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Publications (30)
Introduction Inhibiting the signaling protein/gene involved in cancer progression may affect the signaling cascade and could be a possible targeted approach against progressive cancer. The present study aims to evaluate the anticancer potential of bioactive compounds from selected Himalayan pteridophytes by targeting the phosphoinositide 3 kinase (...
Most cancers have become immune to normal cancer therapy, like chemotherapy and radiation. Therefore, exploring more effective and economical treatment options is important. Plants and herbs contain substances called phytochemicals, which have biological effects. Many phytochemicals having antioxidant and anticancer properties have been studied pre...
High demand and ongoing technological advancements have created a market for sensors that is both varied and rapidly evolving. Bioactive compounds are separated systematically to conduct an in-depth investigation, allowing for the profiling or fingerprinting of different Plantae kingdoms. The profiling field is significant in elucidating the comple...
Psoriasis, an autoimmune inflammatory skin ailment, is among the most prevalent immune-mediated illnesses afflicting people worldwide. At the moment, traditional psoriasis therapeutic approaches have a lot of shortcomings such as limited effectiveness, itchy skin, immunosuppression, and so forth. As a result, researchers must develop a much more ef...
Objective: Fungal infections which are relatively common mainly invades the body of an immunosuppressed patients and people undergoing therapy. These pathogens act through different pathways like the Dihydrofolate reductase (DHFR) has a role in the folate synthetic pathway which is responsible for DNA synthesis. Since the early ages herbal remedies...
Background
Fungal infections have become a worldwide problem due to their involvement in numerous diseases. The risk factors for fungal infections are multiple surgeries, transplant therapies, frequent administration of antibiotics, cancer treatments, and prosthetic devices. The problem of resistance in fungi against drug therapies is widespread, b...
Amyotrophic lateral sclerosis” (ALS) is a progressive neuronal disorder that affects sensory neurons in the brain and spinal cord, causing loss of muscle control. Moreover, additional neuronal subgroups as well as glial cells such as microglia, astrocytes, and oligodendrocytes are also thought to play a role in the aetiology. The disease affects up...
Sesquiterpenes are important in human health because they can treat viral infection, cardiovascular disease, and cancer. Sesquiterpenes have also been shown to increase the sensitivity of tumor cells to conventional pharmacological therapies, in addition to their antiviral effects. The present review article was drafted with an intention to gather...
Background
Nature has bestowed mother Earth with an array of herbals utilized as therapeutics for various human ailments since the origin of life. Bryonia laciniosa (family: Cucurbitaceae) is one such herb which finds its mention in various traditional systems of medicine and has attracted the current researchers due to its significant therapeutic...
Biodegradable materials derived from natural sources are able to substitute synthetic polymer from the biomedical field as well as from other applications due to their advantages in degradability, renewability, lower density, biocompatibility, stability, radiolucent property, etc. As the demand for biomaterial increases, various research has been d...
The phytochemical, antioxidant, and antibacterial properties of Terminalia arjuna were investigated using a standard methodology. It's high in secondary metabolites such as alkaloids, glycosides, tannins, saponins, proteins, and steroid hormones. As well as carbs, The methanol extract had a DPPH value of 208.6. Terminalia On Aspergillus fumigatus (...
Background
Ramalin (γ-glutamyl-N'-(2-hydroxyphenyl) hydrazide), a nitrogen containing lichen secondary metabolite was isolated decennium back from Ramalina terebrata, an Antarctic lichen. Since then it has attracted a number of researchers thus leading to various research investigations exploring the pharmacological potential of Ramalin in the past...
The materials obtained from nature are regarded as the foundation for the development of numerous types of medicinal treatments. In past few years, the substances isolated from plant sources have been used as the advanced vehicles for distribution of drugs. The nanocarriers of protein nature are very abundantly used for the delivery of various phar...
Sleep which is often termed to be affected by psychological and physiological phenomena. It is the circadian rhythm or day and night cycle that is been controlled by suprachiasmatic nucleus of the hypothalamus of the brain. It is during this time that the cortex including the basal ganglia decrease their functions, but the brain is still subconscio...
Aims
To study various types of gynecological cancers and the available therapeutics to investigate safe and effective drugs.
Background
Cancer is the most common cause of mortality throughout the world. When the statistics is considered for gynecological cancers, ovarian, cervical and uterine cancers are among the most prevalent types. They have w...
Fibromyalgia syndrome is a persistent condition characterized by frequent body pain at different tender points, sleep disturbance, fatigue, anxiety, impaired condition, joint stiffness. 5% of the world population mainly middle and old aged people suffer from it. Women are more prone towards this disease. The underlying pathophysiology of this syndr...
The incidence and prevalence of Renal cell carcinoma (RCC) continues to grow making it the 7 th and 8 th most common cancer among men and women in the U.S. respectively. Loss or mutation of VHL (Von-Hippael Lindau) gene is yet known major cause of the development of RCC. This mutation or loss of VHL gene causes increased expression and production o...
Sarcoidosis is a disease in which inflammatory granulomas cells are formed in the affected areas of body. Sarcoidosis, without a known aetiology commonly affects lymph nodes, lung tissues, skin, CNS, eyes, muscles, bone and heart. Cardiac sarcoidosis (CS) an infiltrative granulomatous disease of the myocardium that may present in about 2-7% of sarc...
Background: Alcohol addiction is a social problem leading to both loss of health and economic prosperity among addicted individuals. Common properties of anti-addictive compounds include anti-anxiety, anticonvulsants, anti-depressant, and nootropic actions primarily through modulation of gamma-aminobutyric acid (GABA) and serotonergic systems. Obje...
Background: Alcohol addiction is a social problem leading to both loss of health and economic prosperity among addicted individuals. Common properties of anti‑addictive compounds include anti‑anxiety, anticonvulsants, anti‑depressant, and nootropic actions primarily through modulation of gamma‑aminobutyric acid (GABA) and serotonergic systems. Obje...
1,1-Diphenyl-2-picryl-hydrazyl (DPPH) and Phosphomolybdenum In-vitro assay was
employed to determine the antioxidant potency of peptidomimetics (Glu-arg), (Ile-arg), (Aspglu),
(Leu-arg), (Asp-pro-phe), (Gly-ala-leu-asp) using ascorbic acid as the standard drug.
The percentage scavenging activity of the peptidomimetics were determined at different
c...
1,1-Diphenyl-2-picryl-hydrazyl (DPPH) and Phosphomolybdenum In-vitro assay was
employed to determine the antioxidant potency of peptidomimetics (Glu-arg), (Ile-arg), (Aspglu), (Leu-arg), (Asp-pro-phe), (Gly-ala-leu-asp) using ascorbic acid as the standard drug. The percentage scavenging activity of the peptidomimetics were determined at different c...