Prince N. Agbedanu

Prince N. Agbedanu
Friends University · Health Sciences

PhD

About

28
Publications
2,180
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247
Citations
Citations since 2017
19 Research Items
193 Citations
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Publications

Publications (28)
Preprint
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Background In 2020, COVID-19 spread across the world and brought the world to a halt, causing the shutdown of nearly everything in order to prevent its spread. The NFL, like most of the world, faced shutdowns leaving athletes unable to train in some of the most advanced facilities with many of the best trainers in the world. Through a previous stud...
Preprint
BACKGROUND In 2020, COVID-19 spread across the world and brought the world to a halt, causing the shutdown of nearly everything in order to prevent its spread. The NFL experienced the same effects of the shutdowns leaving athletes unable to train in some of the most advanced facilities with many of the best trainers in the world. Through a previous...
Article
Full-text available
Antibiotic resistance by gram-negative bacteria is becoming a major global health crisis. The objective of this study is to examine the antibacterial activity of Ulmus pumila against a variety of infectious gram-negative bacteria. The extraction of Ulmus pumila leaves and flowers were carried out using 95% ethanol. The homogenate was filtered and s...
Article
Full-text available
This work uncovered the antibacterial properties of Nasturtium against gram-positive Streptococcus agalactiae. Certain strains of Streptococcus have demonstrated antibiotic resistance. Streptococcus agalactiae commonly infects the elderly, neonates, and pregnant women, which makes this a pathogen of concern. Samples of Nasturtium leaves and flowers...
Article
Full-text available
This paper highlights the novel antibacterial properties of Coleus scutellarioides against certain species of the domain bacteria, of which no Coleus antimicrobial activity was previously demonstrated. Coleus has demonstrated antimicrobial properties against many species of bacteria and fungi. However, the search for novel antimicrobial compounds i...
Article
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Due to the rampant microbial resistance to current antibiotics, there must be a necessary search for novel compounds with antimicrobial properties. In effort of this search in plants, this investigation demonstrates the antibacterial characteristics of Crassula ovata (C. ovata) against gram-positive bacteria and gram-negative bacteria. 1-3g samples...
Article
Background Sport injuries have been common among athletes across the globe for decades and have the potential to disrupt athletic careers, performance, and psyche. Many health professionals and organizations have undertaken injury mitigation strategies to prevent sport injuries through protective equipment, training protocols, and a host of other e...
Article
Full-text available
This study was conducted to determine antimicrobial properties of the Taraxacum officinale against Enterobacter cloacae. 2g samples of Taraxacum officinale were extracted with 95% ethanol. The suspension or 95% ethanol was infused into sterile discs. The discs were placed on bacterial plated plates and incubated at 37 degrees Celsius for 24 hours a...
Preprint
Purpose This study explores the antimicrobial spectrum of Ulmus pumila by screening commonly infectious gram-negative bacteria for susceptibility. Currently, many gram-negative bacteria are developing resistance to recommended antibiotic therapies used in clinical practice. It is imperative that we continue to explore new antimicrobial compounds in...
Preprint
This study investigates the antimicrobial properties of Crassula ovata (C. ovata) against both gram-positive and gram-negative bacteria. About 1-3g samples of C. Ovata leaf samples were extracted with 95 % ethanol and the extract infused into paper discs by soaking and drying. The dried discs were screened against various strains of bacteria and th...
Article
Full-text available
1. Aim/Background: Reactive oxygen species (ROS) have been identified as compounds responsible for producing cellular damage. The purpose of this research is to examine if there is production of reactive oxygen species through free radical intermediates within human hepatocytes treated with morphine, bilirubin, or furosemide. The investigation exam...
Preprint
BACKGROUND Sport injuries have been common among athletes across the globe for decades and have the potential to disrupt athletic careers, performance, and psyche. Many health professionals and organizations have undertaken injury mitigation strategies to prevent sport injuries through protective equipment, training protocols, and a host of other e...
Preprint
Full-text available
1. Purpose During the COVID 19 Pandemic, the NFL teams have been reported to have limited training sections in preparation for their games. This study compares the prevalence of injury during the 2018, 2019, and 2020 NFL seasons, with the aim to determine the potential causes of the differences in prevalence. 2. Method Official injury reports from...
Preprint
The concept of bioremediation is quickly becoming the norm in the resolution of environmental issues. The steady increase in carbon dioxide levels, as documented by NASA, inspired scientists to engineer plants to absorb excess carbon dioxide from the atmosphere. Here, we have explored the consequences of the uptake of excess carbon dioxide by selec...
Preprint
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Cancer is a disease characterized by high mitosis rates with a loss of regulation. Many antineoplastics, those drugs used to treat cancer, act by slowing or halting mitosis. We are developing a whole-organism screening protocol to identify novel antineoplastics. After exposing Drosophila melanogaster eggs and larva to a compound, their growth rate...
Article
Full-text available
Lymphatic filariasis (LF) is a socioeconomically devastating mosquito-borne Neglected Tropical Disease caused by parasitic filarial nematodes. The interaction between the parasite and host, both mosquito and human, during infection, development and persistence is dynamic and delicately balanced. Manipulation of this interface to the detriment of th...
Article
Meningeal worms (Parelaphostrongylus tenuis) are a common malady of alpacas, often refractory to conventional treatments. Ivermectin is a very effective anthelmintic used against a variety of parasites but this drug is not consistently effective against alpaca meningeal worms once the parasite has gained access to the CNS, even if used in a protrac...
Article
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Praziquantel (PZQ) is a key therapy for treatment of parasitic flatworm infections of humans and livestock, but the mechanism of action of this drug is unresolved. Resolving PZQ-engaged targets and effectors is important for identifying new druggable pathways that may yield novel antiparasitic agents. Here we use functional, genetic and pharmacolog...
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Neglected diseases caused by helminth infections impose a massive hindrance to progress in the developing world. While basic research on parasitic flatworms (platyhelminths) continues to expand, researchers have yet to broadly adopt a free-living model to complement the study of these important parasites. We report the high-coverage sequencing (RNA...
Article
Full-text available
Author Summary Schistosomiasis (Bilharzia) is one of the most burdensome parasitic worm infections, encumbering third world economies with an annual loss of several million disability-adjusted life years. The key treatment for schistosome infections is the drug praziquantel but the mechanism of action of this drug remains controversial hampering ta...
Article
Objective: To evaluate the effect of IV administration of polymyxin B on clinical and serum biochemical variables in foals with experimental endotoxemia. Design: Prospective experimental study. Animals: 14 healthy neonatal foals. Procedures: Foals were randomly assigned to a treatment or control group and were administered a single dose of l...
Article
Full-text available
Entamoeba histolytica is the causative agent of amoebic dysentery, a worldwide protozoal disease that results in approximately 100,000 deaths annually. The virulence of E. histolytica may be due to interactions with the host bacterial flora, whereby trophozoites engulf colonic bacteria as a nutrient source. The engulfment process depends on trophoz...
Article
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In an effort to investigate the molecular basis of protozoa engulfment-mediated hypervirulence of Salmonella in cattle, we evaluated protozoan G protein-coupled receptors (GPCRs) as transducers of Salmonella engulfment by the model protozoan Tetrahymena. Our laboratory previously demonstrated that non-pathogenic protozoa (including Tetrahymena) eng...
Article
Full-text available
G protein-coupled receptors (GPCRs) represent the largest known superfamily of membrane proteins extending throughout the Metazoa. There exists ample motivation to elucidate the functional properties of GPCRs given their role in signal transduction and their prominence as drug targets. In many target organisms, these efforts are hampered by the unr...

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