Prof. Ali Zarei Mahmoudabadi

Prof. Ali Zarei Mahmoudabadi
Ahvaz Jundishapur University of Medical Sciences | ajums

BSc, MSc, PhD

About

133
Publications
30,733
Reads
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1,553
Citations
Introduction
Prof. Ali Zarei Mahmoudabadi currently works at the Department of Medical Mycology, Ahvaz Jundishapur University of Medical Sciences. Prof. Ali does research in Infectious Diseases. Their current project is 'Genotyping and antifungal susceptibility testing of Candida glabrata strains isolated from patients with Candida vaginitis with Microsatellite length polymorphisms (MLP) method'.
Additional affiliations
March 1992 - present
Ahvaz Jundishapur University of Medical Sciences
Position
  • Academic member, Editor in chief JJM

Publications

Publications (133)
Article
Although Candida albicans is a part of the mycoflora of healthy individuals, it is causing mild to severe forms of candidiasis in patients with underlying diseases. The recent molecular investigations were classified three genotypes, A, B, and C for C. albicans. The aim of the present study was to detect different genotypes of C. albicans complex s...
Article
Aspergillus species are the leading cause of invasive aspergillosis in immunocompromised hosts. The susceptibility of Aspergillus species to antifungal agents might be different.
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Background and Objectives: Catalases are a good scavenger of H2O2 which degrades hydrogen peroxide into water and oxygen. They are considered as a virulence factor that are present in both spores and hypha of fungi. There is limited data regarding catalase activity in Aspergillus species. This study aimed to assess the mycelial catalase activity of...
Article
Background Members of the Nannizzia gypsea complex are globally the most common geophilic dermatophytes which cause infection in animals and human. Although the susceptibility patterns of anthropophilic or zoophilic dermatophyte species to antifungal agents are well documented, the effectiveness of such drugs against geophilic species have rarely b...
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Background Candida albicans is the most common and virulent genus Candida. Detection of virulence factors in this species plays an important role in the better understanding of pathogenesis and antifungal treatment. Molecular typing investigations are important in the epidemiological interpretation of infection. This study aimed to evaluate extrace...
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Background Species from the Trichophyton benhamiae complex are mostly zoophilic dermatophytes which cause inflammatory dermatophytosis in animals and humans worldwide. Objectives This study was purposed to 1) to identify 169 reference and clinical dermatophyte strains from the T. benhamiae complex species by molecular method and adhering to the ne...
Article
The presence of Candida species in urine may be due to colonization of this species in the bladder, urinary catheter, and perineum. Candida albicans has been the most commonly isolated from urine samples in patients with candiduria. Several virulence factors include adhesion to host cells, secreted extracellular enzymes, phenotype switching, and bi...
Chapter
The epidemiological trends of dermatophyte infections (dermatophytosis or Tinea) in Iran from 1960 to 2018 are characterized here. A thorough search in different literature databases was performed together with statistical analyses. Our findings stress that mycological and clinical aspects of dermatophytosis in Iran have notably been revolutionized...
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Background Esophageal candidiasis is the most frequent form of esophagitis. The pathogenicity of Candida spp. is related to a combination of microbial factors, hydrolytic enzyme secretion and phenotypic switching. This study was designed to investigate esophageal candidiasis, antifungal activity, enzymatic activity patterns, phenotyping, and genoty...
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Cryptococcus species is an opportunistic yeast pathogen and classified into different molecular types according to typing techniques including multilocus sequence typing (MLST). The study aimed to investigate the genotypes of environmental Cryptococcus isolates using MLST and the relationship between the in vitro antifungal susceptibility and seque...
Article
Background: Candida glabrata is the second agent of candiduria with increased resistance to antifungals. Microsatellite length polymorphism (MLP) is one of the genotyping techniques used in the epidemiological investigation to improve clinical management. Objectives: We aimed to detect different genotypes of C. glabrata isolates using six microsate...
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Background: Cryptococcus neoformans is an encapsulated yeast pathogen with worldwide distribution, and the highest incidence of cryptococcosis was attributed to C. neoformans (var. grubii. The pathogenicity of Cryptococcus species is associated with several factors, including capsule and melanin production, growth at 37 ºC, and secretion of extrace...
Article
Aims: The present study aimed to determine the microsatellite length polymorphism genotypic patterns and antifungal susceptibility profiles of Candida albicans isolated from patients with candiduria. Methods and results: DNA of 50 C. albicans isolates was used for molecular identification based on the ITS1 -5.8s-ITS2 region. Microsatellite lengt...
