIM patients typically require immunosuppressive therapy, may have multiple disease sequelae, and frequent comorbidities, and thus may be more susceptible to severe COVID-19 infection and complicati...
Article
Objectives COVID-19 vaccines have been proven to be safe in the healthy population. However, gaps remain in the evidence of their safety in patients with systemic autoimmune and inflammatory disorders (SAIDs). COVID-19 vaccination-related adverse events (AEs) in patients with SAIDs and healthy controls (HC) seven days post-vaccination were assessed...
Article
Background Idiopathic inflammatory myopathies (IIM) are a rare, multisystem, heterogeneous diseases, and contribute to high psychological burden. The patients’ perception of physical health, deteriorating independence and social and environmental relationships may not always be a direct function of disease activity. To face with these aspects, seve...
Article
Background Idiopathic inflammatory myopathies (IIM) are a group of heterogeneous autoimmune disorders with limited standardization of treatment protocols. Objectives To evaluate frequency and patterns of various treatments used for IIM based on disease subtype, world region, and organ involvement. Methods Cross-sectional data from the internation...
Article
Background Salivary gland ultrasound (SGUS) is a reliable technique for assessing the salivary glands in patients with primary Sjögren’s syndrome (SS); however, the role of SGUS for diagnosis of secondary SS (sSS) in patients with systemic lupus erythematosus (SLE) was not examined. Objective To assess the diagnostic value of SGUS for sSS in patie...
Article
Full-text available
Objective To examine the frequency of, and risk factors for, disease flare following COVID-19 vaccination in patients with systemic rheumatic disease (SRD). Methods An international study was conducted from April 2 to August 16, 2021, using an online survey of 5619 adults with SRD for adverse events following COVID-19 vaccination, including flares...
Article
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FULL TEXT: https://doi.org/10.2147/OARRR.S355140 Imaging has long been taking its place in the diagnosis, monitor, and prognosis of rheumatic diseases. It plays a vital role in the appraisal of treatment. Key progress in the clinical practice of rheumatology is the innovation of advanced imaging modalities; such as musculoskeletal ultrasound (MSUS)...
Article
Objective To characterize 414 patients with primary SS who developed hematological malignancies and to analyze how the main SS- and lymphoma-related features can modify the presentation patterns and outcomes. Methods By January 2021, the Big Data Sjögren Project Consortium database included 11 966 patients fulfilling the 2002/2016 classification c...
Cover Page
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Bone mineral density, vitamin D receptor gene polymorphisms ( VDR), FRAX, and TBS in rheumatoid arthritis patients
Article
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Purpose To assess vitamin D receptor (VDR) gene polymorphisms and bone mineral density and to investigate the possible risk factors of osteoporosis and fracture in rheumatoid arthritis (RA). Methods A total of 97 RA patients and 45 matched controls were enrolled. Serum vitamin D level, VDR genotyping, dual-energy X-ray absorptiometry (DEXA) scan,...
Article
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The coronavirus disease-2019 (COVID-19) pandemic continues to be a cause of unprecedented global morbidity and mortality. Whilst COVID-19 vaccination has emerged as the only tangible solution to reducing poor clinical outcomes, vaccine hesitancy continues to be an obstacle to achieving high levels of vaccine uptake. This represents particular risk...
Article
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Background: Rheumatoid arthtritis (RA) is a chronic systemic inflammatory autoimmune disease characterized by irreversible joint damage and deformity. The aim of this study is to investigate THRIL and HOTAIR serum expression and their target genes in Egyptian RA patients and to evaluate their relationship to the clinico-pathological data. Methods...
Book
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Our generation has seen unprecedented advances in electromagnetic wave technology. This is considered to be a known reflection to life progression. Thus, the issue is raised to shed light on the effects of non-ionizing radiation of the electromagnetic field (EMF) on the human body, health, rheumatic diseases, and immune system. Is there a possible...
Article
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Background: Vasculitis damage index (VDI) is a validated damage index for systemic vasculitis, and as Behçet's disease is considered one of systemic vascular disease we aimed to study the relationship of the vasculitis damage index to clinical manifestations and comorbidity in patients with Behçet's disease (BD) to determine if VDI could be used t...
Conference Paper
Full-text available
Background/Purpose: Numerous Covid-19 vaccines have demonstrated efficacy and safety against SARS-CoV-2 in general population. Despite favorable adverse effect (ADRs) profile of vaccines, there have been concerns regarding activation of aberrant immune responses. Moreover, vaccine safety data in idiopathic inflammatory myopathies (IIM) and other sy...
Article
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Objective The aim of the work was to delineate the computed tomography pulmonary angiography (CTPA) findings in Behçet’s disease (BD) patients with and without chest manifestations.Patients and methodsThe study included 122 BD adults recruited from 5 Teaching University Hospitals in Egypt of those who agreed to perform a CTPA. The Arabic version of...
