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Publications (22)
With the aim of integrating clinical pharmacology with pharmacogenomics and providing a platform to gather clinicians, academicians, diagnostic laboratory personnel and scientists from related domains, the International Conference on Clinical Pharmacology and Pharmacogenomics 2023 (ICCPP 2023) was jointly organized by the Department of Pharmacology...
Background and Aim The incidence of various cancers including the prostate, is on the rise globally. Prostate cancer is one of the most frequently reported cancer in men worldwide. This study was done to study the correlation of free PSA, percentage free PSA, and PSAD, with prostate biopsy findings, and the role of DRE in screening for carcinoma pr...
Secukinumab is an anti-interleukin (IL)-17A IgG1-κ monoclonal antibody approved for psoriasis, psoriatic arthritis, and ankylosing spondylitis. Its efficacy is well documented, but the complete safety profile of secukinumab, especially on long-term use, needs to be studied. IL-17 inhibitors increase the risk of infections, especially respiratory tr...
Drug use during pregnancy is not common. Drug-induced liver injury (DILI) is a potential complication that is rare but can adversely affect both the mother and the fetus. Although many drugs can directly cause hepatotoxicity, idiosyncratic liver injury is common in pregnancy. Underreporting of adverse drug reactions, lack of adequate literature reg...
Though the incidence of opportunistic infection (OI) is reducing with combination antiretroviral therapy. In this study we aimed to identify the pattern of the occurrence of opportunistic infections in HIV (Human Immunodeficiency Virus) patients. This was a retrospective, case-record based, time-bound study over a four year period (2013-2016) which...
Background
Type 2 diabetic patients often require insulin therapy for better glycaemic control. However, many of these patients do not receive insulin or do not receive it in a timely manner.
Objective
The study was planned to assess the proportion of type 2 diabetic patients attaining treatment goals as per the ADA 2018 guidelines. In addition, p...
Background:
The specific treatment recommendations for type 2 diabetes mellitus (T2DM) differ based on a particular guideline. The goal of pharmacotherapy is to achieve the target HbA1c and fasting and postprandial blood glucose levels to avoid disease complications.
Objective:
To evaluate the profile of T2DM patients on different antidiabetic t...
Background and objectives:
The drugs most commonly implicated in major potential interactions are those used in the day-to-day clinical management of elderly patients with chronic diseases. This study is planned to evaluate the profile of drug-drug interactions in the medications prescribed to elderly population and also to identify the possible p...
Background and Objectives
The objective was to study the adverse drug reaction (ADR) profile in HIV patients receiving first-line antiretroviral therapy.
Methods
This was a prospective, observational study that included 171 HIV patients with a follow-up at six months. Demographic details, medical history, details of HIV infection including most re...
Background: Prescribing multiple medications to a patient increases the
complexity of the treatment regimen and, thereby, the chances of noncompliance
and adverse effects. The phase of discharge from the hospital is a
critical period wherein the patient and/or the caretakers have to assume
the responsibility of taking/providing the medications as d...
Objectives:
The present study is an attempt to standardize and establish validity and reliability of objective structured practical examination (OSPE) as a tool of assessment in pharmacology.
Methods:
The individual stations were standardized by establishing the blueprint of assessment, checklists for individual OSPE stations, and a review and r...
Heart failure (HF) is a syndrome whose cardinal symptoms are dyspnea and fatigue leading to a progressive decrease in exercise capacity. Drugs currently used include angiotensin-converting-enzyme inhibitors, angiotensin receptor blockers (ARB), diuretics, alone or in combination, and in the cases where indicated, digoxin. Sacubitril/valsartan repre...
Objective: To evaluate anti-inflammatory activity of bioenhanced turmeric formulation (BCM-95) compared to commercial Curcumin formulation (Curcuminoids 95%) in Carrageenan-induced acute inflammatory model. Materials and Methods: Thirty six Wistar rats were divided into six groups-Normal control (2 ml of vehicle), Standard control (Indomethacin 10...
Familial hypercholesterolemia (FH) is a genetically transmitted condition, wherein abnormally high levels of total cholesterol and low density lipoproteins (LDL) are seen. Occurrence of premature cardiovascular complications is common, resulting in significant morbidities and fatalities. Currently statins are the first-choice drugs to treat FH, giv...
Introduction:
The present study was carried out to study the role of metabotropic glutamate receptor 7 (mGluR7) using its agonist, N,N'-bis(diphenylmethyl)-1,-ethanediamine (AMN082) for nociceptive stimuli, in animal models. By conducting this research, we aim to introduce a novel target for acute pain management.
Objective:
To study the role of...
A genius in more than one basic field, with many important discoveries/inventions such as folate, methotrexate, aureomycin, and diethylcarbamazine etc., The wonder drugs he created helped conquer many diseases considered incurable till then, and even today, these drugs continue to be used routinely. Also, his discoveries led to better understanding...