Priyani Paranagama

University of Kelaniya · Department of Chemistry

Lasiodiplodia theobromae is one of the frequently isolated fast growing endolichenic fungus. This fungus was isolated from the lichen host, Pyrenula bahiana collected from the mangrove ecosystems in Puttlam lagoon and its identification was confirmed based on rDNA-ITS sequence homology. Secondary metabolites of L. theobromae were extracted into eth...

Fungal involvement in biodeterioration of Low Density Polyethylene (LDPE) has received a great attention in recent years. Among diverse groups of fungi, Endolichenic Fungi (ELF) are adapted to thrive in resource limited conditions. Present study was designed to investigate the potential of mangrove associated ELF, in biodeterioration of LDPE and to...

Bioassay-guided fractionation of the ethyl acetate extract of Phanerochaete sordida, an endolichenic fungus (ELF) isolated from the host lichen Bactrospora myriadea, collected from Negombo lagoon, Sri Lanka, led to the isolation of a bioactive compound. Following the identification of the fungus using morphological and DNA barcoding techniques, the...

Fungi are known to produce diverse scaffolds possessing unique biological activities, however, to date, no molecule discovered from a fungal source has reached the market as an anti‐cancer drug. Every year number of cytotoxic molecules of fungal origin are getting published and critical analysis of those compounds is necessary to identify the poten...

Lichens are used in folklore medicines across the globe for wound healing and to treat skin disorders and respiratory diseases. They are an intricate symbiosis between fungi and algae with the domination of fungal counterparts. Recent research studies pointed out that yeast is a third major partner in lichens. Endolichenic fungi (ELF) are also a pa...

Endolichenic fungi (ELF) serve as a novel source of secondary metabolites. Hypoxylon lividipigmentum is an ELF isolated from the lichen Opegrapha medusulina, collected from mangrove plant Xylocarpus granatum from Negombo lagoon, Sri Lanka. The fungus was identified to the species level using morphological and DNA barcoding techniques. Ethyl acetate...

Endolichenic fungi (ELF) serve as a novel source of natural products with distinctive bioactivities. A total of 58 ELF isolated from 29 lichens collected from mangrove and mangrove-associated plants of Negombo lagoon, Sri Lanka were identified using morphological and DNA barcoding techniques. Ethyl acetate extracts of 18 such identified ELF isolate...

Citation: Wethalawe, A.N.; Alwis, Y.V.; Udukala, D.N.; Paranagama, P.A. Antimicrobial Compounds Isolated from Endolichenic Fungi: A Review. Molecules 2021, 26, 3901. Abstract: A lichen is a symbiotic relationship between a fungus and a photosynthetic organism, which is algae or cyanobacteria. Endolichenic fungi are a group of microfungi that reside...

Brinjal Fruit and Shoot Borer- Leucinodes orbonalis Guenee is a major insect pest on brinjal- Solanum melongena worldwide. An effective strategy used in developing pest controlling agents is the synergism between insect pheromones and host plant volatiles, which can increase the attraction of insect pest. The present study was aimed at investigatin...

Background: Kaluduru Tippili Leha is a Sri Lankan traditional herbal linctus which is given for dysarthria after ischemic stroke for many years. It has Nigella sativa L, Piper longum L, Bees honey, and fresh juice of Punica granatum L. seeds. Phytochemicals and therapeutic properties in plants occur through differences in growth, geographical locat...

The Genus Piper comprises with many economically and medicinally important species in which essential oil is one of the major secondary metabolites responsible for medicinal properties of these plants. The present study was aimed to investigate volatile chemical constituents and in vitro antibacterial, antioxidant and anti-inflammatory activities o...

Endophytic fungi, which are known to inhabit all plants in any surrounding, have been established solidly as luxuriant producers of secondary metabolites and a propitious origin of bioactive compounds with many applications pharmaceutically, agriculturally and industrially. Sri Lanka, a tropical island rightfully recognized as part of the 34 biodiv...

Endolichenic fungi (ELF) have been recognized as a promising source of bioactive secondary metabolites. Sri Lanka, a biodiversity hotspot, harbours a remarkable diversity in mangrove ecosystems. In the present study, endolichenic fungi obtained from mangrove lichens of Puttalam lagoon were studied for their secondary metabolites. An endolichenic fu...

Adenantherq pqvonino L.(vemacular:Madatiya) is a medicinal plant, belongs to family Fabaceae. It is widely used for the treatments of many diseases in various therapeutic systems including Ayurveda. The medicinal uses and the distribution ofthe species were studied using a structured questionnaire survey considering 100 sample population. Morpholog...

r3-,5,,& ,, Abstract.' Substitute of drugs generally done when original drugs are not available or may be available in miniature quantity. Neem gum (gum exudates of tree Azadyrachta indica) has been mentioned as a ' substitute of Guggul (gum exudates of Qommiphora mukul) in order to preparation of decoetions. But. there are no any studies have been...

Corresponding author (priyani@kln.ac.lk; https://orcid.org/0000-0001-5489-081X) This article is published under the Creative Commons CC-BY-ND License (http://creativecommons.org/licenses/by-nd/4.0/). This license permits use, distribution and reproduction, commercial and non-commercial, provided that the original work is properly cited and is not c...

A review of the values of Pouteria campechiana (Rata Lawulu) through phytochemical, Nutritional and Biological potency Abstract Pouteria campechiana (commonly known as Rata La-wulu) to the family Sapotaceae, is an evergreen tree found in almost every part of Sri-Lanka a few decades ago. Now only a few trees are seen in certain places. However, o...