Article
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Objective To examine the potential therapeutic effect of mesenchymal stem cells (MSCs) for experimental scleroderma. Materials and methods Fifty-four mice six-week-old (30-35 g) were studied. Hypochlorous acid (HOCl) induced scleroderma was considered. Mice were divided into 3 groups: (I) Control: Six mice did not receive any treatment and were sa...
Article
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Background We describe the early experiences of adults with systemic rheumatic disease who received the COVID-19 vaccine. Methods From 2 April to 30 April 2021, we conducted an online, international survey of adults with systemic rheumatic disease who received COVID-19 vaccination. We collected patient-reported data on clinician communication, bel...
Article
Objectives: This study aims to present the manifestations of juvenile systemic lupus erythematosus (JSLE) across Egypt, to focus on age at onset and gender-driven influence on disease characteristics, and to compare findings to other countries. Methods: The study included 404 Egyptian children with systemic lupus erythematosus (SLE) presenting to o...
Article
Full-text available
Objectives The aim of the present work was to explore the perspectives of Egyptian Rheumatology staff members as regards the coronavirus disease-19 (COVID-19) vaccine. Methods The survey is composed of 25 questions. Some questions were adapted from the global rheumatology alliance COVID-19 survey for patients. Results 187 rheumatology staff membe...
Article
Full-text available
Background We describe the early experiences of adults with systemic rheumatic disease who received the COVID-19 vaccine. Methods From 2 April to 30 April 2021, we conducted an online, international survey of adults with systemic rheumatic disease who received COVID-19 vaccination. We collected patient-reported data on clinician communication, bel...
Article
Full-text available
Objectives This study aims to present the manifestations of juvenile systemic lupus erythematosus (JSLE) across Egypt, to focus on age at onset and gender-driven influence on disease characteristics, and to compare findings to other countries. Methods The study included 404 Egyptian children with systemic lupus erythematosus (SLE) presenting to on...
Article
Full-text available
Objectives: Several studies have shown associations of ABO and Rh blood groups with various diseases; however, the relationship of ABO and Rh blood groups with rheumatic diseases are scarce. The aim of the present study was to examine whether there is an association between ABO and Rh blood groups and the types of rheumatic diseases. Method: In thi...
Article
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Background Behçet’s disease (BD), commonly seen in the Silk road countries, is a variable vessel vasculitis with no specific investigation that reflects disease activity. The Behçet’s Disease Current Activity Form (BDCAF) is the most famous and acceptable clinical activity score.PurposeTo develop a cross-cultural adaptation of the BDCAF to the Arab...
Article
Full-text available
Objective: The aim of this study was to present the epidemiology, clinical manifestations and treatment pattern of systemic lupus erythematosus (SLE) in Egyptian patients over the country and compare the findings to large cohorts worldwide. Objectives were extended to focus on the age at onset and gender driven influence on the disease characterist...
Article
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Background: Corona virus (COVID-19) is an emerging worldwide infectious disease that may be followed in some patients by post COVID-19 syndrome; patients who experience symptom of disease long time after their recovery. Among the frequent post-COVID-19 symptoms are fatigue, headache, sleep disorder, anxiety and musculoskeletal pain which coincide w...
Preprint
International Journal of Clinical Rheumatology (IJCR) Background: Corona virus (COVID-19) is an emerging worldwide infectious disease that may be followed in some patients by post COVID-19 syndrome; patients who experience symptom of disease long time after their recovery.Among the frequent post-COVID-19 symptoms are fatigue, headache, sleep disor...
Article
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During the coronavirus disease-2019 (COVID-19) pandemic there were several barriers to treatment access and medication adherence in rheumatoid arthritis (RA) patients. There is no information regarding the RA patient health status in Egypt during the COVID-19. Thus,the aim of this work was to study the impact of the pandemic on RA patients through...
Article
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African Journal of Rheumatology: Editorial January, 2021 Rheumatic Diseases (RDs) including Rheumatoid Arthritis (RA) and osteoarthritis, are characterized by immune dysregulation and chronic progressive inflammation that leads to irreversible joint damage. Recently, research has focused on Mesenchymal Stem Cells (MSCs) application in RDs due to t...
Article
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Background: Behçet's disease (BD) is a chronic multisystem variable vessel vasculitis. Disease damage is irreversible and permanent. Validated tools evaluating damage are limited. Enhancements in the clinical treatment of vasculitis will take place from the development of refined and exclusive indices for individual vasculitic syndromes including B...
Article
Objectives: To evaluate the systemic phenotype associated with the presence of isolated anti-La/SSB antibodies in a large international registry of patients with primary Sjögren's syndrome (pSS) fulfilling the 2002 classification criteria. Methods: The Big Data Sjögren Project Consortium is an international, multicentre registry created in 2014....
Article
Full-text available
The aim of this work is to trace how rheumatologists all over Egypt are approaching the COVID-19 pandemic and what changes it has brought about in the patients’ care with special attention to its effect on vulnerable rheumatic disease (RD) patients. This survey further aims to help inform the rheumatology community about the changes in practice dur...