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Luliconazole is an imidazole antifungal agent used in topical form for the treatment of onychomycosis and dermatophytosis. In vitro activity of luliconazole against dermatophytes, Candida, black fungi, Fusarium and Aspergillus species have been investigated. Rhodotorula spp. are environmental yeasts and emerged as opportunistic pathogens among immu...
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Luliconazole is a new antifungal that was primarily used for the treatment of dermatophytosis. However, some studies have shown that it has excellent efficacy against Aspergillus and Candida species in vitro. The present study aimed to evaluate of luliconazole activity against some Fusarium species complex isolates. In this study, 47 isolates of Fu...
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Background and purpose: Candida glabrata is the second cause of candidiasis. The mortality rate of C. glabrata infections is about 40%; accordingly, it may be life threatening, especially in immunocompromised hosts. Regarding this, the current study was conducted to evaluate the regional patterns of the antifungal susceptibility of clinical C. gla...
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Background and purpose: Otomycosis is a secondary ear fungal infection among predisposed individuals in humid conditions. Aspergillus species are the most common etiologic agents of this infection. Several ototopical antifungals are currently used for the treatment of this disease; however, recurrence and treatment failure are usually observed in...
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Background and objectives: Luliconazole is currently confirmed for the topical therapy of dermatophytosis. Moreover, it is found that luliconazole has in vitro activity against some molds and yeast species. The aim of the present study was to evaluate the efficacy of luliconazole in comparison to routine used antifungals on clinical and environmen...
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Introduction: Trichophyton mentagrophytes and T. interdigitale are important causative agents of superficial mycoses, demonstrating emergent antifungal drug resistance. We stu- died the antifungal susceptibility profiles in Iranian isolates of these two species. Methods: A total of 96 T. interdigitale and 45 T. mentagrophytes isolates were subjecte...
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Background Vulvovaginal candidiasis (VVC) is a prevalent infection among HIV-seropositive women that still needs to be subjected to more researches. This study is aimed at determining the occurrence of vulvovaginal Candida species and their antifungal susceptibility pattern in HIV-seropositive women from the Behavioral Disease Counseling Center in...
Article
Background and Objectives: Black Aspergillus strains including, Aspergillus niger and A. tubingensis, are the most cause of otomycosis with worldwide distribution. Although, amphotericin B was a Gold standard for the treatment of invasive fungal infection for several decades, it gradually replaced by fluconazole and /or voriconazole. Moreover, luli...
Data
This table contains accessions with data, generated by Iranian group in the course of the study.
Data
Trichophyton mentagrophytes and T. interdigitale ITS region sequences. The file contains 1205 entries, selected for the analysis. The number includes sequences, generated during the course of the study. Each sequence belongs to a genotype, deposited at least three times by laboratories from at least two countries, according to the 3/2 rule. The dat...
Article
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Background: The fungi Trichophyton mentagrophytes and T. interdigitale account for significant amount of dermatophytosis cases worldwide. These two dermatophytes form a species complex and have a number of ribosomal ITS region genotypes, allowing simultaneous species identification and strain typing. Objectives: Our aim was to describe the geogr...
Article
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Vulvovaginal candidiasis (VVC) is a yeast infection with a global reach and millions of dollars are spent annually for its diagnosis and treatment. Recently, Candida glabrata with different degrees of antifungal resistance has been considered as the second most common cause of vaginal infections. The aim of the present study is to determine the ant...
Preprint
Background: Biosurfactants are amphiphilic surface active compounds that produced by several microorganisms, including, bacteria and fungi. Biodegradability, low toxicity, applications diversity and functionality under extreme conditions are characterized them from chemically biosurfactants. It is found that, Rhodotorula species, read yeasts, have...
Preprint
Full-text available
Black Aspergilli are, the most causes of aspergillosis and Aspergillus niger and A. tubingensis are two more frequently isolates. Although, amphotericin B was a gold standard for the treatment of invasive fungal infection for several decades, it replaced by several new antifungals. Furthermore, a novel antifungal, luliconazole, appears to offer the...
Article
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Background: Candida infections are one of the most important nosocomial infections that have increased by 3.5 to 14 folds over the past decades. Although the sources of infection are human normal flora, hospital environments have an undeniable role. The increased use of antifungals, prolonged prophylaxis, and some organism-associated genetic factor...