Unbelievable benefits of Curcuma longa in Non-communicable diseases - a review Abstract Curcuma longa (CL) is a rhizomatous herbaceous perennial plant of the ginger family, Zingiberaceae. It is native in tropical South Asia. Curcuma longa, the common curry powder, has been used from the ancient period for therapeutic purposes by all Traditional...

A review of the values of Pouteria campechiana (Rata Lawulu) through phytochemical, Nutritional and Biological potency Abstract Pouteria campechiana (commonly known as Rata La-wulu) to the family Sapotaceae, is an evergreen tree found in almost every part of Sri-Lanka a few decades ago. Now only a few trees are seen in certain places. However, o...

The accelerating pharmaceutical problem ofbacteria growing resistant to existing antibrotics forces the scientific community to search for new antibacterial compounds for antibiotic drug development. I-iterature reveals that Sri Lankan mangrove inhabiting endolichenic fungal (ELF) population is rich in nrany such bioactive compounds-Previously isol...

The lichen host, Amandinea medusulina, collected from mangrove habitats in Sri Lanka, and its associated endolichenic fungi were isolated and identified by rDNA-ITS sequence analysis and morphological features. One of the fungal strains frequently isolated from the lichen thalli was identified as Xylaria psidii. This study aimed at the isolation an...

Endolichenic fungi, an unexplored group of microorganisms, are a promising source of bioactive compounds. Secondary metabolites were isolated from the chloroform fraction of crude ethyl acetate extract of endolichenic fungus Daldinia eschscholzii inhabiting the lichen, Parmotrema sp. in Sri Lanka. Two pure compounds, 1 and 2 were isolated and the s...

Fresh-cut fruits and vegetables emerge as popular food for consumers in retail markets. However, a loss of millions of dollars yearly to the food industry has been due to discoloration of fruits and vegetables caused by a pronounced reaction called enzymatic browning, which is caused by the activity of the polyphenol oxidase enzyme present in most...

Leucinodes orbonalis Guenee, Brinjal fruit and shoot borer (BFSB), is the major pest on brinjal world wide. Larvae of this pest cause the damage; which at initial stages adversely affect the shoot growth, and in later stages diminish fruit quality. Spraying of insecticides is the main pest control method. This has been absolutely ineffective due to...

Obesity has become huge health problem in the entire world. In Sri Lanka, the prevalence of obesity is estimated to be 20.3% in men and 36.5% in women in four provinces. Further, the highest prevalence rate in Western Province, especially in Colombo was estimated to be 32.2%, among adults. Obesity is associated with osteoarthritis, obstructive slee...

The genus Cinnamomum comprises approximately 250 species of which 8 species are endemic to Sri Lanka. Among them, there is C. zeylanicum Blume (Linn.) (Kurundu in Sinhala and cinnamon in English), also called true cinnamon, which belongs to the Lauraceae family. The bark and the leaf of C. zeylanicum are the most important and popular species used...

With the revelation of intriguing bioactive properties from natural sources, the thirst to investigate more into the mysteries of nature has immensely expanded. Endolichenic fungi (ELF) became an interesting source during the recent past in this search for novel bioactive compounds and literature sources provide evidence of many such bioactive comp...

Vernonia cinerea is a herb having several medicinal properties such as antidiabetic, antioxidant, antimicrobial, antiinflammatory and anticarcenogenic. This work investigated the proximate and mineral composition in different parts (leaves, roots, stem and flowers) of V. cinerea using standard procedures. Collected data of proximate and mineral ana...

Context: Endolichenic fungi are the microorganisms living inside the thalli of the lichen and found to be a new source of bioactive secondary metabolites. This is an underutilized source of bioactive compounds and has not been studied extensively. Genus, Parmotrema is one of the foliose lichens with largely rounded lobes and occurs on rocks of rain...

In the pharmaceutical industry, the expected surge in production of new therapeutic entities promised by technological advances, such as high-throughput screening, synthetic libraries and advances in molecular biology and genomics, has not materialized. The unique structural diversity of natural products continues to provide opportunities to discov...

Cancer is a global burden. In low- and middle-income countries around 70% of deaths are due to cancer. For a number of years natural products have been a good source of agents for combatting cancer and plants have played a huge role in anti-cancer product development. For many centuries, indigenous cultures around the world have used traditional he...

Endolichenic fungi (ELF) are unexplored group of organisms as a source for the production of bioactive secondary metabolites with radical scavenging activity, antilipase and amylase inhibitory activities. Endolichenic fungi in lichens collected from mangrove or mangrove associated plants are least known for their fungal diversity and potential to p...

Absorbance values obtain in DPPH assay (at 517nm) for all the ELF isolates used in the study. (PDF)

Absorbance values obtain in amylase inhibitory assay (at 540nm) for all the ELF isolates used in the study. (PDF)

Sequence data of ITS-rDNA region of isolated ELF from lichens in Puttalam lagoon and their URLs in GenBank. (PDF)

Absorbance values obtain in lipase inhibitory assay (at 405nm) for all the ELF isolates used in the study. (PDF)

URLs of deposited sequence data in GenBank for endolichenic fungi collected from lichens in Puttalam lagoon. (DOCX)

ABSTRACT: Borassus flabeliffer Linn. (Palmyra Palm) is widely distributed in the Northern parts of Sri Lanka. Its leaves, fruits and pith have various uses. Palmyra based industries provide living for many families in that region. Palmyra pulp obtained from the ripe fruit is used in many traditional food items in the Jaffna Peninsula and surroundin...