Article
Full-text available
The aim of this work is to trace how rheumatologists all over Egypt are approaching the COVID-19 pandemic and what changes it has brought about in the patients' care with special attention to its effect on vulnerable rheumatic disease (RD) patients. This survey further aims to help inform the rheumatology community about the changes in practice dur...
Article
Full-text available
https://eurjrheumatol.org/en/egypt-s-groundwork-blessing-during-the-covid-19-pandemic-curse-rheumatologic-experience-133305
Article
Introduction/objectivesSystemic lupus erythematosus (SLE) and Sjögren’s syndrome (SS) may coexist and carry a higher risk for future comorbidities. Although 14-3-3η protein is recently a known diagnostic marker in rheumatoid arthritis (RA), its role has not been investigated in SLE. The aim of this study was to compare serum 14-3-3η protein level i...
Chapter
The spectrum of spondyloarthritides with inflammatory bowel disease and enteropathic arthritis is examined in an effort to give the reader an insight into the risk factors, treatment and prognosis of this clinically challenging rheumatic disease.
Article
Full-text available
Aim: To investigate serum levels of two Immune-related functional lncRNAs, growth arrest-specific transcript 5 (GAS5) and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), in Egyptian patients with SLE and to evaluate their relationship with disease activity. Method: The present study was a case-control study that was carried out on...
Article
Objective: To characterize the systemic phenotype of primary Sjögren's syndrome at diagnosis by analysing the EULAR-SS disease activity index (ESSDAI) scores. Methods: The Sjögren Big Data Consortium is an international, multicentre registry based on worldwide data-sharing cooperative merging of pre-existing databases from leading centres in cli...
Conference Paper
Full-text available
Background/Purpose: Ocular involvement in Behçet’s Disease (BD) is associated with chronic damage and high morbidity; however, limited evidence is available on risk factors to recognize the subset of BD patients at jeopardy to develop vision-threatening disease (VTD). There is a clear need for identification of those patients early in order to redu...
Article
Full-text available
The wound healing process is a multifaceted sequence of activities associated with tissue restoration. Novel approaches for the perfection of wound healing have been determined as a stitch in time saves nine. Dysregulation of the immune response is a key element in the pathogenesis of rheumatic diseases and serves as a potential target for novel th...
Article
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OBJECTIVE: To determine to neutrophil-to-lymphocyte ratio (NLR) in granulomatosis with polyangiitis (GPA) patients and to study its relation to disease manifestations and activity. METHODS: The study included 44 GPA patients and 44 matched age and sex controls. Full history taking, thorough clinical examination with more attention to ocular examin...
Article
The therapeutic management of Sjögren syndrome (SjS) has not changed substantially in recent decades: treatment decisions remain challenging in clinical practice, without a specific therapeutic target beyond the relief of symptoms as the most important goal. In view of this scenario, the European League Against Rheumatism (EULAR) promoted and suppo...
Article
Full-text available
Objective The anti-aging protein alpha-Klotho has been reported to have an emerging role in the pathogenesis of systemic sclerosis (SSc). More studies are needed to approach this issue. This study aimed to assess the serum levels of α‑Klotho in SSc patients compared to healthy controls, and to correlate them with the disease parameters. Methods Fo...
Presentation
Full-text available
Prof. Gheita participated as a panelist in the session entitled " Rheumatological Debates in HepatoGastroEnterology" Held on the Friday, 27th September, 2019 - Grand Nile Tower In collaboration with Prof. Maisa El-Raziky (Prof. of Tropical Medicine, CU) Prof. Aisha El-Sharkawy (Prof. of Tropical Medicine, CU) Prof. Mohamed Alboraie (AlAzhar Unive...
Article
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The author wishes to correct the record and clarify that in the original version of this article in the Discussion section under “Prevalence over the country governorates” inadvertently presented incorrect data cited in the reference [30].
Conference Paper
Full-text available
Objectives: To analyse the phenotype of patients with primary Sjogren syndrome (SjS) in whom a lymphoproliferative disease is diagnosed concomitantly. Methods: By January 2019, The Big Data Sjögren Project included 11,420 consecutive patients with primary SjS recruited from 24 countries of the five continents. Results: 117 (1%) patients were diagno...
Preprint
*Record the number of positive items (1 point for each unless specified) *Events should be persistent for >3 months unless initially irreversible *Complete the BDI at baseline visit and every 3 months thereafter ------------------------- The BDI is for recording irreversible organ damage that has occurred in Behçet’s disease patients since disease...
Conference Paper
Full-text available
Objectives To analyse how the age at diagnosis modifies the phenotype of primary Sjögren syndrome (SS) Methods The Big Data Sjögren Project was formed in 2014 to take a “high-definition” picture of the main features of primary SS at diagnosis by merging international SS databases. By January 2019, the database included 11,420 patients from 24 coun...