Article
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Although, several categories of nosocomial infections are presented during the recent years, urinary tract infections (UTIs) considered as one of the most important systemic infections. The presence of Candida species in the urinary tract system (Candiduria) is seen in only 10-15% of the cases with UTI, however candiduria has been considered as mor...
Article
Conventional direct microscopy with potassium hydroxide (KOH) and culture were found to lack the ability to establish a fast and specific diagnosis of dermatophytosis. A pan‐dermatophyte nested‐PCR assay was developed using a novel primer pair targeting the translation elongation factor 1‐α (Tef‐1α) sequences for direct detection and identification...
Article
Objective: Usually, 7-20% of preterm neonates colonized by Candida species present invasive candidiasis. Candida albicans, and several non-albicans species cause invasive infection with C. albicans being the most dominant agent. In the last two decades, infection due to non-albicans have been increased dramatically due to their low sensitivity to...
Article
Introduction: Airborne fungi are considered important causes of respiratory allergy and diseases. The knowledge of these fungi in a city or region is important for the ecological diagnosis and specific treatment of respiratory manifestations induced by inhalation of fungal agents. Therefore, in recent years bioaerosols and their density in the air...
Article
Objective: Luliconazole is an inhibitor for sterol 14-α-demethylase in fungal cells with a broad-spectrum antifungal activity against dermatophytes, Candida albicans, Malassezia species, dematiaceous and hyaline hyphomycetes. Furthermore, luliconazole has been clinically used for the treatment of pityriasis versicolor, dermatophytosis, onychomycos...
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Background: Invasive fungal infections acquired in the hospital have progressively emerged as an important cause of lifethreatening infection. In particular, airborne fungi in hospitals are considered critical pathogens of hospital-associated infections. Objectives: This study aimed to investigate the airborne fungi of indoor environments of educat...
Article
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Occurrence and diversity of dermatophyte mycoflora in 298 soil samples from Ahvaz, Southwest of Iran was investigated by using the hair-baiting technique. The samples were collected during spring (n = 210) and autumn (n = 88) of 2015, and the fungal isolates were identified based on the macro- and micro-morphology of colonies and with further ITS-r...
Article
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Background and purpose: Ozone is an inorganic molecule with effective antimicrobial properties. Clinical treatment of ozonated water was used for the elimination of Candidaalbicans, Enterococcus faecalis, endotoxins, and biofilms from root canals. In addition, its therapeutic effects for tinea pedis, ulcers, and leishmaniasis were investigated. Th...
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Background and Purpose: Ozone is an inorganic molecule with effective antimicrobial properties. Clinical treatment of ozonated water was used for the elimination of Candida albicans, Enterococcus faecalis, endotoxins, and biofilms from root canals. In addition, its therapeutic effects for tinea pedis, ulcers, and leishmaniasis were investigated. Th...
Article
Aspergillus terreus is the fourth leading cause of invasive and non-invasive aspergillosis and one of the causative agents of morbidity and mortality among immunocompromised and high-risk patients. A. terreus appears to have increased as a cause of opportunistic fungal infections from superficial to serious invasive infections. Although, invasive a...
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Background and Objectives Vulvovaginal candidiasis is a common fungal infection among women during reproductive ages. Although, Candida albicans is accounted as the main etiologic agent of vaginitis, non-albicans species have arisen during last years. Resistant to antifungal drugs especially, fluconazole has been more reported by researchers from a...
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Background: Neutropenia, as a predisposing factor for invasive candidiasis, is defined as a reduction in neutrophil count to less than 1500/mm(3). It is a common condition in patients with hematological malignancy and cytostatic chemotherapy. Extensive chemotherapy and prophylaxis with antifungals have increased the resistance of Candida isolates...
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Background: Candida species are normal mycoflora of human body which are capable to cause urinary tract infection (UTI). Mannose-binding lectin (MBL) is a kind of innate immune system and decreasing plasma levels of MBL may disrupt the natural immune response and increase susceptibility to infections. Objectives: The aim of the present study was...
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Background and objectives: Pneumocystis jirovecii pneumonia (PJP) is a chronic fungal infection that caused by P. jirovecii. Disease is more prevalent among the HIV-infected patients. The colonization of pneumocystis in human respiratory system is associated with the airway inflammation and obstruction. The current study was conducted to identify...
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Background: The different species of Rhodotorula are living in the environment and considered as normal inhabitants in the human body. In addition, they are found as common contaminants of skin, urine, respiratory and gastrointestinal systems among normal individuals. Out of several species of Rhodotorula, Rhodotorula mucilaginosa, R. glutinis and...
Article
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Background: Otomycosis is a superficial fungal infection often involves the pinna and external auditory canal. It is a pathologic condition, with Candida and Aspergillus, the most common fungal species. It is common worldwide but more prevalent in tropical and subtropical countries. Objectives: The aim of this study was to determine the etiologi...
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Background: The activity and role of different extracellular secreted enzymes has been characterized in the pathogenesis of different fungal species. Phytase, a special class of histidine acid phosphatases has recently been specified in some fungal species but not in Candida albicans. The objective of the present study was to elucidate the ability...
Article
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Several studies have shown that there are an increasing in invasive candidiasis during 2-3 last decades. Although, Candida albicans is considered as the most common candidiasis agents, other non-albicans such as C. glabrata, C. krusei, C. parapsilosis, and C. tropicalis were raised as infectious agents. Resistance to fluconazole among non-albicans...
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Background: Dermatophytosis is a superficial infection caused by filamentous fungi belonging to the following three genera: Microsporum, Trichophyton and Epidermophyton. Arbitrarily primed PCR (AP-PCR) is a rapid and sensitive procedure for the diagnosis of the fungal species. Objectives: To identify various dermatophyte species as rapidly and prec...
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Extracellular phospholipase, proteinase, and coagulase are accounted as the major virulence factors in Candida albicans. Several reports showed that the incidence of resistance to fluconazole has risen during last two decades. The present study has investigated the extracellular enzymes of C. albicans and non-albicans species isolated from both pat...
Article
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Candiduria is a rising condition among hospitalized patients and Candida albicans is the most common recovered agent. However, non-albicans Candida species (NACs) such as C. glabrata, C. krusei, C. parapsilosis, and C. tropicalis are also important. Although most Candida species especially C. albicans are sensitive to routinely used antifungals, an...
Article
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Diabetes mellitus as a chronic metabolic disease occurs in patients with partial or complete deficiency of insulin secretion or disorder in action of insulin on tissue. The disease is known to provide conditions for overgrowth of Candida species. Candida spp. cause candidiasis by many virulence factors such as esterase, hemolysin and phospholipase....
Article
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Background and Purpose Otomycosis is an acute, subacute or chronic fungal infection of the pinna, the external auditory meatus and the ear canal caused mainly by several species of saprophytic fungi. Lamisil (Terbinafine) is an allylamine antifungal agent, that is used both in the topical and oral administration for the treatment of dermatophytosis...
Article
Fungal infection of the external auditory canal (otitis externa and otomycosis) is a chronic, acute, or subacute superficial mycotic infection that rarely involves middle ear. Otomycosis (swimmer’s ear) is usually unilateral infection and affects more females than males. The infection is usually symptomatic and main symptoms are pruritus, otalgia,...
Article
Full-text available
Background: The species of the genus Malassezia are lipophilic and dimorphic yeasts that are regarded as part of the normal flora of the skin of humans and warm-blooded animals. These organisms are the cause of superficial mycosis in humans and other animals, and are common in pityriasis versicolor and seborrheic dermatitis. Objectives: The purpose...
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Background: Phenotype switching in Candida albicans has closely correlated with its pathogenicity. This phenomenon spontaneously occurs at very low frequency in environment. The ability phenotype switching in C. albicans is inherit, reversible and effected by a number of environmental factors including; temperature, pH, and the composition of the s...
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Background: Nowadays Candida albicans has become resistant to the toxic and expensive commercial anti-Candida drugs. Therefore, investigation for new anti-fungal agents is necessary. Objectives: The purpose of this survey was to investigate the in vitro anti-Candida activity of the hydroalcoholic extracts of Heracleum persicum fruit. Materials an...
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Background: The ability of Candida albicans to form biofilms and adhere to host tissues and biomaterial surfaces is an important factor in its pathogenesis. One of the main characteristics of biofilms is their resistance to broad-spectrum anti-microbial drugs. Objectives: In the present study the formation of biofilm by C. albicans from different...
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Background: Tinea versicolor is a superficial mycosis caused by Malassezia furfur, and is exclusively localized in the corneal layer of adults epidermis. Objectives: To evaluate the epidemiological features of tinea versicolor, including its incidence among different age groups, genders and other personal status. Materials and methods: The study wa...
Article
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Seborrheic dermatitis (SD) is a frequent disorder of the skin that is distinguished by the development of erythematous patches and yellow-gray scales. It is a multifactor disease that requires predisposing factors for its progress. Presence of these factors leads to reproduction of opportunistic yeast Malassezia spp. The aim of the present study wa...